troleandomycin has been researched along with pregnenolone carbonitrile in 17 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (pregnenolone carbonitrile) | Trials (pregnenolone carbonitrile) | Recent Studies (post-2010) (pregnenolone carbonitrile) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 402 | 4 | 49 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Bonfils, C; Daujat, M; Fabre, G; Fabre, I; Maurel, P; Pichard, L; Pineau, T | 1 |
| Delaforge, M; Doignon, JL; Grognet, JM; Rivière, R; Sartori, E | 1 |
| Lange, R; Langlois, R; Larroque, C; Maurel, P; van Lier, JE | 1 |
| Arlotto, MP; McKinney, MM; Parkinson, A; Sonderfan, AJ | 1 |
| Arlotto, MP; Klaassen, CD; Parkinson, A; Sonderfan, AJ | 1 |
| Halvorson, MR; Parkinson, A; Phillips, TD; Safe, SH | 1 |
| Beaune, P; Delaforge, M; Mansuy, D; Sartori, E | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Paine, AJ; Wright, MC | 1 |
| Benet, LZ; Salphati, L | 1 |
| Cunninghame, ME; Evans, DC; Lake, BG; Price, RJ; Renwick, AB; Surry, D | 1 |
| Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K | 1 |
| Floreani, M; Geroni, C; Napoli, E; Quintieri, L; Rosato, A; Sola, F; Zanovello, P | 1 |
| Franklin, MR; Kushner, JP; Phillips, JD | 1 |
| Hirayama, T; Honda, A; Ikegami, T; Iwamoto, J; Maeda, T; Matsuzaki, Y; Miyazaki, T; Saito, Y; Teramoto, T | 1 |
17 other study(ies) available for troleandomycin and pregnenolone carbonitrile
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Culture Techniques; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Fetus; Humans; Liver; Male; Pregnancy; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; Sex Characteristics; Troleandomycin | 1991 |
Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dihydroergotamine; Female; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Troleandomycin | 1989 |
Rat liver microsomal progesterone metabolism: evidence for differential troleandomycin and pregnenolone 16 alpha-carbonitrile inductive effects in the cytochrome P-450 III family.
Topics: Animals; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Pregnenolone Carbonitrile; Progesterone; Rats; Rats, Inbred Strains; Troleandomycin | 1989 |
Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16 alpha-carbonitrile.
Topics: Age Factors; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Digitoxin; Female; Glucuronosyltransferase; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Sex Factors; Troleandomycin | 1986 |
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Female; Glucuronosyltransferase; Isoenzymes; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Steroid Hydroxylases; Troleandomycin | 1987 |
Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450.
Topics: Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Hydroxylation; Microsomes, Liver; Mutagenicity Tests; Pregnenolone Carbonitrile; Rats; Sex Factors; Troleandomycin | 1988 |
Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 alpha-pregnenolone carbonitrile.
Topics: Animals; Cytochrome P-450 Enzyme System; Erythromycin; In Vitro Techniques; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Troleandomycin | 1985 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Humans; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Troleandomycin | 1994 |
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Gene Expression; Liver; Male; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger; Sex Characteristics; Troleandomycin | 1998 |
Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clotrimazole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Replication; Enzyme Induction; Female; Isoenzymes; Liver; Miconazole; Mitogens; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Troleandomycin | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Bone Marrow; Coculture Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Doxorubicin; Erythromycin; Female; Leukemia, Experimental; Liver; Liver Neoplasms, Experimental; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; NADP; Neoplasm Transplantation; Neoplasms, Experimental; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Protein Synthesis Inhibitors; Time Factors; Troleandomycin; Tumor Cells, Cultured | 2000 |
CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda.
Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Female; Oxidoreductases, N-Demethylating; Porphyria Cutanea Tarda; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Troleandomycin; Uroporphyrins | 2000 |
Cholesterol 25-hydroxylation activity of CYP3A.
Topics: Animals; Blotting, Western; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gene Expression; Hepatocytes; Humans; Hydroxycholesterols; Lipid Metabolism; Liver; Mice; Polymerase Chain Reaction; Pregnenolone Carbonitrile; RNA, Messenger; Steroid Hydroxylases; Troleandomycin | 2011 |