Page last updated: 2024-08-21

tropolone and beta-thujaplicin

tropolone has been researched along with beta-thujaplicin in 176 studies

Research

Studies (176)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (9.66)	18.7374
1990's	15 (8.52)	18.2507
2000's	53 (30.11)	29.6817
2010's	68 (38.64)	24.3611
2020's	23 (13.07)	2.80

Authors

Authors	Studies
Inamori, Y; Ishida, N; Matsumura, E; Morita, Y; Ohe, T; Okabe, T; Shibata, M; Sugiura, M; Tsujibo, H	1
Fukui, T; Inamori, Y; Ishida, N; Matsumura, E; Morita, Y; Ohe, T; Okabe, T; Shibata, M; Sugiura, M; Tsujibo, H	1
Alexi, X; Alexis, MN; Koufaki, M; Nikoloudaki, F; Theodorou, E	1
Cohen, SM; Fullagar, JL; Jacobsen, JA; Miller, MT	1
Anning, EN; Bryan, LJ; O'Donnell, SR	1
Bryan, LJ; O'Donnell, SR	1
Yamato, M	1
Endo, M; Hashimoto, Y; Ichimaru, M; Kato, A; Matsumura, M; Mizutani, T; Moriyasu, M	1
Kojima, H; Mizuno, K; Suzuki, M; Watanabe, H; Watanabe, I; Watanabe, N	1
Fujita, T; Harima, Y; Koshiro, A; Saeki, E; Yoneda, F	1
Böhme, G; Kunz, W; Küster, U; Lyr, H; Schönfeld, P	1
Aoki, T; Fujita, M	1
Hasegawa, M; Iikura, Y; Kawamitsu, S; Matsunaga, T; Murasaki, Y; Nishitani, K; Ohmayu, S; Ryuno, K; Saruta, K; Sasamoto, K	1
Aso, H; Inamori, Y; Ishida, N; Ishii, F; Mizugaki, M; Ohishi, H; Tsujibo, H	1
Dota, A; Inada, A; Itoh, N; Muto, N; Nakanishi, T; Okabe, M; Tanaka, K; Tanaka, T	1
Dota, A; Inada, A; Itoh, N; Muto, N; Nishina, Y; Tanaka, K; Tanaka, T	1
Inamori, Y; Katagiri, M; Muro, C; Okamoto, Y; Sajima, E; Sakagami, Y; Tanaka, H; Tsujibo, H	1
Arima, Y; Baba, T; Hanada, K; Hashimoto, I; Nakano, H; Sawamura, D; Tamai, K	1
Akiyama, H; Arata, J; Kanzaki, H; Tada, J; Yamasaki, O	1
Arima, Y; Endo, N; Kusagaya, Y; Miyamoto, D; Nakajima, K; Sometani, A; Suzuki, T; Suzuki, Y; Takeo, S	1
Nakagawa, Y; Tayama, K	1
Arima, Y; Endo, N; Miyamoto, D; Oku, N; Suzuki, T; Suzuki, Y	1
Ido, Y; Inada, A; Itoh, N; Kohroki, J; Mano, M; Muto, N; Odani, T; Tanaka, K; Yamamoto, K	1
Inamori, Y; Ishida, N; Kumeda, Y; Morita, Y; Okabe, T; Sakagami, Y; Shinohara, S; Tsujibo, H	1
Ando, H; Aoki, N; Kubo, Y; Nagasawa, A; Ogata, A; Ogawa, H; Yasuda, K	1
Ishidate, M; Itoh, N; Kohroki, J; Muto, N; Onozawa, Y; Satoh, T; Tanaka, K; Tanaka, T	1
Inamori, Y; Ishida, N; Isoyama, N; Morita, Y; Okabe, T; Sakagami, Y; Tsujibo, H	1
Inamori, Y; Ishida, N; Kumeda, Y; Morita, Y; Okabe, T; Sakagami, Y; Shibata, M; Sugiura, M; Tsujibo, H	1
Juránek, I; Katoh, T; Node, M; Suzuki, H; Suzuki, T; Ueda, T; Yamamoto, S	1
Kawahara, H; Masuda, K; Obata, H	1
Date, T; Inamori, Y; Ishida, N; Matsumura, E; Morita, Y; Okabe, T; Tsujibo, H; Yasuda, M	1
Fujita, K; Sakai, K; Yamada, J; Zhao, J	1
Nakagawa, Y	1
Inamori, Y; Ishida, N; Matsumura, E; Morita, Y; Okabe, T; Sakagami, Y; Tsujibo, H; Yasuda, M	1
Fujita, K; Sakai, K; Zhao, J	3
Baya, M; Gelhaye, E; Gérardin, P; Soulounganga, P	1
Fujita, K; Sakai, K; Yamada, J	1
Inamor, Y; Ishida, N; Kumeda, Y; Matsumura, E; Morita, Y; Okabe, T; Sakagami, Y; Tsujibo, H; Yasuda, M	1
Arima, Y; Hayakawa, R; Nakai, Y; Nishino, T	1
Sakai, K; Zhao, J	1
KATSURA, S	4
ABE, T; KATSURA, S; TAMANO, Y	1
FURUDERA, H; KATSURA, S	1
OGIHARA, K	1
MATSUMURA, S; RO, K; SETO, S	1
Ishikawa, T; Nagamine, T; Sawa, Y; Shibata, H; Wang, Y	1
Hirakawa, S; Kasuga, NC; Nomiya, K; Tsukagoshi, K; Watanabe, J; Yoshizawa, A	1
Hori, H; Ishidao, T; Ishimatsu, S; Ohga, Y	1
Chisty, MM; Inaba, T; Ishita, K; Kamiya, H; Nargis, M; Osanai, A	1
Guo, Y; Kosaihira, A; Sakai, K; Zhao, J	1
Ema, M; Fujii, S; Harazono, A; Kawashima, K	1
Dyrskov, L; Hansen, HC; Strobel, BW; Svensmark, B	1
Fujita, K; Sakai, K; Zhao, J; Zheng, SH	1
Kim, DS; Kwon, SB; Li, K; Park, KC; Park, SH; Youn, SW	1
KASSAI, K; KATSURA, M; KATSURA, S; KATSUTA, K; KINOSHITA, Y; TAMAKI, A	1
Fukui, T; Inamori, Y; Ishida, N; Matsumura, E; Morita, Y; Ohe, T; Okabe, T	1
Jang, YS; Kim, JH; Kim, MK; Lee, CH; Lee, HS; Lee, SH	1
Breuil, C; Chedgy, R; Kim, JJ; Lim, YW; Morris, PI	1
Hagiwara, T; Kishimoto, T; Ouchi, K; Sato, K; Shiga, S; Yamano, H; Yamazaki, T	1
Fujita, K; Matsunaga, Y; Sakai, K; Zhao, J	1
Choi, YG; Kim, DS; Kim, MK; Kim, SY; Kwon, SB; Na, JI; Park, KC; Park, SH; Youn, SW	1
Haneda, M; Murakami, K; Ohara, Y; Tsubouchi, R; Yoshino, M	1
Aizu, T; Arima, Y; Hanada, K; Ikenaga, S; Kaneko, T; Matsuzaki, Y; Nakano, H; Tsuchida, S	1
Baba, E; Nakano, Y; Sasai, K; Tani, H; Wada, M	1
Jang, YS; Jeon, JH; Lee, HS	1
Baba, E; Matsuo, S; Nakano, Y; Sasai, K; Tani, H	1
Bae, EJ; Choi, YG; Kim, DS; Kwon, SB; Na, JI; Park, KC; Park, SH	1
Inamori, Y; Ishida, N; Morita, Y; Okabe, T; Sakagami, Y	1
Liu, S; Yamauchi, H	2
Doi, Y; Hagiwara, A; Ichihara, T; Imai, N; Kawabe, M; Nabae, K; Ogawa, K; Shirai, T; Tamano, S	1
Furube, K; Kiuchi, K; Mitsuboshi, S; Muramatsu, K; Obitsu, R; Yoshitake, S	1
Inamori, Y; Ishida, N; Morita, Y; Ohe, T; Okabe, T; Sakagami, Y	1
Chang, HT; Chang, ST; Hsieh, CC; Yen, TB	1
ANDERSON, AB; GRIPENBERG, J	1
Joo, HH; Kim, JC; Lee, HY	1
Komaki, N; Matsumoto, T; Mikami, T; Ogasawara, A; Sato, N; Watanabe, T	1
Hwang, SL; Kim, JC	1
Byeon, SE; Cho, JY; Han, JG; Kim, JC; Lee, HY; Lee, YG	1
Hamada, H; Ishihara, K; Kwon, S; Masuoka, N; Shimoda, K	1
Gaudernak, E; Holzer, B; Krenn, BM; Lanke, K; Seipelt, J; Van Kuppeveld, FJ	1
Ashitani, T; De Alwis, R; Fujita, K; Kuroda, K	1
Kim, JC; Lee, HY; Yang, X	1
Douyon, Y; Gilbard, JP; Huson, RB	1
Kim, JW; Lee, MJ; Yang, EG	1
Chen, QX; Guo, HY; Hu, YH; Li, ZC; Liu, B; Qiu, L; Wang, Q; Zhou, JJ; Zhu, YJ	1
Abe, T; Ebizuka, S; Kamiya, T; Nezu, T; Saeki, K; Sunaga, S; Takahashi, S; Takasawa, R; Takeuchi, S; Tanuma, S; Yoshimori, A	1
Anil, S; Cameron, AR; Harthill, J; Rena, G; Sutherland, E	1
Cho, YM; Hasumura, M; Hirose, M; Imai, T; Nishikawa, A; Ogawa, K; Takami, S	1
Eguchi, N; Goto, H; Ishii, J; Ito, H; Mitsui, T; Omura, H; Ueno, T	1
Chen, LY; Cherng, JY; Shih, MF	1
Bolstad, ES; Hadden, MK; Oblak, EZ; Ononye, SN; Priestley, ND; Wright, DL	1
Abe, S; Fujisaki, R; Inouye, S; Kamei, K; Nishiya, H; Takahashi, M; Yamamura, M	1
Aizawa, S; Imada, M; Katsuyama, N; Matsukawa, M; Murakami, T; Sato, T	1
Chang, KW; Chi, TY; Fuh, LJ; Hsia, SM; Shieh, TM; Shih, YH; Yu, CC	1
Chou, DS; Chung, CL; Huang, SY; Kuo, JR; Lee, HC; Lin, KH; Lu, WJ; Sheu, JR	1
Nakanishi, K	1
Hirofuji, T; Iha, K; Suzuki, N; Takeshita, T; Yoneda, M	1
Akbari, S; Arbe, A; Colmenero, J; Moreno, AJ; Pomposo, JA; Sanchez-Sanchez, A; Verso, FL	1
Choi, KM; Hong, JT; Jeon, YS; Kim, W; Lee, YM; Lee, YS; Yoo, HS; Yun, YP	1
Bae, MK; Bae, SK; Kim, MK; Kim, YD; Park, HJ; Ryu, MH; Takata, T	1
Chou, HC; Lin, KH; Lin, YC; Lu, WJ; Sheu, JR; Wu, MP	1
Ashitani, T; Bunyu, Y; Fujita, K; Kuroda, K; Shigeto, J; Tsutsumi, Y	1
Corona, A; Rösch, P; Schneider, A; Schweimer, K; Tramontano, E; Wöhrl, BM	1
Chang, KW; Chen, YL; Hsia, SM; Hsue, SS; Ko, SY; Lee, SY; Lin, DJ; Shieh, TM; Shih, YH; Wang, TH	1
Chang, WW; Hsieh, JL; Kuo, CY; Lee, CH; Li, TY; Lin, ST; Liu, LW; Wang, WK	1
Gao, Y; Hu, J; Li, S; Pang, S; Shen, Y; Xiao, G; Xu, Y	1
Chen, HW; Chen, WJ; Ho, CC; Ho, CL; Hsieh, WY; Lee, JY; Li, LH; Li, PR; Wang, CC; Wu, P; Yang, SM; Yen, MY	1
Bao, JP; Chen, WP; Fan, TD; Jiang, LF; Li, J; Wu, LD; Xiong, Y; Yang, KH; Zhou, XD	1
Abe, H; Abe, T; Kamiya, T; Oyama, T; Takahashi, S; Tanuma, S; Yoshimori, A	1
Chang, CC; Huang, CH; Jayakumar, T; Lu, SH; Sheu, JR; Thomas, PA	1
Bao, C; Choi, HK; Kim, M; Kim, YS; Ko, J; Lee, HJ; Park, HC	1
Chen, Y; Du, H; Hu, Y; Liu, J; Ming, K; Song, M; Wang, D; Wang, Y; Wu, Y; Xiong, W; Zeng, L	1
Jin, K; Lou, LX; Miao, Q; Xi, Y; Xu, YF; Ye, J; Ye, X	1
Chou, DS; Hsieh, CY; Hsu, MJ; Jayakumar, T; Ko, CY; Wang, MJ; Yang, PS	1
Ito, C; Kato, Y; Nomura, T; Ogita, S; Shichiken, M; Yamashita, T	1
Chang, CC; Choy, CS; Fong, TH; Huang, CH; Jayakumar, T; Lu, SH; Sheu, JR; Thomas, PA	1
Chiang, WC; Hsu, CW; Huang, YF; Kuo, CY; Lee, CH; Lin, YC; Tsao, YT; Wang, WK	1
Lee, JH; Lee, YJ; Moon, JH; Park, SY	2
Hsu, TT; Huang, MH; Huang, TH; Shen, YF; Shie, MY	1
Jin, K; Lou, L; Miao, Q; Wang, S; Xi, Y; Xu, Y; Ye, J; Ye, X	1
Calhelha, RC; Ćirić, A; Ferreira, IC; Fotopoulou, T; Koufaki, M; Kritsi, E; Soković, M; Zoumpoulakis, P	1
De Alwis, R; Fujita, K; Kambe, R; Tsutsumi, Y; Yagi, T	1
Baym, M; Chait, R; Clardy, J; Kishony, R; Lieberman, TD; Stone, LK	1
Anderson, AC; Falcone, ER; Holstein, SA; Li, J; Wiemer, AJ; Wright, DL	1
Choi, JS; Kim, DJ; Kim, SW; Lee, MW; Lee, SG; Park, JY	1
Choi, YH; Kim, HS; Moon, JW; Park, SH; Seo, JS	1
Kajiwara, N; Kamoshida, S; Naito, Y; Shintani, M; Yasui, H; Yoshikawa, Y	1
Inoue, Y; Kanamoto, I; Limmatvapirat, S; Murata, I; Suzuki, R	1
Anderson, JB; Burke, MD; Cioffi, AG; Fan, J; Gewirth, AA; Grillo, AS; Han, M; Hong, JD; Huston, NC; Kafina, MD; Kim, J; Menon, AV; Nardone, C; Nicolau, BG; Paw, BH; SantaMaria, AM; Seo, YA; Subedi, K; Svoboda, DC; Wessling-Resnick, M; Yien, YY	1
Sakaguchi, H	1
Chen, PN; Hsieh, PL; Liao, YW; Lu, KH; Ouyang, WC; Yu, CC	1
Chen, J; Chen, X; Liu, J; Wang, X; Xu, D; Yang, L; Yang, Q; Zhang, P; Zhang, X	1
Brown, PH; Peng, G; Peng, X; Peng, Y; Shen, J; Tu, W; Uray, IP; Wang, L; Zhang, L	1
Fujita, T; Kumamoto, E; Magori, N	1
Cherng, JY; Liu, CC; Pan, KH; Shen, CR; Shih, MF	1
Chiu, YW; Hsieh, PL; Huang, YF; Ju Chueh, P; Liao, YW; Lu, MY; Yang, HW; Yu, CC	1
Hong, H; Pan, Y; Tang, S; Wang, T; Wang, X; Wei, J; Wei, W; Yang, L; Yao, Y; Zhang, J	1
Hsieh, CY; Jayakumar, T; Lee, TY; Liu, CH; Manubolu, M; Sheu, JR; Wu, GY; Yang, CH	1
Chen, RJ; Huang, HC; Lin, KH; Lu, WJ; Sheu, JR; Tseng, MF; Yuan, KC	1
Sumathi, T; Varier, KM	1
Chen, RF; Chen, YF; Lin, CH; Wei, KC	1
Chen, F; He, J; Hu, X; Ma, Y; Mao, Z; Shen, M; Song, H; Ye, X; Zhang, G; Zhu, J	1
Auh, JH; Chen, J; Cho, JS; Kim, GD; Kim, JT; Ko, J; Lee, HJ; Qiu, S	1
Domon, H; Hiyoshi, T; Kawabata, S; Kimura, O; Kunitomo, E; Maekawa, T; Tamura, H; Terao, Y; Yanagihara, K; Yonezawa, D	1
Collins, JF; Garrick, LM; Garrick, MD; Ghio, AJ; Soukup, J; Zhao, L	1
Chang, CW; Chang, KC; Chen, CH; Chen, WC; Ko, CL; Lin, DJ; Wu, YR	1
Domon, H; Hiyoshi, T; Kunitomo, E; Maekawa, T; Tabeta, K; Terao, Y; Yonezawa, D	1
Hsu, WJ; Lee, CH; Liou, HP; Pangilinan, CR; Tyan, YC; Wu, LH; Wu, YJ	1
Chen, BK; Chen, LC; Chen, PH; Wang, CC	1
Han, B; Hoang, BX	1
Domon, H; Hiyoshi, T; Isono, T; Kunitomo, E; Maekawa, T; Nagai, K; Noiri, Y; Takenaka, S; Tamura, H; Terao, Y; Yanagihara, K	1
Chang, KC; Chen, CH; Chen, JC; Chen, WC; Ko, CL; Liu, SM	1
Osada, K; Sakakibara, Y; Shigetomi, K; Ubukata, M; Uraki, Y	1
Chen, C; Ke, W; Li, G; Li, S; Liao, Z; Ling, L; Lu, S; Luo, R; Song, Y; Wang, B; Wang, K; Wu, X; Xiang, Q; Yang, C; Zhang, Y	1
Fu, Z; Li, X; Qian, Y; Sun, P; Wang, K; Wang, Y; Yang, Q; Zhang, T	1
Chaure, A; Doskocil, I; Havlik, J; Houdkova, M; Kokoska, L	1
Ali, M; Chang, HY; Chen, HY; Cheng, WP; Chiang, YF; Hong, YH; Hsia, SM; Huang, TC; Shieh, TM; Wang, KL	1
Abe, H; Abe, T; Kamiya, T; Ogawa, H; Oyama, T; Shirai, Y; Tanuma, SI	1
Chang, W; Chen, J; Duan, X; Jin, X; Liu, Y; Lou, H; Lu, J; Zhang, M	1
Bai, P; Chen, H; Fan, Z; Ge, C; Pei, X; Wan, L; Yan, X; Yang, H; Yue, W; Zeng, Q; Zhang, B; Zhang, Y	1
Chen, HY; Chuang, WL; Hsieh, CP; Huang, YF; Wang, HC; Yang, SC	1
Dai, J; Du, L; Huang, S; Li, X; Lu, K; Mao, ZW; Pan, JA; Tao, X; Wang, PH; Xia, W; Xie, Y; Zhang, L; Zhao, Z	1
Haas, M; Heiduschka, G; Jank, BJ; Kadletz-Wanke, L; Lenz, T	1
Cai, Q; Chen, X; Jin, L; Liang, S; Liu, J; Xiao, H; Yang, Z	1
Liu, Z; Luo, Y; Wang, L; Wu, M; Zhao, X; Zheng, K	1
Alla, GR; Banothu, AK; Bharani, KK; Boinepally, R; Chelpuri, Y; Kamishetti, M; Khurana, A; Pabbathi, S; Yadala, RK	1
Aring, L; Bao, K; Burke, MD; Chang, J; Choi, EK; Choi, HS; Corradini, E; Ekaputri, S; Green, KJ; Iwase, S; Kim, J; Pietrangelo, A; Sabelli, M; Seo, YA	1
Da, H; Ding, Z; Fang, J; He, Y; Wang, Z; Wu, Q; Xi, J; Xu, Y; Zhang, F; Zhang, Z; Zhao, H	1
Machino, K; Ochiai, T; Osada, K; Sakakibara, Y; Shigetomi, K; Uraki, Y	1

