troglitazone has been researched along with thiazoles in 939 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.11) | 18.7374 |
| 1990's | 378 (40.26) | 18.2507 |
| 2000's | 558 (59.42) | 29.6817 |
| 2010's | 2 (0.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gumbiner, B; Nolan, JJ; Olefsky, JM; Suter, SL; Wallace, P | 1 |
| Aizawa, Y; Fujita, T; Horikoshi, H; Kinoshita, T; Kuwano, H; Nakamura, K; Sasahara, K; Yoshioka, T | 1 |
| Awata, T; Inooka, G; Iwamoto, Y; Kumakura, S; Kuzuya, T; Matsuda, A; Shiraishi, I | 1 |
| Fujiwara, T; Fukami, M; Fukuda, K; Horikoshi, H; Wada, M; Yoshioka, S; Yoshioka, T | 1 |
| Akanuma, Y; Iwamoto, Y; Kajinuma, H; Kasuga, M; Kosaka, K; Kuzuya, T; Shigeta, Y; Takebe, K; Yamanouchi, T; Yoshida, S | 1 |
| Ciaraldi, TP; Gilmore, A; Goldberg, M; Heidenreich, KA; Olefsky, JM | 1 |
| Fujiwara, T; Horikoshi, H; Ushiyama, I; Yoshioka, S; Yoshioka, T | 1 |
| Gao, KM; Khoursheed, M; Lee, MK; Miles, PD; Moossa, AR; Olefsky, JM | 2 |
| Amri, EZ; Gaillard, D; Grimaldi, PA; Inadera, H; Staccini, L; Teboul, L | 1 |
| Berti, L; Häring, H; Kellerer, M; Kiehn, R; Kroder, G; Mosthaf, L; Tippmer, S | 1 |
| Reusch, JE | 1 |
| Kaku, K; Kaneko, T; Nagasaka, Y; Nakamura, K | 1 |
| Ciaraldi, TP; Hickman, M; Huber-Knudsen, K; Olefsky, JM | 1 |
| Lee, MK; Olefsky, JM | 1 |
| Fujiwara, T; Horikoshi, H; Okuno, A; Yoshioka, S | 1 |
| Horikoshi, H; Ishida, H; Kato, S; Masuda, K; Miura, T; Okamoto, Y; Seino, Y; Tsuda, K; Tsuura, Y | 1 |
| Izumi, T; Nakagawa, T; Nakao, C; Sawada, T; Shibukawa, A | 1 |
| Inoue, Y; Kato, Y; Kawaguchi, M; Nakamura, S; Tamura, K; Tanigawa, K; Xu, G | 1 |
| Ikegami, H; Masuo, K; Mikami, H; Ogihara, T; Rakugi, H | 1 |
| Daimon, M; Eguchi, H; Igarashi, M; Matsumoto, M; Sasaki, H; Sekikawa, A; Tominaga, M; Yamatani, K | 1 |
| Beerdsen, P; Joyce, M; Ludvik, B; Nolan, JJ; Olefsky, J | 1 |
| Keen, H | 1 |
| Fujiwara, T; Horikoshi, H; Miyadai, K; Ohsumi, J; Sakakibara, S; Serizawa, N; Yamaguchi, J; Yoshioka, S | 1 |
| Akazawa, S; Kawasaki, E; Matsumoto, K; Okuno, S; Takao, Y; Takino, H; Uotani, S; Yamaguchi, Y; Yamasaki, H; Yano, M | 1 |
| Emoto, M; Inoue, Y; Kaku, K; Kaneko, T; Murano, K | 1 |
| Abe, M; Ishii, J; Kashiwabara, H; Katayama, S; Kosegawa, I | 1 |
| Fujiwara, T; Horikoshi, H; Ikeda, K; Koike, H; Nishino, H; Okuno, A; Shiraki, T; Wada, M; Yoshioka, S | 1 |
| Ikeda, S; Nagai, T; Nagata, N; Ono, J; Ryu, S; Yasunami, Y | 2 |
| Kato, Y; Kawaguchi, M; Tanigawa, K | 1 |
| Umeda, F | 1 |
| Higa, S; Ishikawa, K; Mimura, G; Murakami, K; Takasu, N; Yagi, N | 1 |
| Foote, CS; Fu, Y; Fujita, T; Sheu, C | 1 |
| Enomoto, S; Hosiyama, K; Izumi, T; Nakagawa, T; Sasahara, K; Shibukawa, A; Sugiyama, Y | 1 |
| Lambe, KG; Tugwood, JD | 1 |
| Akanuma, Y; Iwamoto, Y; Kaneko, T; Kosaka, K; Kuzuya, T; Shigeta, Y | 2 |
| Caro, JF; Considine, RV; Nolan, JJ; Nyce, MR; Olefsky, JM | 1 |
| Higa, S; Komiya, I; Nagamine, F; Shimabukuro, M; Shinzato, T; Takasu, N | 1 |
| Beck-Nielsen, H; Berthezene, F; Boulton, AJ; Donoghue, S; Kumar, S; Lettis, S; Muggeo, M; Persson, B; Spinas, GA; Stewart-Long, P | 1 |
| Horikoshi, H; Kato, Y; Kodama, T; Niki, E; Noguchi, N; Sakai, H; Tsuchiya, J; Yamamoto, Y | 1 |
| Dunaif, A; Finegood, D; Quintana, B; Scott, D; Whitcomb, R | 1 |
| Harada, Y; Inoue, I; Ishii, J; Itabashi, A; Katayama, S; Negishi, K; Takahashi, K | 1 |
| Bähr, M; Bock, M; Eckel, J; Kiehn, R; Spelleken, M; von Holtey, M | 1 |
| Fulgencio, JP; Girard, J; Kohl, C; Pégorier, JP | 1 |
| Azen, S; Berkowitz, K; Buchanan, TA; Dunn, ME; Goico, J; Kjos, SL; Marroquin, A; Peters, R; Xiang, A | 1 |
| Coats, W; Faxon, D; Graf, K; Hsueh, WA; Law, RE; Meehan, WP; Wuthrich, DA; Xi, XP | 1 |
| Henry, RR | 1 |
| Tafuri, SR | 1 |
| Burant, CF; Polonsky, KS; Pugh, W; Sreenan, S; Sturis, J | 1 |
| Boden, PR; Ibbotson, T; Lee, K; Richardson, PJ | 1 |
| Kawamori, R; Yoshii, H | 1 |
| Davidoff, AJ; Dominguez, LJ; Ren, J; Sowers, JR | 1 |
| Chen, S; Izumida, T; Katayama, S; Noguchi, Y; Tatebe, J | 1 |
| Connell, J; Petrie, J; Small, M | 1 |
| Graf, K; Hsueh, WA; Law, RE; Xi, XP | 1 |
| Cornicelli, JA; Davis, JA; O'Rourke, CM; Saltiel, AR | 1 |
| Antonucci, TK; Driscoll, JH; Faja, BW; Ghazzi, MN; Huang, SM; Perez, JE; Whitcomb, RW | 1 |
| Campagnola, M; Cominacini, L; Davoli, A; Fratta Pasini, A; Garbin, U; Lo Cascio, V; Pastorino, AM; Rigoni, A | 1 |
| Arakawa, K; Saku, K; Zhang, B | 1 |
| Enomoto, S; Hosiyama, K; Izumi, T; Sasahara, K; Sugiyama, Y | 1 |
| Barazi, M; Dominguez, LJ; Igwe, R; Ram, JL; Song, J; Sowers, JR; Walsh, MF | 1 |
| Kondo, M; Sakane, N; Yoshida, T | 1 |
| Boden, P; Lee, K | 1 |
| Enomoto, S; Hoshiyama, K; Izumi, T; Sasahara, K; Sugiyama, Y | 2 |
| Antonucci, T; Lockwood, D; McLain, R; Norris, RM; Whitcomb, R | 1 |
| Benson, SC; Kurtz, TW; Morikang, E; Pershadsingh, HA | 1 |
| Bressler, R; Johnson, DG | 1 |
| Reddy, SS; Speerhas, RA; Vidt, DG | 1 |
| Ikeda, T; Iwabuchi, H; Kawai, K; Kawasaki-Tokui, Y; Kazui, M; Kinoshita, T; Komai, T; Nakamura, K; Nakamura, T; Odaka, T; Tsuruta, F; Yoshioka, T | 1 |
| Nestler, JE | 1 |
| Dunaif, A; Flier, JS; Mantzoros, CS | 1 |
| Fujiwara, T; Horikoshi, H; Ikeda, K; Okuno, A; Shiota, M; Sugano, T; Yoshioka, S | 1 |
| Inoue, I; Katayama, S; Komoda, T; Miyazaki, T; Negishi, K; Sonoda, M; Takahashi, K | 1 |
| Hirose, T; Kurebayashi, S | 1 |
| Markham, A; Spencer, CM | 1 |
| Cavaghan, MK; Ehrmann, DA; Imperial, J; Polonsky, KS; Rosenfield, RL; Schneider, DJ; Sobel, BE | 1 |
| Kaneko, T | 1 |
| Flórez, H | 1 |
| Byrne, MM; Cavaghan, MK; Ehrmann, DA; Polonsky, KS | 1 |
| Linday, LA | 1 |
| Ishikawa, S; Iwamoto, Y; Kuzuya, T; Nagasaka, S; Saito, T | 1 |
| Kondo, M; Yokoo, S; Yoshida, T; Yoshioka, K | 1 |
| Teter, ML | 1 |
| Akazawa, S; Chikuba, N; Ishibashi, M; Izumino, K; Matsumoto, K; Nagataki, S; Sakamaki, H; Takino, H; Tokuyama, K; Yamaguchi, Y; Yamasaki, H | 1 |
| Lee, Y; Shimabukuro, M; Unger, RH; Zhou, YT | 2 |
| Santiago, JV | 1 |
| Hamada, Y; Ikegami, H; Ogihara, T | 1 |
| Katayama, S | 1 |
| Anichini, R; Ferrannini, E; Foot, E; Gastaldelli, A; Pecori, N; Seghieri, G; Sironi, AM; Vichi, S | 1 |
| Fujii, M; Hasegawa, G; Kondo, M; Nakano, K; Shigeta, H; Takemura, R; Yamaguchi, M | 1 |
| Koyama, K; Lee, Y; Shimabukuro, M; Unger, RH | 1 |
| Peraldi, P; Spiegelman, BM; Xu, M | 1 |
| Arakawa, K; Ohta, T; Saku, K; Zhang, B | 1 |
| Bright, SW; Dominianni, SJ; Fitch, LL; Gold, G; Schmiegel, KK; Tinsley, FC | 1 |
| Eastmond, R; Foot, EA | 1 |
| Campagnola, M; Capriati, A; Cominacini, L; Contessi, GB; Davoli, A; Fratta Pasini, A; Garbin, U; Lo Cascio, V; Rigoni, A; Young, MM | 1 |
| Kliewer, SA; Lehmann, JM; Lenhard, JM; Paulik, MA; Plunket, KD; Weiel, JE | 1 |
| Bloomgarden, ZT | 2 |
| Cohen, A; Higo, K; Miles, PD; Olefsky, JM; Rafaat, K; Romeo, OM | 1 |
| Fujita, T; Yoshioka, T | 1 |
| Hirsch, IB; Purnell, JQ | 1 |
| Hansson, A; Hehenberger, K | 1 |
| Nightingale, SL | 2 |
| Burant, CF; Davidson, NO; Graves, RA; Hirano, K; Lohmiller, J; Lukens, J; Ross, S; Sreenan, S; Tai, TA | 1 |
| Mitsuo, M; Nakai, I; Oka, T; Shimizu, Y; Uchiyama, K; Yasunami, Y | 1 |
| Hirose, T; Kasayama, S; Kishimoto, T; Kurebayashi, S; Miyashita, Y | 1 |
| Adams, M; Chatterjee, VK; Digby, JE; Holder, JC; Lazar, MA; Montague, CT; O'Rahilly, S; Prins, JB; Sanders, L; Sewter, CP; Smith, SA | 1 |
| Kano, H; Kohno, M; Minami, M; Yasunari, K; Yokokawa, K; Yoshikawa, J | 1 |
| Iwamoto, Y | 2 |
| Bright, SW; Dominianni, SJ; Fitch, LL; Gold, G; Kellam, ML; Sage, SW; Schmiegel, KK; Sportsman, JR; Tinsley, FC; Yen, TT | 1 |
| Sternon, J | 1 |
| Matsumoto, K; Miyake, S; Tominaga, Y; Ueki, Y; Yano, M | 2 |
| Bisschop, M; Fürnsinn, C; Neschen, S; Noe, C; Roden, M; Schneider, B; Vogl, C; Waldhäusl, W | 1 |
| Campagnola, M; Cominacini, L; Davoli, A; Ferrannini, E; Foot, E; Fratta Pasini, A; Garbin, U; Lo Cascio, V; Sighieri, G; Sironi, AM | 1 |
| Mori, M; Ohtani, KI; Sato, N; Shimizu, H | 1 |
| Camirand, A; Marie, V; Rabelo, R; Silva, JE | 1 |
| Jiang, C; Seed, B; Ting, AT | 1 |
| Akatsuka, H; Arakawa, K; Homma, K; Iijima, I; Inamasu, M; Kawanami, S; Matsumoto, M; Okumura, K; Ozeki, M; Saiga, Y; Watanabe, A; Yasuda, K | 1 |
| Sakamoto, N; Uno, T | 1 |
| Inoue, I; Ishii, J | 1 |
| Fujiwara, T; Horikoshi, H | 2 |
| Kitaoka, H | 2 |
| Hari, J | 1 |
| Ciaraldi, T; Henry, RR | 1 |
| Wise, J | 1 |
| Zurlinden, J | 2 |
| Buchanan, TA; Burant, CF; Cline, G; Gumbiner, B; Hsueh, WA; Inzucchi, S; Kelley, D; Maggs, DG; Nolan, J; Olefsky, JM; Polonsky, KS; Shulman, GI; Silver, D; Valiquett, TR | 1 |
| Levi, M; Shimabukuro, M; Unger, RH; Zhou, YT | 1 |
| Lisi, DM | 1 |
| Foster, SE; Judd, RL; Raman, P; Stokes, MC; Strenge, JK | 1 |
| Eastmond, R; Lettis, S; Young, MA | 3 |
| Oxender, DL; Saltiel, AR; Su, TZ; Wang, M | 1 |
| Hattori, J; Ishimori, M; Nakashima, K; Okumura, S; Sugimoto, M; Takami, K; Takami, R; Takeda, N; Yasuda, K; Yoshino, K | 1 |
| Akanuma, Y; Fujiwara, T; Horikoshi, H; Iwamoto, K; Kadowaki, T; Mori, Y; Okuno, A; Tamemoto, H; Tobe, K; Ueki, K; Umesono, K; Yazaki, Y | 1 |
| Abel, R; Alvey, CW; Koup, JR; Loi, CM; Randinitis, EJ; Young, MA | 1 |
| Kazierad, DJ; Koup, JR; Loi, CM; Randinitis, EJ; Sedman, AJ; Vassos, AB | 1 |
| Kahn, SE; Porte, D; Prigeon, RL | 1 |
| Inoue, D; Koshiyama, H; Minamikawa, J; Yamauchi, M | 1 |
| Hompes, PG; Lambalk, CB; van Hooff, MH; van Montfrans, JM | 1 |
| Fonseca, V; Graveline, JF; Raskin, P; Schwartz, S | 1 |
| Inzucchi, SE; Maggs, DG; Page, SL; Rife, FS; Shulman, GI; Spollett, GR; Walton, V | 1 |
| Imura, H | 1 |
| Watkins, PB; Whitcomb, RW | 1 |
| Higo, K; Lee, MK; Miles, PD; Olefsky, JM; Rafaat, K; Romeo, OM | 1 |
| Gowen, M; Nadeau, DP; Nuttall, ME; Olivera, DL; Patton, AJ | 1 |
| Kobayashi, M; Mitsuo, M; Nakai, I; Oka, T; Shimizu, Y; Takata, Y; Uchiyama, K | 1 |
| Campbell, LK; Campbell, RK; Johnson, MD | 1 |
| Funahashi, T; Kameda-Takemura, K; Kihara, S; Matsuzawa, Y; Nakamura, T; Ouchi, N; Shinohara, E; Yamashita, S | 1 |
| Funahashi, T; Kihara, S; Matsuzawa, Y; Ouchi, N; Shinohara, E; Tamura, R; Yamashita, S | 1 |
| Knowlton, PW; Koup, JR; Loi, CM; Randinitis, EJ; Sedman, AJ; Stern, R; Vassos, AB | 1 |
| Azen, SP; Berkowitz, K; Buchanan, TA; Kjos, S; Peters, RK; Xiang, A | 1 |
| Bornkessel, B | 1 |
| Chen, C | 1 |
| Buckingham, RE; Chattington, PD; Naderali, EK; Walker, AB; Williams, G | 1 |
| Demacker, PN; Smits, P; Stalenhoef, AF; Tack, CJ | 2 |
| Abrams-Carter, L; Ciaraldi, TP; Henry, RR; Mudaliar, S; Nikoulina, SE; Park, KS | 1 |
| Inoue, D; Koshiyama, H; Minamikawa, J; Tanaka, S; Yamauchi, M | 1 |
| Whitcomb, RW | 1 |
| Morreale, AP; Plowman, BK | 1 |
| Bachman, KH | 1 |
| Ozawa, T; Sato, M; Sugawara, M; Umezawa, Y | 1 |
| Bonomini, L; DeFranco, P; Friedman, G; Jacobs, M; Kaplan, B; Lyman, N; Mulgaonkar, SP; Viscuso, R | 1 |
| Lutterman, JA; Ong, MK; Smits, P; Tack, CJ | 1 |
| Cooper, ME; Gilbert, RE; Krum, H | 1 |
| Breider, MA; Gralinski, MR; Rowse, PE | 1 |
| Ako, J; Eto, M; Hashimoto, M; Iijima, K; Kim, S; Liang, YQ; Ouchi, Y; Sudoh, N; Sugimoto, N; Toba, K; Yoshizumi, M | 1 |
| Buckholz, RG; Dallas, WS; Hull-Ryde, EA; Lancaster, ME; Lenhard, JM; Paulik, MA; Weiel, JE | 1 |
| Greer, IA; Hopkinson, ZE; Sattar, N | 1 |
| Gitlin, N; Juarbe, HM; Julie, NL; Lim, KN; Spurr, CL | 1 |
| Brunt, EM; Isley, WL; Neuschwander-Tetri, BA; Oki, JC; Phillips, NJ; Quiason, SG; Ramrakhiani, S | 1 |
| Libby, P; Marx, N; Murphy, C; Plutzky, J; Sukhova, G | 1 |
| Hattori, J; Ishimori, M; Nakashima, K; Okumura, S; Sasaki, A; Sugimoto, M; Takami, K; Takami, R; Takeda, N; Yasuda, K; Yoshino, K | 1 |
| Eastmond, R; Eckland, DJ; Lettis, S; Young, MA | 1 |
| Hirano, T; Kazumi, T; Yoshino, G | 1 |
| Asou, H; Elstner, E; Heber, D; Koeffler, HP; Koshizuka, K; Müller, C; Park, D; Said, JW; Shintaku, P; Williamson, EA | 1 |
| Hayashibe, M; Ino, Y; Kurumi, M; Matsuzaki, Y; Muta, Y; Nomura, Y; Suzuki, S; Ueda, N | 1 |
| Bassilian, S; Bergner, EA; Edmond, J; Lee, WN; Lim, S | 1 |
| Gorson, DM | 2 |
| Rusk, MH | 1 |
| Asou, H; Holden, S; Koeffler, HP; Koshizuka, K; Kubota, T; Miyoshi, I; Said, JW; Williamson, EA | 1 |
| Brennan, DC; Burgess, SJ; Singer, GG | 1 |
| Al Rayyes, O; Florén, CH | 1 |
| Bethel, MA; Feinglos, MN | 1 |
| Abrams-Carter, L; Ciaraldi, TP; Henry, RR; Lindgren, K; Mudaliar, S; Nikoulina, SE; Park, KS; Tufari, SR; Veerkamp, JH; Vidal-Puig, A | 1 |
| Ishizawa, M; Ishizuka, T; Itaya, S; Kajita, K; Kanoh, Y; Kimura, M; Miura, A; Muto, N; Wada, H; Yasuda, K | 1 |
| Riddle, MC | 1 |
| Buse, JB; Faja, BW; Gumbiner, B; Mathias, NP; Nelson, DM; Whitcomb, RW | 1 |
| Ghazzi, MN; Horton, ES; Venable, TC; Whitcomb, RW; Whitehouse, F | 1 |
| Kobayashi, I; Mori, M; Sato, N; Shimizu, H; Shimomura, Y; Tsuchiya, T | 1 |
| Seed, B | 1 |
| Chen, LB; DeAngelo, DJ; Fletcher, C; Holden, SA; Jones, D; King, FJ; Mueller, E; Partridge, JB; Sarraf, P; Singer, S; Spiegelman, BM | 1 |
| Auwerx, J; Briggs, M; Chen, I; Desreumaux, P; Fruchart, JC; Geboes, K; Heyman, R; Lefebvre, AM; Najib, J | 1 |
