Page last updated: 2024-08-24

trovafloxacin and ciprofloxacin

trovafloxacin has been researched along with ciprofloxacin in 137 studies

Research

Studies (137)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	63 (45.99)	18.2507
2000's	60 (43.80)	29.6817
2010's	12 (8.76)	24.3611
2020's	2 (1.46)	2.80

Authors

Authors	Studies
Inagaki, H; Kawakami, K; Kawato, HC; Matsuhashi, N; Miyauchi, RN; Miyauchi, S; Ohki, H; Takahashi, H; Takemura, M	1
Koike, T; Kuramoto, Y; Ohshita, Y; Shiro, M; Yazaki, A; Yoshida, J	1
Choi, DR; Jung, YH; Shin, JH; Yang, J; Yoon, SH	1
Jolivette, LJ; Ward, KW	1
Jolivette, LJ; Nagilla, R; Ward, KW	1
Appelbaum, PC; Bhawsar, SB; Bozdogan, B; de Souza, NJ; Desai, VN; Deshpande, PK; Gupte, SV; Hooper, DC; Jacobs, MR; Jha, R; Khorakiwala, HF; Patel, MV; Shetty, N; Shukla, MC; Strahilevitz, J; Yeole, RD	1
Ho, YR; Hung, KH; Janapatla, RP; Wu, CW; Wu, HM; Wu, JJ; Yan, JJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
Gikas, A; Psaroulaki, A; Spyridaki, I; Tselentis, Y; Vranakis, I	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Azéma, J; Dewelle, J; Guidetti, B; Kiss, R; Korolyov, A; Le Calve, B; Malet-Martino, M; Martino, R; Mijatovic, T; Vaysse, J	1
Inagaki, H; Ito, M; Kawakami, K; Matsuhashi, N; Miyauchi, R; Ohki, H; Takahashi, H; Takemura, M	1
Avdeef, A; Sun, N; Tam, KY; Tsinman, O	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Acar Çevik, U; Gençer, HK; Ilgın, S; Levent, S; Özkay, Y	1
Blaskovich, MAT; Pham, TDM; Ziora, ZM	1
Brady, SF; Koirala, B; Peek, J	1
Bhagwat, S; Bhawsar, S; Deshpande, P; Joshi, S; Patel, M; Yeole, R	1
Cooper, B; Freeman, C; Mazens-Sullivan, M; Nightingale, C; Quintiliani, R; Robinson, A	1
Appelbaum, PC; Jacobs, MR; Spangler, SK	2
Anderson, MR; Brighty, KE; Castaldi, MJ; Gootz, TD; Haskell, SL; McGuirk, PR; Schmieder, BJ; Sutcliffe, JA	1
Chin, NX; Neu, HC	1
Kluytmans, JA; Stolz, E; van Rijsoort-Vos, JH; Verbrugh, HA	1
Jones, RN	1
Appelbaum, PC; Jacobs, MR; Visalli, MA	1
Coque, TM; Murray, BE; Singh, KV	1
Barry, AL; Brown, SD; Fuchs, PC	2
Verbist, L; Verhaegen, J	1
Aoun, M; Crokaert, F; Duchateau, V; Grenier, P; Klastersky, J; Vandermies, A	1
Bonilla, HF; Bradley, SF; Kauffman, CA; Zarins, LT	1
Hecht, DW; Osmolski, JR	1
Ballesta, S; García, I; Pascual, A; Perea, EJ	1
Courvalin, P; Girard, D; Gootz, TD; Haskell, S; Polzer, RJ; Schmieder, B; Tankovic, J; Zaniewski, R	1
Andrews, JM; Boswell, F; Brenwald, NP; Wise, R	1
Morrissey, I	1
Dvorak, T; Ho, DH; LeBlanc, B; Rolston, KV; Streeter, H	1
Cunha, BA; Domenico, P; Qadri, SM; Ueno, Y; Walters, EA	1
Andriole, VT; Dembry, LM; Farrel, PA; Gerrity, LA; Orcutt, DR	1
Bhogal, H; Felmingham, D; Grüneberg, RN; Ingley, K; Leakey, A; Mathias, I; Ridgway, GL; Robbins, MJ	1
Maskell, JP; Rafay, AM; Sefton, AM; Whiley, A; Williams, JD	1
Cohen, MA; Gage, JW; Gracheck, SJ; Huband, MD; Roland, GE; Yoder, SL	1
Falagas, ME; McDermott, L; Snydman, DR	1
Barrett, MS; Deguchi, T; Jones, RN	1
Hoogkamp-Korstanje, JA	1
Chen, RJ; Liu, XP; Sugar, AM	1
Bauernfeind, A	1
Canawati, HN; Montgomerie, JZ; Schick, DG	1
Firsov, AA; Shevchenko, AA; Vostrov, SN; Zinner, SH	1
Evans, ME; Titlow, WB	1
Citron, DM; Goldstein, EJ; Hudspeth, M; Hunt Gerardo, S; Merriam, CV	1
Hoban, DJ; Karlowsky, JA; Zhanel, GG	1
Dalhoff, A; Hoppe, JE; Pfründer, D	1
Delucia, JL; Dubin, DT; Fitzgibbon, JE; John, JF	1
Gikas, A; Kofterithis, D; Psaroulaki, A; Spyridaki, I; Tselentis, Y	1
Bouchillon, S; Johnson, J; Pontani, D; Washton, H	1
Alarcón, T; Domingo, D; López-Brea, M; Prieto, N; Sánchez, S	1
Firsov, AA; Portnoy, YA; Shevchenko, AA; Vostrov, SN; Zinner, SH	1
Alperstein, P; France, K; Isenberg, HD	2
Chambers, HF; Chow, LL; Kim, YS; Liu, Q; Täuber, MG	1
Entenza, JM; Glauser, MP; Moreillon, P; Vouillamoz, J	1
Beach, ML; Doern, GV; Jones, RN; Pfaller, MA	1
Biavasco, F; Mingoia, M; Montanari, MP; Prenna, M; Ripa, S; Varaldo, PE	1
Heisig, P; Jones, ME; Klootwijk, M; Schmitz, FJ; Verhoef, J; Visser, MR	1
Armitage, HT; Kerr, KG; McWhinney, PH	1
Jalal, S; Wretlind, B	1
Firsov, AA; Kononenko, OV; Portnoy, YA; Vostrov, SN; Zinner, SH	1
Araki, H; Minami, S; Mitsuyama, J; Narita, H; Takahata, M; Todo, Y; Watanabe, Y; Yamashiro, Y; Yonezawa, M	1
Lister, PD; Sanders, CC	1
Firsov, AA; Kononenko, OV; Lubenko, IY; Vasilov, RG; Vostrov, SN; Zinner, SH	1
Appelbaum, PC; Hoellman, DB; Jacobs, MR; Lin, G	1
Dubin, DT; Fitzgibbon, JE; John, JF; Nahvi, MD	1
Gootz, TD; Haskell, SL; Kaczmarek, FS; Maurice, AE; Zaniewski, RP	1
Beyer, R; Cianciotto, NP; Noskin, GA; Pestova, E; Peterson, LR	1
Brisse, S; Fluit, AC; Köhrer, K; Martin, N; Milatovic, D; Scheuring, S; Schmitz, FJ; Verhoef, J	1
Baddour, LM; Smith, EA	1
Galas, M; Guelfand, L; Lopardo, H; Rossi, A; Tokumoto, M	1
Banevicius, MA; Lacy, MK; Nicolau, DP; Nightingale, CH; Quintiliani, R	1
Chuah, SK; Gollapudi, S; Hanna, N; Rana, G; Reddy, U; Thadepalli, H	1
Davis, TM; Hamzah, J; Skinner-Adams, T	1
Hershberger, E; Rybak, MJ	1
Amsterdam, D; Hardy, D; Mandell, LA; Rotstein, C	1
Anderson, VE; Gootz, TD; Kaczmarek, FS; Osheroff, N; Zaniewski, RP	1
Aguilar, L; Alou, L; Fuentes, F; Giménez, MJ; Marco, F; Prieto, J	1
Al-Ajmi, H; Colman, PJ; Ferguson, J; McEwen, J; Purkins, L; Willavize, SA	1
King, DE; Lilley, SH; Malone, R	1
Block, LH; Knoefler, M; Meinhardt, G; Meyer, H; Reinisch, W; Schrattbauer, K; Zakeri, SM	1
Bachoual, R; Dubreuil, L; Soussy, CJ; Tankovic, J	1
Coyle, EA; Hershberger, E; Kaatz, GW; Rybak, MJ; Zervos, MJ	1
Edmond, M; Heinemann, B; Seifert, H; Wisplinghoff, H	1
Eckert, SJ; McNeeley, DF; Noel, GJ	1
Bebear, C; Bebear, CM; Charron, A; Gruson, D; Lefrancois, M; Renaudin, H	1
Appelbaum, PC; Davies, TA; Dewasse, BE; Jacobs, MR; Nagai, K; Pankuch, GA	1
Burgess, DS; Hastings, RW	1
Kanayama, A; Kobayashi, I; Mochida, O; Naito, S; Saika, T; Tanaka, M; Tunoe, H	1
Araujo, FG; Khan, AA; Remington, JS; Slifer, TR; Suzuki, Y	1
Gootz, TD	1
Hollauer, K; Kirchbauer, D; Naber, KG; Witte, W	1
Arora, H; Eckert, S; Johann-Liang, R; Noel, GJ; Purswani, M	1
Bravos, PD; Frenkel, B; Holtom, PD; Patzakis, MJ; Pavkovic, SA; Shepherd, LE	1
Carbon, C; Chau, F; Dautrey, S; Faurisson, F; Join-Lambert, OF; Köhler, T; Michéa-Hamzehpour, M; Pechère, J; Vissuzaine, C	1
Doern, GV; Ernst, EJ; Klepser, ME; Petzold, CR; Rhomberg, P	1
Shultz, TR; Tapsall, JW; White, PA	1
Dworkin, RJ; Gilbert, DN; Grunkemeier, G; Kohlhepp, SJ; Leggett, JE; Lewis, G; Slama, KA; Slaughter, SE	1
Fernández, F; Martínez-Martínez, L; Perea, EJ	1
Barzilai, A; Diamantstein, L; Gruzman, G; Keller, N; Rubinovitch, B; Rubinstein, E; Yoseph, G	1
Alfonso, EC; Feuer, WJ; Lam, BL; McCulley, TJ; Miller, D; Song, A	1
Ball, P	1
Appelbaum, PC; Davies, TA; Dewasse, BE; Jacobs, MR; Nagai, K	1
Aguilar, L; Alou, L; Dal-Ré, R; Frías, J; Fuentes, F; Giménez, MJ; Prieto, J; Sörgel, F	1
Ambler, J; Cardeñosa, O; Lemme, L; Lopez, H; Scarano, S; Smayevsky, J; Stepanik, D; Sucari, A; Vilches, V	1
Carabias, ML; Cervera, LA; entelles, ML; García-Navas, BL	1
Aguilar, L; García, I; Giménez, MJ; Joyanes, P; Pascual, A; Perea, E	1
Blanco, MT; Gómez-García, AC; Hurtado, C; Morán, FJ; Pérez-Giraldo, C; Sánchez-Silos, RM	1
Evans, ME	1
Calvo, A; García, R; Gómez-Lus, ML; Leturia, A; Sevillano, D; Valero, E	1
Picazo, JJ; Rodríguez-Avial, C; Rodríguez-Avial, I	1
Appelbaum, PC; Bozdogan, B; Clark, CL; Davies, TA; Dewasse, B; Jacobs, MR; Nagai, K	1
Firsov, AA; Lubenko, IY; Portnoy, YA; Vostrov, SN; Zinner, SH	1
Aguilar, L; Alou, L; Calvo, A; Giménez, MJ; Gómez-Lus, ML; Prieto, J	1
Frisbee-Hume, S; Ho, DH; LeBlanc, BM; Rolston, KV; Streeter, H	1
Dalhoff, A; Shalit, I	1
Aguilar, L; Garcia-Mendez, E; Jiménez De Anta, MT; Marco, F; Mensa, J; Ruiz, J; Sierra, JM; Vila, J	1
Almer, LS; Balli, DJ; Beyer, JM; Cai, Y; Flamm, RK; Hensey-Rudloff, D; Nilius, AM; Shen, LL	1
Barequet, IS; Denton, P; O'Brien, TP; Osterhout, GJ; Tuli, S	1
Cabeza, JG; Hernandez, J; Llagostera, M; Mensa, J; Montero, T; Ruiz Chaler, M; Sierra, JM; Vila, J	1
Ali, SH; Chandraker, A; DeCaprio, JA	1
Takač, MJ	1
Marchant, J	1

Reviews

3 review(s) available for trovafloxacin and ciprofloxacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Quinolone antibiotics. MedChemComm, 2019, Oct-01, Volume: 10, Issue:10 Topics:	2019
Immunomodulatory effects of quinolones. The Lancet. Infectious diseases, 2003, Volume: 3, Issue:6 Topics: Adjuvants, Immunologic; Animals; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Clinical Trials as Topic; Cytokines; Fluoroquinolones; Humans; Immune System; Models, Animal; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines	2003

Trials

3 trial(s) available for trovafloxacin and ciprofloxacin

Article	Year
A comparison of the photosensitizing potential of trovafloxacin with that of other quinolones in healthy subjects. The Journal of antimicrobial chemotherapy, 2000, Volume: 45, Issue:4 Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Male; Naphthyridines; Photosensitivity Disorders; Quinolones; Single-Blind Method; Skin; Ultraviolet Rays	2000
Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers. International journal of antimicrobial agents, 2001, Volume: 18, Issue:3 Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Male; Microbial Sensitivity Tests; Naphthyridines; Serum Bactericidal Test; Streptococcus pneumoniae	2001
Ex vivo serum activity (killing rates) after gemifloxacin 320 mg versus trovafloxacin 200 mg single doses against ciprofloxacin-susceptible and -resistant Streptococcus pneumoniae. International journal of antimicrobial agents, 2002, Volume: 20, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Cross-Over Studies; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Humans; Male; Microbial Sensitivity Tests; Naphthyridines; Serum Bactericidal Test; Streptococcus pneumoniae	2002

Other Studies

131 other study(ies) available for trovafloxacin and ciprofloxacin

Article	Year
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 Topics: Anti-Bacterial Agents; Cyclopropanes; Drug Resistance, Bacterial; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Stereoisomerism; Structure-Activity Relationship	2003
A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2,4-difluorophenyl) group. Journal of medicinal chemistry, 2003, May-08, Volume: 46, Issue:10 Topics: Anti-Bacterial Agents; Azetidines; Crystallography, X-Ray; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Quinolines; Quinolones; Structure-Activity Relationship	2003
Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine. Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5 Topics: Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Fluoroquinolones; Microbial Sensitivity Tests; Pyrrolidines; Rats; Stereoisomerism	2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:2 Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Haplorhini; Humans; Models, Statistical; Rats; Software; Species Specificity; Xenobiotics	2005
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Dogs; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Mutation; Prodrugs; Quinolizines; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vancomycin Resistance	2005
Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Bacterial Proteins; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Ofloxacin; Streptococcus agalactiae; Taiwan	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Coxiella burnetii; Humans; Microbial Sensitivity Tests; Minocycline; Q Fever; Tigecycline; Vero Cells	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. Bioorganic & medicinal chemistry, 2009, Aug-01, Volume: 17, Issue:15 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Humans; Maximum Tolerated Dose; Mice; Neoplasms; Piperazine; Piperazines	2009
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Anti-Bacterial Agents; Drug Design; Drug Resistance, Multiple; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinolones; Structure-Activity Relationship	2009
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Caco-2 Cells; Cell Membrane Permeability; Humans; Hydrogen-Ion Concentration; Membranes, Artificial; Molecular Structure; Pharmaceutical Preparations	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors. Bioorganic & medicinal chemistry letters, 2017, 03-01, Volume: 27, Issue:5 Topics: Anti-Bacterial Agents; Bacteria; DNA Gyrase; Enzyme Inhibitors; Microbial Sensitivity Tests; Naphthyridines	2017
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics. Bioorganic & medicinal chemistry letters, 2022, 02-01, Volume: 57 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Fluoroquinolones; HEK293 Cells; Humans; Microbial Sensitivity Tests; Rifamycins; Staphylococcus aureus	2022
WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections. Bioorganic & medicinal chemistry letters, 2022, 05-01, Volume: 63 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Piperidines; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus; Streptococcus pneumoniae; Structure-Activity Relationship	2022
In vitro antimicrobial susceptibility of glycopeptide-resistant enterococci. Diagnostic microbiology and infectious disease, 1995, Volume: 21, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Depsipeptides; Drug Resistance, Microbial; Enterococcus; Fluoroquinolones; Fusidic Acid; Microbial Sensitivity Tests; Minocycline; Naphthyridines; Novobiocin; Peptides, Cyclic; Quinolones; Teicoplanin; Vancomycin; Virginiamycin	1995
Activity of CP 99,219 compared with those of ciprofloxacin, grepafloxacin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam against 489 anaerobes. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Cefoxitin; Ciprofloxacin; Fluoroquinolones; Metronidazole; Microbial Sensitivity Tests; Naphthyridines; Penicillanic Acid; Piperacillin; Piperazines; Quinolones; Tazobactam	1994
In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial. Diagnostic microbiology and infectious disease, 1994, Volume: 19, Issue:4 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type II; DNA, Bacterial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Quinolones	1994
In vitro activity of the new fluoroquinolone CP-99,219. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Quinolones	1994
In-vitro activity of a new quinolone (CP-99,219) compared with ciprofloxacin, pefloxacin, azithromycin and penicillin against Neisseria gonorrhoeae. The Journal of antimicrobial chemotherapy, 1995, Volume: 36, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Ciprofloxacin; Fluoroquinolones; Gonorrhea; Humans; Microbial Sensitivity Tests; Naphthyridines; Neisseria gonorrhoeae; Pefloxacin; Penicillins	1995
In vitro antimicrobial activity of CP-99,219, a new 7-azabicyclonaphthyridone. Drugs, 1995, Volume: 49 Suppl 2 Topics: Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	1995
Activity of CP 99,219 (trovafloxacin) compared with ciprofloxacin, sparfloxacin, clinafloxacin, lomefloxacin and cefuroxime against ten penicillin-susceptible and penicillin-resistant pneumococci by time-kill methodology. The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:1 Topics: Anti-Infective Agents; Cefuroxime; Ciprofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Penicillin Resistance; Quinolones; Streptococcus pneumoniae	1996
Comparative in-vitro activity of the new fluoroquinolone trovafloxacin (CP-99,219) against gram-positive cocci. The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:5 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enterococcus; Fluoroquinolones; Gram-Positive Cocci; Microbial Sensitivity Tests; Naphthyridines; Staphylococcus; Time Factors	1996
In-vitro selection of quinolone-resistant staphylococcal mutants by a single exposure to ciprofloxacin or trovafloxacin (CP-99,219) -letter-. The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Mutation; Naphthyridines; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis	1996
In vitro activity of trovafloxacin versus ciprofloxacin against clinical isolates. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:8 Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines	1996
In vitro activity of trovafloxacin (CP-99,219), sparfloxacin, ciprofloxacin, and fleroxacin against respiratory pathogens. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:8 Topics: Anti-Infective Agents; Ciprofloxacin; Fleroxacin; Fluoroquinolones; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella catarrhalis; Naphthyridines; Quinolones; Respiratory Tract Infections; Streptococcus pneumoniae	1996
Susceptibility of ciprofloxacin-resistant staphylococci and enterococci to trovafloxacin. Diagnostic microbiology and infectious disease, 1996, Volume: 26, Issue:1 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enterococcus faecium; Fluoroquinolones; Gram-Positive Bacterial Infections; Humans; Methicillin; Microbial Sensitivity Tests; Naphthyridines; Penicillins; Staphylococcal Infections; Staphylococcus aureus	1996
Comparison of activities of trovafloxacin (CP-99,219) and five other agents against 585 anaerobes with use of three media. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 23 Suppl 1 Topics: Anti-Infective Agents; Bacteria, Anaerobic; Ciprofloxacin; Clindamycin; Culture Media; Drug Resistance, Microbial; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Imipenem; In Vitro Techniques; Metronidazole; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	1996
Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:2 Topics: Anti-Infective Agents; Cell Survival; Cells, Cultured; Ciprofloxacin; Epithelium; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Macrophages, Peritoneal; Naphthyridines; Neutrophils; Ofloxacin; Staphylococcus aureus; Temperature	1997
Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:12 Topics: Animals; Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Gene Amplification; Genes, Bacterial; Mice; Microbial Sensitivity Tests; Mutation; Naphthyridines; Pneumonia, Pneumococcal; Sequence Analysis, DNA; Streptococcus pneumoniae; Topoisomerase II Inhibitors	1996
The activity of the methylpiperazinyl fluoroquinolone CG 5501: a comparison with other fluoroquinolones. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:4 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Bacteroides fragilis; Chlamydia; Ciprofloxacin; Clarithromycin; Doxycycline; Enterobacter; Erythromycin; Fluoroquinolones; Gatifloxacin; Gram-Positive Bacteria; Haemophilus influenzae; Microbial Sensitivity Tests; Naphthyridines; Piperazines; Pseudomonas aeruginosa; Quinolones; Streptococcus pneumoniae	1997
Bactericidal index: a new way to assess quinolone bactericidal activity in vitro. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:6 Topics: Anti-Infective Agents; Ciprofloxacin; Enterococcus faecalis; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones	1997
In-vitro activity of trovafloxacin against clinical bacterial isolates from patients with cancer. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Neoplasms; Norfloxacin; Ofloxacin; Quinolones	1997
Time-kill study of the activity of trovafloxacin compared with ciprofloxacin, sparfloxacin, metronidazole, cefoxitin, piperacillin and piperacillin/tazobactam against six anaerobes. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Anti-Infective Agents; Bacteroides; Bacteroides fragilis; Cefoxitin; Ciprofloxacin; Clostridium perfringens; Fluoroquinolones; Fusobacterium; Gram-Negative Anaerobic Bacteria; Metronidazole; Microbial Sensitivity Tests; Naphthyridines; Penicillanic Acid; Peptostreptococcus; Piperacillin; Prevotella melaninogenica; Quinolones; Tazobactam	1997
Antibacterial activity of trovafloxacin against nosocomial Gram-positive and Gram-negative isolates. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cross Infection; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Lactams; Microbial Sensitivity Tests; Naphthyridines; Norfloxacin	1997
In-vitro activity of trovafloxacin against sensitive and resistant aerobic bacteria using the standard microdilution broth method and Etest. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Ampicillin; Anti-Infective Agents; Bacteria, Aerobic; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Fluoroquinolones; Gentamicins; Gram-Negative Aerobic Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Sulbactam; Vancomycin	1997
In-vitro activity of trovafloxacin, a new fluoroquinolone, against recent clinical isolates. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Anti-Infective Agents; Chlamydia; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Mycoplasma; Naphthyridines; Ofloxacin; Ureaplasma	1997
The in-vitro activity of trovafloxacin, a new fluoroquinolone, against Gram-positive bacteria. The Journal of antimicrobial chemotherapy, 1997, Volume: 39 Suppl B Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Clindamycin; Erythromycin; Fluoroquinolones; Gram-Positive Bacteria; Lactams; Microbial Sensitivity Tests; Naphthyridines; Vancomycin	1997
In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Quinolones	1997
Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:9 Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteroides fragilis; Ciprofloxacin; Clindamycin; Drug Therapy, Combination; Fluoroquinolones; Hydrogen-Ion Concentration; Imipenem; Meropenem; Microbial Sensitivity Tests; Naphthyridines; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sulbactam; Thienamycins	1997
Antimicrobial activity of trovafloxacin tested against ciprofloxacin-susceptible and -resistant Neisseria gonorrhoeae. Interpretive criteria and comparisons with Etest results. Diagnostic microbiology and infectious disease, 1997, Volume: 28, Issue:4 Topics: Agar; Anti-Infective Agents; Bacteriological Techniques; Ciprofloxacin; Culture Media; Drug Resistance, Microbial; Drug Stability; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Neisseria gonorrhoeae; Sensitivity and Specificity; Species Specificity	1997
In-vitro activities of ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, pefloxacin, sparfloxacin and trovafloxacin against gram-positive and gram-negative pathogens from respiratory tract infections. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pefloxacin; Quinolones; Respiratory Tract Infections	1997
Effectiveness of quinolone antibiotics in modulating the effects of antifungal drugs. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:11 Topics: Amphotericin B; Animals; Anti-Infective Agents; Antifungal Agents; Candidiasis; Ciprofloxacin; Drug Synergism; Drug Therapy, Combination; Fluconazole; Fluoroquinolones; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Naphthyridines; Topoisomerase II Inhibitors	1997
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:5 Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Enterobacteriaceae; Fluoroquinolones; Gatifloxacin; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Quinolones; Staphylococcus aureus	1997
In vitro activity of the combination of trovafloxacin and other antibiotics against enterococci. Diagnostic microbiology and infectious disease, 1997, Volume: 29, Issue:4 Topics: Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Enterococcus; Enterococcus faecalis; Fluoroquinolones; Gentamicins; Humans; Microbial Sensitivity Tests; Naphthyridines; Novobiocin; Rifampin; Sulbactam; Teicoplanin; Vancomycin	1997
Inter- and intraquinolone predictors of antimicrobial effect in an in vitro dynamic model: new insight into a widely used concept. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:3 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Colony Count, Microbial; Escherichia coli; Fluoroquinolones; Klebsiella pneumoniae; Microbial Sensitivity Tests; Naphthyridines; Pseudomonas aeruginosa; Time Factors	1998
Selection of fluoroquinolone-resistant methicillin-resistant Staphylococcus aureus with ciprofloxacin and trovafloxacin. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Methicillin Resistance; Naphthyridines; Staphylococcus aureus	1998
Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens. The Journal of antimicrobial chemotherapy, 1998, Volume: 41, Issue:3 Topics: Animals; Anti-Bacterial Agents; Azithromycin; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Bites and Stings; Bites, Human; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Species Specificity; Wound Infection	1998
In vitro activities of six fluoroquinolones against Canadian isolates of vancomycin-sensitive and vancomycin-resistant Enterococcus species. Diagnostic microbiology and infectious disease, 1998, Volume: 31, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Canada; Ciprofloxacin; Drug Resistance, Microbial; Enterococcus; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Vancomycin	1998
In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to BAY 12-8039, trovafloxacin, and ciprofloxacin. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7 Topics: Anti-Infective Agents; Aza Compounds; Bordetella; Bordetella pertussis; Ciprofloxacin; Fluoroquinolones; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Quinolines; Quinolones	1998
Topoisomerase mutations in trovafloxacin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:8 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mutation; Naphthyridines; Staphylococcus aureus	1998
In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:10 Topics: Anti-Infective Agents; Ciprofloxacin; Clarithromycin; Coxiella burnetii; Doxycycline; Fluoroquinolones; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pefloxacin	1998
Susceptibility of European respiratory tract isolates to trovafloxacin, ciprofloxacin, clarithromycin, azithromycin and ampicillin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:6 Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Ciprofloxacin; Clarithromycin; Drug Resistance, Microbial; Europe; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Cocci; Haemophilus influenzae; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Moraxella catarrhalis; Naphthyridines; Pseudomonas aeruginosa; Respiratory System; Staphylococcus aureus; Streptococcus pneumoniae	1998
[In vitro activity of trovafloxacin in 238 respiratory pathogens]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 1998, Volume: 11, Issue:1 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Haemophilus influenzae; Humans; In Vitro Techniques; Klebsiella pneumoniae; Microbial Sensitivity Tests; Moraxella catarrhalis; Naphthyridines; Respiratory Tract Infections; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes	1998
A new approach to in vitro comparisons of antibiotics in dynamic models: equivalent area under the curve/MIC breakpoints and equiefficient doses of trovafloxacin and ciprofloxacin against bacteria of similar susceptibilities. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:11 Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Dose-Response Relationship, Drug; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines	1998