Reviews

3 review(s) available for tropolone and beta-thujaplicin

Article	Year
[Study on the development of biological-active compounds after the model of natural products]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1992, Volume: 112, Issue:2 Topics: Analgesics; Animals; Antineoplastic Agents; Benzopyrans; Benzoxazoles; DNA, Neoplasm; Drug Design; Humans; Isocoumarins; Monoterpenes; Quinolines; Structure-Activity Relationship; Sweetening Agents; Tropolone	1992
The excellence of Aomori Hiba (Hinokiasunaro) in its use as building materials of Buddhist temples and Shinto shrines. Biocontrol science, 2006, Volume: 11, Issue:2 Topics: Buddhism; Cupressaceae; Fungicides, Industrial; Insecticides; Japan; Molecular Structure; Monoterpenes; Plant Oils; Tropolone; Wood	2006
Treatment and Prevention of Oral Candidiasis in Elderly Patients. Medical mycology journal, 2017, Volume: 58, Issue:2 Topics: Aged; Aged, 80 and over; Antifungal Agents; Candidiasis, Oral; Drug Therapy, Combination; Female; Humans; Male; Miconazole; Monoterpenes; Recurrence; Secondary Prevention; Tropolone	2017

Trials

3 trial(s) available for tropolone and beta-thujaplicin

Article	Year
[A clinical re-evaluation of an Hinoporon on periodontal disease using the double blind method]. Aichi Gakuin Daigaku Shigakkai shi, 1987, Volume: 25, Issue:1 Topics: Administration, Topical; Anti-Inflammatory Agents; Benzocaine; Clinical Trials as Topic; Cycloheptanes; Gingivitis; Humans; Hydrocortisone; Monoterpenes; Periodontitis; Tropolone	1987
Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa. The Journal of veterinary medical science, 2006, Volume: 68, Issue:4 Topics: Animals; Anti-Infective Agents; Dermatomycoses; Dog Diseases; Dogs; Malassezia; Monoterpenes; Otitis Externa; Time Factors; Tropolone	2006
Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study. Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 116, Issue:4 Topics: Adult; Aged; Anti-Infective Agents; Candida albicans; Cetylpyridinium; Chromatography, Gas; Cupressaceae; Dental Plaque Index; Female; Halitosis; Humans; Male; Middle Aged; Monoterpenes; Mouth; Phytotherapy; Pilot Projects; Plant Oils; Saliva; Toothbrushing; Toothpastes; Tropolone	2013