| Alvarez, JG; Baird, SM; Evans, RM; Ming, UT; Nelson, MC; Saez, E; Thomazy, VA; Tontonoz, P | 1 |
| Barnett, AH; Kumar, S; Lettis, S; Prange, A; Schulze, J | 1 |
| Fonseca, VA; Ghazzi, MN; Huang, SM; Valiquett, TR; Whitcomb, RW | 1 |
| Kern, PA; Ranganathan, S | 1 |
| Abe, I; Fujishima, M; Fujishima, S; Nakamura, Y; Ohya, Y; Onaka, U | 1 |
| Anderson, GD; Koup, JR; Loi, CM | 1 |
| Casanova, P; Flórez, H | 1 |
| Skyler, JS | 1 |
| Akanuma, Y; Kaneko, T; Kosaka, K; Kuzuya, T; Shigeta, Y | 1 |
| May, DB; Terra, SG; Washam, JB | 1 |
| Fierro, L; Fraser, CG | 1 |
| Batchelor, K; Beales, PE; Giorgini, AE; Liddi, R; Pozzilli, P; Procaccini, E; Signore, A | 1 |
| Ikeda, S; Watanabe, T | 1 |
| Amin, NM; Benjamin, E; Finnegan, J; Pershadsingh, HA; Sproul, JA | 1 |
| Bell, DS; Ovalle, F | 3 |
| Komers, R; Vrána, A | 1 |
| Mokuda, O; Sakamoto, Y | 1 |
| Frantz, RP; Nguyen, TT | 1 |
| Goud, C; Pitt, B; Richey, JM; Webb, RC | 1 |
| Kotchen, TA; Sonnenberg, GE | 1 |
| Fujimura, S; Nakamura, K; Ono, J; Suzumiya, J | 1 |
| Lazar, MA; Libby, P; Marx, N; Plutzky, J; Schönbeck, U | 1 |
| Ott, P; Ranek, L; Young, MA | 1 |
| Bodenburg, Y; Gasic, S; Green, A; Nagamani, M; Urban, RJ | 1 |
| Fujishima, M; Hirano, K; Kanaide, H; Kawasaki, J; Nishimura, J | 1 |
| Fukuzawa, M; Masuda, T; Muto, G; Muto, Y; Qiang, X; Sagara, M; Sakata, Y; Satoh, J; Takahashi, K; Toyota, T | 1 |
| Arai, K; Hori, M; Imano, E; Kajimoto, Y; Kanda, T; Motomura, M; Nakatani, Y; Nishida, T; Yamasaki, Y | 1 |
| Fujita, Y; Kuwao, S; Saigenji, K; Shibuya, A; Takahashi, H; Takeuchi, H; Watanabe, M | 1 |
| Howard, BV; Howard, WJ | 1 |
| Fujiwara, T; Horikoshi, H; Ikeda, K; Matsuda, K; Ohsawa, T; Okuno, A; Takahashi, S; Ushiyama, S | 1 |
| Kametani, T; Koshida, H; Shibata, K | 1 |
| Gura, T | 1 |
| Avena, R; Curry, KM; Mitchell, ME; Nylen, ES; Sidawy, AN | 1 |
| Haug, MT; Park, MH; Pelegrin, D; Young, JB | 1 |
| Ehrmann, DA | 1 |
| de Groen, PC; Dinneen, SF; Vella, A | 1 |
| Chakrabarti, R; Kumar, TD; Madhusudhan, G; Prabhakar, C; Rajagopalan, R; Rao, CS; Reddy, CM; Reddy, GO; Sahadev, K; Sarma, MR | 1 |
| Ali, SS; Igwe, RC; Sowers, JR; Walsh, MF | 1 |
| Hara, M; Hashimoto, N; Hashimoto, Y; Isoo, N; Kimura, S; Maekawa, H; Satoh, H; Togo, M; Tsukamoto, K; Watanabe, T | 1 |
| Fujii, S; Fujita, K; Ishii, T; Kurimasa, H; Mori, T; Sato, T; Tanaka, S; Yamakita, T; Yoshioka, K | 1 |
| Cimons, M | 1 |
| Matsui, K; Nagao, K; Shibata, T; Shinkai, H; Wakitani, K; Yonemori, F | 1 |
| Fonseca, VA; Granberry, MC | 1 |
| Bernlohr, DA; Frohnert, BI; Hui, TY | 1 |
| Hasegawa, I; Kurabayashi, T; Murakawa, H; Suzuki, M; Tanaka, K; Yamamoto, Y | 1 |
| Ciletti, N; Deplewski, D; Kentsis, A; Rosenfield, RL | 1 |
| Hayakawa, T; Ito, T; Nakashima, Y; Okumura, K; Osanai, H; Toki, Y | 1 |
| Horikoshi, H; Ito, T; Shiomi, M; Tsujita, Y; Tsukada, T | 1 |
| Horikoshi, H; Inoue, T; Yokoyama, T; Yoshida, Y | 1 |
| Englisch, R; Fürnsinn, C; Graf, J; Preininger, K; Roden, M; Stingl, H; Waldhäusl, W | 1 |
| McCarty, MF | 2 |
| Cooksey, RC; Garvey, WT; Hebert, LF; McClain, DA; Wofford, P; Zhu, JH | 1 |
| Choudhary, C; Herrine, SK | 1 |
| Misbin, RI | 1 |
| Kanayama, S; Kitamura, S; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y | 1 |
| Burris, TP; Cryan, E; Demarest, KT; Osborne, MC; Pelton, PD; Zhou, L | 1 |
| Beales, PE; Giorgini, AE; Liddi, R; Mire-Sluis, A; Pozzilli, P; Scott, D | 1 |
| Hisatome, I; Ikeda, T; Ogino, K; Shimoyama, M; Tanaka, Y | 1 |
| Romanelli, AM; Umland, EM | 1 |
| Miller, JL | 2 |
| Aaronson, PI; Knock, GA; Mishra, SK | 1 |
| Campbell, N; Demetri, GD; Fletcher, CD; Mueller, E; Naujoks, R; Sarraf, P; Singer, S; Spiegelman, BM | 1 |
| Chait, A; Crawford, RS; Henry, RR; Mudaliar, SR | 1 |
| Faulds, D; Plosker, GL | 1 |
| Knowlton, P; Koup, JR; Loi, CM; Sedman, AJ; Stern, R; Vassos, AB | 1 |
| Bleavins, MR; de la Iglesia, FA; Dethloff, LA; Duddy, SK; Gorospe, S; Gough, AW; Parker, RF; Rowse, PE | 1 |
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| Funk, C; Gasser, R; Jehle, L; Lazendic, M; Pantze, M; Ponelle, C; Scheuermann, G | 1 |
| Inoue, K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y; Yoshikawa, T; Yoshimura, R | 1 |
| Hayashi, T; Hosoda, K; Inoue, G; Nakao, K; Nishimura, H; Ogawa, Y; Shintani, M; Yonemitsu, S | 1 |
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| Hevener, AL; Janez, A; Olefsky, J; Reichart, D | 1 |
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| Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K | 1 |
| Davies, GF; Juurlink, BH; Khandelwal, RL; Roesler, WJ; Wu, L | 1 |
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| Funahashi, T; Hotta, K; Ishikawa, K; Kawamoto, T; Kihara, S; Kishino, BI; Kuriyama, H; Matsuzawa, Y; Mineo, I; Nakagawa, C; Nakamura, T; Nishida, M; Nishida, Y; Nishimura, T; Ohuchi, N; Takahashi, M; Tarui, S; Tokunaga, K; Watanabe, F; Yamashita, S | 1 |
| Badimon, JJ; Crandall, JP; Fallon, JT; Fuster, V; Heflt, G; Herson, P; Lev, EI; Osende, JI; Rabito, P; Rauch, U; Rodriguez, OJ; Vidhun, R; Zaman, A | 1 |
| Breyer, MD; Breyer, RM; Davis, L; Guan, Y; Schneider, A; Zhang, Y | 1 |
| Collins, AR; Fleck, E; Goetze, S; Hsueh, WA; Kaneshiro, K; Kim, S; Kintscher, U; Law, RE; Meehan, WP | 1 |
| Ciletti, N; Deplewski, D; Kim, MJ; Michel, S; Reichert, U; Rosenfield, RL | 1 |
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| Kitamura, R; Tanaka, Y | 1 |
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| Davies, GF; Eftekharpour, E; Juurlink, BH; Roesler, WJ; Wu, L | 1 |
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| McCarthy, K; Routh, R; Welbourne, T | 1 |
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| Bécuwe, P; Bianchi, A; Bordji, K; Boyault, S; Dauça, M; Gouze, E; Netter, P; Simonin, MA; Terlain, B | 1 |
| Hiraoka, S; Kitamura, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Nagasawa, Y; Shinomura, Y; Takakura, R; Toyota, M | 1 |
| Hashimoto, Y; Hosotani, R; Imamura, M; Itami, A; Kato, M; Kawamura, J; Shimada, Y; Watanabe, G | 1 |
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| Brunmair, B; Fürnsinn, C; Gras, F; Nowotny, P; Roden, M; Vierhapper, H; Waldhäusl, W | 1 |
| Davies, GF; Khandelwal, RL; McFie, PJ; Roesler, WJ | 1 |
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| Nakajima, M; Yamamoto, Y; Yamazaki, H; Yokoi, T | 1 |
| Abe, M; Arima, S; Ikeda, Y; Ito, S; Kohagura, K; Omata, K; Sugawara, A; Takeuchi, K; Taniyama, Y | 1 |
