troleandomycin has been researched along with ketoconazole in 50 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (ketoconazole) | Trials (ketoconazole) | Recent Studies (post-2010) (ketoconazole) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 6,202 | 706 | 1,269 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.00) | 18.7374 |
| 1990's | 17 (34.00) | 18.2507 |
| 2000's | 21 (42.00) | 29.6817 |
| 2010's | 10 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K | 1 |
| Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K | 1 |
| Davis, CD; Dworetzky, S; Fitzpatrick, WC; Harden, D; He, H; Knox, RJ; Newton, AE; Philip, T; Polson, C; Sinz, MW; Sivarao, DV; Sun, LQ; Tertyshnikova, S; Weaver, D; Wu, YJ; Yeola, S; Zoeckler, M | 1 |
| Pratim Roy, P; Roy, K | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Guzelian, PS; Hostetler, KA; Levin, W; Molowa, DT; Thomas, PE; Wrighton, SA | 1 |
| Advenier, C; Naline, E; Pays, M; Sanceaume, M | 1 |
| Burmaster, SD; Cheng, LK; Hook, RH; Leeson, GA; Ling, KH; Reith, MK | 1 |
| Barra, Y; Maurel, P; Placidi, M; Rahmani, R; Sérée, E; Zhou, XJ; Zhou-Pan, XR | 1 |
| Oster, G; Thompson, D | 1 |
| Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N | 1 |
| Bader, A; Christians, U; Gonschior, AK; Hackbarth, I; Lampen, A; Sewing, KF; von Engelhardt, W | 1 |
| Balani, SK; Chiba, M; Hensleigh, M; Lin, JH; Nishime, JA | 1 |
| Hiroki, S; Shimada, T; Urano, T; Yamazaki, H | 1 |
| Artursson, P; Dobson, GL; Guo, Z; Hidalgo, IJ; Raeissi, SD | 1 |
| Ishizaki, T; Zhao, XJ | 1 |
| Ishizaki, T; Kawashiro, T; Zhao, XJ | 1 |
| Haaz, MC; Riché, C; Rivory, L; Robert, J; Vernillet, L | 1 |
| Haaz, MC; Riché, C; Rivory, LP; Robert, J | 1 |
| Aguilar, AJ; Grace, JM; Skanchy, DJ | 1 |
| Baner, K; Benet, LZ; Christians, U; Deters, M; Hackbarth, I; Hallensleben, K; Jacobsen, W; Kirchner, G; Mancinelli, L; Sewing, KF | 1 |
| Erickson, DA; Keirns, JJ; Levy, RH; Mather, G; Trager, WF | 1 |
| Ashton, M; Svensson, US | 1 |
| Arai, N; Fujimaki, Y; Inaba, T | 1 |
| Obach, RS | 1 |
| Gunnarsson, PO; Persson, R; Seidegård, J; Tuvesson, H; Wienkers, LC | 1 |
| Cook, CS; Engel, LC; Fitzloff, JF; Zhang, L | 1 |
| Liu, XQ; Qian, ZY; Ren, YL; Wang, GJ | 1 |
| Boobis, AR; Edwards, RJ; Kappers, WA; Murray, S | 1 |
| Baldwin, A; Huang, Z; Jounaidi, Y; Waxman, DJ | 1 |
| Greenblatt, DJ; Harmatz, JS; Hesse, LM; Richert, C; von Moltke, LL; Weemhoff, JL | 1 |
| Greenblatt, DJ; Perloff, MD; Von Moltke, LL | 1 |
| Kohno, Y; Suzuki, A; Yamamoto, T | 1 |
| Bell, NH; Gupta, RP; Halpert, JR; He, YA; Patrick, KS | 1 |
| Dale, O; Kharasch, ED; Klees, TM; Sheffels, P | 1 |
| Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T | 1 |
| Beulz-Riché, D; Filaquier, C; Grudé, P; Puozzo, C; Ratanasavanh, D; Riché, C; Sautel, F | 1 |
| Davis, CL; Hashizume, T; Kalhorn, TF; Nelson, WL; Sakaki, T; Schuetz, EG; Shuhart, MC; Thummel, KE; Watkins, PB; Xu, Y | 1 |
| Al-Shurbaji, A; Annas, A; Artursson, P; Lazorova, L; Svensson, JO; Yasar, U | 1 |
| Liu, ZG; Mei, QB; Yang, TH; Yang, ZF; Zhou, SY | 1 |
| Cao, YF; Fang, ZZ; Ge, GB; Hu, D; Huang, T; Huo, H; Li, J; Liu, HX; Sun, DX; Wang, YC; Yang, L; Yin, J; Zhang, YY | 1 |
| Cui, SL; Deng, JT; Kong, WL; Li, H; Tian, XT; Wen, YY; Xie, L; Zhuang, XM | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
| Jiang, H; Ma, L; Shen, Q; Tian, Y; Wang, L; Yu, L; Zeng, S; Zhou, H; Zhou, Q; Zuo, M | 1 |
| Fukami, T; Iida, A; Nakajima, M; Sasaki, E; Tsuneyama, K; Yano, A; Yokoi, T | 1 |
| Conzen, SD; Greene, GL; House, L; Isikbay, M; Mirkov, S; Ramirez, J; Ratain, MJ; Sachleben, JR; Seminerio, MJ; Singhal, H; Skor, M; Vander Griend, D | 1 |
50 other study(ies) available for troleandomycin and ketoconazole
| Article | Year |
|---|---|
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine | 2002 |
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine | 2002 |
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibiti
Topics: Administration, Oral; Animals; Biological Availability; Cell Line; Cinnamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Fluorine; Injections, Intravenous; Ion Channel Gating; KCNQ2 Potassium Channel; Male; Membrane Potentials; Migraine Disorders; Morpholines; Parietal Lobe; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2003 |