Other Studies

170 other study(ies) available for tropolone and beta-thujaplicin

Article	Year
Biological activity of tropolone. Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:10 Topics: Animals; Antifungal Agents; Insecta; Insecticides; Pythium; Tropolone	2003
Biological activity of alpha-thujaplicin, the isomer of hinokitiol. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:6 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Leukemia P388; Mice; Monoterpenes; Stereoisomerism; Tropolone	2004
Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Death; Cell Line; Hippocampus; Molecular Structure; Monoterpenes; Neurons; Neuroprotective Agents; Tropolone	2010
Identifying chelators for metalloprotein inhibitors using a fragment-based approach. Journal of medicinal chemistry, 2011, Jan-27, Volume: 54, Issue:2 Topics: Antigens, Bacterial; Bacterial Toxins; Chelating Agents; Copper; Drug Design; Humans; Hydroxyquinolines; Iron; Ligands; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Monophenol Monooxygenase; Nitric Oxide Synthase Type II; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides; Zinc	2011
The extraneuronal accumulation of isoprenaline in trachea and atria of guinea-pig and cat: a fluorescence histochemical study. British journal of pharmacology, 1979, Volume: 65, Issue:2 Topics: Animals; Catechol O-Methyltransferase Inhibitors; Cats; Female; Fluorescent Antibody Technique; Formaldehyde; Guinea Pigs; In Vitro Techniques; Isoproterenol; Monoterpenes; Myocardium; Phenoxybenzamine; Time Factors; Trachea; Tropolone	1979
Comparison of the effects of tropolone, beta-thujaplicin and U-0521 on the extraneuronal accumulation of isoprenaline in guinea-pig trachealis smooth muscle cells. A quantitative fluorescence histochemical study. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 307, Issue:3 Topics: Animals; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cycloheptanes; Female; Guinea Pigs; Histocytochemistry; In Vitro Techniques; Isoproterenol; Kinetics; Monoterpenes; Muscle, Smooth; Propiophenones; Trachea; Tropolone	1979
High-performance liquid chromatographic determination of hinokitiol in cosmetics by the formation of difluoroborane compounds. Journal of chromatography, 1988, Nov-25, Volume: 455 Topics: Chromatography, High Pressure Liquid; Cosmetics; Cycloheptanes; Monoterpenes; Tropolone	1988
[Methylation of hinokitiol and 7-iodohinokitiol and the syntheses of Schiff bases of hydrazinotropone derivatives and 5-aminohinokitiol]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1983, Volume: 103, Issue:12 Topics: Anti-Infective Agents; Cycloheptanes; Methylation; Monoterpenes; Schiff Bases; Tropolone	1983
The multifunctional actions of beta-thujaplicin on the oxidative energy transformations as a consequence of its lipophilic and chelating properties. Acta biologica et medica Germanica, 1980, Volume: 39, Issue:11-12 Topics: Adenosine Diphosphate; Animals; Cycloheptanes; Dinitrophenols; Edetic Acid; Iron Chelating Agents; Kinetics; Magnesium; Mersalyl; Mitochondria, Liver; Mitochondrial Swelling; Monoterpenes; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rotenone; Tropolone	1980
Allergic contact dermatitis to pyridoxine ester and hinokitiol. Contact dermatitis, 1983, Volume: 9, Issue:1 Topics: Adolescent; Adult; Cycloheptanes; Dermatitis, Contact; Female; Humans; Male; Middle Aged; Monoterpenes; Patch Tests; Pyridoxine; Tropolone	1983
[On the antibacterial effect of hinokitiol against Staphylococcus aureus showing double zone phenomenon]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1995, Volume: 69, Issue:1 Topics: Dose-Response Relationship, Drug; Drug Resistance, Microbial; Methicillin Resistance; Monoterpenes; Staphylococcus aureus; Tropolone	1995
Cytotoxic effect of hinokitiol and tropolone on the growth of mammalian cells and on blastogenesis of mouse splenic T cells. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:5 Topics: Animals; Cell Division; Cell Survival; Concanavalin A; Humans; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Monoterpenes; Spleen; T-Lymphocytes; Thymidine; Tropolone; Tumor Cells, Cultured	1993
Hinokitiol induces differentiation of teratocarcinoma F9 cells. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers; Butyrates; Butyric Acid; Cell Differentiation; DNA, Neoplasm; Embryonal Carcinoma Stem Cells; Mice; Monoterpenes; Neoplastic Stem Cells; Plasminogen Activators; Structure-Activity Relationship; Tropolone; Tumor Cells, Cultured	1995
Induction of differentiation of embryonal carcinoma F9 cells by iron chelators. Research communications in molecular pathology and pharmacology, 1995, Volume: 90, Issue:2 Topics: Animals; Anticarcinogenic Agents; Carcinoma, Embryonal; Cations; Cell Differentiation; Iron Chelating Agents; Kinetics; Metals; Mice; Monoterpenes; Teratocarcinoma; Tropolone; Tumor Cells, Cultured	1995
Biological activity of purpurogallin. Bioscience, biotechnology, and biochemistry, 1997, Volume: 61, Issue:5 Topics: Anti-Bacterial Agents; Benzocycloheptenes; Brassica; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Molecular Structure; Monoterpenes; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Tropolone	1997
Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. The Journal of investigative dermatology, 1998, Volume: 110, Issue:1 Topics: Animals; Anti-Infective Agents; Apoptosis; Biotin; Cadmium; Cell Survival; Cells, Cultured; DNA Fragmentation; DNA Nucleotidylexotransferase; Female; Keratinocytes; Metallothionein; Mice; Mice, Inbred BALB C; Monoterpenes; RNA, Messenger; Sunburn; Tropolone; Ultraviolet Rays	1998
Effects of zinc oxide on the attachment of Staphylococcus aureus strains. Journal of dermatological science, 1998, Volume: 17, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Blood Coagulation; Colony Count, Microbial; Dermatologic Agents; Microbial Sensitivity Tests; Monoterpenes; Rabbits; Staphylococcus aureus; Tropolone; Zinc Oxide	1998
Thujaplicin-copper chelates inhibit replication of human influenza viruses. Antiviral research, 1998, Volume: 39, Issue:2 Topics: Animals; Antiviral Agents; Apoptosis; Cell Line; Cell Survival; Chelating Agents; Copper; Dogs; Humans; Influenza A virus; Monoterpenes; Tropolone; Viral Plaque Assay; Virus Replication	1998
Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes. Chemico-biological interactions, 1998, Nov-06, Volume: 116, Issue:1-2 Topics: Animals; Calcium; Cations, Divalent; Cells, Cultured; Chelating Agents; Drug Interactions; Edetic Acid; Iron Chelating Agents; Liver; Magnesium; Male; Mitochondria, Liver; Monoterpenes; Rats; Rats, Inbred F344; Tropolone	1998
Beta-thujaplicin zinc chelate induces apoptosis in mouse high metastatic melanoma B16BL6 cells. Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:12 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Chelating Agents; DNA Fragmentation; HeLa Cells; Humans; Iron Chelating Agents; Melanoma, Experimental; Mice; Monoterpenes; Neoplasm Metastasis; Tropolone; Tumor Cells, Cultured; Zinc	1998
Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell proliferation, 1999, Volume: 32, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Aniline Compounds; Apoptosis; Caspase 3; Caspases; Cell-Free System; Cysteine Proteinase Inhibitors; DNA Fragmentation; Embryonal Carcinoma Stem Cells; Enzyme Activation; Iron Chelating Agents; Monoterpenes; Neoplastic Stem Cells; Oligopeptides; Teratocarcinoma; Tropolone	1999
Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constituents of Thujopsis dolabrata S. and Z. hondai MAK. Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:9 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Carboxypeptidases; Carboxypeptidases A; Cycadopsida; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Monoterpenes; Penicillium; Protease Inhibitors; Thermolysin; Tropolone	1999
Teratogenicity of thujaplicin in ICR mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, Volume: 37, Issue:11 Topics: Abnormalities, Drug-Induced; Animals; Anti-Infective Agents; Apoptosis; Culture Techniques; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Food Additives; Iron Chelating Agents; Male; Mice; Mice, Inbred ICR; Monoterpenes; Pregnancy; Teratogens; Tropolone	1999
Apoptosis during iron chelator-induced differentiation in F9 embryonal carcinoma cells. Cell biology international, 1999, Volume: 23, Issue:8 Topics: Animals; Antineoplastic Agents; Apoptosis; Butyrates; Cell Differentiation; Chelating Agents; Deferoxamine; Dithizone; DNA Fragmentation; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Image Cytometry; Iron Chelating Agents; Monoterpenes; Neoplastic Stem Cells; Tretinoin; Tropolone	1999
Phytogrowth-Inhibitory activities of beta-dolabrin and gamma-thujaplicin, hinokitiol-related compounds and constituents of Thujopsis dolabrata Sieb. et Zucc. var hondai Makino. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5 Topics: Brassica; Cycadopsida; Cycloheptanes; Monoterpenes; Plant Growth Regulators; Tropolone	2000
Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:8 Topics: Antifungal Agents; Basidiomycota; Insecticides; Monoterpenes; Plants; Tropolone	2000
Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase. Biochemical and biophysical research communications, 2000, Sep-07, Volume: 275, Issue:3 Topics: Animals; Anti-Infective Agents; Arachidonate 12-Lipoxygenase; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Leukocytes; Lipoxygenase Inhibitors; Membrane Proteins; Monoterpenes; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Substrate Specificity; Time Factors; Trees; Tropolone	2000
Identification of a compound in Chamaecyparis taiwanensis inhibiting the ice-nucleating activity of Pseudomonas fluorescens KUIN-1. Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:12 Topics: Bicyclic Monoterpenes; Cyclohexenes; Drug Evaluation, Preclinical; Gas Chromatography-Mass Spectrometry; Ice; Limonene; Monoterpenes; Plant Extracts; Pseudomonas fluorescens; Spectrophotometry, Ultraviolet; Terpenes; Trees; Tropolone	2000
Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin. Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Carcinoma, Ehrlich Tumor; Cycloheptanes; Drug Screening Assays, Antitumor; Humans; Lethal Dose 50; Male; Mice; Monoterpenes; Stomach Neoplasms; Tropolone; Tumor Cells, Cultured	2001
Improved beta-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate. Applied microbiology and biotechnology, 2001, Volume: 55, Issue:3 Topics: Acetates; Alginates; Anti-Infective Agents; Cell Count; Cells, Cultured; Chitin; Culture Media; Cyclopentanes; Dose-Response Relationship, Drug; Fungi; Glucuronic Acid; Hexuronic Acids; Monoterpenes; Oxylipins; Plant Growth Regulators; Plants; Tropolone	2001
Cytotoxic effects of beta-thujaplicin on rat thymocytes and prevention by the compound in tributyltin-induced thymocyte damage. Bulletin of environmental contamination and toxicology, 2001, Volume: 67, Issue:1 Topics: Animals; Anti-Infective Agents; Apoptosis; DNA Damage; Male; Monoterpenes; Rats; Rats, Inbred F344; Thymus Gland; Trialkyltin Compounds; Tropolone	2001
Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO. Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:6 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gram-Positive Bacteria; Humans; Male; Mice; Monoterpenes; Plant Growth Regulators; Trees; Tropolone; Tumor Cells, Cultured	2001
Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes. Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:5 Topics: Acids; Cell Culture Techniques; Citric Acid Cycle; Culture Media; Kinetics; Monoterpenes; Terpenes; Trees; Tropolone	2001
Fungicidal activity of beta-thujaplicin analogues. Pest management science, 2001, Volume: 57, Issue:9 Topics: Anti-Infective Agents; Basidiomycota; Biodegradation, Environmental; Dose-Response Relationship, Drug; Fungicides, Industrial; Molecular Structure; Monoterpenes; Mycelium; Tropolone; Wood	2001
Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica. Phytochemistry, 2002, Volume: 60, Issue:5 Topics: Cell Count; Cells, Cultured; Culture Media; Cupressus; Feedback, Physiological; Molecular Structure; Monoterpenes; Time Factors; Tropolone	2002
Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata SIeb. et Zucc. hondai Mak. Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:8 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Cell Division; Humans; Mice; Microbial Sensitivity Tests; Monoterpenes; Tropolone; Tumor Cells, Cultured	2002
Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis. The Journal of antimicrobial chemotherapy, 2003, Volume: 51, Issue:1 Topics: Adolescent; Adult; Anti-Bacterial Agents; Cell Survival; Dermatitis, Atopic; Drug Therapy, Combination; Female; Humans; Infant; Male; Microbial Sensitivity Tests; Monoterpenes; Staphylococcus aureus; Statistics, Nonparametric; Tropolone; Zinc Oxide	2003
Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Journal of experimental botany, 2003, Volume: 54, Issue:383 Topics: Acetates; Calcimycin; Calcium; Cells, Cultured; Cholera Toxin; Cupressus; Cyclopentanes; Egtazic Acid; Fungi; GTP Phosphohydrolases; GTP-Binding Proteins; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Lanthanum; Lipoxygenase; Monoterpenes; Oxylipins; Peptides; Plant Growth Regulators; Signal Transduction; Suramin; Tropolone; Verapamil; Wasp Venoms	2003
[Therapeutic uses of hinokitiol (m-isopropyltropolone) in tuberculous fistula and pulmonary tuberculosis]. Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung, 1954, Volume: 110, Issue:6 Topics: Alcohols; Anal Canal; Fistula; Monoterpenes; Tropolone; Tuberculosis; Tuberculosis, Pulmonary	1954
[Pharmacological studies on hinokitiol (4-isopropyl tropolone)]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1954, Volume: 221, Issue:3 Topics: Monoterpenes; Plants; Tropolone	1954
[Therapeutic uses of hinokitiol (m-isopropyltropolone) in lung gangrene]. Zeitschrift fur klinische Medizin, 1953, Volume: 151, Issue:2 Topics: Alcohols; Gangrene; Humans; Lung; Lung Abscess; Monoterpenes; Tropolone	1953
[Antibacterial effect of the hinokitiol (m-isopropyltropolone)]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale, 1954, Volume: 161, Issue:2-3 Topics: Anti-Bacterial Agents; Bacteria; Humans; Monoterpenes; Pharmaceutical Preparations; Tropolone	1954
[Therapeutic use of hinokitiol in pulmonary gangrene not well responding to antibiotics]. Medizinische Klinik, 1956, Nov-30, Volume: 51, Issue:48 Topics: Anti-Bacterial Agents; Gangrene; Humans; Lung Diseases; Monoterpenes; Oils; Plant Extracts; Tropolone	1956
[Further experiences with hinokitiol therapy in large cavernous, chemotherapeutic resistent pulmonary tuberculosis]. Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung, 1957, Volume: 116, Issue:6 Topics: Aldehydes; Monoterpenes; Tropolone; Tuberculosis; Tuberculosis, Pulmonary	1957
[Experimental and clinical studies on unsaturated 7-membered ring compounds. 39. Experimental studies of azulen and hinokitiol on cicatrization of wounds]. Japanese journal of medical science & biology, 1961, Jun-10, Volume: 50 Topics: Anti-Infective Agents, Local; Antitubercular Agents; Biomedical Research; Cicatrix; Cycloparaffins; Humans; Monoterpenes; Tropolone; Wound Healing	1961
Synethesis of beta-dolabrin from beta-thujaplicin (hinokitiol). Chemical & pharmaceutical bulletin, 1962, Volume: 10 Topics: Chemistry, Pharmaceutical; Cycloheptanes; Cycloparaffins; Monoterpenes; Tropolone	1962
Generation of reactive oxygen species from Hinokitiol under near-UV irradiation. Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:9 Topics: Colony Count, Microbial; Electron Spin Resonance Spectroscopy; Escherichia coli; Hydroxyl Radical; Monoterpenes; Photolysis; Reactive Oxygen Species; Spectrophotometry, Ultraviolet; Superoxides; Tropolone; Ultraviolet Rays	2003
Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities. Journal of inorganic biochemistry, 2004, Volume: 98, Issue:1 Topics: Aluminum; Anti-Infective Agents; Cobalt; Crystallography, X-Ray; Metals; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Monoterpenes; Organometallic Compounds; Oxygen; Silver; Spectrophotometry, Infrared; Tropolone	2004
[Antimicrobial activity of hinokitiol against Legionella pneumophila]. Journal of UOEH, 2003, Dec-01, Volume: 25, Issue:4 Topics: Anti-Bacterial Agents; Chamaecyparis; Legionella pneumophila; Microbial Sensitivity Tests; Monoterpenes; Oils, Volatile; Tropolone	2003
Transmission electron microscopy of Schistosoma mansoni cercariae treated with hinokitiol (beta-thujaplicin), a compound for potential skin application against cercarial penetration. The Tohoku journal of experimental medicine, 2004, Volume: 202, Issue:1 Topics: Animals; Anti-Infective Agents; Biomphalaria; Dose-Response Relationship, Drug; Gerbillinae; Kinetics; Microscopy, Electron; Monoterpenes; Schistosoma mansoni; Tropolone	2004
Rapid accumulation and metabolism of polyphosphoinositol and its possible role in phytoalexin biosynthesis in yeast elicitor-treated Cupressus lusitanica cell cultures. Planta, 2004, Volume: 219, Issue:1 Topics: Calcium; Cells, Cultured; Cupressus; Inositol 1,4,5-Trisphosphate; Monoterpenes; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phytoalexins; Plant Extracts; Sesquiterpenes; Signal Transduction; Terpenes; Tropolone; Type C Phospholipases; Yeasts	2004
Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2004, Volume: 42, Issue:3 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Infective Agents; Body Weight; Bone Development; Dose-Response Relationship, Drug; Eating; Embryonic and Fetal Development; Embryonic Development; Female; Fetal Resorption; Fetal Weight; Litter Size; Male; Maternal Exposure; Monoterpenes; No-Observed-Adverse-Effect Level; Pregnancy; Rats; Rats, Wistar; Tropolone	2004
Beta-thujaplicin: new quantitative CZE method and adsorption to goethite. Journal of agricultural and food chemistry, 2004, Mar-24, Volume: 52, Issue:6 Topics: Adsorption; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Iron Compounds; Minerals; Monoterpenes; Soil; Tropolone	2004
Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. Journal of experimental botany, 2004, Volume: 55, Issue:399 Topics: Cells, Cultured; Cupressus; Cyclopentanes; Ethylenes; Kinetics; Monoterpenes; Oxylipins; Plant Growth Regulators; Signal Transduction; Tropolone	2004
(-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production. Archives of pharmacal research, 2004, Volume: 27, Issue:3 Topics: Animals; Catechin; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Combinations; Humans; Melanins; Mice; Microphthalmia-Associated Transcription Factor; Monoterpenes; Transcription Factors; Tropolone	2004
[On the therapeutic effect of Hinokitiol on decubitus ulcers]. Medizinische Klinik, 1961, Jun-23, Volume: 56 Topics: Anti-Infective Agents, Local; Humans; Monoterpenes; Oils; Oils, Volatile; Pressure Ulcer; Tropolone	1961
Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:10 Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cycloheptanes; Fungi; Fungicides, Industrial; Legionella; Mice; Microbial Sensitivity Tests; Monoterpenes; Plants; Thuja; Tropolone	2004
Acaricidal activity of active constituent isolated in Chamaecyparis obtusa leaves against Dermatophagoides spp. Journal of agricultural and food chemistry, 2005, Mar-23, Volume: 53, Issue:6 Topics: Benzoates; DEET; Gas Chromatography-Mass Spectrometry; Insecticides; Methanol; Monoterpenes; Plant Extracts; Plant Leaves; Pyroglyphidae; Tick Control; Tracheophyta; Tropolone	2005
Fungal diversity from western redcedar fences and their resistance to beta-thujaplicin. Antonie van Leeuwenhoek, 2005, Volume: 87, Issue:2 Topics: Antifungal Agents; Ascomycota; Basidiomycota; Canada; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal Spacer; Fungi; Molecular Sequence Data; Monoterpenes; Sequence Analysis, DNA; Sequence Homology; Soil Microbiology; Thuja; Tropolone; Wood	2005
Oxidative stress in plant cell culture: a role in production of beta-thujaplicin by Cupresssus lusitanica suspension culture. Biotechnology and bioengineering, 2005, Jun-05, Volume: 90, Issue:5 Topics: Antioxidants; Cells, Cultured; Cupressus; Hydrogen Peroxide; Iron; Monoterpenes; Oxidative Stress; Plant Proteins; Reactive Oxygen Species; Signal Transduction; Tropolone	2005
In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:6 Topics: Anti-Infective Agents; Chlamydia trachomatis; Dose-Response Relationship, Drug; HeLa Cells; Humans; Microbial Sensitivity Tests; Monoterpenes; Tropolone	2005
Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures. Metabolic engineering, 2006, Volume: 8, Issue:1 Topics: Monoterpenes; Signal Transduction; Tracheophyta; Tropolone	2006
Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:12 Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Drug Synergism; Humans; Hypopigmentation; Melanins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Monoterpenes; Resorcinols; Signal Transduction; Skin Pigmentation; Tropolone	2005
Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species. Basic & clinical pharmacology & toxicology, 2005, Volume: 97, Issue:6 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitate Hydratase; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Ascorbic Acid; Copper Sulfate; Deoxyguanosine; DNA; Ferrous Compounds; Fructose-Bisphosphate Aldolase; Glyceraldehyde-3-Phosphate Dehydrogenases; Monoterpenes; Oxidants; Reactive Oxygen Species; Tropolone; Yeasts	2005
Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species. Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:1 Topics: Acetylcysteine; Alkaloids; Benzophenanthridines; Blotting, Western; Enzyme Inhibitors; Epidermal Cells; Free Radical Scavengers; Genes, Reporter; Humans; Keratinocytes; Metallothionein; Monoterpenes; Phenanthridines; Plasmids; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Tropolone; Up-Regulation	2006
Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. The Journal of veterinary medical science, 2005, Volume: 67, Issue:12 Topics: Animals; Antifungal Agents; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Fungal; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Monoterpenes; Naphthalenes; Nystatin; Otitis Externa; Species Specificity; Terbinafine; Tropolone	2005
Mosquito larvicidal activity of active constituent derived from Chamaecyparis obtusa leaves against 3 mosquito species. Journal of the American Mosquito Control Association, 2005, Volume: 21, Issue:4 Topics: Aedes; Animals; Chamaecyparis; Culex; Larva; Monoterpenes; Mosquito Control; Ochlerotatus; Organothiophosphorus Compounds; Plant Extracts; Plant Leaves; Tropolone	2005
Differential regulation of melanosomal proteins after hinokitiol treatment. Journal of dermatological science, 2006, Volume: 43, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Down-Regulation; Flavonoids; Hypopigmentation; Intramolecular Oxidoreductases; Melanins; Melanosomes; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monophenol Monooxygenase; Monoterpenes; Oxidoreductases; Phosphorylation; Protein Biosynthesis; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Tropolone	2006
Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. Biochemical and biophysical research communications, 2006, Dec-08, Volume: 351, Issue:1 Topics: Androgens; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Humans; Male; Metals; Monoterpenes; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tropolone	2006
Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats. The Journal of toxicological sciences, 2006, Volume: 31, Issue:4 Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Food Additives; Male; Monoterpenes; Neoplasms, Experimental; Rats; Rats, Inbred F344; Tropolone	2006
Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis. The New phytologist, 2007, Volume: 175, Issue:2 Topics: Cell Death; Cells, Cultured; Cupressus; Hydrogen Peroxide; Monoterpenes; Nitric Oxide; Nitric Oxide Synthase; Phytoalexins; Reactive Oxygen Species; Sesquiterpenes; Terpenes; Time Factors; Tropolone	2007