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| Chu, N; Ciaraldi, TP; Henry, RR; Kahn, BB; Kim, D; Kim, YB; Kong, A; Mohideen, P; Mudaliar, S | 1 |
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| Armstrong, D; Baxi, S; Caulfield, M; Chu, NV; Deutsch, R; Henry, RR; Kim, DD; Kong, AP; Mudaliar, SR; Reaven, PD; Reitz, R | 1 |
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| Kitamura, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Nagasawa, Y; Shinomura, Y; Toyota, M | 1 |
| Abe, N; Hirayama, H; Makino, N; Yano, K; Yonemochi, H | 1 |
| Marck, BT; Matsumoto, AM; Wolden-Hanson, T | 1 |
| Kobayashi, K; Nagai, Y; Nohara, E; Takamura, T; Yamashita, H | 1 |
| Altrogge, DM; de la Iglesia, FA; Masuda, H; McGuire, EJ; Rothwell, C | 1 |
| Häring, HU; Kausch, C; Machicao, F; Rett, K; Stumvoll, M; Wahl, HG | 1 |
| Dixon, C; Doseff, AI; Hilbelink, T; Kotur, M; Lu, L; Rovin, BH; Wilmer, WA | 1 |
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| Khan, MA; St Peter, JV; Xue, JL | 1 |
| Barthel, A; Joost, HG; Krüger, KD; Roth, RA | 1 |
| Alessandra Gobbi, G; Lattanzi, G; Lucarelli, E; Maini, V; Marmiroli, S; Mordenti, M; Picci, P; Reggiani, M; Sangiorgi, L; Scrimieri, F; Zambon Bertoja, A | 1 |
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| Adachi, Y; Araki-Sasaki, R; Furuta, M; Gabazza, EC; Hori, Y; Katsuki, A; Nakatani, K; Sumida, Y; Tanaka, T; Yano, Y | 1 |
| Hiraishi, H; Kojima, K; Shimada, T; Terano, A; Yoshiura, K | 1 |
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| Hiraishi, H; Kojima, K; Mitobe, Y; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Barker, N; Goi, K; Inukai, T; Kagami, K; Nakamura, M; Nakazawa, S; Sato, H; Sugita, K; Uno, K; Yamakawa-Karakida, N | 1 |
| Fukuhara, H; Hata, T; Kobayashi, K | 1 |
| Breyer, B; Cheng, H; Feng, T; Haydon, RC; He, TC; Ishikawa, A; Jiang, W; Montag, A; Peabody, T; Simon, MA; Zhou, L | 1 |
| Battarbee, H; Coates, G; McCarthy, K; Routh, R; Su, G; Welbourne, T | 1 |
| Kitayama, J; Nagawa, H; Osada, T; Saito, S; Shibata, Y; Sunami, E; Tomozawa, S; Tsuno, NH; Tsuruo, T; Yamaguchi, H | 1 |
| Baik, EJ; Kim, EJ; Kwon, KJ; Lee, SH; Moon, CH; Park, JY | 1 |
| Abourjaily, HM; Alsheikh-Ali, AA; Karas, RH | 1 |
| Abe, M; Anai, M; Asano, T; Fujishiro, M; Fukushima, Y; Inukai, K; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Onishi, Y; Ono, H; Sakoda, H; Shojima, N | 1 |
| Desouza, C; Dicker-Brown, A; Fonseca, V; Keebler, M; McNamara, DB; Murthy, SN; Poirier, LA | 1 |
| Iida, KT; Kawakami, Y; Okuda, Y; Shimano, H; Sone, H; Suzuki, H; Toyoshima, H; Yamada, N | 1 |
| Chikara, S; Fukuda, N; Hu, WY; Kanmatsuse, K; Kishioka, H; Nakayama, M; Teng, J | 1 |
| Hattori, J; Ishimori, M; Nakashima, K; Okumura, S; Sugimoto, M; Takeda, N; Yasuda, K; Yoshino, K | 1 |
| Blaschke, F; Bungenstock, A; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Stawowy, P | 1 |
| Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y | 1 |
| de la Iglesia, FA; Dethloff, LA; Gough, AW; Herman, JR; Masuda, H; McGuire, EJ; Parker, RF; Walsh, KM | 1 |
| Desvergne, B; Liu, P; Noy, N; Shaw, NS; Tan, NS; Vinckenbosch, N; Wahli, W; Yasmin, R | 1 |
| Fujieda, M; Kato, M; Nagaya, T; Saito, K; Seo, H; Yoshida, J | 1 |
| Ishihara, S; Kadowaki, Y; Kinoshita, Y; Ortega, C; Rumi, MA; Sato, H | 1 |
| Kantoff, PW; Smith, MR | 1 |
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| Guan, Y; Harendza, S; Panzer, U; Reinking, R; Schneider, A; Stahl, RA; Thaiss, F; Wolf, G; Zahner, G | 1 |
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| Honma, W; Ikeda, T; Miyata, M; Nagata, K; Ozawa, S; Sasano, H; Shimada, M; Yamazoe, Y | 1 |
| Clyne, CD; Duong, JH; Gong, C; Murata, Y; Rubin, GL; Simpson, ER; Speed, CJ | 1 |
| Azar, R; Banner, B; Bird, S; Bonkovsky, HL; Szabo, G | 1 |
| Cho, KY; Kim, DK; Lee, MK; Min, KM; Park, GS; Park, SW; Song, MS | 1 |
| Coleman, RA; Krisans, SK; Lewin, TM; Van Horn, CG | 1 |
| Kohgo, Y; Motomura, W; Nagamine, M; Okumura, T; Takahashi, N; Takeuchi, S | 1 |
| Aso, Y; Inukai, T; Takanashi, K; Takemura, Y; Tayama, K | 1 |
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| Goto, K; Irukayama-Tomobe, Y; Miyauchi, T; Ogata, T; Sakai, S; Yamaguchi, I | 1 |
| Beck-Nielsen, H; Eirich, A; Grimmsmann, T; Klein, HH; Levin, K; Meyer, MM; Perwitz, N | 1 |
| Azen, SP; Berkowitz, K; Buchanan, TA; Goico, J; Hodis, HN; Kjos, SL; Marroquin, A; Ochoa, C; Peters, RK; Tan, S; Xiang, AH | 1 |
| Brant, BP; Garvey, WT; Kennedy, A; Rogers, NL; Wallace, P; Willi, SM | 1 |
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| Gales, TL; Hart, TK; Hu, CX; Kurali, E; Maleeff, BE; Narayanan, PK; Schwartz, LW; Thomas, HC; Tirmenstein, MA | 1 |
| Battarbee, H; Coates, G; Nissim, I; Welbourne, T | 1 |
| Füzesi, L; Krüger, U; Middel, P; Mössner, R; Neumann, C; Reich, K; Schinner, S; Schulz, U | 1 |
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| Hase, T; Kawahito, Y; Mitsuhashi, M; Nakatani, T; Sano, H; Segawa, Y; Wada, S; Yoshimura, R | 1 |
| Ganaway, E; Garvey, WT; Kennedy, A; Rogers, NL; Wallace, P; Willi, SM | 1 |
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| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Campbell, N; Chen, JH; Cory, DG; Dorfman, D; Enloe, BM; Fletcher, CD; Singer, S; Weybright, P | 1 |
| Bakke, I; Hammer, TA; Sandvik, AK; Waldum, HL | 1 |
| Iwatani, M; Wasada, T | 1 |
| Georgiou, HM; Lappas, M; Permezel, M; Rice, GE | 1 |
| Homma, H; Honda, T; Ide, H; Kawakami, Y; Ohno, K; Sakaue, S; Tagami, S; Yoshimura, H | 1 |
| Kawasaki, T; Miyamoto, A; Suzuki, N; Takemura, A; Tsutsumi, S; Yoshioka, T | 1 |
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| Endo, A; Furuse, Y; Hisatome, I; Igawa, O; Ikawa, S; Kato, M; Kinugawa, T; Ogino, K; Osaki, S; Shigemasa, C; Shimoyama, M; Uchida, K | 1 |
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| Fujita, T; Fukumoto, S; Harigaya, K; Inoue, D; Ishii, G; Kaneta, Y; Matsumoto, T; Nakayama, K; Takeda, S; Takeuchi, Y; Watanabe, S | 1 |
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| Fackett, A; Hayden, MJ; Hewitt, NJ; Li, AP; Lloyd, S; Sakai, Y; Silber, PM | 1 |
| Butler, R; Fackett, A; Hayden, M; Hewitt, NJ; Li, AP; Lloyd, S; Sakai, Y; Springer, R | 1 |
| Fackett, A; Li, AP; Lloyd, S; McClellan, HA; Prabhu, S; Silber, PM; Terrell, CM | 1 |
| Hishinuma, T; Mizugaki, M; Suzuki, H; Tomioka, Y; Yamazaki, T; Yokoo, T | 1 |
| Chen, J; Chen, M; Hu, R; Li, F; Tang, J; Yang, Y; Yin, J | 1 |
| Bungenstock, A; Czupalla, C; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Nürnberg, B; Spencer-Hänsch, C; Stawowy, P | 1 |
| Cioca, DP; Kawa, S; Kiyosawa, K; Tanaka, E; Yoshizawa, K | 1 |
| Bollheimer, LC; Buettner, R; Hügl, SR; Kagerbauer, SM; Kemptner, DM; Palitzsch, KD; Schölmerich, J | 1 |
| Hasegawa, H; Kasahara, K; Kawasaki, T; Suzuki, N | 1 |
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| Nakajima, M; Watanabe, Y; Yokoi, T | 1 |
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| Okada, M; Pinsky, DJ; Yan, SF | 1 |
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| Aburatani, H; Blumberg, RS; Kadowaki, T; Matsuhashi, N; Nagai, R; Nakajima, A; Saubermann, LJ; Terauchi, Y; Wada, K; Zhao, S | 1 |
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| Hayashi, K; Homma, K; Kanda, T; Kumagai, H; Okubo, K; Saruta, T; Takamatsu, I; Tatematsu, S; Tokuyama, H | 1 |
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| Hanada, S; Harada, M; Koga, H; Kumashiro, R; Kumemura, H; Namba, M; Ohira, H; Sata, M; Sato, Y; Shishido, S; Taniguchi, E; Ueno, T | 1 |
| Huang, H; Li, J; Wang, H; Xiong, Z | 1 |
| Drinkard, CR; Graham, DJ; Shatin, D | 1 |
| Bae, MA; Song, BJ | 1 |
| Kaplowitz, N; Lewis, JH; Watkins, PB | 1 |
| Barak, Y; Evans, RM; Miles, PD; Olefsky, JM | 1 |
| Fujisawa, N; Ishimine, S; Kadowaki, T; Kawamori, T; Matsuhashi, N; Nakagama, H; Nakajima, A; Ochiai, M; Osawa, E; Sekihara, H; Wada, K | 1 |
| Davies, T; Kostrubsky, VE; Lodola, A; Rahbari, R | 1 |
| Iida, KT; Iwama, Y; Kamata, K; Kawakami, Y; Mokuno, H; Shimada, K; Shimano, H; Sone, H; Suzuki, M; Toyoshima, H; Watanabe, Y; Yamada, N | 1 |
| Davies, GF; Juurlink, BH; Roesler, WJ; Wu, L | 1 |
| Baron, AD; Hook, G; Paradisi, G; Shepard, MK; Steinberg, HO | 1 |
| Barbier, O; Bocher, V; Duhem, C; Fontaine, C; Fruchart, JC; Guillemette, C; Kosykh, V; Staels, B; Torra, IP; Villeneuve, L | 1 |
| Camirand, A; López-Solache, I; Marie, V; Silva, JE; Vignault, E | 1 |
| Brennan, TA; Mello, MM; Studdert, DM | 1 |
| Hase, T; Kawahito, Y; Matsuyama, M; Mitsuhashi, M; Nakatani, T; Sano, H; Segawa, Y; Tsuchida, K; Wada, S; Yoshimura, R | 1 |
| Bae, MA; Rhee, H; Song, BJ | 1 |
| Gotoh, Y; Kadowaki, T; Kato, S; Matsumoto, K; Ogawa, S; Ohtake, F; Shibuya, H; Suzawa, M; Takada, I; Takeuchi, Y; Yamauchi, T; Yanagisawa, J | 1 |
| Abou-Elenin, K; Caballero, AE; Hamdy, O; Horton, ES; Lim, SC; Logerfo, FW; O'Connor, C; Saouaf, R; Veves, A | 1 |
| Kobayashi, H; Minami, S; Saitoh, T; Shiraishi, S; Sugano, T; Wada, A; Yanagita, T; Yokoo, H | 1 |
| Aroda, V; Bandukwala, R; Baxi, S; Carter, L; Ciaraldi, TP; Henry, RR; Kong, AP; Mudaliar, SR; Phillips, SA | 1 |
| Grellner, WJ; Harris, WS; Isley, WL; Klein, S; Miles, JM; Windsor, S; Wooldridge, D | 1 |
| Moses Babu, J; Nageshwar, D; Om Reddy, G; Prabhakar, C; Ravindra Kumar, Y; Sarma, MR; Vyas, K | 1 |
| Chen, YE; Fu, M; Lin, Y; Mao, Z; Zhang, J; Zhu, X | 1 |
| Abe, M; Furukawa, Y; Hasegawa, K; Hirai, M; Kawamura, T; Kita, T; Morimoto, T; Wada, H; Yanazume, T | 1 |
| Inoue, H; Miwa, Y; Miyagi, M; Morimoto, S; Sasaguri, T; Taba, Y; Takahashi-Yanaga, F | 1 |
| Ackerson, L; Chan, KA; Everhart, JE; Gurwitz, JH; Hurley, JS; Martinson, B; Moseley, RH; Platt, R; Selby, JV; Terrault, N; Truman, A | 1 |
| Frieswyk, D; Kokmeyer, D; Louters, LL; Van Dyke, DA; Walters, L | 1 |
| Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Fraioli, A; Laurora, S; Maggio, M; Pizzimenti, S; Reffo, P | 1 |
| Menzel, EJ; Sinzinger, H; Sobal, G | 1 |
| Ehrenborg, E; Hall, K; Hilding, A; Lewitt, MS; Skogsberg, J | 1 |
| Chen, A; Fu, Y; Xu, J | 1 |
| Fujioka, Y; Iwasaki, T; Masai, M; Morimoto, S; Ohyanagi, M; Okumura, T; Tsuboi, S; Tsujino, T | 1 |
| Inoue, T; Kashiwabara, A; Kawasaki, T; Ogata, N; Sawashige, K; Sekino, N; Yamanouchi, T | 1 |
| Graham, DJ; Green, L; Nourjah, P; Senior, JR | 1 |
| Abe, A; Emi, N; Kanbe, E; Kawabe, T; Saito, H; Towatari, M | 1 |
| Carter, L; Ciaraldi, TP; Henry, RR; Mudaliar, SR; Reehman, N; Wilmsen, HM | 1 |
| Bierhaus, A; Brodbeck, K; Häring, HU; Schleicher, ED; Weigert, C | 1 |
| Augstein, P; Berg, S; Dunger, A; Hehmke, B; Heinke, P; Salzsieder, E; Wachlin, G | 1 |
| Gen, M; Greyson, C; Kinugawa, K; Lee, J; Long, CS; Lu, L; Schwartz, GG; Xu, Y | 1 |
| Hanada, S; Harada, M; Koga, H; Kumashiro, R; Kumemura, H; Ohtsubo, M; Sata, M; Shishido, S; Taniguchi, E; Ueno, T; Yamashita, K | 1 |
| Bouche, C; Goldfine, AB | 1 |
| Boudoulas, H; Osei, K; Schuster, DP; Sparks, EA; Stakos, DA; Wooley, CF | 1 |
| Lodish, HF; Pownall, HJ; Ruan, H | 1 |
| Furukawa, H; Haruyama, H; Izumi, T; Koga, T; Koishi, R; Matsushita, Y; Miyoshi, K; Nakamura, K; Shimizu, M; Sugawara, M; Takahashi, T; Tomita, A; Watanabe, I; Yasumo, H | 1 |
| Angulo, P | 1 |
| Bruemmer, D; de Dios, ST; Dilley, RJ; Ivey, ME; Jennings, GL; Law, RE; Little, PJ | 1 |
| Bernal, MR; Calle-Pascual, AL; Fernández-Cruz, A; Goldfine, A; Horton, E; Jarolim, P; Libby, P; Nuzzo, R; Schönbeck, U; Varo, JJ; Varo, N; Veves, A; Vicent, D | 1 |
| Azziz, R; Ehrmann, DA; Fereshetian, AG; Ghazzi, MN; Legro, RS; O'Keefe, M | 1 |
| Chu, N; Ciaraldi, TP; Cui, L; Henry, RR; Ju, Y; Kim, D; Kong, A; Mathieu-Costello, O; Mudaliar, S | 1 |
| Alegret, M; Cabrero, A; Carrera, MV; Cubero, M; Jové, M; Laguna, JC; Llaverías, G; Planavila, A; Sánchez, R | 1 |
| Aneja, A; El-Atat, F; McFarlane, SI; Muniyappa, R | 1 |
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| Ashton, S; Cook, J; Gilkeson, G; Guyton, K; Halushka, P; Reilly, C; Tempel, G; Teti, G; Zingarelli, B | 1 |
| Burgermeister, E; Liscovitch, M; Tencer, L | 1 |
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| Burstein, HJ; Demetri, GD; Mueller, E; Sarraf, P; Spiegelman, BM; Winer, EP | 1 |
| Aprath-Husmann, I; Halbleib, M; Hauner, H; Lee, YM; Röhrig, K; Skurk, T; van Harmelen, V | 1 |
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| Berger, JP; Blaschke, F; Bruemmer, D; Fleck, E; Forman, BM; Law, RE; Liu, J; Sakai, T; Van Herle, AJ; Yin, F | 1 |
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| Dono, K; Hayashi, N; Hiraoka, N; Monden, M; Nagano, H; Nakamori, S; Okami, J; Sakon, M; Tsujie, M; Umeshita, K | 1 |
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| Chen, Q; Qiu, Z; Xia, Y | 1 |
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122 review(s) available for troglitazone and thiazoles
| Article | Year |
|---|---|
Potential role of thiazolidinediones in older diabetic patients.
Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Japan; Mice; Pioglitazone; Randomized Controlled Trials as Topic; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Effects of troglitazone on insulin sensitivity.
Topics: Animals; Blood Glucose; Blood Pressure; Chromans; Diabetes Mellitus, Type 2; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
[Drug therapy in subjects with impaired glucose tolerance].
Topics: Acarbose; Biguanides; Chromans; Diabetes Mellitus, Type 2; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Metformin; Pioglitazone; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1996 |
Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus.
Topics: Acarbose; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1997 |
Troglitazone: a new antihyperglycemic agent.
Topics: Chromans; Diabetes Mellitus, Type 2; Gluconeogenesis; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Ovary; Polycystic Ovary Syndrome; Steroid 17-alpha-Hydroxylase; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Adipocyte differentiation and nuclear receptor].
Topics: Adipocytes; Cell Differentiation; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Insulin Resistance; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1997 |
Troglitazone.
Topics: Animals; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone (CS-045): a new antidiabetic agent.
Topics: Animals; Chromans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Steps toward the primary prevention of type II diabetes mellitus. Various epidemiological considerations].
Topics: Adult; Aged; Chromans; Comorbidity; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Diet, Reducing; Exercise; Female; Glucose Tolerance Test; Humans; Hypertension; Hypoglycemic Agents; Life Style; Male; Metformin; Middle Aged; National Institutes of Health (U.S.); Obesity; Prediabetic State; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1997 |
Troglitazone.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Insulin, as a regulating factor of blood pressure].
Topics: Animals; Cell Division; Chromans; Humans; Hyperinsulinism; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Kidney; Muscle, Smooth, Vascular; Sodium; Sympathetic Nervous System; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Treatment of hypertension associated with diabetes mellitus].
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cerebrovascular Disorders; Chromans; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Metformin; Obesity; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Studies on compounds with antioxidant activity--development of hypoglycemic agents, troglitazone (CS-045)].
Topics: Animals; Antioxidants; Chromans; Drug Design; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
New oral therapies for type 2 diabetes.
Topics: Acarbose; Administration, Oral; Algorithms; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1997 |
[Post myocardial infarction management].
Topics: Aftercare; Anticholesteremic Agents; Antioxidants; Atorvastatin; Chromans; Clopidogrel; Diet, Fat-Restricted; Heptanoic Acids; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrroles; Risk Factors; Thiazoles; Thiazolidinediones; Ticlopidine; Troglitazone | 1997 |
[Oral hypoglycemic agents--overview].
Topics: Acarbose; Administration, Oral; Biguanides; Chromans; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inositol; Insulin Resistance; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1997 |
[Measures to meet the side effects of the orally administered antihyperglycemic drugs].
Topics: Acarbose; Administration, Oral; Animals; Biguanides; Cardiovascular System; Chromans; Drug Interactions; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Inositol; Insulin Resistance; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1997 |
[Troglitazone: its pharmacology and mechanism of action].
Topics: Animals; Chromans; Diabetes Mellitus; Disease Models, Animal; Glycogen; Glycolysis; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Liver; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Clinical results of troglitazone (CS-045)].
Topics: Chromans; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Double-Blind Method; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Alpha-glucosidase inhibitor and insulin sensitizer combination therapy in NIDDM].
Topics: Acarbose; Animals; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inositol; Insulin Resistance; Pioglitazone; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1997 |
[Combination therapy of insulin sensitizer and sulfonylurea].
Topics: Blood Glucose; Chromans; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Pioglitazone; Protein Precursors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Meta-analysis of steady-state pharmacokinetics of troglitazone and its metabolites.
Topics: Age Factors; Area Under Curve; Body Weight; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Sex Factors; Smoking; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Treatment of hyperinsulinaemia in polycystic ovary syndrome?
Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone: review and assessment of its role in the treatment of patients with impaired glucose tolerance and diabetes mellitus.
Topics: Animals; Chromans; Clinical Trials as Topic; Diabetes Mellitus; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
[Thiazolidindiones in type II diabetes mellitus].
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone: an antidiabetic agent.
Topics: Adult; Aged; Antihypertensive Agents; Biological Availability; Chromans; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
Drug administration in patients with diabetes mellitus. Safety considerations.
Topics: Acarbose; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Chromans; Diabetes Complications; Diabetes Mellitus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypoglycemic Agents; Insulin; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1998 |
Treatment of type 2 diabetes mellitus.
Topics: Biguanides; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Diet, Diabetic; Exercise Therapy; Glycoside Hydrolase Inhibitors; Health Care Costs; Humans; Hypoglycemic Agents; Insulin; Patient Compliance; Patient Participation; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Learning to use troglitazone.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Thiazolidinediones--tools for the research of metabolic syndrome X.
Topics: Antioxidants; Blood Vessels; Chromans; Humans; Hypoglycemic Agents; Insulin Resistance; Microvascular Angina; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
New therapeutic approaches to reversing insulin resistance.
Topics: Animals; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Humans; Hypertension; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
Attenuation of hyperinsulinemia in polycystic ovary syndrome: what are the options?
Topics: Chromans; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Insulin resistance syndrome: options for treatment.
Topics: Arteriosclerosis; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Microvascular Angina; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Cardiovascular effects of troglitazone.
Topics: Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Cholesterol, LDL; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone: a review of its use in the management of type 2 diabetes mellitus.
Topics: Adult; Aged; Animals; Area Under Curve; Chromans; Diabetes Mellitus, Type 2; Drug Interactions; Glucose; Glyburide; Half-Life; Humans; Hypoglycemic Agents; Randomized Controlled Trials as Topic; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
[Insulin-sensitizing agent].
Topics: Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone. Is it all over?
Topics: Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistance; Liver Function Tests; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Pharmacologic therapy for type 2 diabetes mellitus.
Topics: Acarbose; Administration, Oral; Algorithms; Carbamates; Chromans; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Insulin; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1999 |
[Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs].
Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exercise; Fenfluramine; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Lactones; Lipase; Metformin; Orlistat; Peroxisome Proliferators; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone: antihyperglycemic activity and potential role in the treatment of type 2 diabetes.
Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
[Clinical researchers and pharmaceutical industry. The examples of troglitazone and mibefradil].
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chromans; Drug and Narcotic Control; Drug Approval; Drug Industry; Humans; Hypoglycemic Agents; Mibefradil; Netherlands; Product Surveillance, Postmarketing; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1999 |
Clinical pharmacokinetics of troglitazone.
Topics: Biological Availability; Biomarkers; Chromans; Clinical Trials as Topic; Comorbidity; Drug Interactions; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
The use of insulin secretagogues in the treatment of type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Piperidines; Protein Precursors; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
The use of insulin alone and in combination with oral agents in type 2 diabetes.
Topics: Acarbose; Blood Glucose; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Self Care; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
A review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering.
Topics: Antioxidants; Blood Coagulation; Cardiovascular Diseases; Cardiovascular System; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Metformin; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Clinical efficacy of metformin against insulin resistance parameters: sinking the iceberg.
Topics: Animals; Blood Glucose; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Male; Metformin; Rats; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New drugs for diabetes.
Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver; Liver Failure; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
New directions in type 2 diabetes mellitus: an update of current oral antidiabetic therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Improving management of type 2 diabetes mellitus: 5. Thiazolidinediones.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Combinations; Drug Interactions; Drug Monitoring; Humans; Hypoglycemic Agents; Liver Function Tests; Patient Selection; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Failure; Troglitazone | 2000 |
Hepatic injury due to troglitazone.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Mice; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Clinical effect and side effect of troglitazone].
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypoglycemic Agents; Liver Function Tests; Male; Middle Aged; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
[Proper usage of thiazolidinediones].
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Liver Failure, Acute; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Troglitazone].
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin Resistance; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Insulin sensitizer and hypertension].
Topics: Animals; Cholesterol, HDL; Cholesterol, LDL; Chromans; Humans; Hyperinsulinism; Hypertension; Hypoglycemic Agents; Insulin Resistance; Rats; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Dyslipidemia in insulin resistance and its improvement by troglitazone].
Topics: Cholesterol, HDL; Chromans; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Insulin sensitizer and urate metabolism].
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Gout; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone; Uric Acid | 2000 |
[Cardiovascular effects of the thiazolidinedione troglitazone].
Topics: Animals; Arteriosclerosis; Cardiovascular Diseases; Cardiovascular System; Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Risk Factors; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Kidney disease and insulin resistance--clinical impact of thiazolidinedione compounds for kidney disease].
Topics: Animals; Chromans; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Kidney Diseases; Protein Kinase C; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Skeletal effects of thiazolidinediones].
Topics: Adipocytes; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Osteoclasts; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
[Troglitazone for treatment of polycystic ovary syndrome].
Topics: Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Insulin resistance induced by drugs or agents].
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Chromans; Contraceptives, Oral; Diuretics; Glucocorticoids; Humans; Hypoglycemic Agents; Insulin Resistance; Niacin; Rats; Sodium Chloride Symporter Inhibitors; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Thiazolidinediones].
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New agents for Type 2 diabetes.
Topics: Anti-Obesity Agents; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
[PPAR gamma and thiozolidinedione derivatives as an antidiabetic drug for treating insuline resistance].
Topics: Animals; Chromans; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
The thiazolidinediones or "glitazones" a treatment option for type 2 diabetes mellitus.
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Synergism; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Male; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2000 |
[Hypoglycemic agents to improve insulin resistance].
Topics: Adipocytes; Animals; Cell Differentiation; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Obesity; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.
Topics: Animals; Arteriosclerosis; Blood Coagulation Disorders; Cardiac Output; Cholesterol; Chromans; Endothelium, Vascular; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Fatty Liver, Alcoholic; Kupffer Cells; Liver; Liver Diseases; Peroxisomes; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
The glitazones: proceed with caution.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Evaluation; Humans; Hypoglycemic Agents; Liver; Pioglitazone; Prognosis; Rosiglitazone; Safety; Thiazoles; Thiazolidinediones; Troglitazone; Weight Gain | 2000 |
Thiazolidinediones, dyslipidaemia and insulin resistance syndrome.
Topics: Chromans; Clinical Trials as Topic; Glucose; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Phenotype; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Islets of Langerhans; Mice; Mice, Knockout; Models, Biological; Mutation; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
[Insulin-sensitizing agents and hypertension].
Topics: Animals; Chromans; Humans; Hypertension; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone and related compounds: therapeutic potential beyond diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Microvascular Angina; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Medical management of unresectable, recurrent low-grade retroperitoneal liposarcoma: integration of cytotoxic and non-cytotoxic therapies into multimodality care.
Topics: Chromans; Combined Modality Therapy; Disease Progression; Fatal Outcome; Humans; Liposarcoma; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Retroperitoneal Neoplasms; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Recent advances in the pharmacologic management of diabetes mellitus.
Topics: Acarbose; Administration, Oral; Carbamates; Chromans; Diabetes Mellitus; Drug Overdose; Emergencies; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers.
Topics: Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2001 |
The polycystic ovary syndrome: treatment with insulin sensitizing agents.
Topics: Chromans; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Obesity; Ovary; Polycystic Ovary Syndrome; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Using dose-response characteristics of therapeutics agents for treatment decisions in type 2 diabetes.
Topics: Acarbose; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Combination therapy in type 2 diabetes: the role of repaglinide.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Insulin resistance and its treatment by thiazolidinediones.
Topics: Adipose Tissue; Binding Sites; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dimerization; Drug Interactions; Endothelium, Vascular; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Male; Models, Biological; Muscle, Smooth; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sex Factors; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
[Glitazones. Profile of a new class of substances].
Topics: Albuminuria; Animals; Anticholesteremic Agents; Chromans; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Germany; Humans; Hypoglycemic Agents; Isoenzymes; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2001 |
[Lipodystrophia].
Topics: Animals; Cardiomyopathy, Hypertrophic; Chromans; Diabetes Mellitus; Diagnosis, Differential; Fatty Liver; Humans; Hyperinsulinism; Hypertriglyceridemia; Insulin Resistance; Insulin-Like Growth Factor I; Lipid Metabolism; Lipodystrophy; Prognosis; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Lessons from the glitazones: a story of drug development.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Drug Approval; Drug Therapy, Combination; Europe; Humans; Hypoglycemic Agents; Liver Failure; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2001 |
[The expression of PPAR gamma in gastric cancer].
Topics: Animals; Antineoplastic Agents; Cell Division; Chromans; Humans; Ligands; Receptors, Cytoplasmic and Nuclear; Stomach Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
[Thiazolidinediones: clinical data and perspectives].
Topics: Animals; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Safety of drugs commonly used to treat hypertension, dyslipidemia, and Type 2 diabetes (the metabolic syndrome): part 2.
Topics: Acarbose; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin; Metformin; Safety; Sulfonylurea Compounds; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Thiazolidinediones--a new class of oral antidiabetic drugs].
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metabolic Syndrome; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
[Peroxisome proliferator-activated receptors (PPARs) in the vessel wall: new regulators of gene expression in vascular cells].
Topics: Animals; Arteriosclerosis; Chromans; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Female; Fenofibrate; Gemfibrozil; Gene Expression Regulation; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Ligands; Male; Mice; Muscle, Smooth, Vascular; Peroxisome Proliferators; Rats; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
[Glitazone--a new class of drugs for the treatment of type 2 diabetes].
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
[The thiazolidinedione derivates: a new class of oral blood glucose lowering agents].
Topics: Administration, Oral; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
[Evaluation of thiazolidinedione derivative drugs for safety].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Edema; Heart Failure; Humans; Hypoglycemic Agents; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
[Clinical usefulness of combination treatment with thiazolidinedione and insulin].
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Multicenter Studies as Topic; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Hepatotoxicity with thiazolidinediones: is it a class effect?
Topics: Aged; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Rosiglitazone; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Topics: Analgesics; Androgen Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chromans; Drug-Related Side Effects and Adverse Reactions; Flutamide; Humans; Hypoglycemic Agents; Indoles; Molecular Structure; Oxindoles; Pharmaceutical Preparations; Quinolones; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Thiophenes; Troglitazone | 2001 |
Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry.
Topics: Aryl Hydrocarbon Hydroxylases; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Design; Glutathione; Humans; Hypoglycemic Agents; Oxidoreductases, N-Demethylating; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Oral antihyperglycemic therapy for type 2 diabetes: scientific review.
Topics: Administration, Oral; Biguanides; Blood Glucose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Diet; Drug Therapy, Combination; Enzyme Inhibitors; Exercise; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Thiazolidinediones and PPARgamma system in repair of liver damage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arteriosclerosis; Chromans; Diabetes Mellitus, Type 2; Eicosanoids; Fatty Acids; Forecasting; Humans; Hypoglycemic Agents; In Vitro Techniques; Inflammation; Liver Cirrhosis; Neoplasms; Obesity; Receptors, Cytoplasmic and Nuclear; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
[Polycystic ovary syndrome: treatment with insulin-sensitizing agents].
Topics: Androgens; Chromans; Female; Hirsutism; Humans; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Metformin; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Antioxidant and anti-AGE therapeutics: evaluation and perspectives].
Topics: Antioxidants; Chromans; Diabetes Mellitus; Gliclazide; Glycation End Products, Advanced; Guanidines; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Thiazolidinedione hepatotoxicity: a class effect?
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma (PPargamma) as a novel target for prostate cancer.
Topics: Antineoplastic Agents; Chromans; Clinical Trials as Topic; Humans; Male; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
[Insulin resistance in myotonic dystrophy].
Topics: Chromans; Humans; Hyperinsulinism; Insulin Resistance; Insulin-Like Growth Factor I; Myotonic Dystrophy; Myotonin-Protein Kinase; Protein Kinases; Protein Serine-Threonine Kinases; Thiazoles; Thiazolidinediones; Trinucleotide Repeats; Troglitazone | 2002 |
[Uric acid metabolism and insulin resistance in type 2 diabetes].
Topics: Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Humans; Hyperuricemia; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone; Uric Acid | 2002 |
Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions.
Topics: Adipose Tissue; Animals; Chromans; Coronary Artery Disease; Diabetes Mellitus; Diabetic Angiopathies; Humans; Hypoglycemic Agents; Insulin Resistance; Lipoproteins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
[Primary prevention of diabetes mellitus by pharmacological intervention].
Topics: Acarbose; Angiotensin-Converting Enzyme Inhibitors; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lactones; Metformin; Orlistat; Pravastatin; Primary Prevention; Ramipril; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Insulin sensitizer drugs--review].
Topics: Adipose Tissue; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Efficacy of combination therapy of alpha-glucosidase inhibitor and insulin sensitizer in patients with type 2 diabetes].
Topics: Acarbose; Animals; Biguanides; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inositol; Insulin Resistance; Pioglitazone; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Combination therapy of insulin sensitizer, thiazolidinedione drugs, and sulfonylurea].
Topics: Blood Glucose; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Combination therapy with biguanides].
Topics: Acarbose; Biguanides; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
Repaglinide in combination therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Pioglitazone; Piperidines; Postprandial Period; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
Prevention of type 2 diabetes: are we ready?