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.
Topics: Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Imidazoles; Isoenzymes; Ketoconazole; Liver; Miconazole; Rats; Rats, Inbred Strains; RNA, Messenger; Troleandomycin | 1989 |
Application of theophylline metabolite assays to the exploration of liver microsome oxidative function in man.
Topics: Adult; Biotransformation; Cimetidine; Humans; Ketoconazole; Male; Microsomes, Liver; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Theophylline; Troleandomycin | 1988 |
Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes.
Topics: Alcohols; Biotransformation; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Reagent Kits, Diagnostic; Terfenadine; Troleandomycin | 1995 |
Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.
Topics: Adolescent; Adult; Antibodies; Base Sequence; Binding, Competitive; Biotransformation; Blotting, Western; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; RNA, Messenger; Troleandomycin; Vinblastine; Vindesine | 1993 |
Use of terfenadine and contraindicated drugs.
Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin | 1996 |
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin | 1996 |
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gastric Mucosa; Immunosuppressive Agents; Ketoconazole; Oxidoreductases, N-Demethylating; Swine; Tacrolimus; Troleandomycin; Vasodilator Agents; Verapamil | 1996 |
Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.
Topics: Anti-Bacterial Agents; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; HIV Protease Inhibitors; Humans; Hydroxylation; Indinavir; Isoenzymes; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Troleandomycin | 1996 |
Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes.
Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roxithromycin; Testosterone; Troleandomycin | 1996 |
Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine.
Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxylation; Intestinal Mucosa; Jejunum; Ketoconazole; Microsomes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Steroid Hydroxylases; Terfenadine; Troleandomycin | 1997 |
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes.
Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin | 1997 |
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin | 1998 |
Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.
Topics: Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Biotransformation; Camptothecin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Ketoconazole; Microsomes, Liver; Molecular Structure; Oxidoreductases, N-Demethylating; Recombinant Proteins; Structure-Activity Relationship; Transfection; Troleandomycin | 1998 |
Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Troleandomycin | 1998 |
Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.
Topics: Adult; Aged; Antifungal Agents; Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Glycyrrhiza; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Isoenzymes; Ketoconazole; Liver; Male; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Paeonia; Quinidine; Recombinant Proteins; Sesquiterpenes; Sulfaphenazole; Troleandomycin; Vasodilator Agents; Verapamil | 1999 |
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Intestine, Small; Ketoconazole; Lovastatin; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pravastatin; Swine; Troleandomycin | 1999 |
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.
Topics: Antibodies; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Nevirapine; Phenotype; Recombinant Proteins; Reverse Transcriptase Inhibitors; Troleandomycin | 1999 |
Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin.
Topics: Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cell Line; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Mixed Function Oxygenases; Orphenadrine; Oxidoreductases, N-Demethylating; Regression Analysis; Sesquiterpenes; Time Factors; Troleandomycin | 1999 |
Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent.
