Page last updated: 2024-08-24

trovafloxacin and levofloxacin

trovafloxacin has been researched along with levofloxacin in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (23.88)	18.2507
2000's	38 (56.72)	29.6817
2010's	9 (13.43)	24.3611
2020's	4 (5.97)	2.80

Authors

Authors	Studies
Inagaki, H; Kawakami, K; Kawato, HC; Matsuhashi, N; Miyauchi, RN; Miyauchi, S; Ohki, H; Takahashi, H; Takemura, M	1
Appelbaum, PC; Bhawsar, SB; Bozdogan, B; de Souza, NJ; Desai, VN; Deshpande, PK; Gupte, SV; Hooper, DC; Jacobs, MR; Jha, R; Khorakiwala, HF; Patel, MV; Shetty, N; Shukla, MC; Strahilevitz, J; Yeole, RD	1
Ho, YR; Hung, KH; Janapatla, RP; Wu, CW; Wu, HM; Wu, JJ; Yan, JJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Azéma, J; Dewelle, J; Guidetti, B; Kiss, R; Korolyov, A; Le Calve, B; Malet-Martino, M; Martino, R; Mijatovic, T; Vaysse, J	1
Inagaki, H; Ito, M; Kawakami, K; Matsuhashi, N; Miyauchi, R; Ohki, H; Takahashi, H; Takemura, M	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blaskovich, MAT; Pham, TDM; Ziora, ZM	1
Bhagwat, S; Bhawsar, S; Deshpande, P; Joshi, S; Patel, M; Yeole, R	1
Hecht, DW; Wexler, HM	1
Goldstein, EJ	1
Dvorak, T; Ho, DH; LeBlanc, B; Rolston, KV; Streeter, H	1
Hoogkamp-Korstanje, JA	1
Ernst, EJ; Ernst, ME; Klepser, ME	1
Bauernfeind, A	1
Brookings, E; Gray, B; Nix, S; Robinson, A; Swiatlo, E; Waites, K	1
Citron, DM; Goldstein, EJ; Hudspeth, M; Hunt Gerardo, S; Merriam, CV	1
Alperstein, P; France, K; Isenberg, HD	2
Giamarellos-Bourboulis, EJ; Giamarellou, H; Grecka, P; Sambatakou, H	1
Heisig, P; Jones, ME; Klootwijk, M; Schmitz, FJ; Verhoef, J; Visser, MR	1
Appelbaum, PC; Hoellman, DB; Jacobs, MR; Lin, G	1
Gootz, TD; Haskell, SL; Kaczmarek, FS; Maurice, AE; Zaniewski, RP	1
Beyer, R; Cianciotto, NP; Noskin, GA; Pestova, E; Peterson, LR	1
Brisse, S; Fluit, AC; Köhrer, K; Martin, N; Milatovic, D; Scheuring, S; Schmitz, FJ; Verhoef, J	1
Hershberger, E; Rybak, MJ	1
Anderson, VE; Gootz, TD; Kaczmarek, FS; Osheroff, N; Zaniewski, RP	1
Bjarnason, J; Blondeau, JM; Laskowski, R; Stewart, C	1
Armbruster, C; Griesmacher, A; Robibaro, B; Vorbach, H	1
