troleandomycin has been researched along with fentanyl in 4 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (fentanyl) | Trials (fentanyl) | Recent Studies (post-2010) (fentanyl) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 15,288 | 4,310 | 4,483 |
| Protein | Taxonomy | troleandomycin (IC50) | fentanyl (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 6.5 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.6342 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0122 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.1888 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0122 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0058 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.3092 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 5.893 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 1.58 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0031 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 1.8197 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 4.973 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.354 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Guengerich, FP; Krivoruk, Y; Tateishi, T; Ueng, YF; Wood, AJ; Wood, M | 1 |
| Feldman, J; Ibrahim, AE; Karim, A; Kharasch, ED | 1 |
| Hoffer, C; Kharasch, ED; Whittington, D | 1 |
2 trial(s) available for troleandomycin and fentanyl
| Article | Year |
|---|---|
Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
Topics: Adult; Affect; Alfentanil; Algorithms; Analgesics, Opioid; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Female; Fentanyl; Half-Life; Hemodynamics; Humans; Isoxazoles; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Respiratory Mechanics; Troleandomycin | 2003 |
Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
Topics: Adult; Analgesics, Opioid; Antibiotics, Antitubercular; Antiemetics; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; Fentanyl; Food-Drug Interactions; Half-Life; Humans; Intestines; Liver; Male; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Spectrometry, Mass, Electrospray Ionization; Troleandomycin | 2004 |
2 other study(ies) available for troleandomycin and fentanyl
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Topics: Analgesics, Opioid; Animals; Antibodies; Antibody Specificity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; Humans; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Norpregnenes; Rabbits; Sufentanil; Troleandomycin | 1996 |