Topics: Anti-Ulcer Agents; Benzamides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Isoenzymes; Ketoconazole; Miconazole; Microsomes, Liver; NADP; Substrate Specificity; Troleandomycin | 1999 |
Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
Topics: Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Guinea Pigs; Haplorhini; Humans; Isoenzymes; Ketoconazole; Kinetics; Metabolic Clearance Rate; Microsomes, Liver; Neurokinin-1 Receptor Antagonists; Quinidine; Rats; Species Specificity; Sulfaphenazole; Tritium; Troleandomycin | 2000 |
Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man.
Topics: Antibodies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Female; Gene Expression; Humans; Hydroxylation; Hydroxyquinolines; Ketoconazole; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Testosterone; Troleandomycin | 2000 |
Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disopyramide; Dogs; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Recombinant Proteins; Species Specificity; Troleandomycin | 2001 |
Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes.
Topics: Calcium Channel Blockers; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Nimodipine; Troleandomycin | 2000 |
Diazinon is activated by CYP2C19 in human liver.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazinon; Dose-Response Relationship, Drug; Humans; Insecticides; Ketoconazole; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Theophylline; Troleandomycin | 2001 |
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Coculture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dacarbazine; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Female; Genetic Therapy; Ifosfamide; Inhibitory Concentration 50; Ketoconazole; Liver; Male; Microsomes, Liver; Models, Chemical; Neoplasms; Procarbazine; Prodrugs; Rats; Tamoxifen; Time Factors; Troleandomycin; Tumor Cells, Cultured | 2003 |
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin | 2003 |
Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression.
Topics: Algorithms; Animals; Anti-Anxiety Agents; Antibodies, Blocking; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; In Vitro Techniques; Intestinal Mucosa; Isoenzymes; Ketoconazole; Kinetics; Mice; Mice, Inbred ICR; Microsomes; Microsomes, Liver; Midazolam; Organ Specificity; Ritonavir; Troleandomycin | 2003 |
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil | 2004 |
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
Topics: Animals; Baculoviridae; Cholestanetriol 26-Monooxygenase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Insecta; Isoniazid; Ketoconazole; Kinetics; Microsomes, Liver; Mutagenesis, Site-Directed; Recombinant Proteins; Steroid Hydroxylases; Transfection; Troleandomycin; Vitamin D; Vitamin D3 24-Hydroxylase | 2005 |
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
Topics: Alfentanil; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochromes b5; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Oxidoreductases, N-Demethylating; Troleandomycin | 2005 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin | 2005 |
Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine.
Topics: Adult; Aged; Animals; Antibodies; Antineoplastic Agents, Phytogenic; Blotting, Western; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Time Factors; Tritium; Troleandomycin; Vinblastine; Vinorelbine | 2005 |
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Topics: Base Sequence; Caco-2 Cells; Calbindins; Calcitriol; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Primers; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Intestine, Small; Ketoconazole; Kinetics; Liver; Midazolam; Osteomalacia; Recombinant Proteins; S100 Calcium Binding Protein G; Troleandomycin | 2006 |
Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isonipecotic Acids; Ketoconazole; Kinetics; Meperidine; Microsomes, Liver; Mutagenesis, Site-Directed; Phenols; Substrate Specificity; Sulfaphenazole; Troleandomycin; Verapamil | 2005 |
[Metabolic kinetics of MN9202 in Beagle dog liver microsomes].
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A Inhibitors; Dihydropyridines; Dogs; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Nitrobenzenes; Tranylcypromine; Troleandomycin | 2005 |
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.
Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Ketoconazole; Lignans; Mass Spectrometry; Metabolic Networks and Pathways; Microsomes, Liver; Polycyclic Compounds; Rats; Swine; Swine, Miniature; Troleandomycin | 2010 |
[Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes].
Topics: Anti-HIV Agents; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Intestinal Mucosa; Ketoconazole; Metabolic Clearance Rate; Microsomes; Ritonavir; Troleandomycin | 2010 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |
Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Benzylisoquinolines; Buthionine Sulfoximine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Glutathione; Hep G2 Cells; Humans; Indolequinones; Ketoconazole; Kinetics; Madin Darby Canine Kidney Cells; Microsomes, Liver; Troleandomycin | 2014 |
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Antifungal Agents; Buthionine Sulfoximine; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hydroxylation; Ketoconazole; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Troleandomycin | 2015 |
Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.
Topics: Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Glucuronides; Humans; Ketoconazole; Kinetics; Megestrol Acetate; Metabolome; Microsomes, Liver; Oxidation-Reduction; Prostate-Specific Antigen; Proton Magnetic Resonance Spectroscopy; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Substrate Specificity; Troleandomycin | 2018 |