Edmond, M; Heinemann, B; Seifert, H; Wisplinghoff, H	1
Coleman, EJ; Mandell, GL	1
Kanayama, A; Kobayashi, I; Mochida, O; Naito, S; Saika, T; Tanaka, M; Tunoe, H	1
Ferraro, MJ; Jorgensen, JH; Swenson, JM; Tenover, FC; Weigel, LM; Whitney, CG	1
Bravos, PD; Frenkel, B; Holtom, PD; Patzakis, MJ; Pavkovic, SA; Shepherd, LE	1
Doern, GV; Ernst, EJ; Klepser, ME; Petzold, CR; Rhomberg, P	1
Dworkin, RJ; Gilbert, DN; Grunkemeier, G; Kohlhepp, SJ; Leggett, JE; Lewis, G; Slama, KA; Slaughter, SE	1
Hovde, LB; Peterson, ML; Ross, GH; Rotschafer, JC; Wright, DH	1
Ball, P	1
Bonner, D; Fung-Tomc, J; Gradelski, E; Kolek, B; Valera, L	1
Adrián, F; del Campo, R; García, C; Gómez-Lus, P; Gómez-Lus, R; Rubio, MC; Sánchez, S	1
Mendes, CM; Nicodemo, AC; Oplustil, CP; Sinto, S	1
Yagawa, K	1
Ambler, J; Cardeñosa, O; Lemme, L; Lopez, H; Scarano, S; Smayevsky, J; Stepanik, D; Sucari, A; Vilches, V	1
Brown, GH; Hoang, AD; Hovde, LB; Peterson, ML; Rotschafer, JC; Wright, DH	1
Evans, ME	1
Picazo, JJ; Rodríguez-Avial, C; Rodríguez-Avial, I	1
Appelbaum, PC; Bozdogan, B; Clark, CL; Davies, TA; Dewasse, B; Jacobs, MR; Nagai, K	1
Frisbee-Hume, S; Ho, DH; LeBlanc, BM; Rolston, KV; Streeter, H	1
Aguilar, L; Garcia-Mendez, E; Jiménez De Anta, MT; Marco, F; Mensa, J; Ruiz, J; Sierra, JM; Vila, J	1
Hanssen, AD; Patel, R; Perry, AC; Piper, KE; Prpa, B; Rouse, MS; Steckelberg, JM	1
Almer, LS; Balli, DJ; Beyer, JM; Cai, Y; Flamm, RK; Hensey-Rudloff, D; Nilius, AM; Shen, LL	1
Schooley, S; Stein, GE	1
Cabeza, JG; Hernandez, J; Llagostera, M; Mensa, J; Montero, T; Ruiz Chaler, M; Sierra, JM; Vila, J	1
Ali, SH; Chandraker, A; DeCaprio, JA	1
Ganey, PE; Hopfensperger, MJ; Roth, RA; Shaw, PJ	1
Blomme, EA; Ditewig, AC; Ganey, PE; Liguori, MJ; Roth, RA; Shaw, PJ; Waring, JF	1
Crogan-Grundy, C; Funk, J; Nguyen, DG; Presnell, SC; Robbins, JB; Roth, AB; Singer, T	1
Bleumink, R; Bol-Schoenmakers, M; Giustarini, G; Kruijssen, L; Pieters, R; Smit, J; van Roest, M; Weaver, RJ	1
Marchant, J	1
Cui, HR; Hu, YS; Tang, HB; Wang, JG	1
Ahn, J; Ahn, JH; Cho, HS; Choi, MS; Han, HY; Jegal, H; Kim, S; Oh, JH; Park, SM; Yoon, S	1
Graf, K; Kaden, T; Li, R; Mosig, AS; Raasch, M; Rennert, K	1

