troleandomycin has been researched along with ifosfamide in 9 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (ifosfamide) | Trials (ifosfamide) | Recent Studies (post-2010) (ifosfamide) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 5,045 | 1,430 | 1,113 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Beaune, PH; Beloc, C; Boddy, AV; Cholerton, S; Daly, AK; Flinois, JP; Lind, MJ; Monkman, SC; Pearson, AD; Walker, D | 1 |
| Waxman, DJ; Weber, GF | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Waxman, DJ; Yu, LJ | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ | 1 |
| Huang, Z; Roy, P; Waxman, DJ | 1 |
| Baldwin, A; Huang, Z; Jounaidi, Y; Waxman, DJ | 1 |
9 other study(ies) available for troleandomycin and ifosfamide
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide.
Topics: Antibodies; Biotransformation; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Flavanones; Flavonoids; Humans; Hydroxylation; Ifosfamide; Inactivation, Metabolic; Microsomes, Liver; Mixed Function Oxygenases; Troleandomycin | 1994 |
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Topics: Animals; Antibodies; Biotransformation; Cisplatin; Clofibrate; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Ifosfamide; Kinetics; Male; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1993 |
Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
Topics: Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cytochrome P-450 Enzyme System; Dexamethasone; Ifosfamide; Male; Metyrapone; Microsomes, Liver; Orphenadrine; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1998 |
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Disease Models, Animal; Enzyme Induction; Female; Gliosarcoma; Half-Life; Hydroxylation; Ifosfamide; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1999 |
Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Chromatography, High Pressure Liquid; Cyclophosphamide; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Fluorometry; Humans; Ifosfamide; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Troleandomycin | 2000 |
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Coculture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dacarbazine; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Female; Genetic Therapy; Ifosfamide; Inhibitory Concentration 50; Ketoconazole; Liver; Male; Microsomes, Liver; Models, Chemical; Neoplasms; Procarbazine; Prodrugs; Rats; Tamoxifen; Time Factors; Troleandomycin; Tumor Cells, Cultured | 2003 |