troleandomycin has been researched along with quinidine in 22 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (quinidine) | Trials (quinidine) | Recent Studies (post-2010) (quinidine) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 6,608 | 387 | 594 |
| Protein | Taxonomy | troleandomycin (IC50) | quinidine (IC50) |
|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | 6.4 | |
| Cholinesterase | Homo sapiens (human) | 1.23 | |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 10 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 3.32 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 2.8 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.3532 | |
| Potassium voltage-gated channel subfamily A member 5 | Homo sapiens (human) | 7.3 | |
| Cholinesterase | Equus caballus (horse) | 7.37 | |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | 6.4 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.7882 | |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | 6.4 | |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | 6.4 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 6.9 | |
| Potassium voltage-gated channel subfamily D member 2 | Rattus norvegicus (Norway rat) | 2.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (54.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Belghiti, J; Larrey, D; Lettéron, P; Loeper, J; Maurel, P; Pessayre, D; Tinel, M | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K | 1 |
| Kanakubo, Y; Kitada, M; Kiuchi, M; Ohmori, S; Rikihisa, T; Takeda, S | 1 |
| Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N | 1 |
| Juvonen, RO; Kojo, A; Komulainen, H; Liesivuori, J; Pasanen, M; Pennanen, S | 1 |
| Ekström, G; Gunnarsson, UB | 1 |
| Ishizaki, T; Kawashiro, T; Zhao, XJ | 1 |
| Kudo, S; Odomi, M | 1 |
| Fujita, S; Funae, Y; Hirota, T; Imaoka, S; Kazusaka, A; Masuda, M; Morino, A; Nakamura, A; Tasaki, T; Yamamoto, Y | 1 |
| Aguilar, AJ; Grace, JM; Skanchy, DJ | 1 |
| Kitamura, S; Konishi, T; Nishikawa, H; Taguchi, K | 1 |
| Gorski, JC; Hall, SD; Hamman, MA; Jones, DR; Wrighton, SA | 1 |
| Obach, RS | 1 |
| Paine, MF; Pusek, SN; Wanwimolruk, S; Watkins, PB | 1 |
| Di Marco, A; Laufer, R; Yao, D | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
1 trial(s) available for troleandomycin and quinidine
| Article | Year |
|---|---|
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
Topics: Administration, Oral; Adult; Aged; Antimalarials; Area Under Curve; Breath Tests; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Erythromycin; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Ovarian Neoplasms; Quinidine; Quinine; Troleandomycin | 2002 |
21 other study(ies) available for troleandomycin and quinidine
| Article | Year |
|---|---|
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450.
Topics: Antidepressive Agents, Tricyclic; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Glutathione; Humans; Isoenzymes; Microsomes, Liver; NADP; Oxygen; Piperonyl Butoxide; Pyridines; Quinidine; Troleandomycin | 1990 |
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin | 1995 |
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin | 1993 |
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin | 1996 |
CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver.
Topics: Aged; Animals; Antibodies, Monoclonal; Caproates; Cytochrome P-450 Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Isoenzymes; Male; Methylation; Metyrapone; Mice; Microsomes, Liver; Middle Aged; NADPH-Ferrihemoprotein Reductase; Occupational Exposure; Proadifen; Quinidine; Rats; Rats, Wistar; Troleandomycin | 1996 |
Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes.
Topics: Amides; Anesthetics, Local; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Quinidine; Ropivacaine; Substrate Specificity; Troleandomycin | 1996 |
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin | 1998 |
Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation.
Topics: Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antiparkinson Agents; Biotransformation; Biperiden; Carteolol; Cell Line, Transformed; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Haloperidol; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes; Mixed Function Oxygenases; Oxidation-Reduction; Quinidine; Sparteine; Troleandomycin | 1998 |
Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cholinergic Antagonists; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Lymphocytes; Male; Microsomes, Liver; Phenylacetates; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Troleandomycin | 1999 |
Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.
Topics: Adult; Aged; Antifungal Agents; Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Glycyrrhiza; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Isoenzymes; Ketoconazole; Liver; Male; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Paeonia; Quinidine; Recombinant Proteins; Sesquiterpenes; Sulfaphenazole; Troleandomycin; Vasodilator Agents; Verapamil | 1999 |
Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Combinations; Drugs, Chinese Herbal; Enzyme Inhibitors; Glycyrrhiza; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Paeonia; Phenylpropionates; Quinidine; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Troleandomycin | 1999 |
Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily.
Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; B-Lymphocytes; Benzoflavones; Biotransformation; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypnotics and Sedatives; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Recombinant Proteins; Sulfaphenazole; Troleandomycin | 1999 |
Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
Topics: Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Guinea Pigs; Haplorhini; Humans; Isoenzymes; Ketoconazole; Kinetics; Metabolic Clearance Rate; Microsomes, Liver; Neurokinin-1 Receptor Antagonists; Quinidine; Rats; Species Specificity; Sulfaphenazole; Tritium; Troleandomycin | 2000 |
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Topics: Animals; Benzoflavones; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Hepatocytes; Inhibitory Concentration 50; Kinetics; Male; Methylation; Microsomes, Liver; Oxidoreductases, O-Demethylating; Protein Binding; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2003 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |