Page last updated: 2024-09-05

troleandomycin and lopinavir

troleandomycin has been researched along with lopinavir in 3 studies

Compound Research Comparison

Studies (troleandomycin)	Trials (troleandomycin)	Recent Studies (post-2010) (troleandomycin)	Studies (lopinavir)	Trials (lopinavir)	Recent Studies (post-2010) (lopinavir)
569	26	23	2,383	499	1,358

Protein Interaction Comparison

Protein	Taxonomy	lopinavir (IC50)
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.7
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	9.12
Gag-Pol polyprotein	Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)	0.035
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	8.5114
Protease	Human immunodeficiency virus 1	0.025
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	7.6
Protease	Human immunodeficiency virus 1	0.0175

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dansette, PM; Fontana, E; Poli, SM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Greenblatt, DJ; Harmatz, JS; Hesse, LM; Richert, C; von Moltke, LL; Weemhoff, JL	1

Reviews

1 review(s) available for troleandomycin and lopinavir

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005

Other Studies

2 other study(ies) available for troleandomycin and lopinavir

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3 Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin	2003

Article

Year

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chemical research in toxicology, 2010, Volume: 23, Issue:1

Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010

Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.

The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3

Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin

2003