troleandomycin has been researched along with midazolam in 14 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (midazolam) | Trials (midazolam) | Recent Studies (post-2010) (midazolam) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 9,834 | 3,191 | 3,301 |
| Protein | Taxonomy | troleandomycin (IC50) | midazolam (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 2.7427 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bonomo, F; Motta, P; Pagliarusco, S; Pellegatti, M; Pons, N | 1 |
| Gonzalez, FJ; Kronbach, T; Mathys, D; Meyer, UA; Umeno, M | 1 |
| Barra, Y; Cano, JP; Covo, J; Crevat-Pisano, P; Dragna, S; Fabre, G | 1 |
| Gorski, JC; Haehner, BD; Hall, SD; Janardan, SK; Vandenbranden, M; Watkins, PB; Wrighton, SA | 1 |
| Agouridas, C; de Sousa, G; Fontaine, F; Gugenheim, J; Ledirac, N; Lorenzon, G; Rahmani, R | 1 |
| Asada, A; Hamaoka, N; Hase, I; Oda, Y | 1 |
| Greenblatt, DJ; Perloff, MD; Von Moltke, LL | 1 |
| Kohno, Y; Suzuki, A; Yamamoto, T | 1 |
| Davis, CL; Hashizume, T; Kalhorn, TF; Nelson, WL; Sakaki, T; Schuetz, EG; Shuhart, MC; Thummel, KE; Watkins, PB; Xu, Y | 1 |
| Giroli, M; Kawabe, K; Misaka, S; Onoue, S; Watanabe, H; Werba, JP; Yamada, S | 1 |
| Gallagher, R; Grimsley, A; Hutchison, M; Pickup, K; Samuelsson, K; Wilson, ID | 1 |
| Abraham, TL; Bedwell, DW; Hall, SD; Hansen, K; Rougée, LRA | 1 |
14 other study(ies) available for troleandomycin and midazolam
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.
Topics: Adult; Cells, Cultured; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Models, Molecular; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperazines; Piperidines; Recombinant Proteins; Young Adult | 2011 |
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.
Topics: Animals; Autoantibodies; Cytochrome P-450 Enzyme System; DNA; Humans; Isoenzymes; Kinetics; Liver; Midazolam; Rats; Rats, Inbred Strains; Triazolam; Troleandomycin | 1989 |
Involvement of the macrolide antibiotic inducible cytochrome P-450 LM3c in the metabolism of midazolam by microsomal fractions prepared from rabbit liver.
Topics: Animals; Cyclosporins; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Midazolam; Rabbits; Rifampin; Troleandomycin | 1988 |
Bimodal distribution of renal cytochrome P450 3A activity in humans.
Topics: Antibodies; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Kidney; Kidney Cortex; Kidney Medulla; Kidney Neoplasms; Male; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; RNA, Messenger; Testicular Neoplasms; Transcription, Genetic; Troleandomycin | 1996 |
Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin.
Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Cell Survival; Cells, Cultured; Coloring Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hepatocytes; Humans; Midazolam; Neutral Red; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Species Specificity; Troleandomycin | 2000 |
Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies.
Topics: Anesthetics, Intravenous; Anti-Anxiety Agents; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes, Liver; Midazolam; Orphenadrine; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Troleandomycin | 2001 |
Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression.
Topics: Algorithms; Animals; Anti-Anxiety Agents; Antibodies, Blocking; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; In Vitro Techniques; Intestinal Mucosa; Isoenzymes; Ketoconazole; Kinetics; Mice; Mice, Inbred ICR; Microsomes; Microsomes, Liver; Midazolam; Organ Specificity; Ritonavir; Troleandomycin | 2003 |
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil | 2004 |
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Topics: Base Sequence; Caco-2 Cells; Calbindins; Calcitriol; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Primers; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Intestine, Small; Ketoconazole; Kinetics; Liver; Midazolam; Osteomalacia; Recombinant Proteins; S100 Calcium Binding Protein G; Troleandomycin | 2006 |
Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.
Topics: Animals; Camellia sinensis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Microsomes, Liver; Midazolam; Plant Extracts; Rats; Simvastatin; Troleandomycin | 2013 |
Drug-drug interactions and metabolism in cytochrome P450 2C knockout mice: application to troleandomycin and midazolam.
Topics: Animals; Bile; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Mice; Mice, Knockout; Midazolam; Troleandomycin | 2013 |
Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4.
Topics: Carbamazepine; Clarithromycin; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Microsomes, Liver; Midazolam; Troleandomycin | 2023 |