troleandomycin has been researched along with alpha-naphthoflavone in 16 studies
| Studies (troleandomycin) | Trials (troleandomycin) | Recent Studies (post-2010) (troleandomycin) | Studies (alpha-naphthoflavone) | Trials (alpha-naphthoflavone) | Recent Studies (post-2010) (alpha-naphthoflavone) |
|---|---|---|---|---|---|
| 569 | 26 | 23 | 665 | 1 | 142 |
| Protein | Taxonomy | troleandomycin (IC50) | alpha-naphthoflavone (IC50) |
|---|---|---|---|
| Carboxylic ester hydrolase | Sus scrofa (pig) | 0.0478 | |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | 2.3034 | |
| Cytochrome P450 1A1 | Homo sapiens (human) | 0.1921 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.1698 | |
| Aromatase | Homo sapiens (human) | 1.035 | |
| Substance-K receptor | Homo sapiens (human) | 5.8471 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.01 | |
| Thromboxane-A synthase | Homo sapiens (human) | 6.7608 | |
| Adenosine receptor A1 | Homo sapiens (human) | 1.1325 | |
| Aryl hydrocarbon receptor | Mus musculus (house mouse) | 0.025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.05 | |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | 4.98 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.0449 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.355 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 11 (68.75) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Branch, RA; Fleming, CM; Guengerich, FP; Wilkinson, GR | 1 |
| Eaton, DL; Eddy, AC; Parkinson, A; Ramsdell, HS | 1 |
| Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR | 1 |
| Guengerich, FP; Shimada, T | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K | 1 |
| Hashimoto, H; Itoh, S; Kamataki, T; Nakagawa, T; Sawada, M; Yokoi, T | 1 |
| Chang, TK; Gonzalez, FJ; Waxman, DJ | 1 |
| Cho, AK; Funae, Y; Horie, T; Masubuchi, Y; Matsumoto, T; Mochida, M; Nagata, K; Narimatsu, S; Suzuki, T | 1 |
| Ekström, G; Gunnarsson, UB | 1 |
| Crivello, J; Wall, KL | 1 |
| Kitamura, S; Konishi, T; Nishikawa, H; Taguchi, K | 1 |
| Gorski, JC; Hall, SD; Hamman, MA; Jones, DR; Wrighton, SA | 1 |
| Fitzpatrick, JL; Pierce, WM; Prough, RA; Ripp, SL; Smith, NB | 1 |
| Di Marco, A; Laufer, R; Yao, D | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
1 review(s) available for troleandomycin and alpha-naphthoflavone
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
15 other study(ies) available for troleandomycin and alpha-naphthoflavone
| Article | Year |
|---|---|
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Topics: Antibodies; Benzoflavones; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Kinetics; Microsomes, Liver; Norpregnenes; Troleandomycin | 1992 |
Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes.
Topics: Aflatoxin B1; Aflatoxins; Benzoflavones; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Troleandomycin | 1991 |
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin | 1991 |
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
Topics: Aflatoxin B1; Aflatoxins; Antibodies; Benzoflavones; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Immunochemistry; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Sterigmatocystin; Troleandomycin | 1989 |
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin | 1995 |
Fetus-specific CYP3A7 and adult-specific CYP3A4 expressed in Chinese hamster CHL cells have similar capacity to activate carcinogenic mycotoxins.
Topics: Adult; Aflatoxin B1; Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Biotransformation; Carcinogens; Cell Line; Clone Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Fetus; Gene Expression; Guinea Pigs; Humans; Mycotoxins; Sensitivity and Specificity; Transfection; Transformation, Genetic; Troleandomycin | 1995 |
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.
Topics: Benzoflavones; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Ditiocarb; DNA, Complementary; Humans; Isoenzymes; Kinetics; Liver Neoplasms; Recombinant Proteins; Troleandomycin; Tumor Cells, Cultured | 1994 |
Cytochrome P450 enzymes involved in the enhancement of propranolol N-desisopropylation after repeated administration of propranolol in rats.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Inhibitors; Hydroxylation; Immunoblotting; Isoenzymes; Male; Microsomes, Liver; Propranolol; Rats; Rats, Wistar; Troleandomycin | 1996 |
Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes.
Topics: Amides; Anesthetics, Local; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Quinidine; Ropivacaine; Substrate Specificity; Troleandomycin | 1996 |
Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts.
Topics: Aniline Compounds; Animals; Benzoflavones; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Ditiocarb; Enzyme Inhibitors; Female; Flounder; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Substrate Specificity; Troleandomycin; Water Pollutants, Chemical | 1998 |
Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Combinations; Drugs, Chinese Herbal; Enzyme Inhibitors; Glycyrrhiza; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Paeonia; Phenylpropionates; Quinidine; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Troleandomycin | 1999 |
Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily.
Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; B-Lymphocytes; Benzoflavones; Biotransformation; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypnotics and Sedatives; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Recombinant Proteins; Sulfaphenazole; Troleandomycin | 1999 |
Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.
Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Humans; In Vitro Techniques; Male; Mass Spectrometry; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Troleandomycin | 2001 |
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Topics: Animals; Benzoflavones; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Hepatocytes; Inhibitory Concentration 50; Kinetics; Male; Methylation; Microsomes, Liver; Oxidoreductases, O-Demethylating; Protein Binding; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2003 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |