troleandomycin has been researched along with rifampin in 23 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (rifampin) | Trials (rifampin) | Recent Studies (post-2010) (rifampin) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 20,468 | 1,499 | 6,552 |
| Protein | Taxonomy | troleandomycin (IC50) | rifampin (IC50) |
|---|---|---|---|
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 2.949 | |
| Caspase-1 | Homo sapiens (human) | 8.319 | |
| Alpha-synuclein | Homo sapiens (human) | 7.1 | |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | 0.03 | |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | 0.01 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.5 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Gamby, T; Givaudan, JF; Privat, Y | 1 |
| Peyrard, P; Piette, F | 1 |
| Natsuhori, M; Van 't Klooster, GA; Van Miert, AS; Witkamp, RF | 1 |
| Fishman, K; Guzelian, PS; Hamilton, T; Kolars, JC; Lown, KS; Saenger, P; Turgeon, DK; Voorhees, JJ; Watkins, PB | 1 |
| Bonfils, C; Daujat, M; Fabre, G; Fabre, I; Maurel, P; Pichard, L; Pineau, T | 1 |
| Barra, Y; Cano, JP; Covo, J; Crevat-Pisano, P; Dragna, S; Fabre, G | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Kunii, O | 1 |
| Eckels, DD; Gershwin, ME; Scharre, KA | 1 |
| Benet, LZ; Salphati, L | 1 |
| Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E | 1 |
| Hoffmaster, KA; Paine, MF; Wagner, DA; Watkins, PB | 1 |
| Hoffer, C; Kharasch, ED; Whittington, D | 1 |
| Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A | 1 |
| Craig, K; Hoffer, C; Kharasch, ED; Krudys, K; Lalovic, B; Sheffels, P; Vicini, P; Whittington, D | 1 |
| Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T | 1 |
| Hu, X; Wang, P; Zhang, L; Zhang, LF | 1 |
1 review(s) available for troleandomycin and rifampin
| Article | Year |
|---|---|
[Toxic hepatitis induced by antibiotics].
Topics: Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Chloramphenicol; Erythromycin Estolate; Humans; Isoniazid; Rifampin; Tetracyclines; Troleandomycin | 1985 |
3 trial(s) available for troleandomycin and rifampin
| Article | Year |
|---|---|
Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
Topics: Adult; Analgesics, Opioid; Antibiotics, Antitubercular; Antiemetics; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; Fentanyl; Food-Drug Interactions; Half-Life; Humans; Intestines; Liver; Male; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Spectrometry, Mass, Electrospray Ionization; Troleandomycin | 2004 |
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Anti-Bacterial Agents; Antibiotics, Antitubercular; Aryl Hydrocarbon Hydroxylases; Beverages; Biological Availability; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Female; Food-Drug Interactions; Humans; Injections, Intravenous; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Troleandomycin | 2004 |
Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.
Topics: Administration, Oral; Adult; Algorithms; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Male; Methadyl Acetate; Miosis; Models, Biological; Receptors, Opioid, mu; Reproducibility of Results; Rifampin; Troleandomycin | 2005 |
19 other study(ies) available for troleandomycin and rifampin
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
[Cholestatic jaundice following rifampicin-troleandomycin: one new case].
Topics: Aged; Cholestasis; Humans; Male; Rifampin; Troleandomycin | 1979 |
[Benign drug jaundice during treatment combining rifampicin and triacetyloleandomycin].
Topics: Aged; Drug Therapy, Combination; Female; Humans; Jaundice; Rifampin; Troleandomycin | 1979 |
Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin.
Topics: Animals; Antipyrine; Biotransformation; Enzyme Induction; Female; Goats; Male; Oxidation-Reduction; Phenobarbital; Rifampin; Sulfamethazine; Troleandomycin | 1992 |
Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity.
Topics: Aryl Hydrocarbon Hydroxylases; Breath Tests; Carbon Dioxide; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydrocortisone; Liver; Oxidoreductases, N-Demethylating; Psoriasis; Regression Analysis; Rifampin; Troleandomycin | 1992 |
Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Culture Techniques; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Fetus; Humans; Liver; Male; Pregnancy; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; Sex Characteristics; Troleandomycin | 1991 |
Involvement of the macrolide antibiotic inducible cytochrome P-450 LM3c in the metabolism of midazolam by microsomal fractions prepared from rabbit liver.
Topics: Animals; Cyclosporins; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Midazolam; Rabbits; Rifampin; Troleandomycin | 1988 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents.
Topics: Adult; Antifungal Agents; Chloramphenicol; Clindamycin; Clone Cells; Erythromycin; Humans; Mycobacterium; Rifampin; T-Lymphocytes; Troleandomycin; Vancomycin | 1981 |
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Gene Expression; Liver; Male; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger; Sex Characteristics; Troleandomycin | 1998 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breath Tests; Carbon Dioxide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Female; Humans; Male; Rifampin; Troleandomycin | 2002 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin | 2005 |
[Metabolism of osthol in isolated hepatocytes of rat].
Topics: Animals; Cells, Cultured; Cnidium; Coumarins; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hepatocytes; Male; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Rifampin; Sulfaphenazole; Troleandomycin; Yohimbine | 2009 |