troleandomycin has been researched along with indinavir sulfate in 5 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (indinavir sulfate) | Trials (indinavir sulfate) | Recent Studies (post-2010) (indinavir sulfate) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 1,834 | 328 | 146 |
| 569 | 26 | 23 | 23 | 0 | 9 |
| Protein | Taxonomy | troleandomycin (IC50) | indinavir sulfate (IC50) |
|---|---|---|---|
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (BRU ISOLATE) | 0.0004 | |
| Gag polyprotein | HIV-1 M:B_MN | 0.02 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.2 | |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | 0.0261 | |
| Substance-K receptor | Homo sapiens (human) | 5.101 | |
| Thromboxane-A synthase | Homo sapiens (human) | 1.851 | |
| Protease | Human immunodeficiency virus 1 | 0.0349 | |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 7.8 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 3.8 | |
| Protease | Human immunodeficiency virus 1 | 0.0044 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Balani, SK; Chiba, M; Hensleigh, M; Lin, JH; Nishime, JA | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
1 review(s) available for troleandomycin and indinavir sulfate
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
4 other study(ies) available for troleandomycin and indinavir sulfate
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.
Topics: Anti-Bacterial Agents; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; HIV Protease Inhibitors; Humans; Hydroxylation; Indinavir; Isoenzymes; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Troleandomycin | 1996 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |