Compounds > troleandomycin

Page last updated: 2024-09-05

troleandomycin and warfarin

troleandomycin has been researched along with warfarin in 12 studies

Compound Research Comparison

Studies (troleandomycin)	Trials (troleandomycin)	Recent Studies (post-2010) (troleandomycin)	Studies (warfarin)	Trials (warfarin)	Recent Studies (post-2010) (warfarin)
569	26	23	36,573	2,143	14,728

Protein Interaction Comparison

Protein	Taxonomy	troleandomycin (IC50)	warfarin (IC50)
Vitamin K epoxide reductase complex subunit 1	Homo sapiens (human)		0.0088

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (16.67)	18.7374
1990's	3 (25.00)	18.2507
2000's	2 (16.67)	29.6817
2010's	5 (41.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Baciewicz, AM	1
Hulla, JE; Juchau, MR; Namkung, MJ; Yang, HL	1
Beaune, PH; Beloc, C; Boddy, AV; Cholerton, S; Daly, AK; Flinois, JP; Lind, MJ; Monkman, SC; Pearson, AD; Walker, D	1
Heyn, H; Stevens, JC; White, RB	1
Gorski, JC; Hall, SD; Hamman, MA; Jones, DR; Wrighton, SA	1
Fowler, SM; Friedberg, T; Riley, RJ; Taylor, JM; Wolf, CR	1
Hu, X; Wang, P; Zhang, L; Zhang, LF	1
Cui, SL; Deng, JT; Kong, WL; Li, H; Tian, XT; Wen, YY; Xie, L; Zhuang, XM	1

Reviews

1 review(s) available for troleandomycin and warfarin

Article	Year
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986

Other Studies

11 other study(ies) available for troleandomycin and warfarin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
On the substrate specificity of cytochrome P450IIIA1. Molecular pharmacology, 1988, Volume: 34, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dealkylation; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Isoenzymes; Pregnenolone; Rats; Rats, Inbred Strains; Substrate Specificity; Testosterone; Troleandomycin; Warfarin	1988
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide. Biochemical pharmacology, 1994, Mar-29, Volume: 47, Issue:7 Topics: Antibodies; Biotransformation; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Flavanones; Flavonoids; Humans; Hydroxylation; Ifosfamide; Inactivation, Metabolic; Microsomes, Liver; Mixed Function Oxygenases; Troleandomycin	1994
Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9 Topics: Antibodies, Monoclonal; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Troleandomycin	1996
Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:9 Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; B-Lymphocytes; Benzoflavones; Biotransformation; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypnotics and Sedatives; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Recombinant Proteins; Sulfaphenazole; Troleandomycin	1999
CYP3A4 active site volume modification by mutagenesis of leucine 211. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:4 Topics: Amino Acid Substitution; Anti-Anxiety Agents; Anti-Bacterial Agents; Binding Sites; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Activation; Enzyme Inhibitors; Erythromycin; Hydroxylation; Kinetics; Leucine; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Oxidation-Reduction; Structure-Activity Relationship; Substrate Specificity; Testosterone; Troleandomycin	2002
[Metabolism of osthol in isolated hepatocytes of rat]. Yao xue xue bao = Acta pharmaceutica Sinica, 2009, Volume: 44, Issue:10 Topics: Animals; Cells, Cultured; Cnidium; Coumarins; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hepatocytes; Male; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Rifampin; Sulfaphenazole; Troleandomycin; Yohimbine	2009
[Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:9 Topics: Anti-HIV Agents; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Intestinal Mucosa; Ketoconazole; Metabolic Clearance Rate; Microsomes; Ritonavir; Troleandomycin	2010