Compounds > troleandomycin
Page last updated: 2024-09-05

troleandomycin and dextromethorphan

troleandomycin has been researched along with dextromethorphan in 4 studies

Compound Research Comparison

Studies
(troleandomycin)		Trials
(troleandomycin)		Recent Studies (post-2010)
(troleandomycin)		Studies
(dextromethorphan)		Trials
(dextromethorphan)		Recent Studies (post-2010) (dextromethorphan)
56926232,020342593

Protein Interaction Comparison

ProteinTaxonomytroleandomycin (IC50)dextromethorphan (IC50)
Sodium channel protein type 1 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 3 subunit alphaRattus norvegicus (Norway rat)1.3
Cytochrome P450 2D26Rattus norvegicus (Norway rat)5.6
Cytochrome P450 2D6Homo sapiens (human)2.1768
Sodium-dependent serotonin transporterHomo sapiens (human)0.0027
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.1236

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Belghiti, J; Larrey, D; Lettéron, P; Loeper, J; Maurel, P; Pessayre, D; Tinel, M1
Di Marco, A; Laufer, R; Yao, D1

Other Studies

4 other study(ies) available for troleandomycin and dextromethorphan

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450.
    Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3

    Topics: Antidepressive Agents, Tricyclic; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Glutathione; Humans; Isoenzymes; Microsomes, Liver; NADP; Oxygen; Piperonyl Butoxide; Pyridines; Quinidine; Troleandomycin

1990
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
    European journal of biochemistry, 2003, Volume: 270, Issue:18

    Topics: Animals; Benzoflavones; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Hepatocytes; Inhibitory Concentration 50; Kinetics; Male; Methylation; Microsomes, Liver; Oxidoreductases, O-Demethylating; Protein Binding; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin

2003