In vitro susceptibility of recent gram-positive isolates to ciprofloxacin, levofloxacin, and trovafloxacin. Diagnostic microbiology and infectious disease, 1998, Volume: 32, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Corynebacterium; Drug Resistance, Microbial; Fluoroquinolones; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin	1998
Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:12 Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Endocarditis, Bacterial; Fluoroquinolones; Heart; Methicillin Resistance; Microbial Sensitivity Tests; Naphthyridines; Rabbits; Staphylococcal Infections; Staphylococcus aureus	1998
Efficacy of trovafloxacin in treatment of experimental staphylococcal or streptococcal endocarditis. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:1 Topics: Animals; Anti-Infective Agents; Blood Proteins; Ciprofloxacin; Endocarditis, Subacute Bacterial; Fluoroquinolones; Methicillin Resistance; Microbial Sensitivity Tests; Naphthyridines; Penicillin Resistance; Protein Binding; Rats; Staphylococcal Infections; Staphylococcus aureus; Time Factors	1999
Antimicrobial activity of gatifloxacin tested against 1676 strains of ciprofloxacin-resistant gram-positive cocci isolated from patient infections in North and South America. Diagnostic microbiology and infectious disease, 1998, Volume: 32, Issue:3 Topics: Anti-Infective Agents; Antitubercular Agents; Bacteriological Techniques; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Naphthyridines; North America; Quinolones; South America	1998
Antistaphylococcal and antistreptococcal killing kinetics of ciprofloxacin, ofloxacin, sparfloxacin, and trovafloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pneumoniae; Streptococcus pyogenes	1998
Comparative activities of clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin, and trovafloxacin and nonquinolones linozelid, quinupristin-dalfopristin, gentamicin, and vancomycin against clinical isolates of ciprofloxacin-re Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gentamicins; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Quinolones; Staphylococcus aureus; Vancomycin; Virginiamycin	1999
Activity of quinolones against viridans group streptococci isolated from blood cultures of patients with haematological malignancy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1999, Volume: 7, Issue:1 Topics: Adult; Anti-Infective Agents; Bacteremia; Ciprofloxacin; Fleroxacin; Fluoroquinolones; Hematologic Neoplasms; Humans; Naphthyridines; Neutropenia; Risk Factors; Streptococcal Infections; Streptococcus	1999
Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa. Microbial drug resistance (Larchmont, N.Y.), 1998,Winter, Volume: 4, Issue:4 Topics: Anti-Infective Agents; Bacterial Proteins; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Microbial; Fluoroquinolones; Humans; Mutation; Naphthyridines; Norfloxacin; Pseudomonas aeruginosa; Transcription Factors	1998
In vitro activity of trovafloxacin against ciprofloxacin-susceptible and -resistant clinical bacterial isolates and assessment of the trovafloxacin disk test. Diagnostic microbiology and infectious disease, 1999, Volume: 33, Issue:1 Topics: Anti-Infective Agents; Bacteria; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines	1999
Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:3 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Escherichia coli; Fluoroquinolones; Half-Life; Kinetics; Microbial Sensitivity Tests; Models, Biological; Naphthyridines; Staphylococcus aureus	1999
In vitro activity of ciprofloxacin, levofloxacin, and trovafloxacin, alone and in combination with beta-lactams, against clinical isolates of Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Burkholderia cepacia. Diagnostic microbiology and infectious disease, 1999, Volume: 33, Issue:2 Topics: Anti-Infective Agents; beta-Lactams; Burkholderia cepacia; Ciprofloxacin; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Pseudomonas aeruginosa; Xanthomonas	1999
In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:5 Topics: Administration, Oral; Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Fluoroquinolones; Indoles; Injections, Subcutaneous; Isoindoles; Male; Mice; Naphthyridines; Ofloxacin; Quinolones	1999
Pharmacodynamics of trovafloxacin, ofloxacin, and ciprofloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:5 Topics: Administration, Oral; Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Streptococcus pneumoniae	1999
Prediction of the antimicrobial effects of trovafloxacin and ciprofloxacin on staphylococci using an in-vitro dynamic model. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:4 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Dose-Response Relationship, Drug; Fluoroquinolones; Gram-Negative Bacteria; Humans; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Models, Biological; Naphthyridines; Staphylococcus aureus	1999
Anti-pneumococcal activity of gatifloxacin compared with other quinolone and non-quinolone agents. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:5 Topics: Amoxicillin; Anti-Infective Agents; Ceftriaxone; Cefuroxime; Cephalosporins; Ciprofloxacin; Clarithromycin; Fluoroquinolones; Gatifloxacin; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Penicillin Resistance; Streptococcus pneumoniae	1999
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:7 Topics: Anti-Infective Agents; Base Sequence; Ciprofloxacin; Coagulase; Codon; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Oxacillin; Staphylococcus	1999
Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Adrenergic Uptake Inhibitors; Anti-Infective Agents; Antitubercular Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA, Bacterial; DNA, Superhelical; Drug Interactions; Drug Resistance, Microbial; Enzyme Inhibitors; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Reserpine; Staphylococcus aureus; Topoisomerase II Inhibitors	1999
Contribution of topoisomerase IV and DNA gyrase mutations in Streptococcus pneumoniae to resistance to novel fluoroquinolones. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Anti-Infective Agents; Antitubercular Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA, Bacterial; Drug Resistance, Microbial; Fluoroquinolones; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Phenotype; Streptococcus pneumoniae; Transformation, Bacterial	1999
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterat Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Enterobacter cloacae; Fluoroquinolones; Gatifloxacin; Humans; Klebsiella pneumoniae; Levofloxacin; Microbial Sensitivity Tests; Molecular Sequence Data; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	1999
Multidrug resistance among Streptococcus pneumoniae isolated at a university hospital in eastern Tennessee. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1999, Volume: 29, Issue:1 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Multiple; Fluoroquinolones; Hospitals, University; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Penicillins; Prospective Studies; Streptococcus pneumoniae; Tennessee	1999
[In vitro activity of trovafloxacin, of other fluoroquinolones and of related antimicrobials against clinical isolates. Grupo colaborativo WHONET-Argentina]. Medicina, 1999, Volume: 59 Suppl 1 Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Naphthyridines; Ofloxacin	1999
Protective effect of trovafloxacin, ciprofloxacin and ampicillin against Streptococcus pneumoniae in a murine sepsis model. The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:4 Topics: Ampicillin; Animals; Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Mice; Naphthyridines; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae	1999
Evaluation of trovafloxacin in the treatment of Klebsiella pneumoniae lung infection in tumour-bearing mice. The Journal of antimicrobial chemotherapy, 2000, Volume: 45, Issue:1 Topics: Animals; Anti-Infective Agents; Antibiotics, Antineoplastic; Ciprofloxacin; Daunorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluoroquinolones; Granulocyte Colony-Stimulating Factor; Klebsiella Infections; Klebsiella pneumoniae; Leukemia P388; Leukocyte Count; Male; Mice; Mice, Inbred DBA; Naphthyridines; Neoplasm Transplantation; Pneumonia, Bacterial; Recombinant Proteins	2000
In vitro antimalarial activity of trovafloxacin, a fourth-generation fluoroquinolone. Acta tropica, 2000, Jan-05, Volume: 74, Issue:1 Topics: Animals; Anti-Infective Agents; Cells, Cultured; Ciprofloxacin; Fluoroquinolones; Naphthyridines; Norfloxacin; Plasmodium falciparum	2000
Activities of trovafloxacin, gatifloxacin, clinafloxacin, sparfloxacin, levofloxacin, and ciprofloxacin against penicillin-resistant Streptococcus pneumoniae in an in vitro infection model. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3 Topics: Anti-Infective Agents; Blood Coagulation; Ciprofloxacin; Fibrin; Fluoroquinolones; Gatifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Penicillin Resistance; Pneumococcal Infections; Streptococcus pneumoniae	2000
Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Bacteremia; Ciprofloxacin; Fluoroquinolones; Gemifloxacin; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines	2000
Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement. Biochemistry, 2000, Mar-14, Volume: 39, Issue:10 Topics: Anti-Infective Agents; Catalysis; Ciprofloxacin; DNA; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Levofloxacin; Naphthyridines; Ofloxacin; Staphylococcus aureus; Topoisomerase II Inhibitors	2000
In vitro susceptibility to gemifloxacin and trovafloxacin of Streptococcus pneumoniae strains exhibiting decreased susceptibility to ciprofloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2000, Volume: 19, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Microbial Sensitivity Tests; Naphthyridines; Pneumococcal Infections; Respiratory Tract Infections; Streptococcus pneumoniae	2000
New classification and update on the quinolone antibiotics. American family physician, 2000, May-01, Volume: 61, Issue:9 Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Naphthyridines	2000
Effects of trovafloxacin on the IL-1-dependent activation of E-selectin in human endothelial cells in vitro. Immunopharmacology, 2000, Volume: 48, Issue:1 Topics: Anti-Infective Agents; Cell Cycle; Cell Division; Cell Membrane; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; E-Selectin; Endothelium, Vascular; Flow Cytometry; Fluoroquinolones; Humans; Interleukin-1; Naphthyridines; Propidium; RNA, Messenger; Time Factors	2000
Roles of gyrA mutations in resistance of clinical isolates and in vitro mutants of Bacteroides fragilis to the new fluoroquinolone trovafloxacin. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:7 Topics: Anti-Infective Agents; Bacteroides fragilis; Ciprofloxacin; DNA Gyrase; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mutation; Naphthyridines; Norfloxacin	2000
Comparison of a rabbit model of bacterial endocarditis and an in vitro infection model with simulated endocardial vegetations. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:7 Topics: Animal Testing Alternatives; Animals; Anti-Infective Agents; Blood Platelets; Cattle; Ciprofloxacin; Disease Models, Animal; Drug Evaluation, Preclinical; Endocarditis, Bacterial; Enterococcus; Fluoroquinolones; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Naphthyridines; Rabbits; Staphylococcus aureus	2000
Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:8 Topics: Acinetobacter; Acinetobacter Infections; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Disease Outbreaks; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Germany; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines	2000
Antimicrobial-resistant enterococcal isolates from fluoroquinolone-naive children. The Pediatric infectious disease journal, 2000, Volume: 19, Issue:7 Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child, Preschool; Ciprofloxacin; Drug Resistance, Microbial; Enterococcus faecalis; Enterococcus faecium; Fluoroquinolones; Gram-Positive Bacterial Infections; Humans; Infant; Infant, Newborn; Naphthyridines; Penicillins; Vancomycin	2000
In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:9 Topics: Anti-Bacterial Agents; Ciprofloxacin; Doxycycline; Drug Resistance, Microbial; Erythromycin; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Mycoplasma hominis; Naphthyridines; Ofloxacin; Ureaplasma urealyticum	2000
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:10 Topics: Anti-Infective Agents; Bacterial Proteins; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Microbial; Fluoroquinolones; Microbial Sensitivity Tests; Mutation; Naphthyridines; Reverse Transcriptase Polymerase Chain Reaction; Serotyping; Streptococcus pneumoniae	2000
Activity of piperacillin/tazobactam in combination with amikacin, ciprofloxacin, and trovafloxacin against Pseudomonas aeruginosa by time-kill. Diagnostic microbiology and infectious disease, 2000, Volume: 38, Issue:1 Topics: Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Chi-Square Distribution; Ciprofloxacin; Colony Count, Microbial; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fluoroquinolones; Humans; Naphthyridines; Penicillanic Acid; Penicillins; Piperacillin; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam	2000
Antimicrobial activity of gemifloxacin (SB-265805), a newer fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae, including fluoroquinolone-resistant isolates. Diagnostic microbiology and infectious disease, 2000, Volume: 38, Issue:2 Topics: Amoxicillin; Anti-Infective Agents; Ciprofloxacin; Clavulanic Acid; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Gonorrhea; Humans; Levofloxacin; Naphthyridines; Neisseria gonorrhoeae; Norfloxacin; Ofloxacin	2000
Protection against lipopolysaccharide-induced death by fluoroquinolones. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cytokines; Death; Drug Interactions; Fluoroquinolones; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Monocytes; Naphthyridines; Protective Agents; Shock, Septic	2000
Bactericidal assays for fluoroquinolones. Methods in molecular biology (Clifton, N.J.), 2001, Volume: 95 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Topoisomerases, Type II; DNA, Superhelical; Escherichia coli; Fluoroquinolones; Kinetics; Microbial Sensitivity Tests; Naphthyridines; Nephelometry and Turbidimetry; Plasmids; Quality Control; Topoisomerase II Inhibitors	2001
In vitro activity of gatifloxacin compared with gemifloxacin, moxifloxacin, trovafloxacin, ciprofloxacin and ofloxacin against uropathogens cultured from patients with complicated urinary tract infections. International journal of antimicrobial agents, 2000, Volume: 16, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Escherichia coli; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Klebsiella; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Urinary Tract Infections	2000
The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: evidence for down-regulation of cytokine mRNA transcription by trovafloxacin. The Journal of antimicrobial chemotherapy, 2000, Volume: 46, Issue:6 Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Ciprofloxacin; Cytokines; Fluoroquinolones; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Naphthyridines; RNA, Messenger; Teichoic Acids	2000
Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2000, Volume: 18, Issue:5 Topics: Animals; Anti-Infective Agents; Bromodeoxyuridine; Calcification, Physiologic; Cell Count; Cell Division; Cells, Cultured; Ciprofloxacin; Dose-Response Relationship, Drug; Extracellular Matrix; Fluoroquinolones; Levofloxacin; Mice; Naphthyridines; Ofloxacin; Osteoblasts	2000
Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in an experimental model of Pseudomonas aeruginosa acute pneumonia in rats. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:2 Topics: Acute Disease; Animals; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Lung; Male; Mutation; Naphthyridines; Pneumonia, Bacterial; Pseudomonas aeruginosa; Rats; Rats, Sprague-Dawley	2001
Comparative bactericidal activities of ciprofloxacin, clinafloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Streptococcus pneumoniae in a dynamic in vitro model. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Colony Count, Microbial; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Models, Biological; Moxifloxacin; Naphthyridines; Ofloxacin; Piperazines; Quinolines; Streptococcus pneumoniae; Time Factors	2001
Correlation of in vitro susceptibilities to newer quinolones of naturally occurring quinolone-resistant Neisseria gonorrhoeae strains with changes in GyrA and ParC. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Neisseria gonorrhoeae; Phenotype; Statistics as Topic	2001
Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Enterobacteriaceae; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Mutation; Naphthyridines; Ofloxacin; Phenotype; Pseudomonas aeruginosa; Regression Analysis; Reproducibility of Results; Staphylococcus aureus	2001
Relationship between haemolysis production and resistance to fluoroquinolones among clinical isolates of Escherichia coli. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:2 Topics: Amoxicillin; Ampicillin; Animals; Anti-Infective Agents; Ciprofloxacin; Clavulanic Acid; Drug Resistance, Microbial; Escherichia coli; Fluoroquinolones; Gentamicins; Hemolysin Proteins; Hemolysis; Humans; Microbial Sensitivity Tests; Nalidixic Acid; Naphthyridines; Pefloxacin; Tetracycline	1999
The effect of albumin, globulin, pus and dead bacteria in aerobic and anaerobic conditions on the antibacterial activity of moxifloxacin, trovafloxacin and ciprofloxacin against Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2000, Volume: 6, Issue:12 Topics: Albumins; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Globulins; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Pneumococcal Infections; Quinolines; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Suppuration	2000
Pseudomonas aeruginosa in vitro corneal isolate sensitivity to ofloxacin, ciprofloxacin, and trovafloxacin: a comparative study. American journal of ophthalmology, 2001, Volume: 131, Issue:6 Topics: Anti-Infective Agents; Ciprofloxacin; Cornea; Fluoroquinolones; Humans; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Pseudomonas aeruginosa	2001
Safety of the new fluoroquinolones compared with ciprofloxacin. Journal of chemotherapy (Florence, Italy), 2000, Volume: 12 Suppl 1 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Interactions; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Piperazines	2000
Single- and multi-step resistance selection study of gemifloxacin compared with trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin in Streptococcus pneumoniae. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:3 Topics: Anti-Infective Agents; Aza Compounds; Biological Transport; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Gatifloxacin; Gemifloxacin; Humans; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Naphthyridines; Quinolines; Selection, Genetic; Serotyping; Streptococcus pneumoniae	2001
Multicentre study of the in vitro evaluation of moxifloxacin and other quinolones against community acquired respiratory pathogens. International journal of antimicrobial agents, 2001, Volume: 18, Issue:4 Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Community-Acquired Infections; Fluoroquinolones; Haemophilus influenzae; Humans; Levofloxacin; Microbial Sensitivity Tests; Moraxella catarrhalis; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Respiratory Tract Infections; Streptococcus pneumoniae; Streptococcus pyogenes	2001
[Are the antimicrobials used in community-acquired respiratory infection useful for preventing transmission of meningococcal disease? In vitro study]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2001, Volume: 14, Issue:2 Topics: Amoxicillin; Anti-Infective Agents; Ciprofloxacin; Clarithromycin; Community-Acquired Infections; Drug Resistance; Fluoroquinolones; Humans; Meningococcal Infections; Microbial Sensitivity Tests; Naphthyridines; Nasopharynx; Neisseria meningitidis; Respiratory Tract Infections; Rifampin; Time Factors	2001
Differences between two new quinolones (gemifloxacin and trovafloxacin) and ciprofloxacin in their concentration-dependent killing of Streptococcus pneumoniae. Chemotherapy, 2001, Volume: 47, Issue:6 Topics: Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Microbial Sensitivity Tests; Naphthyridines; Streptococcus pneumoniae	2001
Resistance to vancomycin, LY333328, ciprofloxacin and trovafloxacin of community-acquired and nosocomial strains of Enterococcus faecalis isolated in Badajoz (Spain) with and without high-level resistance to streptomycin and gentamicin. Chemotherapy, 2001, Volume: 47, Issue:6 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Community-Acquired Infections; Cross Infection; Drug Resistance, Bacterial; Enterococcus faecalis; Fluoroquinolones; Gentamicins; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Incidence; Lipoglycopeptides; Microbial Sensitivity Tests; Naphthyridines; Spain; Streptomycin; Vancomycin	2001
Determining the frequency of resistance of Streptococcus pneumoniae to ciprofloxacin, levofloxacin, trovafloxacin, grepafloxacin, and gemifloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2001, Volume: 20, Issue:12 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Gemifloxacin; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Piperazines; Streptococcus pneumoniae	2001
[Activity of new fluoroquinolones against clinical isolates of Acinetobacter baumannii]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2001, Volume: 14, Issue:4 Topics: Acinetobacter; Acinetobacter Infections; Ampicillin; Anti-Infective Agents; Aza Compounds; Cefepime; Cephalosporins; Ciprofloxacin; Colistin; Fluoroquinolones; Gatifloxacin; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Moxifloxacin; Nalidixic Acid; Naphthyridines; Norfloxacin; Ofloxacin; Opportunistic Infections; Quinolines; Sulbactam; Thienamycins	2001
[In vitro activity of six fluoroquinolones and penicillin against 101 viridans group streptococci characterized by their susceptibility to erythromycin]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2001, Volume: 14, Issue:4 Topics: Anti-Infective Agents; Aza Compounds; Bacteremia; Ciprofloxacin; Drug Resistance; Drug Resistance, Multiple, Bacterial; Erythromycin; Fluoroquinolones; Humans; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Norfloxacin; Ofloxacin; Penicillins; Quinolines; Streptococcal Infections; Streptococcus	2001
Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2002, Volume: 8, Issue:6 Topics: Anti-Infective Agents; Aza Compounds; Biological Transport; Ciprofloxacin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Indoles; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Ofloxacin; Quinolines; Quinolones; Streptococcus pneumoniae	2002
Bacterial strain-independent AUC/MIC and strain-specific dose-response relationships reflecting comparative fluoroquinolone anti-pseudomonal pharmacodynamics in an in vitro dynamic model. International journal of antimicrobial agents, 2002, Volume: 20, Issue:1 Topics: Anti-Infective Agents; Area Under Curve; Ciprofloxacin; Dose-Response Relationship, Drug; Fluoroquinolones; Microbial Sensitivity Tests; Models, Biological; Naphthyridines; Pseudomonas aeruginosa	2002
Antimicrobial activity of a novel des-fluoro (6) quinolone, garenoxacin (BMS-284756), compared to other quinolones, against clinical isolates from cancer patients. Diagnostic microbiology and infectious disease, 2002, Volume: 44, Issue:2 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Female; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Indoles; Levofloxacin; Male; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Quinolones; Sensitivity and Specificity	2002
In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene. International journal of antimicrobial agents, 2003, Volume: 22, Issue:1 Topics: Anti-Infective Agents; Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Genes, Bacterial; Gonorrhea; Humans; In Vitro Techniques; Levofloxacin; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Nalidixic Acid; Naphthyridines; Neisseria gonorrhoeae; Ofloxacin; Quinolines	2003
In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:10 Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Blood Proteins; Ciprofloxacin; DNA Topoisomerases, Type II; Drug Resistance, Bacterial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Levofloxacin; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Protein Binding; Quinolones; Rats	2003
Treatment of experimental bacterial keratitis with topical trovafloxacin. Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:1 Topics: Administration, Topical; Animals; Anti-Infective Agents; Biological Availability; Ciprofloxacin; Colony Count, Microbial; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Infections, Bacterial; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Naphthyridines; Ofloxacin; Ophthalmic Solutions; Pseudomonas Infections; Rabbits; Staphylococcal Infections; Streptococcal Infections	2004
The selection of resistance to and the mutagenicity of different fluoroquinolones in Staphylococcus aureus and Streptococcus pneumoniae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005, Volume: 11, Issue:9 Topics: Aza Compounds; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Fluoroquinolones; Gemifloxacin; Levofloxacin; Moxifloxacin; Mutagenicity Tests; Naphthyridines; Ofloxacin; Quinolines; Selection, Genetic; Staphylococcus aureus; Streptococcus pneumoniae	2005
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antiviral therapy, 2007, Volume: 12, Issue:1 Topics: Antigens, Polyomavirus Transforming; Antiviral Agents; Cell Line, Tumor; Ciprofloxacin; Cytopathogenic Effect, Viral; DNA Helicases; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoroquinolones; Humans; Levofloxacin; Naphthyridines; Ofloxacin; Reproducibility of Results; Simian virus 40; Time Factors; Viral Plaque Assay; Virus Replication	2007
Effects of substituents on the NMR features of basic bicyclic ring systems of fluoroquinolone antibiotics and the relationships between NMR chemical shifts, molecular descriptors and drug-likeness parameters. Acta pharmaceutica (Zagreb, Croatia), 2010, Volume: 60, Issue:3 Topics: Anti-Bacterial Agents; Ciprofloxacin; Fluoroquinolones; Magnetic Resonance Spectroscopy; Naphthyridines; Pefloxacin; Quantitative Structure-Activity Relationship	2010
When antibiotics turn toxic. Nature, 2018, 03-22, Volume: 555, Issue:7697 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antioxidants; Ciprofloxacin; Female; Fluoroquinolones; Genetic Testing; Humans; Inactivation, Metabolic; Levofloxacin; Male; Mice; Mitochondria; Naphthyridines; Ofloxacin; Oxidative Stress; Syndrome; Topoisomerase II Inhibitors; United States; United States Food and Drug Administration	2018