Page last updated: 2024-09-05

troleandomycin and clarithromycin

troleandomycin has been researched along with clarithromycin in 13 studies

Compound Research Comparison

Studies (troleandomycin)	Trials (troleandomycin)	Recent Studies (post-2010) (troleandomycin)	Studies (clarithromycin)	Trials (clarithromycin)	Recent Studies (post-2010) (clarithromycin)
569	26	23	7,149	1,606	2,504

Protein Interaction Comparison

Protein	Taxonomy	clarithromycin (IC50)
ATP-dependent translocase ABCB1	Homo sapiens (human)	5.5
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	3.3113
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	3.0903

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (7.69)	18.7374
1990's	3 (23.08)	18.2507
2000's	3 (23.08)	29.6817
2010's	5 (38.46)	24.3611
2020's	1 (7.69)	2.80

Authors

Authors	Studies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Dansette, PM; Fontana, E; Poli, SM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Descatoire, V; Labbe, G; Larrey, D; Letteron, P; Loeper, J; Pessayre, D; Tinel, M	1
Oster, G; Thompson, D	1
Flurer, CL	1
Counihan, M; Duan, SX; Durol, AL; Graf, JA; Greenblatt, DJ; Harmatz, JS; Mertzanis, P; Shader, RI; von Moltke, LL; Wright, CE	1
Kim, SG; Kim, SH; Kim, WB; Kwon, JW; Lee, AK; Lee, JH; Lee, MG	1
Albaugh, DR; Fisher, MB; Fullenwider, CL; Hutzler, JM	1
Abraham, TL; Bedwell, DW; Hall, SD; Hansen, K; Rougée, LRA	1

Reviews

1 review(s) available for troleandomycin and clarithromycin

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005

Trials

1 trial(s) available for troleandomycin and clarithromycin

Article	Year
Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:3 Topics: Administration, Oral; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Azithromycin; Clarithromycin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Erythromycin; Humans; Hypnotics and Sedatives; In Vitro Techniques; Microsomes, Liver; Oxidoreductases, N-Demethylating; Time Factors; Triazolam; Troleandomycin	1998

Article

Year

Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences.

Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:3

Topics: Administration, Oral; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Azithromycin; Clarithromycin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Erythromycin; Humans; Hypnotics and Sedatives; In Vitro Techniques; Microsomes, Liver; Oxidoreductases, N-Demethylating; Time Factors; Triazolam; Troleandomycin

1998

Other Studies

11 other study(ies) available for troleandomycin and clarithromycin

Article	Year
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2 Topics: Animals; Clarithromycin; Cytochrome P-450 Enzyme System; Dealkylation; Dexamethasone; Enzyme Induction; Erythromycin; Iron; Isoenzymes; Male; Rats; Rats, Inbred Strains; Troleandomycin	1989
Use of terfenadine and contraindicated drugs. JAMA, 1996, May-01, Volume: 275, Issue:17 Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin	1996
Analysis of macrolide antibiotics by capillary electrophoresis. Electrophoresis, 1996, Volume: 17, Issue:2 Topics: Acetonitriles; Anti-Bacterial Agents; Buffers; Carbohydrate Sequence; Cholic Acid; Cholic Acids; Clarithromycin; Electrophoresis, Capillary; Erythromycin; Molecular Sequence Data; Molecular Structure; Oleandomycin; Spiramycin; Troleandomycin	1996
Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate. Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:6 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Clarithromycin; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Half-Life; Injections, Intravenous; Isoenzymes; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Time Factors; Troleandomycin; Uranyl Nitrate	2004
Time-dependent inhibition and estimation of CYP3A clinical pharmacokinetic drug-drug interactions using plated human cell systems. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:7 Topics: Cells, Cultured; Clarithromycin; Cryopreservation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Hepatocytes; Humans; Kinetics; Microsomes, Liver; Troleandomycin; Verapamil	2012
Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:10 Topics: Carbamazepine; Clarithromycin; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Microsomes, Liver; Midazolam; Troleandomycin	2023