troxacitabine has been researched along with cytarabine in 14 studies
| Studies (troxacitabine) | Trials (troxacitabine) | Recent Studies (post-2010) (troxacitabine) | Studies (cytarabine) | Trials (cytarabine) | Recent Studies (post-2010) (cytarabine) |
|---|---|---|---|---|---|
| 72 | 17 | 2 | 15,487 | 2,424 | 3,188 |
| Protein | Taxonomy | troxacitabine (IC50) | cytarabine (IC50) |
|---|---|---|---|
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 7.533 | |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | 0.02 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 11 (78.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adema, AD; Alexander, LE; Cho, JH; Chu, CK; Daft, JR; Hoebe, EK; Peters, GJ; Radi, M | 1 |
| Cheng, YC; Chu, CK; Gao, Z; Grove, KL; Guo, X; Liu, SH | 1 |
| Cheng, YC; Grove, KL | 1 |
| Cheng, YC; Chou, KM; Kukhanova, M | 1 |
| Dumontet, C; Galmarini, CM; Mackey, JR | 1 |
| Johnson, SA | 1 |
| Cass, CE; Clarke, ML; Gourdeau, H; Jolivet, J; Lafrenière, RG; Lee, N; Mackey, JR; Mowles, D; Ouellet, F; Richard, A; Selner, M; Young, JD | 1 |
| Giles, FJ | 1 |
| Cortes, JE; Douer, D; Estey, EH; Faderl, S; Garcia-Manero, G; Giles, FJ; Jeha, SS; Kantarjian, HM; Koller, CA; Levine, AM; O'Brien, SM; Thomas, DA | 1 |
| Berry, DA; Cortes, JE; Estey, EH; Faderl, S; Ferrajoli, A; Garcia-Manero, G; Giles, FJ; Kantarjian, HM; O'Brien, S; Thomas, DA; Verstovsek, S; Wathen, JK; Xiao, LC | 1 |
| Barbeau, S; Bouffard, DY; Gourdeau, H; Hamelin, B; Jolivet, J; Leblond, L; Ouellet, F; Richard, A | 1 |
| Boivin, AJ; Gourdeau, H; Momparler, RL | 1 |
| Liu, X; Matsuda, A; Plunkett, W; Wang, Y | 1 |
| Czemerska, M; Grzybowska-Izydorczyk, O; Pluta, A; Robak, T; Szmigielska-Kapłon, A; Wierzbowska, A; Wolska, A | 1 |
4 review(s) available for troxacitabine and cytarabine
| Article | Year |
|---|---|
Nucleoside analogues: mechanisms of drug resistance and reversal strategies.
Topics: 2-Chloroadenosine; 5'-Nucleotidase; Acute Disease; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Biological Transport; Carrier Proteins; Cytarabine; Cytidine Deaminase; Cytosine; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dioxolanes; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Gemcitabine; Hematopoietic Cell Growth Factors; Humans; Leukemia, Myeloid; Lymphoproliferative Disorders; Neoplastic Stem Cells; Nucleosides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Remission Induction; Ribonucleotide Reductases; Vidarabine | 2001 |
Nucleoside analogues in the treatment of haematological malignancies.
Topics: Antimetabolites, Antineoplastic; Arabinonucleosides; Biological Transport; Cladribine; Clinical Trials as Topic; Cytarabine; Cytosine; Deoxycytidine; Dioxolanes; Economics, Pharmaceutical; Gemcitabine; Guidelines as Topic; Hematologic Neoplasms; Humans; Molecular Structure; Nucleosides; Pentostatin; Vidarabine | 2001 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytosine; Dioxolanes; Humans; Idarubicin; Leukemia; Remission Induction; Topotecan | 2002 |
Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.
Topics: Adenine Nucleotides; Animals; Arabinonucleosides; Azacitidine; Benzamides; Clofarabine; Cytarabine; Cytosine; Daunorubicin; Decitabine; Dioxolanes; Farnesyltranstransferase; Histone Deacetylase Inhibitors; Humans; Hydrazines; Imatinib Mesylate; Leukemia, Myeloid, Acute; Liposomes; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Sulfonamides; TOR Serine-Threonine Kinases; Valproic Acid; Vascular Endothelial Growth Factor Receptor-1 | 2011 |
2 trial(s) available for troxacitabine and cytarabine
| Article | Year |
|---|---|
Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Cytosine; Dioxolanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Idarubicin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Topotecan; Treatment Outcome | 2003 |
Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxacitabine and idarubicin in untreated patients 50 years or older with adverse karyotype acute myeloid leukemia.
Topics: Acute Disease; Age Factors; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytosine; Dioxolanes; Female; Humans; Idarubicin; Infusions, Intravenous; Karyotyping; Leukemia, Myeloid; Male; Middle Aged; Prognosis; Survival; Treatment Outcome | 2003 |
8 other study(ies) available for troxacitabine and cytarabine
| Article | Year |
|---|---|
In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytosine; Dioxolanes; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2007 |
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Cytarabine; Cytosine; Dioxolanes; Drug Screening Assays, Antitumor; Humans; KB Cells; Leukemia P388; Liver Neoplasms; Male; Mice; Molecular Structure; Phosphorylation; Prostatic Neoplasms; Stereoisomerism; Tumor Cells, Cultured | 1995 |
Uptake and metabolism of the new anticancer compound beta-L-(-)-dioxolane-cytidine in human prostate carcinoma DU-145 cells.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Line; Cytarabine; Cytosine; Dioxolanes; DNA, Neoplasm; Humans; Kinetics; Male; Prostatic Neoplasms; Tritium; Tumor Cells, Cultured | 1996 |
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.
Topics: Anions; Antineoplastic Agents; Antiviral Agents; Blotting, Western; Carbon-Oxygen Lyases; Cations; Chromatography, Agarose; Chromatography, Ion Exchange; Cytarabine; Cytosine; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonuclease IV (Phage T4-Induced); Dioxolanes; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Electrophoresis, Polyacrylamide Gel; Endonucleases; Humans; Oligonucleotides; Recombinant Proteins; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thionucleosides; Tumor Cells, Cultured; Zalcitabine | 2000 |
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cytarabine; Cytidine Deaminase; Cytosine; Deoxycytidine; Deoxycytidine Kinase; Dioxolanes; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Male; Membrane Proteins; Molecular Sequence Data; Nucleoside Transport Proteins; Phosphorylation; Prostatic Neoplasms; Sequence Homology, Amino Acid; Sodium; Stereoisomerism; Tritium; Tumor Cells, Cultured; Uridine | 2001 |
Complementary antineoplastic activity of the cytosine nucleoside analogues troxacitabine (Troxatyl) and cytarabine in human leukemia cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line, Tumor; Cell Survival; Cytarabine; Cytosine; Dioxolanes; DNA, Neoplasm; Female; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Leukemia, Experimental; Mice; Mice, SCID; Neoplasm Transplantation | 2003 |
Action of troxacitabine on cells transduced with human cytidine deaminase cDNA.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cytarabine; Cytidine Deaminase; Cytosine; Dioxolanes; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Transduction, Genetic; Tumor Cells, Cultured | 2004 |
Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cytarabine; Cytosine; Dioxolanes; DNA Damage; DNA Repair; HeLa Cells; Humans; Mice; Transcription, Genetic; Tumor Suppressor Protein p53 | 2008 |