Reviews

6 review(s) available for trovafloxacin and levofloxacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Quinolone antibiotics. MedChemComm, 2019, Oct-01, Volume: 10, Issue:10 Topics:	2019
Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Bacterial Infections; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolones; Safety; Syndrome	1996
Levofloxacin and trovafloxacin: the next generation of fluoroquinolones? American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Nov-15, Volume: 54, Issue:22 Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin	1997
Latest industry information on the safety profile of levofloxacin in Japan. Chemotherapy, 2001, Volume: 47 Suppl 3 Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Central Nervous System; Chemical and Drug Induced Liver Injury; Dermatitis, Phototoxic; Drug Industry; Fluoroquinolones; Heart Diseases; Humans; Japan; Levofloxacin; Naphthyridines; Ofloxacin; Seizures; Substance Withdrawal Syndrome	2001
Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis. Medicine, 2020, Aug-21, Volume: 99, Issue:34 Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Case-Control Studies; Child; Child, Preschool; Female; Fluoroquinolones; Humans; Infant; Infant, Newborn; Levofloxacin; Male; Musculoskeletal System; Naphthyridines; Retrospective Studies; Sensitivity and Specificity; Topoisomerase II Inhibitors	2020

Other Studies

61 other study(ies) available for trovafloxacin and levofloxacin

Article	Year
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 Topics: Anti-Bacterial Agents; Cyclopropanes; Drug Resistance, Bacterial; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Stereoisomerism; Structure-Activity Relationship	2003
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Dogs; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Mutation; Prodrugs; Quinolizines; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vancomycin Resistance	2005
Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Bacterial Proteins; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Ofloxacin; Streptococcus agalactiae; Taiwan	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. Bioorganic & medicinal chemistry, 2009, Aug-01, Volume: 17, Issue:15 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Humans; Maximum Tolerated Dose; Mice; Neoplasms; Piperazine; Piperazines	2009
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Anti-Bacterial Agents; Drug Design; Drug Resistance, Multiple; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections. Bioorganic & medicinal chemistry letters, 2022, 05-01, Volume: 63 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperidines; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus; Streptococcus pneumoniae; Structure-Activity Relationship	2022
In vitro susceptibility of anaerobes to quinolones in the United States. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Culture Media; Drug Resistance, Microbial; Evaluation Studies as Topic; Fluoroquinolones; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Quinolones; United States	1996
In-vitro activity of trovafloxacin against clinical bacterial isolates from patients with cancer. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Neoplasms; Norfloxacin; Ofloxacin; Quinolones	1997
In-vitro activities of ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, pefloxacin, sparfloxacin and trovafloxacin against gram-positive and gram-negative pathogens from respiratory tract infections. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pefloxacin; Quinolones; Respiratory Tract Infections	1997
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:5 Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Enterobacteriaceae; Fluoroquinolones; Gatifloxacin; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Quinolones; Staphylococcus aureus	1997
Comparative in vitro activities of four new fluoroquinolones against Streptococcus pneumoniae determined by Etest. International journal of antimicrobial agents, 1998, Volume: 9, Issue:4 Topics: Anti-Infective Agents; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Streptococcus pneumoniae	1998
Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:3 Topics: Animals; Anti-Bacterial Agents; Azithromycin; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Bites and Stings; Bites, Human; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Species Specificity; Wound Infection	1998
In vitro susceptibility of recent gram-positive isolates to ciprofloxacin, levofloxacin, and trovafloxacin. Diagnostic microbiology and infectious disease, 1998, Volume: 32, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Corynebacterium; Drug Resistance, Microbial; Fluoroquinolones; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	1998
In vitro activity of quinupristin/dalfopristin and newer quinolones combined with gentamicin against resistant isolates of Enterococcus faecalis and Enterococcus faecium. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:9 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Enterococcus faecium; Fluoroquinolones; Gentamicins; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Virginiamycin	1998
Comparative activities of clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and nonquinolones linozelid, quinupristin-dalfopristin, gentamicin, and vancomycin against clinical isolates of ciprofloxacin-re Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gentamicins; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Quinolones; Staphylococcus aureus; Vancomycin; Virginiamycin	1999
In vitro activity of ciprofloxacin, levofloxacin, and trovafloxacin, alone and in combination with beta-lactams, against clinical isolates of Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Burkholderia cepacia. Diagnostic microbiology and infectious disease, 1999, Volume: 33, Issue:2 Topics: Anti-Infective Agents; beta-Lactams; Burkholderia cepacia; Ciprofloxacin; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Pseudomonas aeruginosa; Xanthomonas	1999
Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:5 Topics: Amoxicillin; Anti-Infective Agents; Ceftriaxone; Cefuroxime; Cephalosporins; Ciprofloxacin; Clarithromycin; Fluoroquinolones; Gatifloxacin; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Penicillin Resistance; Streptococcus pneumoniae	1999
Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Adrenergic Uptake Inhibitors; Anti-Infective Agents; Antitubercular Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA, Bacterial; DNA, Superhelical; Drug Interactions; Drug Resistance, Microbial; Enzyme Inhibitors; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Reserpine; Staphylococcus aureus; Topoisomerase II Inhibitors	1999
Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Anti-Infective Agents; Antitubercular Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA, Bacterial; Drug Resistance, Microbial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Phenotype; Streptococcus pneumoniae; Transformation, Bacterial	1999
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterat Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Enterobacter cloacae; Fluoroquinolones; Gatifloxacin; Humans; Klebsiella pneumoniae; Levofloxacin; Microbial Sensitivity Tests; Molecular Sequence Data; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	1999
Activities of trovafloxacin, gatifloxacin, clinafloxacin, sparfloxacin, levofloxacin, and ciprofloxacin against penicillin-resistant Streptococcus pneumoniae in an in vitro infection model. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3 Topics: Anti-Infective Agents; Blood Coagulation; Ciprofloxacin; Fibrin; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae	2000
Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement. Biochemistry, 2000, Mar-14, Volume: 39, Issue:10 Topics: Anti-Infective Agents; Catalysis; Ciprofloxacin; DNA; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Levofloxacin; Naphthyridines; Ofloxacin; Staphylococcus aureus; Topoisomerase II Inhibitors	2000
Comparative in vitro activity of gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin and trovafloxacin against 4151 Gram-negative and Gram-positive organisms. International journal of antimicrobial agents, 2000, Volume: 14, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines	2000
Endothelial cell compatibility of trovafloxacin and levofloxacin for intravenous use. The Journal of antimicrobial chemotherapy, 2000, Volume: 45, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anti-Infective Agents; Cell Survival; Chromatography, High Pressure Liquid; Culture Media; Endothelium, Vascular; Female; Fluoroquinolones; Guanosine Diphosphate; Guanosine Triphosphate; Humans; In Vitro Techniques; Levofloxacin; Naphthyridines; Ofloxacin; Pregnancy; Umbilical Veins	2000
Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:8 Topics: Acinetobacter; Acinetobacter Infections; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Disease Outbreaks; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Germany; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	2000
Activities of antimicrobial agents against intracellular pneumococci. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:9 Topics: Anti-Bacterial Agents; Aza Compounds; Azithromycin; Fluoroquinolones; Gentamicins; Humans; Ketolides; Levofloxacin; Macrolides; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Penicillin G; Quinolines; Rifampin; Streptococcus pneumoniae; Tumor Cells, Cultured	2000
Antimicrobial activity of gemifloxacin (SB-265805), a newer fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae, including fluoroquinolone-resistant isolates. Diagnostic microbiology and infectious disease, 2000, Volume: 38, Issue:2 Topics: Amoxicillin; Anti-Infective Agents; Ciprofloxacin; Clavulanic Acid; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Gonorrhea; Humans; Levofloxacin; Naphthyridines; Neisseria gonorrhoeae; Norfloxacin; Ofloxacin	2000
Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11 Topics: Anti-Bacterial Agents; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Streptococcus pneumoniae	2000
Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2000, Volume: 18, Issue:5 Topics: Animals; Anti-Infective Agents; Bromodeoxyuridine; Calcification, Physiologic; Cell Count; Cell Division; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; Extracellular Matrix; Fluoroquinolones; Levofloxacin; Mice; Naphthyridines; Ofloxacin; Osteoblasts	2000
Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Colony Count, Microbial; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Models, Biological; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Streptococcus pneumoniae; Time Factors	2001
Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enterobacteriaceae; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Phenotype; Pseudomonas aeruginosa; Regression Analysis; Reproducibility of Results; Staphylococcus aureus	2001
Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:7 Topics: Anti-Infective Agents; Bacteroides; Drug Resistance, Microbial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Time Factors	2001
Safety of the new fluoroquinolones compared with ciprofloxacin. Journal of chemotherapy (Florence, Italy), 2000, Volume: 12 Suppl 1 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Piperazines	2000
Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and beta-lactams. International journal of antimicrobial agents, 2001, Volume: 18, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; beta-Lactams; Enterobacteriaceae; Enterococcus faecalis; Fluoroquinolones; Indoles; Kinetics; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Staphylococcus aureus; Streptococcus; Vancomycin	2001
Comparative in vitro bacteriostatic and bactericidal activity of trovafloxacin, levofloxacin and moxifloxacin against clinical and environmental isolates of Legionella spp. International journal of antimicrobial agents, 2001, Volume: 18, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Fluoroquinolones; Humans; Legionella; Legionellosis; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Rifampin	2001
In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2001, Volume: 5, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Gatifloxacin; Levofloxacin; Macrolides; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pneumococcal Infections; Streptococcus pneumoniae	2001
Multicentre study of the in vitro evaluation of moxifloxacin and other quinolones against community acquired respiratory pathogens. International journal of antimicrobial agents, 2001, Volume: 18, Issue:4 Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Community-Acquired Infections; Fluoroquinolones; Haemophilus influenzae; Humans; Levofloxacin; Microbial Sensitivity Tests; Moraxella catarrhalis; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Respiratory Tract Infections; Streptococcus pneumoniae; Streptococcus pyogenes	2001
Pharmacodynamics of trovafloxacin and levofloxacin against Bacteroides fragilis in an in vitro pharmacodynamic model. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:1 Topics: Anti-Infective Agents; Area Under Curve; Bacteroides fragilis; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Time Factors	2002