Growth inhibitory effect of shelf life extending agents on Bacillus subtilis IAM 1026. Biocontrol science, 2007, Volume: 12, Issue:2 Topics: Bacillus subtilis; Chitosan; Food Microbiology; Food Preservatives; Monoterpenes; Polylysine; Tropolone	2007
The mechanism of the bactericidal activity of hinokitiol. Biocontrol science, 2007, Volume: 12, Issue:3 Topics: Adenine; Anti-Infective Agents; Cell Membrane Permeability; Escherichia coli; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Monoterpenes; Oxygen Consumption; Staphylococcus aureus; Tropolone	2007
Antifungal properties of ethanolic extract and its active compounds from Calocedrus macrolepis var. formosana (Florin) heartwood. Bioresource technology, 2008, Volume: 99, Issue:11 Topics: Antifungal Agents; Cupressaceae; Drug Evaluation, Preclinical; Ethanol; Fungi; Hexanes; Microbial Sensitivity Tests; Monoterpenes; Plant Extracts; Solubility; Trees; Tropolone; Wood	2008
Antibiotic substances from the heart wood of Thuja plicata D. Don; the constitution of beta-thujaplicin. Acta chemica Scandinavica, 1948, Volume: 2, Issue:8 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Dermatologic Agents; Monoterpenes; Thuja; Tropolone; Wood	1948
In vitro permeation study of hinokitiol: effects of vehicles and enhancers. Drug delivery, 2008, Volume: 15, Issue:1 Topics: Administration, Cutaneous; Animals; Chromatography, High Pressure Liquid; Diffusion; Diffusion Chambers, Culture; Ethanol; Fatty Alcohols; Female; Lauric Acids; Mice; Mice, Hairless; Monoterpenes; Permeability; Pharmaceutical Vehicles; Propylene Glycol; Pyrrolidinones; Skin; Skin Absorption; Time Factors; Tropolone	2008
Antifungal mechanism of hinokitiol against Candida albicans. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:4 Topics: Adenosine Triphosphate; Aerobiosis; Antifungal Agents; Candida albicans; Indicators and Reagents; Microbial Sensitivity Tests; Monoterpenes; RNA, Fungal; RNA, Messenger; Signal Transduction; Tropolone	2008
In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(epsilon-caprolacton) nanocapsules. Journal of microencapsulation, 2008, Volume: 25, Issue:5 Topics: Animals; Cosmetics; Electrophoresis; Hair; Hydrogen-Ion Concentration; Iron Chelating Agents; Light; Male; Mice; Mice, Inbred C57BL; Minoxidil; Monoterpenes; Nanocapsules; Polyesters; Scattering, Radiation; Tropolone	2008
Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB. Planta medica, 2008, Volume: 74, Issue:8 Topics: Anti-Infective Agents; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Macrophages; Monoterpenes; NF-kappa B; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Tropolone; Tumor Necrosis Factor-alpha	2008
High production of beta-thujaplicin glycosides by immobilized plant cells of Nicotiana tabacum. Acta biologica Hungarica, 2008, Volume: 59, Issue:3 Topics: Cell Line; Glycosides; Molecular Structure; Monoterpenes; Nicotiana; Tropolone	2008
Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. Journal of virology, 2009, Volume: 83, Issue:1 Topics: Antiviral Agents; Cytosol; Enterovirus; Eukaryotic Initiation Factor-4G; HeLa Cells; Humans; Mengovirus; Mitochondria; Monoterpenes; Polyproteins; Pyridines; Rhinovirus; Thiones; Tropolone; Viral Proteins; Virus Replication; Zinc	2009
Volatile and non-volatile monoterpenes produced by elicitor-stimulated Cupressus lusitanica cultured cells. Journal of plant physiology, 2009, May-01, Volume: 166, Issue:7 Topics: Cell Extracts; Cells, Cultured; Cupressus; Gas Chromatography-Mass Spectrometry; Monoterpenes; Solid Phase Microextraction; Time Factors; Tropolone; Volatilization; Yeasts	2009
p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. Cancer letters, 2009, Dec-28, Volume: 286, Issue:2 Topics: Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Humans; Immunoblotting; Melanoma; Monoterpenes; Phosphorylation; Protein Binding; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; S Phase; S-Phase Kinase-Associated Proteins; Tropolone	2009
In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid. Drug development and industrial pharmacy, 2010, Volume: 36, Issue:5 Topics: Administration, Cutaneous; Animals; Chlorides; Drug Carriers; Female; Methylamines; Mice; Mice, Hairless; Monoterpenes; Permeability; Skin; Skin Absorption; Stearic Acids; Tropolone	2010
Time-kill assay results for a linalool-hinokitiol-based eyelid cleanser for lid hygiene. Cornea, 2010, Volume: 29, Issue:5 Topics: Acyclic Monoterpenes; Anti-Infective Agents, Local; Bacteria; Colony Count, Microbial; Disinfectants; Drug Therapy, Combination; Eyelids; Fungi; Microbial Sensitivity Tests; Monoterpenes; Tropolone	2010
Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases. Biochemical and biophysical research communications, 2010, May-28, Volume: 396, Issue:2 Topics: Cell Line, Tumor; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Iron Chelating Agents; Mixed Function Oxygenases; Monoterpenes; Procollagen-Proline Dioxygenase; Repressor Proteins; Transcription, Genetic; Tropolone; Vascular Endothelial Growth Factor A	2010
Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6 Topics: Agaricales; Animals; Anti-Bacterial Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Food Preservatives; Fungal Proteins; Gram-Negative Bacteria; Gram-Positive Endospore-Forming Rods; Kinetics; Melanins; Melanocytes; Melanoma, Experimental; Mice; Microbial Sensitivity Tests; Monophenol Monooxygenase; Monoterpenes; Substrate Specificity; Tropolone	2010
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22 Topics: Agaricales; Amino Acid Sequence; Amino Acids; Bacterial Proteins; Binding Sites; Binding, Competitive; Catalytic Domain; Crystallography, X-Ray; Isomerism; Kinetics; Molecular Sequence Data; Monophenol Monooxygenase; Monoterpenes; Protein Binding; Sequence Alignment; Streptomyces; Tropolone	2010
Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes. Metallomics : integrated biometal science, 2010, Volume: 2, Issue:3 Topics: Blotting, Western; Cell Line; Disulfiram; Ditiocarb; Forkhead Box Protein O1; Forkhead Transcription Factors; Gluconeogenesis; Glucose-6-Phosphatase; Humans; Insulin; Monoterpenes; Phosphoenolpyruvate Carboxykinase (ATP); Receptor, IGF Type 1; Signal Transduction; Tropolone; Zinc	2010
A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:8 Topics: Animals; Body Weight; Cholesterol; Creatinine; Diet; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocyte Count; Erythrocyte Indices; Female; Heart; Kidney; Liver; Male; Monoterpenes; Myocarditis; Nitrogen; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Inbred F344; Toxicity Tests, Chronic; Tropolone	2011
Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet. Animal science journal = Nihon chikusan Gakkaiho, 2012, Volume: 83, Issue:1 Topics: Animal Feed; Animals; Anti-Infective Agents; Cattle; Citric Acid; Diet; Digestion; Drug Resistance, Bacterial; Edible Grain; Female; Fermentation; Megasphaera; Monoterpenes; Rumen; Streptococcus bovis; Tropolone	2012
Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts. The American journal of Chinese medicine, 2012, Volume: 40, Issue:2 Topics: Cell Line; Chamaecyparis; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-6; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Monoterpenes; Plant Extracts; Protective Agents; Skin; Tropolone; Ultraviolet Rays	2012
The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs. Organic & biomolecular chemistry, 2012, Nov-21, Volume: 10, Issue:43 Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Candida glabrata; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enterococcus faecalis; Furans; Humans; MCF-7 Cells; Molecular Structure; Monoterpenes; Staphylococcus aureus; Structure-Activity Relationship; Tropolone	2012
In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol. The Southeast Asian journal of tropical medicine and public health, 2012, Volume: 43, Issue:2 Topics: Administration, Cutaneous; Animals; Benzoquinones; Carum; In Vitro Techniques; Inhibitory Concentration 50; Injections, Subcutaneous; Male; Mice; Monarda; Monoterpenes; Myristica; Oils, Volatile; Plasmodium; Santalum; Tropolone	2012
Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor. Neuroreport, 2012, Dec-19, Volume: 23, Issue:18 Topics: Adrenocorticotropic Hormone; Animals; Male; Mice; Mice, Inbred C57BL; Monoterpenes; Odorants; Predatory Behavior; Septal Nuclei; Stress, Psychological; Tropolone	2012
In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. Microbiological research, 2013, Jun-12, Volume: 168, Issue:5 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Candida albicans; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Microbial Viability; Monoterpenes; Tropolone	2013
Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. Biochemical pharmacology, 2013, May-15, Volume: 85, Issue:10 Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Gene Expression Regulation; Humans; Hydroxyl Radical; Mice; Mitogen-Activated Protein Kinases; Monoterpenes; Phospholipase C gamma; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Signal Transduction; Thrombin; Thrombosis; Tropolone	2013
Tetsuo Nozoe's "Autograph Books by Chemists 1953-1994": an essay. Chemical record (New York, N.Y.), 2013, Volume: 13, Issue:3 Topics: Chemistry; History, 20th Century; Monoterpenes; Tropolone	2013
Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos. Macromolecular rapid communications, 2013, Volume: 34, Issue:21 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Folic Acid; Humans; Intrinsically Disordered Proteins; Melanoma; Molecular Dynamics Simulation; Molecular Mimicry; Monoterpenes; Nanoparticles; Protective Agents; Skin; Tropolone	2013
Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. Journal of natural products, 2013, Dec-27, Volume: 76, Issue:12 Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Colonic Neoplasms; Genes, bcl-2; HCT116 Cells; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Monoterpenes; rho GTP-Binding Proteins; S Phase; Tropolone; Xenograft Model Antitumor Assays	2013
Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible factor-1α (HIF-1α) upregulation. Archives of oral biology, 2014, Volume: 59, Issue:2 Topics: Blotting, Western; Dental Pulp; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Iron Chelating Agents; Mitogen-Activated Protein Kinases; Monoterpenes; Neovascularization, Physiologic; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tropolone; Up-Regulation	2014
Hinokitiol is a novel glycoprotein VI antagonist on human platelets. Platelets, 2014, Volume: 25, Issue:8 Topics: Blood Platelets; Glycoproteins; Humans; Monoterpenes; Platelet Activation; Tropolone	2014
A novel synthetic pathway for tropolone ring formation via the olefin monoterpene intermediate terpinolene in cultured Cupressus lusitanica cells. Journal of plant physiology, 2014, May-01, Volume: 171, Issue:8 Topics: Cell Extracts; Cells, Cultured; Cupressus; Cyclohexane Monoterpenes; Deuterium; Gas Chromatography-Mass Spectrometry; Monoterpenes; Terpenes; Tropolone	2014
Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 RNase H inhibitors. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Anti-HIV Agents; Caproates; Catalytic Domain; Crystallography, X-Ray; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Monoterpenes; Nuclear Magnetic Resonance, Biomolecular; Pyrroles; Reverse Transcriptase Inhibitors; Ribonuclease H; Spumavirus; Tropolone	2014
Evaluation physical characteristics and comparison antimicrobial and anti-inflammation potentials of dental root canal sealers containing hinokitiol in vitro. PloS one, 2014, Volume: 9, Issue:6 Topics: Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Cells, Cultured; Cyclooxygenase 2; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Methicillin-Resistant Staphylococcus aureus; Monoterpenes; Pit and Fissure Sealants; Protein-Lysine 6-Oxidase; RNA, Messenger; Root Canal Filling Materials; Streptococcus mutans; Tropolone	2014
Hinokitiol induces autophagy in murine breast and colorectal cancer cells. Environmental toxicology, 2016, Volume: 31, Issue:1 Topics: Animals; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Female; Mice; Monoterpenes; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Tropolone	2016
Application of hinokitiol potassium salt for wood preservative. Journal of environmental sciences (China), 2013, Volume: 25 Suppl 1 Topics: Antifungal Agents; Fungi; Monoterpenes; Potassium; Salts; Tropolone; Wood	2013
Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PloS one, 2014, Volume: 9, Issue:8 Topics: Acridine Orange; Adenocarcinoma; Adenocarcinoma of Lung; Annexin A5; Antineoplastic Agents, Phytogenic; Autophagy; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cupressaceae; DNA Damage; Drug Resistance, Neoplasm; ErbB Receptors; Gas Chromatography-Mass Spectrometry; Gefitinib; Gene Expression Profiling; Humans; Lung Neoplasms; Monoterpenes; Oils, Volatile; Quinazolines; Real-Time Polymerase Chain Reaction; Taiwan; Tropolone; Tumor Stem Cell Assay	2014
Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo. International immunopharmacology, 2014, Volume: 23, Issue:1 Topics: Animals; Anti-Inflammatory Agents; beta Catenin; Cells, Cultured; Chondrocytes; Collagen Type II; Cupressaceae; Gene Expression Regulation; Humans; Interleukin-1beta; Knee; Matrix Metalloproteinases; Models, Animal; Monoterpenes; Osteoarthritis; Phytotherapy; Rats; Rats, Inbred Strains; Signal Transduction; Tropolone; Wnt Proteins	2014
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Sequence Data; Monophenol Monooxygenase; Monoterpenes; Sequence Alignment; Structure-Activity Relationship; Tropolone	2014
Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation. European journal of pharmacology, 2015, Jan-05, Volume: 746 Topics: Animals; Carcinogenesis; Cell Movement; Gene Expression Regulation, Neoplastic; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Lung; Matrix Metalloproteinase 1; Melanoma, Experimental; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monoterpenes; Neoplasm Metastasis; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proteolysis; Transcription Factor RelA; Tropolone	2015
β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells. Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:6 Topics: Anticarcinogenic Agents; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Estrogen Receptor alpha; G1 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Monoterpenes; Proteolysis; Resting Phase, Cell Cycle; Signal Transduction; Tropolone	2015
Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments. Virus research, 2015, Jun-02, Volume: 204 Topics: Animals; Antioxidants; Ducks; Hepatitis Virus, Duck; Hepatitis, Viral, Animal; Immunosuppressive Agents; Liver; Monoterpenes; Picornaviridae Infections; Plant Roots; Polysaccharides; Poultry Diseases; Random Allocation; Sophora; Sulfates; Tacrolimus; Tropolone	2015
Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study. Eye (London, England), 2015, Volume: 29, Issue:7 Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Line; Cell Survival; Dimethyl Sulfoxide; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Gene Expression Profiling; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Monoterpenes; NF-kappa B; Poly I-C; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tropolone	2015
Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells. Molecules (Basel, Switzerland), 2015, May-07, Volume: 20, Issue:5 Topics: Animals; Becaplermin; Cell Cycle Checkpoints; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Male; MAP Kinase Signaling System; Monoterpenes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Resting Phase, Cell Cycle; Signal Transduction; Tropolone	2015
A stepwise protocol for induction and selection of prominent coniferous cell cultures for the production of β-thujaplicin. Natural product communications, 2015, Volume: 10, Issue:5 Topics: Cell Culture Techniques; Cells, Cultured; Monoterpenes; Plant Extracts; Tracheophyta; Tropolone	2015
Hinokitiol Exerts Anticancer Activity through Downregulation of MMPs 9/2 and Enhancement of Catalase and SOD Enzymes: In Vivo Augmentation of Lung Histoarchitecture. Molecules (Basel, Switzerland), 2015, Sep-25, Volume: 20, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Catalase; Enzyme Activation; Gene Expression Regulation, Neoplastic; Hydroxyl Radical; Lung; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma, Experimental; Mice; Monoterpenes; Superoxide Dismutase; Tropolone	2015
Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells. International journal of molecular sciences, 2016, Feb-18, Volume: 17, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Monoterpenes; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Tropolone	2016
Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1. Oncotarget, 2016, May-24, Volume: 7, Issue:21 Topics: Adenine; Androstadienes; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Microscopy, Electron, Transmission; Monoterpenes; Neurons; Neuroprotective Agents; Peptide Fragments; Primary Cell Culture; Prion Diseases; Prions; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Signal Transduction; Tropolone; Wortmannin	2016
Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol. Materials science & engineering. C, Materials for biological applications, 2016, Aug-01, Volume: 65 Topics: Anti-Infective Agents; Cell Differentiation; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dental Cements; Dental Pulp; Enterococcus faecalis; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1; Microscopy, Electron, Scanning; Monoterpenes; Odontogenesis; Silicate Cement; Tropolone	2016
Protective Role of Hinokitiol Against H Current eye research, 2017, Volume: 42, Issue:1 Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Catalase; Cell Survival; Cells, Cultured; Cytoprotection; Dimethyl Sulfoxide; Epithelium, Corneal; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Monoterpenes; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase; Tropolone	2017
Antimicrobial/Antibiofilm Activity and Cytotoxic Studies of β-Thujaplicin Derivatives. Archiv der Pharmazie, 2016, Volume: 349, Issue:9 Topics: Animals; Anti-Infective Agents; Biofilms; Cell Line; Cell Line, Tumor; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Monoterpenes; Quorum Sensing; Structure-Activity Relationship; Swine; Tropolone	2016
Airborne Monoterpenes Emitted from a Cupressus lusitanica Cell Culture Induce a Signaling Cascade that Produces β-Thujaplicin. Journal of chemical ecology, 2016, Volume: 42, Issue:8 Topics: Air; Cells, Cultured; Cupressus; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Monoterpenes; Signal Transduction; Terpenes; Tropolone	2016
Compounds that select against the tetracycline-resistance efflux pump. Nature chemical biology, 2016, Volume: 12, Issue:11 Topics: Anti-Bacterial Agents; Disulfiram; Dose-Response Relationship, Drug; Escherichia coli; Escherichia coli Proteins; Microbial Sensitivity Tests; Molecular Structure; Monoterpenes; Structure-Activity Relationship; Tetracycline Resistance; Tropolone	2016
Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis. Pharmacological research, 2016, Volume: 113, Issue:Pt A Topics: Acetylation; Amino Acid Chloromethyl Ketones; Apoptosis; Caspases; Cell Line; Cell Proliferation; Cell Survival; DNA Repair; Histones; Humans; Leukemia; Leukocytes, Mononuclear; Monoterpenes; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tropolone; Tumor Suppressor Protein p53; Up-Regulation	2016
Inhibitory activity of hinokitiol against biofilm formation in fluconazole-resistant Candida species. PloS one, 2017, Volume: 12, Issue:2 Topics: Antifungal Agents; Biofilms; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Drug Resistance, Fungal; Fluconazole; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Monoterpenes; Real-Time Polymerase Chain Reaction; Tropolone	2017
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC cell biology, 2017, 02-27, Volume: 18, Issue:1 Topics: 5-Methylcytosine; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Mixed Function Oxygenases; Monoterpenes; Neoplasm Proteins; Proto-Oncogene Proteins; RNA, Messenger; Time Factors; Tropolone; Ubiquitin-Protein Ligases	2017
Anti-hyperglycemic Effect of Long-Term Bis(hinokitiolato)zinc Complex ([Zn(hkt) Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:3 Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Insulin; Insulin Resistance; Islets of Langerhans; Male; Mice, Inbred Strains; Monoterpenes; Rats; Trace Elements; Tropolone; Zinc; Zinc Compounds	2017
SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol. The Journal of investigative dermatology, 2017, Volume: 137, Issue:6 Topics: Analysis of Variance; Anti-Inflammatory Agents; Cells, Cultured; Drug Interactions; Humans; Immunohistochemistry; Inflammation; Keratinocytes; Lipopolysaccharides; Monoterpenes; Real-Time Polymerase Chain Reaction; Sirtuin 1; Tropolone	2017
Molecular interactions of the inclusion complexes of hinokitiol and various cyclodextrins. AAPS PharmSciTech, 2017, Volume: 18, Issue:7 Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Monoterpenes; Solubility; Tropolone	2017
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (New York, N.Y.), 2017, 05-12, Volume: 356, Issue:6338 Topics: Animals; Caco-2 Cells; Gastrointestinal Absorption; Hemoglobins; Humans; Iron; Iron-Binding Proteins; Monoterpenes; Rats; Saccharomyces cerevisiae; Tropolone	2017
Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:2 Topics: AC133 Antigen; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Phytogenic; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Flow Cytometry; Gene Expression Regulation; Glioma; Humans; Isoenzymes; Monoterpenes; Neoplasm Invasiveness; Neoplastic Stem Cells; NF-E2-Related Factor 2; Retinal Dehydrogenase; Reverse Transcriptase Polymerase Chain Reaction; Tropolone	2017
Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells. European journal of pharmacology, 2017, Nov-15, Volume: 815 Topics: A549 Cells; Apoptosis; Caspases; Cell Proliferation; Cell Survival; Copper; Drug Synergism; Humans; K562 Cells; Monoterpenes; Organometallic Compounds; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Tropolone; Ubiquitin; Ubiquitination	2017
Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy. DNA repair, 2017, Volume: 60 Topics: Antineoplastic Agents; Cell Line, Tumor; Cupressaceae; DNA; DNA Breaks, Double-Stranded; Drug Therapy, Combination; Female; High-Throughput Screening Assays; Humans; Monoterpenes; Neoplasms; Plant Extracts; Poly(ADP-ribose) Polymerase Inhibitors; Rad51 Recombinase; Radiation-Sensitizing Agents; Recombinational DNA Repair; Tropolone	2017
Hinokitiol inhibits compound action potentials in the frog sciatic nerve. European journal of pharmacology, 2018, Jan-15, Volume: 819 Topics: Action Potentials; Animals; Anura; Dose-Response Relationship, Drug; Monoterpenes; Sciatic Nerve; Tropolone	2018
Treatment of β-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression. Regulatory toxicology and pharmacology : RTP, 2018, Volume: 92 Topics: Animals; Atherosclerosis; Cell Line; Diethylhexyl Phthalate; Disease Progression; E-Selectin; Endothelial Cells; Inflammation; Intercellular Adhesion Molecule-1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Monoterpenes; Muscle, Smooth, Vascular; Plasticizers; Rats; RAW 264.7 Cells; Tropolone; Vascular Cell Adhesion Molecule-1	2018
Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail. Environmental toxicology, 2018, Volume: 33, Issue:4 Topics: Actins; Animals; Areca; Arecoline; Cell Transdifferentiation; Humans; Monoterpenes; Myofibroblasts; Oral Submucous Fibrosis; Precancerous Conditions; Snail Family Transcription Factors; Tropolone	2018
