Page last updated: 2024-09-05

troleandomycin and alfentanil

troleandomycin has been researched along with alfentanil in 3 studies

Compound Research Comparison

Studies (troleandomycin)	Trials (troleandomycin)	Recent Studies (post-2010) (troleandomycin)	Studies (alfentanil)	Trials (alfentanil)	Recent Studies (post-2010) (alfentanil)
569	26	23	1,731	757	172

Protein Interaction Comparison

Protein	Taxonomy	troleandomycin (IC50)	alfentanil (IC50)
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		0.0389
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.015

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Feldman, J; Ibrahim, AE; Karim, A; Kharasch, ED	1
Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A	1
Dale, O; Kharasch, ED; Klees, TM; Sheffels, P	1

Trials

2 trial(s) available for troleandomycin and alfentanil

Article	Year
Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology, 2003, Volume: 98, Issue:4 Topics: Adult; Affect; Alfentanil; Algorithms; Analgesics, Opioid; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Female; Fentanyl; Half-Life; Hemodynamics; Humans; Isoxazoles; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Respiratory Mechanics; Troleandomycin	2003
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:5 Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Anti-Bacterial Agents; Antibiotics, Antitubercular; Aryl Hydrocarbon Hydroxylases; Beverages; Biological Availability; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Female; Food-Drug Interactions; Humans; Injections, Intravenous; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Troleandomycin	2004

Article

Year

Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.

Anesthesiology, 2003, Volume: 98, Issue:4

Topics: Adult; Affect; Alfentanil; Algorithms; Analgesics, Opioid; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Female; Fentanyl; Half-Life; Hemodynamics; Humans; Isoxazoles; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Respiratory Mechanics; Troleandomycin

2003

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.

Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:5

Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Anti-Bacterial Agents; Antibiotics, Antitubercular; Aryl Hydrocarbon Hydroxylases; Beverages; Biological Availability; Citrus; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Double-Blind Method; Female; Food-Drug Interactions; Humans; Injections, Intravenous; Liver; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Pupil; Rifampin; Troleandomycin

2004

Other Studies

1 other study(ies) available for troleandomycin and alfentanil

Article	Year
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3 Topics: Alfentanil; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochromes b5; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Oxidoreductases, N-Demethylating; Troleandomycin	2005

Article

Year

Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.

Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

Topics: Alfentanil; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochromes b5; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Oxidoreductases, N-Demethylating; Troleandomycin

2005