troleandomycin has been researched along with nifedipine in 17 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (nifedipine) | Trials (nifedipine) | Recent Studies (post-2010) (nifedipine) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 16,024 | 2,496 | 1,505 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pratim Roy, P; Roy, K | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bonomo, F; Motta, P; Pagliarusco, S; Pellegatti, M; Pons, N | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Eaton, DL; Eddy, AC; Parkinson, A; Ramsdell, HS | 1 |
| Guengerich, FP; Shimada, T | 1 |
| Guengerich, FP | 1 |
| Hiroki, S; Shimada, T; Urano, T; Yamazaki, H | 1 |
| Ishizaki, T; Zhao, XJ | 1 |
| Anzenbacher, P; Anzenbacherová, E; Gut, I; Hrubý, K; Kvĕtina, J; Soucek, P; Svoboda, Z | 1 |
| Mason, SR; Read, MA; Reilly, PE | 1 |
| Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T | 1 |
| Choi, YH; Lee, MG | 1 |
| Cruz, A; González-Curbelo, MÁ; León, J; Murcia, H | 1 |
17 other study(ies) available for troleandomycin and nifedipine
| Article | Year |
|---|---|
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.
Topics: Adult; Cells, Cultured; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Models, Molecular; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperazines; Piperidines; Recombinant Proteins; Young Adult | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes.
Topics: Aflatoxin B1; Aflatoxins; Benzoflavones; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Troleandomycin | 1991 |
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
Topics: Aflatoxin B1; Aflatoxins; Antibodies; Benzoflavones; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Immunochemistry; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Sterigmatocystin; Troleandomycin | 1989 |
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Humans; Immunologic Techniques; In Vitro Techniques; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Substrate Specificity; Troleandomycin | 1988 |
Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes.
Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roxithromycin; Testosterone; Troleandomycin | 1996 |
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes.
Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin | 1997 |
Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.
Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Swine; Swine, Miniature; Troleandomycin | 1998 |
Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein.
Topics: Alligators and Crocodiles; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Inhibitors; Female; Humans; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nifedipine; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Substrate Specificity; Troleandomycin | 1999 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin | 2005 |
Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.
Topics: Administration, Oral; Animals; Baculoviridae; Blood Proteins; Cell Line; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Humans; Injections, Intravenous; Intestinal Mucosa; Intestines; Isoenzymes; Kinetics; Male; Metformin; Microsomes, Liver; Nifedipine; Protein Binding; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2012 |
Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescen
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Microsomes, Liver; Nifedipine; Oxazines; Poultry; Theophylline; Troleandomycin | 2019 |