Compounds > troleandomycin
Page last updated: 2024-09-05

troleandomycin and orphenadrine

troleandomycin has been researched along with orphenadrine in 7 studies

Compound Research Comparison

Studies
(troleandomycin)		Trials
(troleandomycin)		Recent Studies (post-2010)
(troleandomycin)		Studies
(orphenadrine)		Trials
(orphenadrine)		Recent Studies (post-2010) (orphenadrine)
56926235416159

Protein Interaction Comparison

ProteinTaxonomytroleandomycin (IC50)orphenadrine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)2.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.534
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.666
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.376
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.125
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.028
Alpha-2A adrenergic receptorHomo sapiens (human)2.156
Cytochrome P450 2D6Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.148
Alpha-2B adrenergic receptorHomo sapiens (human)1.895
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.175
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.666
Histamine H2 receptorHomo sapiens (human)6.961
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.436
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.534
Sodium-dependent serotonin transporterHomo sapiens (human)0.458
Histamine H1 receptorHomo sapiens (human)1.241
5-hydroxytryptamine receptor 2BHomo sapiens (human)3.391
5-hydroxytryptamine receptor 6Homo sapiens (human)1.121
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.8511

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Kalhorn, TF; Ren, S; Slattery, JT; Yang, JS1
Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ1
Ashton, M; Svensson, US1
Asada, A; Hamaoka, N; Hase, I; Oda, Y1
Choi, YH; Lee, JH; Lee, MG; Lee, U; Yang, KH1

Other Studies

7 other study(ies) available for troleandomycin and orphenadrine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes.
    Cancer research, 1997, Oct-01, Volume: 57, Issue:19

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cyclophosphamide; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Orphenadrine; Oxidation-Reduction; Prodrugs; Recombinant Fusion Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Troleandomycin

1997
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
    British journal of cancer, 1998, Volume: 77, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin

1998
Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:4

    Topics: Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cell Line; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Mixed Function Oxygenases; Orphenadrine; Oxidoreductases, N-Demethylating; Regression Analysis; Sesquiterpenes; Time Factors; Troleandomycin

1999
Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies.
    British journal of anaesthesia, 2001, Volume: 86, Issue:4

    Topics: Anesthetics, Intravenous; Anti-Anxiety Agents; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes, Liver; Midazolam; Orphenadrine; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Troleandomycin

2001
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:1

    Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cimetidine; Cytochrome P-450 Enzyme System; Diuretics; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Furosemide; Half-Life; Infusions, Intravenous; Injections, Intravenous; Isoniazid; Male; Methylcholanthrene; Orphenadrine; Proadifen; Quinine; Rats; Rats, Sprague-Dawley; Troleandomycin; Weight Gain

2009