Compounds > troleandomycin
Page last updated: 2024-09-05

troleandomycin and metyrapone

troleandomycin has been researched along with metyrapone in 10 studies

Compound Research Comparison

Studies
(troleandomycin)		Trials
(troleandomycin)		Recent Studies (post-2010)
(troleandomycin)		Studies
(metyrapone)		Trials
(metyrapone)		Recent Studies (post-2010) (metyrapone)
56926233,415128250

Protein Interaction Comparison

ProteinTaxonomytroleandomycin (IC50)metyrapone (IC50)
Cytochrome P450 1A2Homo sapiens (human)4.8
Cytochrome P450 3A4Homo sapiens (human)2.8659
Cytochrome P450 2C8Homo sapiens (human)5
Cytochrome P450 2D6Homo sapiens (human)4.6
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)7.83
Cytochrome P450 11B1, mitochondrialRattus norvegicus (Norway rat)4.7357
Cytochrome P450 11B1, mitochondrialHomo sapiens (human)0.0181
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.0838
Cytochrome P450 2C19Homo sapiens (human)5

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (60.00)18.2507
2000's2 (20.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pratim Roy, P; Roy, K1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR1
Kupfer, D; Mani, C; Parkinson, A; Pearce, R1
Paine, AJ; Wright, MC1
Golub-Ciosk, B; Hanstein, WG; Kallweit, P; Kauczinski, D; Roos, PH1
Juvonen, RO; Kojo, A; Komulainen, H; Liesivuori, J; Pasanen, M; Pennanen, S1
Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ1
Bortolato, S; Ferrara, R; Manno, M; Tolando, R; Zanovello, A1
Kubickova, B; Martinkova, M; Stiborova, M1

Other Studies

10 other study(ies) available for troleandomycin and metyrapone

ArticleYear
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro.
    Biochemical pharmacology, 1991, Sep-27, Volume: 42, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin

1991
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin

1994
Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein.
    Biochemical and biophysical research communications, 1994, Jun-15, Volume: 201, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Humans; Kinetics; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Troleandomycin

1994
Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes.
    Biochemical pharmacology, 1993, Jun-09, Volume: 45, Issue:11

    Topics: Animals; Antibodies; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrophotometry; Troleandomycin

1993
CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver.
    Human & experimental toxicology, 1996, Volume: 15, Issue:5

    Topics: Aged; Animals; Antibodies, Monoclonal; Caproates; Cytochrome P-450 Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Isoenzymes; Male; Methylation; Metyrapone; Mice; Microsomes, Liver; Middle Aged; NADPH-Ferrihemoprotein Reductase; Occupational Exposure; Proadifen; Quinidine; Rats; Rats, Wistar; Troleandomycin

1996
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
    British journal of cancer, 1998, Volume: 77, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin

1998
Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).
    Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Fomepizole; Free Radicals; Glutathione; Hepatocytes; Isoenzymes; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrazoles; Pyridines; Rats; Rats, Wistar; Troleandomycin

2001
Effects of cytochrome P450 inhibitors on peroxidase activity.
    Neuro endocrinology letters, 2012, Volume: 33 Suppl 3

    Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin

2012