Stimulation of cell responses and bone ingrowth into macro-microporous implants of nano-bioglass/polyetheretherketone composite and enhanced antibacterial activity by release of hinokitiol. Colloids and surfaces. B, Biointerfaces, 2018, Apr-01, Volume: 164 Topics: Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Apatites; Benzophenones; Body Fluids; Bone and Bones; Bone Development; Bone Morphogenetic Protein 2; Cell Line; Cell Proliferation; Cell Shape; Ceramics; Colony Count, Microbial; Cytoskeleton; Drug Liberation; Implants, Experimental; Ketones; Mice; Microbial Sensitivity Tests; Microbial Viability; Minerals; Monoterpenes; Nanoparticles; Polyethylene Glycols; Polymers; Porosity; Tropolone; X-Ray Diffraction; X-Ray Microtomography	2018
Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis. International journal of molecular sciences, 2018, Mar-22, Volume: 19, Issue:4 Topics: A549 Cells; Apoptosis; Caspase 3; Caspase 9; Catalase; Cell Movement; Cell Proliferation; Cytochromes c; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Monoterpenes; Superoxide Dismutase; Tropolone	2018
New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury. Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:3 Topics: Animals; Anti-Infective Agents; Apoptosis; Inflammation; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Monoterpenes; NF-kappa B; Shock, Hemorrhagic; Signal Transduction; Tropolone	2019
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Neurotoxicity research, 2019, Volume: 35, Issue:4 Topics: alpha-Synuclein; Apoptosis; Cell Line, Tumor; Down-Regulation; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Monoamine Oxidase; Monoterpenes; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Protein Deglycase DJ-1; Protein Kinases; PTEN Phosphohydrolase; RNA, Messenger; Tropolone	2019
Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression. Toxicology and applied pharmacology, 2019, 03-01, Volume: 366 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Dual Specificity Phosphatase 6; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Melanoma, Experimental; Mice; Monoterpenes; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Survivin; Tropolone; Ubiquitination	2019
β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. Cell death & disease, 2019, 03-15, Volume: 10, Issue:4 Topics: Aged; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagic Cell Death; Autophagosomes; Carcinoma, Hepatocellular; Cells, Cultured; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondria; Monoterpenes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tropolone	2019
β-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3β/β-catenin signaling. Food & function, 2019, May-22, Volume: 10, Issue:5 Topics: Animals; beta Catenin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chamaecyparis; Cyclin D1; Cyclin-Dependent Kinase 4; Drugs, Chinese Herbal; Female; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3 beta; Humans; Mice, Inbred BALB C; Monoterpenes; Phosphorylation; Signal Transduction; Thuja; Tropolone	2019
Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria that predominate in the oral cavity and upper airways. Microbiology and immunology, 2019, Volume: 63, Issue:6 Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria; Cell Line, Tumor; Cell Survival; Epithelial Cells; Fusobacterium nucleatum; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Monoterpenes; Mouth; Porphyromonas gingivalis; Prevotella intermedia; Staphylococcus aureus; Streptococcus mutans; Streptococcus pneumoniae; Streptococcus pyogenes; Streptococcus sobrinus; Tropolone	2019
A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2019, Volume: 32, Issue:5 Topics: Ferrous Compounds; Genetic Therapy; HEK293 Cells; Humans; Iron; Kinetics; Manganese; Monoterpenes; Transcription Factors; Tropolone	2019
Characterization of genipin-crosslinked gelatin/hyaluronic acid-based hydrogel membranes and loaded with hinokitiol: In vitro evaluation of antibacterial activity and biocompatibility. Materials science & engineering. C, Materials for biological applications, 2019, Volume: 105 Topics: Animals; Anti-Bacterial Agents; Cross-Linking Reagents; Drug Evaluation, Preclinical; Gelatin; Hyaluronic Acid; Hydrogels; Iridoids; Materials Testing; Membranes, Artificial; Mice; Monoterpenes; NIH 3T3 Cells; Tropolone	2019
Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice. Archives of oral biology, 2020, Volume: 112 Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacterial Load; Cytokines; Disease Models, Animal; Ligation; Mice; Monoterpenes; Periodontitis; Tropolone	2020
Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway. International journal of medical sciences, 2020, Volume: 17, Issue:3 Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Glucuronidase; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monoterpenes; Proto-Oncogene Proteins c-akt; Signal Transduction; Tropolone	2020
Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. Taiwanese journal of obstetrics & gynecology, 2020, Volume: 59, Issue:5 Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Movement; Epidermal Growth Factor; Female; HeLa Cells; Humans; Monoterpenes; Tropolone; Uterine Cervical Neoplasms	2020
A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections. Medical hypotheses, 2020, Volume: 145 Topics: Anti-Infective Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Homeostasis; Humans; Hydroxychloroquine; Ionophores; Models, Theoretical; Monoterpenes; Risk; Tropolone; Zinc	2020
Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model. PloS one, 2020, Volume: 15, Issue:10 Topics: Animals; Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Cytokines; Drug Resistance, Bacterial; Interleukin-6; Lung; Male; Mice; Mice, Inbred BALB C; Monoterpenes; Neutrophil Infiltration; Neutrophils; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Tropolone	2020
Chemical cross-linking on gelatin-hyaluronan loaded with hinokitiol for the preparation of guided tissue regeneration hydrogel membranes with antibacterial and biocompatible properties. Materials science & engineering. C, Materials for biological applications, 2021, Volume: 119 Topics: Anti-Bacterial Agents; Biocompatible Materials; Cross-Linking Reagents; Gelatin; Guided Tissue Regeneration; Hyaluronic Acid; Hydrogels; Monoterpenes; Tropolone	2021
Direct deuteration of hinokitiol and its mechanistic study. Bioscience, biotechnology, and biochemistry, 2021, Feb-18, Volume: 85, Issue:2 Topics: Catalysis; Deuterium; Models, Molecular; Molecular Conformation; Monoterpenes; Palladium; Trifluoroacetic Acid; Tropolone	2021
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Adolescent; Adult; Aged; Cation Transport Proteins; Cell Survival; Child; Cytoprotection; DNA-Binding Proteins; Down-Regulation; Female; Ferroptosis; Homeostasis; Humans; Intervertebral Disc Degeneration; Intracellular Space; Iron; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Models, Biological; Monoterpenes; Nucleus Pulposus; Oxidative Stress; Reactive Oxygen Species; tert-Butylhydroperoxide; Transcription Factor MTF-1; Transcription Factors; Tropolone; Young Adult	2021
Hinokitiol inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo. International immunopharmacology, 2021, Volume: 96 Topics: Actins; Animals; Bone Density Conservation Agents; Bone Resorption; Cell Line; Disease Models, Animal; Female; Macrophages; MAP Kinase Signaling System; Mice, Inbred C57BL; Monoterpenes; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteoporosis; Ovariectomy; Primary Cell Culture; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RANK Ligand; Transcription Factor AP-1; Tropolone	2021
New Broth Macrodilution Volatilization Method for Antibacterial Susceptibility Testing of Volatile Agents and Evaluation of Their Toxicity Using Modified MTT Assay In Vitro. Molecules (Basel, Switzerland), 2021, Jul-09, Volume: 26, Issue:14 Topics: Administration, Inhalation; Anti-Bacterial Agents; Bacteria; Benzoquinones; Haemophilus influenzae; Microbial Sensitivity Tests; Monoterpenes; Oils, Volatile; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Thymol; Tropolone; Volatile Organic Compounds; Volatilization	2021
Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE). International journal of molecular sciences, 2021, Jul-31, Volume: 22, Issue:15 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Endometrial Neoplasms; Female; Humans; Monoterpenes; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Tropolone; Tumor Suppressor Protein p53	2021
Hinokitiol-induced decreases of tyrosinase and microphthalmia-associated transcription factor are mediated by the endoplasmic reticulum-associated degradation pathway in human melanoma cells. Biochimie, 2022, Volume: 192 Topics: Cell Line, Tumor; Endoplasmic Reticulum-Associated Degradation; Humans; Melanoma; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Monoterpenes; Neoplasm Proteins; Tropolone	2022
Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration. Journal of advanced research, 2021, Volume: 34 Topics: Animals; Candida albicans; Iron; Microbial Sensitivity Tests; Mitochondria; Monoterpenes; Respiration; Tropolone	2021
Screening a redox library identifies the anti-tumor drug Hinokitiol for treating intrahepatic cholangiocarcinoma. Frontiers in bioscience (Landmark edition), 2022, 01-13, Volume: 27, Issue:1 Topics: Animals; Antineoplastic Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Mice; Monoterpenes; Oxidation-Reduction; Tropolone	2022
Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines. International journal of molecular sciences, 2022, Jan-31, Volume: 23, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Chloroquine; DNA Damage; Drug Synergism; Humans; Monoterpenes; Osteosarcoma; S Phase Cell Cycle Checkpoints; Tropolone; Tumor Suppressor Protein p53	2022
Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol. Journal of inorganic biochemistry, 2022, Volume: 231 Topics: Animals; Antiviral Agents; COVID-19 Drug Treatment; Gluconates; Mammals; Monoterpenes; Peptide Hydrolases; SARS-CoV-2; Tropolone; Zinc	2022
The radiosensitizing effect of β-Thujaplicin, a tropolone derivative inducing S-phase cell cycle arrest, in head and neck squamous cell carcinoma-derived cell lines. Investigational new drugs, 2022, Volume: 40, Issue:4 Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Head and Neck Neoplasms; Humans; Monoterpenes; Radiation-Sensitizing Agents; Squamous Cell Carcinoma of Head and Neck; Tropolone	2022
Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3 Oxidative medicine and cellular longevity, 2022, Volume: 2022 Topics: Apoptosis; Autophagy; Glycogen Synthase Kinase 3 beta; Humans; Monoterpenes; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Tropolone	2022
Highly effective antibacterial AgNPs@hinokitiol grafted chitosan for construction of durable antibacterial fabrics. International journal of biological macromolecules, 2022, Jun-01, Volume: 209, Issue:Pt A Topics: Anti-Bacterial Agents; Chitosan; Cotton Fiber; Escherichia coli; Metal Nanoparticles; Monoterpenes; Staphylococcus aureus; Tropolone	2022
Tropolone derivative hinokitiol ameliorates cerulein-induced acute pancreatitis in mice. International immunopharmacology, 2022, Volume: 109 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Ceruletide; Cytokines; Disease Models, Animal; Mice; Monoterpenes; NF-kappa B; Pancreas; Pancreatitis; Tropolone; Tumor Necrosis Factor-alpha	2022
A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages. Proceedings of the National Academy of Sciences of the United States of America, 2022, 06-28, Volume: 119, Issue:26 Topics: Animals; Cation Transport Proteins; Ferritins; Humans; Iron; Macrophages; Mice; Monoterpenes; Transferrin; Tropolone; Zebrafish	2022
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free radical biology & medicine, 2022, Volume: 190 Topics: Animals; Ferroptosis; Mice; Monoterpenes; Neuroprotection; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Paclitaxel; Tropolone; Zebrafish	2022
Pseudomonas bohemica strain ins3 eliminates antibacterial hinokitiol from its culture broth. Bioscience, biotechnology, and biochemistry, 2023, Jan-24, Volume: 87, Issue:2 Topics: Anti-Bacterial Agents; Dioxygenases; Monoterpenes; Pseudomonas; Tropolone	2023