Page last updated: 2024-09-05

troleandomycin and cyclosporine

troleandomycin has been researched along with cyclosporine in 19 studies

Compound Research Comparison

Studies (troleandomycin)	Trials (troleandomycin)	Recent Studies (post-2010) (troleandomycin)	Studies (cyclosporine)	Trials (cyclosporine)	Recent Studies (post-2010) (cyclosporine)
569	26	23	377	2	170
569	26	23	30,547	3,802	6,558

Protein Interaction Comparison

Protein	Taxonomy	cyclosporine (IC50)
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	0.6315
Bile salt export pump	Rattus norvegicus (Norway rat)	0.6
Bile salt export pump	Homo sapiens (human)	3.5
Interleukin-2	Mus musculus (house mouse)	0.005
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	0.7
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.6792
Cytochrome P450 3A4	Homo sapiens (human)	3.734
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	5.82
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Cytochrome P450 3A5	Homo sapiens (human)	2.06
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	4.8
Substance-K receptor	Homo sapiens (human)	4.139
Peptidyl-prolyl cis-trans isomerase B	Homo sapiens (human)	0.0088
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Cytochrome P450 3A7	Homo sapiens (human)	2.06
Cytochrome P450 2C19	Homo sapiens (human)	7
Multidrug resistance-associated protein 1	Homo sapiens (human)	3.5082
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	9.34
Peptidyl-prolyl cis-trans isomerase A	Homo sapiens (human)	0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4	Homo sapiens (human)	0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Homo sapiens (human)	0.183
Peptidyl-prolyl cis-trans isomerase D	Homo sapiens (human)	0.0036
Sodium/bile acid cotransporter	Homo sapiens (human)	1
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	0.455
Cytochrome P450 3A43	Homo sapiens (human)	2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Mus musculus (house mouse)	0.57
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	4.3
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	0.95

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (42.11)	18.2507
2000's	5 (26.32)	29.6817
2010's	6 (31.58)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K	1
Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Fishman, K; Guzelian, PS; Hamilton, T; Kolars, JC; Lown, KS; Saenger, P; Turgeon, DK; Voorhees, JJ; Watkins, PB	1
Moss, RB	1
Sadrieh, N; Thomas, PE	1
Basu, AK; Ghosh, S; Mohanty, PK; Watlington, CO	1
Augustijns, PF; Bradshaw, TP; Gan, LS; Hendren, RW; Khosla, B; Moseley, MA; Thakker, DR	1
Bader, A; Christians, U; Hackbarth, I; Lampen, A; Sewing, KF	1
Spector, SL	1
Baner, K; Benet, LZ; Christians, U; Deters, M; Hackbarth, I; Hallensleben, K; Jacobsen, W; Kirchner, G; Mancinelli, L; Sewing, KF	1
Argyros, G; Niven, AS	1
Benet, LZ; Wu, CY	1
Chen, H; Hu, JP; Li, Y; Sheng, L; Tan, W	1

Reviews

3 review(s) available for troleandomycin and cyclosporine

Article	Year
Alternative pharmacotherapies for steroid-dependent asthma. Chest, 1995, Volume: 107, Issue:3 Topics: Adrenal Cortex Hormones; Asthma; Clinical Trials as Topic; Cyclosporine; Dapsone; Furosemide; Gold; Humans; Hydroxychloroquine; Magnesium Sulfate; Methotrexate; Treatment Outcome; Troleandomycin	1995
Alternative treatments in the patient with intractable asthma. Current opinion in pulmonary medicine, 1997, Volume: 3, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents; Antirheumatic Agents; Asthma; Cyclosporine; Dapsone; Humans; Hydroxychloroquine; Immunization, Passive; Immunosuppressive Agents; Methotrexate; Organogold Compounds; SRS-A; Troleandomycin	1997
Alternate treatments in asthma. Chest, 2003, Volume: 123, Issue:4 Topics: Anti-Asthmatic Agents; Anticoagulants; Asthma; Cyclosporine; Diuretics; Folic Acid Antagonists; Furosemide; Gold; Heparin; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Methotrexate; T-Lymphocytes; Troleandomycin	2003

Other Studies

16 other study(ies) available for troleandomycin and cyclosporine

Article	Year
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Molecular pharmacology, 2002, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine	2002
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine	2002
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Breath Tests; Carbon Dioxide; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydrocortisone; Liver; Oxidoreductases, N-Demethylating; Psoriasis; Regression Analysis; Rifampin; Troleandomycin	1992
Characterization of rat cytochrome P450 isozymes involved in the covalent binding of cyclosporin A to microsomal proteins. Toxicology and applied pharmacology, 1994, Volume: 127, Issue:2 Topics: Aging; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Catalysis; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Female; Glutathione; Isoenzymes; Kidney; Male; Mannitol; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Testosterone; Tritium; Troleandomycin	1994
Augmented arterial pressure responses to cyclosporine in spontaneously hypertensive rats. Role of cytochrome P-450 3A. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 24, Issue:4 Topics: Animals; Blood Pressure; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Hypertension; Kidney; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Steroid Hydroxylases; Troleandomycin	1994
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:3 Topics: Anti-Bacterial Agents; Caco-2 Cells; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Immunosuppressive Agents; In Vitro Techniques; Mixed Function Oxygenases; Oxidation-Reduction; Troleandomycin	1996
Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine. Pharmacology, 1996, Volume: 52, Issue:3 Topics: Adult; Anti-Bacterial Agents; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Immunosuppressive Agents; In Vitro Techniques; Intestine, Small; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Troleandomycin	1996
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Intestine, Small; Ketoconazole; Lovastatin; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pravastatin; Swine; Troleandomycin	1999
Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:11 Topics: Acridines; Animals; Cyclosporine; Drug Interactions; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley; Tacrolimus; Tetrahydroisoquinolines; Troleandomycin	2003
[Effect of CYP3A and P-glycoprotein on the absorption of buagafuran in rat intestinal lumen]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:1 Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Intestinal Absorption; Male; Mesenteric Veins; Perfusion; Permeability; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Troleandomycin	2010