Determining the frequency of resistance of Streptococcus pneumoniae to ciprofloxacin, levofloxacin, trovafloxacin, grepafloxacin, and gemifloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2001, Volume: 20, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Streptococcus pneumoniae	2001
[In vitro activity of six fluoroquinolones and penicillin against 101 viridans group streptococci characterized by their susceptibility to erythromycin]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2001, Volume: 14, Issue:4 Topics: Anti-Infective Agents; Aza Compounds; Bacteremia; Ciprofloxacin; Drug Resistance; Drug Resistance, Multiple, Bacterial; Erythromycin; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Norfloxacin; Ofloxacin; Penicillins; Quinolines; Streptococcal Infections; Streptococcus	2001
Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2002, Volume: 8, Issue:6 Topics: Anti-Infective Agents; Aza Compounds; Biological Transport; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Indoles; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Streptococcus pneumoniae	2002
Antimicrobial activity of a novel des-fluoro (6) quinolone, garenoxacin (BMS-284756), compared to other quinolones, against clinical isolates from cancer patients. Diagnostic microbiology and infectious disease, 2002, Volume: 44, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Female; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Indoles; Levofloxacin; Male; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Sensitivity and Specificity	2002
In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene. International journal of antimicrobial agents, 2003, Volume: 22, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Genes, Bacterial; Gonorrhea; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Nalidixic Acid; Naphthyridines; Neisseria gonorrhoeae; Ofloxacin; Quinolines	2003
Levofloxacin and trovafloxacin inhibition of experimental fracture-healing. Clinical orthopaedics and related research, 2003, Issue:414 Topics: Animals; Anti-Infective Agents; Biomechanical Phenomena; Femoral Fractures; Fluoroquinolones; Fracture Healing; Levofloxacin; Male; Naphthyridines; Ofloxacin; Radiography; Random Allocation; Rats; Rats, Wistar	2003
In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:10 Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Blood Proteins; Ciprofloxacin; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Protein Binding; Quinolones; Rats	2003
Urinary concentrations and bactericidal activities of newer fluoroquinolones in healthy volunteers. International journal of antimicrobial agents, 2004, Volume: 24, Issue:2 Topics: Adult; Anti-Infective Agents; Aza Compounds; Enterobacteriaceae; Enterococcus faecalis; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Male; Microbial Sensitivity Tests; Middle Aged; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	2004
The selection of resistance to and the mutagenicity of different fluoroquinolones in Staphylococcus aureus and Streptococcus pneumoniae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:9 Topics: Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Levofloxacin; Moxifloxacin; Mutagenicity Tests; Naphthyridines; Ofloxacin; Quinolines; Selection, Genetic; Staphylococcus aureus; Streptococcus pneumoniae	2005
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antiviral therapy, 2007, Volume: 12, Issue:1 Topics: Antigens, Polyomavirus Transforming; Antiviral Agents; Cell Line, Tumor; Ciprofloxacin; Cytopathogenic Effect, Viral; DNA Helicases; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Reproducibility of Results; Simian virus 40; Time Factors; Viral Plaque Assay; Virus Replication	2007
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 100, Issue:1 Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Etanercept; Fluoroquinolones; Immunoglobulin G; Inflammation; Levofloxacin; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Naphthyridines; Ofloxacin; Pentoxifylline; Receptors, Tumor Necrosis Factor; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha	2007
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 107, Issue:1 Topics: Analysis of Variance; Animals; Chemical and Drug Induced Liver Injury; Female; Fluoroquinolones; Gene Expression; Hepatocytes; Inflammation; Interferon-gamma; Interleukin-18; Janus Kinases; Levofloxacin; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Necrosis; Ofloxacin; Oligonucleotide Array Sequence Analysis; STAT Transcription Factors; Transcriptional Activation	2009
Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro. PloS one, 2016, Volume: 11, Issue:7 Topics: Albumins; Bioprinting; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Drug-Related Side Effects and Adverse Reactions; Fluoroquinolones; Hepatocytes; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Levofloxacin; Lipopolysaccharides; Liver; Naphthyridines; Platelet Endothelial Cell Adhesion Molecule-1	2016
Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice. Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:5 Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Flow Cytometry; Fluoroquinolones; Leukocytes; Levofloxacin; Liver; Male; Mice; Mice, Inbred C57BL; Monocytes; Naphthyridines; Neutrophils; Tumor Necrosis Factor-alpha	2018
When antibiotics turn toxic. Nature, 2018, 03-22, Volume: 555, Issue:7697 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antioxidants; Ciprofloxacin; Female; Fluoroquinolones; Genetic Testing; Humans; Inactivation, Metabolic; Levofloxacin; Male; Mice; Mitochondria; Naphthyridines; Ofloxacin; Oxidative Stress; Syndrome; Topoisomerase II Inhibitors; United States; United States Food and Drug Administration	2018
TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicology letters, 2021, May-15, Volume: 342 Topics: Antimalarials; Autophagy; Cell Survival; Chloroquine; Fluoroquinolones; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Levofloxacin; MAP Kinase Kinase 4; Naphthyridines; Piperazines; Ribosomal Protein S6 Kinases, 70-kDa; Serotonin and Noradrenaline Reuptake Inhibitors; TOR Serine-Threonine Kinases; Triazoles; Tumor Necrosis Factor-alpha	2021
Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. Scientific reports, 2023, 08-16, Volume: 13, Issue:1 Topics: Animals; Cytokines; Drug-Related Side Effects and Adverse Reactions; Endothelial Cells; Fluoroquinolones; Hepatitis; Humans; Levofloxacin	2023