Compounds > trovirdine

trovirdine and 2--3--didehydro-2--3--dideoxyuridine

trovirdine has been researched along with 2--3--didehydro-2--3--dideoxyuridine* in 1 studies

Other Studies

1 other study(ies) available for trovirdine and 2--3--didehydro-2--3--dideoxyuridine

ArticleYear
Synthesis and anti-HIV activity of [d4U]-[trovirdine analogue] and [d4T]-[trovirdine analogue] heterodimers as inhibitors of HIV-1 reverse transcriptase.
    Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:8-9

    A series of eleven heterodimers containing both a nucleoside analogue (d4U, d4T) and a non-nucleoside type inhibitor (Trovirdine analogue) were synthesized and evaluated for their ability to inhibit HIV replication. Unfortunately, the (N-3)d4U-Trovirdine conjugates (9a-e) and (N-3)d4T-Trovirdine conjugates (10a-f) were found to be inactive suggesting that the two individual inhibitor compounds do not bind simultaneously in their respective sites.

    Topics: Anti-HIV Agents; Dideoxynucleosides; Dimerization; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Humans; Lymphocytes; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; Tumor Cells, Cultured; Zidovudine

2002