troleandomycin has been researched along with quinine in 13 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (quinine) | Trials (quinine) | Recent Studies (post-2010) (quinine) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 6,859 | 398 | 1,099 |
| Protein | Taxonomy | troleandomycin (IC50) | quinine (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | 0.28 | |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | 2.8 | |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | 3.85 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.7 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 0.094 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.6285 | |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | 2.0333 | |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | 1.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Kanakubo, Y; Kitada, M; Kiuchi, M; Ohmori, S; Rikihisa, T; Takeda, S | 1 |
| Ishizaki, T; Zhao, XJ | 1 |
| Ishizaki, T; Kawashiro, T; Zhao, XJ | 1 |
| Fujita, S; Funae, Y; Hirota, T; Imaoka, S; Kazusaka, A; Masuda, M; Morino, A; Nakamura, A; Tasaki, T; Yamamoto, Y | 1 |
| Kobayashi, S; Kumai, T; Tanaka, M; Tateishi, T; Watanabe, M | 1 |
| Paine, MF; Pusek, SN; Wanwimolruk, S; Watkins, PB | 1 |
| Di Marco, A; Laufer, R; Yao, D | 1 |
| Choi, YH; Lee, MG | 2 |
| Choi, YH; Lee, JH; Lee, MG; Lee, U; Yang, KH | 1 |
1 trial(s) available for troleandomycin and quinine
| Article | Year |
|---|---|
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
Topics: Administration, Oral; Adult; Aged; Antimalarials; Area Under Curve; Breath Tests; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Erythromycin; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Ovarian Neoplasms; Quinidine; Quinine; Troleandomycin | 2002 |
12 other study(ies) available for troleandomycin and quinine
| Article | Year |
|---|---|
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin | 1993 |
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes.
Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin | 1997 |
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin | 1998 |
Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cholinergic Antagonists; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Lymphocytes; Male; Microsomes, Liver; Phenylacetates; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Troleandomycin | 1999 |
Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Erythromycin; Half-Life; Haloperidol; Immune Sera; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Propionates; Quinine; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Theophylline; Troleandomycin | 1999 |
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Topics: Animals; Benzoflavones; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Hepatocytes; Inhibitory Concentration 50; Kinetics; Male; Methylation; Microsomes, Liver; Oxidoreductases, O-Demethylating; Protein Binding; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2003 |
Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.
Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Hypoglycemic Agents; Liver; Male; Membrane Proteins; Metformin; Protein Binding; Quinine; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Sulfaphenazole; Troleandomycin | 2006 |
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cimetidine; Cytochrome P-450 Enzyme System; Diuretics; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Furosemide; Half-Life; Infusions, Intravenous; Injections, Intravenous; Isoniazid; Male; Methylcholanthrene; Orphenadrine; Proadifen; Quinine; Rats; Rats, Sprague-Dawley; Troleandomycin; Weight Gain | 2009 |
Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.
Topics: Administration, Oral; Animals; Baculoviridae; Blood Proteins; Cell Line; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Humans; Injections, Intravenous; Intestinal Mucosa; Intestines; Isoenzymes; Kinetics; Male; Metformin; Microsomes, Liver; Nifedipine; Protein Binding; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2012 |