troleandomycin has been researched along with miconazole in 15 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (miconazole) | Trials (miconazole) | Recent Studies (post-2010) (miconazole) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 2,309 | 238 | 476 |
| Protein | Taxonomy | troleandomycin (IC50) | miconazole (IC50) |
|---|---|---|---|
| Metabotropic glutamate receptor 6 | Homo sapiens (human) | 6.5 | |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 2.4 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 5.314 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 1A2 | Mus musculus (house mouse) | 4.55 | |
| Cytochrome P450 1A2 | Rattus norvegicus (Norway rat) | 4.55 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 4.55 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 4.16 | |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | 5.8 | |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 2 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 2.939 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 4.336 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 3.197 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 3 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.4938 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 3.966 | |
| Adenosine receptor A3 | Homo sapiens (human) | 2.811 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.32 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 3.971 | |
| Aromatase | Homo sapiens (human) | 0.6 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.2 | |
| Beta-3 adrenergic receptor | Homo sapiens (human) | 5.482 | |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | 3.7 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 7.089 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 2.811 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 3.598 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 3.154 | |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | 7.8 | |
| Substance-K receptor | Homo sapiens (human) | 4.839 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 6.247 | |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | 5.8 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 2.939 | |
| Thromboxane-A synthase | Homo sapiens (human) | 0.263 | |
| Histamine H2 receptor | Homo sapiens (human) | 6.75 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 3.046 | |
| Substance-P receptor | Homo sapiens (human) | 6.813 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 3.907 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 5.314 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.778 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.008 | |
| Mu-type opioid receptor | Homo sapiens (human) | 6.059 | |
| D(3) dopamine receptor | Homo sapiens (human) | 3.199 | |
| Delta-type opioid receptor | Homo sapiens (human) | 3.387 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 6.594 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 5.545 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 2.811 | |
| Cholinesterase | Equus caballus (horse) | 5.55 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.701 | |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | 0.2 | |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | 6.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K | 1 |
| Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K | 1 |
| Pratim Roy, P; Roy, K | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Guzelian, PS; Hostetler, KA; Levin, W; Molowa, DT; Thomas, PE; Wrighton, SA | 1 |
| Conforto, A; Dudek, RR; Pinto, V; Suzuki, H; Wildhirt, S | 1 |
| Cunninghame, ME; Evans, DC; Lake, BG; Price, RJ; Renwick, AB; Surry, D | 1 |
| Aguilar, AJ; Grace, JM; Skanchy, DJ | 1 |
| Arai, N; Fujimaki, Y; Inaba, T | 1 |
| Fitzpatrick, JL; Pierce, WM; Prough, RA; Ripp, SL; Smith, NB | 1 |
| Allen, C; Evans, DC; Evers, R; Hargreaves, R; Lake, BG; O'Connor, D | 1 |
| Bertholet, V; Bonnert, TP; de Longueville, F; Dos Santos-Mendes, S; Evrard, S; Jack, A; Meneses-Lorente, G; Pike, A; Remacle, J; Scott-Stevens, P; Sohal, B | 1 |
| Kohno, Y; Suzuki, A; Yamamoto, T | 1 |
15 other study(ies) available for troleandomycin and miconazole
| Article | Year |
|---|---|
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine | 2002 |
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine | 2002 |
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.
Topics: Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Imidazoles; Isoenzymes; Ketoconazole; Liver; Miconazole; Rats; Rats, Inbred Strains; RNA, Messenger; Troleandomycin | 1989 |
Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cattle; Dihydroergotamine; Endothelium, Vascular; Miconazole; NADPH-Ferrihemoprotein Reductase; Nitric Oxide Synthase; Nitroarginine; Troleandomycin | 1995 |
Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clotrimazole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Replication; Enzyme Induction; Female; Isoenzymes; Liver; Miconazole; Mitogens; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Troleandomycin | 1998 |
Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.
Topics: Adult; Aged; Antifungal Agents; Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Glycyrrhiza; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Isoenzymes; Ketoconazole; Liver; Male; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Paeonia; Quinidine; Recombinant Proteins; Sesquiterpenes; Sulfaphenazole; Troleandomycin; Vasodilator Agents; Verapamil | 1999 |
Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent.
Topics: Anti-Ulcer Agents; Benzamides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Isoenzymes; Ketoconazole; Miconazole; Microsomes, Liver; NADP; Substrate Specificity; Troleandomycin | 1999 |
Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.
Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Humans; In Vitro Techniques; Male; Mass Spectrometry; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Troleandomycin | 2001 |
Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Genes, MDR; Humans; Indoles; Injections, Intravenous; Male; Mice; Mice, Mutant Strains; Miconazole; Microsomes, Liver; Oxazolidinones; Oxidoreductases, N-Demethylating; Phenotype; Piperidines; Pyrrolidines; Recombinant Proteins; Statistics as Topic; Sumatriptan; Triazoles; Troleandomycin; Tryptamines | 2003 |
An evaluation of a low-density DNA microarray using cytochrome P450 inducers.
Topics: Administration, Oral; Animals; Clofenapate; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Female; Forecasting; Gene Expression; Gene Expression Profiling; Genetic Markers; Hybridization, Genetic; Liver; Miconazole; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Troleandomycin | 2003 |
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil | 2004 |