troleandomycin has been researched along with phenobarbital in 31 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (phenobarbital) | Trials (phenobarbital) | Recent Studies (post-2010) (phenobarbital) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 18,336 | 619 | 1,117 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (32.26) | 18.7374 |
| 1990's | 16 (51.61) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Natsuhori, M; Van 't Klooster, GA; Van Miert, AS; Witkamp, RF | 1 |
| Cope, BC; McGowan, LT; Payne, E; Smith, JF | 1 |
| Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR | 1 |
| Bement, WJ; Guzelian, PS; Lambrecht, LK; McCaffrey, J; Park, SS; Schenkman, JB; Sinclair, JF; Sinclair, PR; Smith, EL; Wood, SG | 1 |
| Delaforge, M; Doignon, JL; Grognet, JM; Rivière, R; Sartori, E | 1 |
| Ciaccio, PJ; Halpert, JR | 1 |
| Baciewicz, AM | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Guzelian, PS; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Babany, G; Cobert, B; Funck-Brentano, C; Larrey, D; Pessayre, D; Tinel, M | 1 |
| Delaforge, M; Jaouen, M; Mansuy, D | 1 |
| Lavarenne, J; Paire, M | 1 |
| Andrews, F; Brenner, M; Ellis, EF; Jusko, WJ; Rose, JQ; Spector, SL; Szefler, SJ; Yurchak, AM | 1 |
| Franklin, MR; Pershing, LK | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Paine, AJ; Wright, MC | 1 |
| Beck, G; Chasserot-Golaz, S; Venetianer, A | 1 |
| Blaauboer, BJ; Horbach, GJ; Natsuhori, M; Noordhoek, J; van Miert, AS; van't Klooster, GA | 1 |
| Hanssen, BR; Lindstrom, TD; Wrighton, SA | 1 |
| Waxman, DJ; Weber, GF | 1 |
| Golub-Ciosk, B; Hanstein, WG; Kallweit, P; Kauczinski, D; Roos, PH | 1 |
| Batzias, J; Horbach, GJ; Maas, RF; van Miert, AS; Witkamp, RF; Zweers-Zeilmaker, WM | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ | 1 |
| Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K | 1 |
| Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E | 1 |
| Laczay, P; Monostory, K; Szucs, G; Tamási, V | 1 |
| Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P | 1 |
1 review(s) available for troleandomycin and phenobarbital
| Article | Year |
|---|---|
Carbamazepine drug interactions.
Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin | 1986 |
30 other study(ies) available for troleandomycin and phenobarbital
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin.
Topics: Animals; Antipyrine; Biotransformation; Enzyme Induction; Female; Goats; Male; Oxidation-Reduction; Phenobarbital; Rifampin; Sulfamethazine; Troleandomycin | 1992 |
Studies on the role of liver cytochrome P-450 and oestradiol metabolism in the effects of nutrition and phenobarbital on ovulation rate in the ewe.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Liver; Ovulation; Oxidoreductases, N-Demethylating; Phenobarbital; Sheep; Troleandomycin | 1991 |
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin | 1991 |
Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.
Topics: Acetaminophen; Animals; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Ethanol; Hydroxylation; Liver; Male; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin | 1991 |
Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dihydroergotamine; Female; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Troleandomycin | 1989 |
Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Topics: Amino Acid Sequence; Animals; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Immunoblotting; Immunoglobulin G; Kinetics; Male; Microsomes, Liver; Molecular Sequence Data; Molecular Weight; NADP; Phenobarbital; Rats; Spectrophotometry; Steroid Hydroxylases; Troleandomycin | 1989 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Immunosorbent Techniques; Isoenzymes; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Spectrophotometry; Troleandomycin | 1985 |
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Glutathione; Male; Methylcholanthrene; Oleandomycin; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin | 1983 |
Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Erythromycin; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Troleandomycin | 1983 |
[Drug interactions with macrolids compared action of two macrolids on liver microsomal activity ].
Topics: Adult; Anti-Bacterial Agents; Antipyrine; Drug Interactions; Female; Humans; Kinetics; Leucomycins; Male; Microsomes, Liver; Phenobarbital; Troleandomycin | 1982 |
Steroid-specific and anticonvulsant interaction aspects of troleandomycin-steroid therapy.
Topics: Asthma; Dose-Response Relationship, Drug; Drug Interactions; Humans; Methylprednisolone; Phenobarbital; Phenytoin; Prednisolone; Troleandomycin | 1982 |
Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents.
Topics: Animals; Anti-Bacterial Agents; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Troleandomycin | 1982 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Humans; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Troleandomycin | 1994 |
Biotransformation of 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) in rat hepatoma variants.
Topics: Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Mifepristone; Phenobarbital; Rats; Troleandomycin; Tumor Cells, Cultured | 1993 |
Hepatic cytochrome P450 induction in goats. Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine, and on apoprotein and mRNA levels.
Topics: Animals; Apolipoproteins; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Ethylmorphine; Female; Goats; Isoenzymes; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Testosterone; Troleandomycin | 1993 |
Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Dexamethasone; Erythromycin; Humans; In Vitro Techniques; Macrolides; Male; Microsomes, Liver; NADP; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Troleandomycin | 1993 |
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Topics: Animals; Antibodies; Biotransformation; Cisplatin; Clofibrate; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Ifosfamide; Kinetics; Male; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1993 |
Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes.
Topics: Animals; Antibodies; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrophotometry; Troleandomycin | 1993 |
In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers.
Topics: Animals; Antipyrine; beta-Naphthoflavone; Biotransformation; Blotting, Western; Caffeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Goats; Isoniazid; Microsomes, Liver; Phenobarbital; Sulfamethazine; Troleandomycin | 1996 |
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1998 |
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Disease Models, Animal; Enzyme Induction; Female; Gliosarcoma; Half-Life; Hydroxylation; Ifosfamide; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1999 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
Biochemical background of toxic interaction between tiamulin and monensin.
Topics: Administration, Oral; Aminopyrine; Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Dexamethasone; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Ethylmorphine; Female; Ionophores; Male; Microsomes, Liver; Monensin; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Troleandomycin | 2004 |
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; Dexamethasone; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Lyases; Male; Methyl Ethers; Oxidoreductases, N-Demethylating; Phenobarbital; Propionates; Rats; Rats, Inbred F344; Sevoflurane; Sulfoxides; Troleandomycin | 2004 |