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactones; Life Style; Lipase; Metformin; Orlistat; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Current best treatment for non-alcoholic fatty liver disease.
Topics: Antioxidants; Chromans; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Fatty Liver; Gemfibrozil; Humans; Hypolipidemic Agents; Liver Transplantation; Obesity; Thiazoles; Thiazolidinediones; Troglitazone; Weight Loss | 2003 |
[Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents].
Topics: Acarbose; Chromans; Enzyme Inhibitors; Female; Glucose Intolerance; Glucosidases; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone; Weight Loss | 2003 |
Insulin sensitizers for polycystic ovary syndrome.
Topics: Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Hepatotoxicity of the thiazolidinediones.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2003 |
Prevention of type 2 diabetes.
Topics: Acarbose; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Female; Humans; Hypoglycemic Agents; Male; Obesity; Risk Factors; Risk Reduction Behavior; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Drug-induced hepatotoxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chemical and Drug Induced Liver Injury; Chromans; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Pharmaceutical Preparations; Pharmacology; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.
Topics: Anovulation; Chromans; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Ovulation Induction; Pioglitazone; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
109 trial(s) available for troglitazone and thiazoles
| Article | Year |
|---|---|
Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1991 |
A pilot clinical trial of a new oral hypoglycemic agent, CS-045, in patients with non-insulin dependent diabetes mellitus.
Topics: Biomarkers; Blood Glucose; Body Mass Index; Chromans; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Fructosamine; Glycated Hemoglobin; Hexosamines; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Pilot Projects; Thiazoles; Thiazolidinediones; Troglitazone | 1991 |
Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives.
Topics: Aged; Blood Glucose; Blood Pressure; Chromans; Diabetes Mellitus, Type 2; Female; Heart Rate; Hemoglobin A; Humans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Renin; Single-Blind Method; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
Topics: Adult; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Lipids; Male; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1994 |
Effects of troglitazone: a new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Body Weight; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Diet, Diabetic; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Placebos; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1996 |
Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Fatty Acids, Nonesterified; Female; Fructosamine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Leukocyte Count; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Neutrophils; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1996 |
The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Chromans; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Blind Method; Estradiol; Estrone; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Regression Analysis; Testosterone; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; California; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Glucose Intolerance; Glucose Tolerance Test; Hispanic or Latino; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Placebos; Pregnancy; Risk Assessment; Risk Factors; Thiazoles; Thiazolidinediones; Tolbutamide; Triglycerides; Troglitazone | 1996 |
Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group.
Topics: Blood Glucose; C-Peptide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Confidence Intervals; Diabetes Mellitus, Type 2; Echocardiography; Female; Glyburide; Glycated Hemoglobin; Heart; Heart Function Tests; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Stroke Volume; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides; Troglitazone | 1997 |
Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglitazone.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Chromans; Double-Blind Method; Ethnicity; Glucose Intolerance; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Prospective Studies; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides; Troglitazone | 1997 |
Effect of combination therapy of troglitazone and sulphonylureas in patients with Type 2 diabetes who were poorly controlled by sulphonylurea therapy alone.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Glucose; Chromans; Demography; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Lipids; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1996 |
Leptin concentrations in the polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Chromans; Double-Blind Method; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Obesity; Osmolar Concentration; Polycystic Ovary Syndrome; Proteins; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.
Topics: Administration, Oral; Adult; Animals; Chromans; Double-Blind Method; Female; Glucose; Glucose Intolerance; Glucose Tolerance Test; Guinea Pigs; Humans; Hypoglycemic Agents; Islets of Langerhans; Male; Middle Aged; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1997 |
Trivalent chromium and the diabetes prevention program.
Topics: Chromans; Chromium; Clinical Protocols; Complementary Therapies; Diabetes Mellitus, Type 2; Diet; Exercise; Glucose Intolerance; Humans; Hypoglycemic Agents; Metformin; Safety; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Efficacy of troglitazone measured by insulin resistance index.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1997 |
Effects of troglitazone on insulin action and cardiovascular risk factors in patients with non-insulin-dependent diabetes.
Topics: Administration, Oral; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Middle Aged; Potassium; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Good metabolic and safety profile of troglitazone alone and following alcohol in NIDDM subjects.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Chromans; Creatinine; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Ethanol; Fasting; Female; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Lipids; Male; Middle Aged; Proinsulin; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone increases the resistance of low density lipoprotein to oxidation in healthy volunteers.
Topics: Administration, Oral; Adult; Antioxidants; Chromans; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Male; Reference Values; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides; Troglitazone | 1997 |
Increase of lipoprotein (a) with troglitazone.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone reduces LDL oxidation and lowers plasma E-selectin concentration in NIDDM patients.
Topics: Analysis of Variance; Arteriosclerosis; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; E-Selectin; Endothelium, Vascular; Female; Fluorescence; Humans; Hypoglycemic Agents; Male; Middle Aged; Oxidation-Reduction; Peroxides; Thiazoles; Thiazolidinediones; Thiobarbituric Acid Reactive Substances; Troglitazone; Vitamin E | 1998 |
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Analysis of Variance; Blood Glucose; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Middle Aged; Placebos; Regression Analysis; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Improvement in the gastrointestinal absorption of troglitazone when taken with, or shortly after, food.
Topics: Adult; Chromans; Cross-Over Studies; Digestive System; Eating; Food; Humans; Hypoglycemic Agents; Intestinal Absorption; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Concomitant administration of cholestyramine influences the absorption of troglitazone.
Topics: Absorption; Administration, Oral; Adult; Animals; Anticholesteremic Agents; Cholestyramine Resin; Chromans; Cross-Over Studies; Dogs; Drug Administration Schedule; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Male; Middle Aged; Regression Analysis; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Treatment of hyperinsulinaemia in polycystic ovary syndrome?
Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group.
Topics: Administration, Oral; Adult; Aged; Blood Glucose; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.
Topics: Administration, Oral; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.
Topics: Adolescent; Adult; Blood Glucose; Carotid Stenosis; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Infant, Newborn; Middle Aged; Pregnancy; Pregnancy in Diabetics; Quality of Life; Recurrence; Risk Factors; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1998 |
Differential vasoactive effects of the insulin sensitizers rosiglitazone (BRL 49653) and troglitazone on human small arteries in vitro.
Topics: Adipose Tissue; Animals; Arteries; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Hypoglycemic Agents; Male; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
Troglitazone decreases the proportion of small, dense LDL and increases the resistance of LDL to oxidation in obese subjects.
Topics: Adult; Blood Glucose; Body Weight; Cholesterol, LDL; Chromans; Cross-Over Studies; Double-Blind Method; Fasting; Female; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Peroxidation; Lipids; Male; Obesity; Oxidation-Reduction; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes.
Topics: Carotid Arteries; Chromans; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone.
Topics: Acetylcholine; Adult; Analysis of Variance; Biomarkers; Blood Glucose; Cardiovascular System; Case-Control Studies; Chromans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Fasting; Female; Forearm; Glucose Clamp Technique; Hemodynamics; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Middle Aged; Nitroprusside; Obesity; omega-N-Methylarginine; Reference Values; Regional Blood Flow; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation; Vasodilator Agents | 1998 |
Establishing the dose response curve for metabolic control with troglitazone, an insulin action enhancer, in type 2 diabetes patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Fatty Acids, Nonesterified; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Troglitazone use in insulin-treated type 2 diabetic patients. The Troglitazone Insulin Study Group.
Topics: Adult; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes. The Troglitazone Study Group.
Topics: Blood Glucose; Body Weight; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1998 |
Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients.
Topics: Blood Glucose; Body Mass Index; Chromans; Diabetes Mellitus, Type 2; Energy Intake; Feeding Behavior; Glycated Hemoglobin; Humans; Hunger; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Leptin; Lipids; Middle Aged; Proteins; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone, an insulin action enhancer, improves glycaemic control and insulin sensitivity in elderly type 2 diabetic patients.
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Fatigue; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone; Vomiting | 1998 |
Troglitazone monotherapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, controlled study. The Troglitazone Study Group.
Topics: Aged; Blood Glucose; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Placebos; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Coadministration of acetaminophen and troglitazone: pharmacokinetics and safety.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Chromans; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Humans; Hypoglycemic Agents; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Pharmacokinetics of troglitazone, a PPAR-gamma agonist, in patients with hepatic insufficiency.
Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver Diseases; Male; Middle Aged; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy.
Topics: Aged; Albuminuria; Blood Glucose; Blood Pressure; C-Peptide; Cholesterol; Cholesterol, HDL; Chromans; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome.
Topics: Adult; Androgens; Chromans; Female; Gonadotropins; Hormones; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Ovulation; Polycystic Ovary Syndrome; Prospective Studies; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Topics: Adult; Biopsy; Cell Differentiation; Chromans; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Ligands; Liposarcoma; Male; Middle Aged; Phosphatidylcholines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Triglycerides; Troglitazone | 1999 |
The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Intake; Exercise Therapy; Female; Glucose Tolerance Test; Health Policy; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Life Style; Liver; Male; Metformin; Middle Aged; Obesity; Outcome and Process Assessment, Health Care; Quality of Life; Research Design; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Effect of troglitazone on the pharmacokinetics of an oral contraceptive agent.
Topics: Adult; Area Under Curve; Chromans; Contraceptives, Oral; Drug Interactions; Ethinyl Estradiol; Female; Humans; Hypoglycemic Agents; Metabolic Clearance Rate; Norethindrone; Patient Compliance; Patient Dropouts; Progesterone; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone in combination with sulphonylurea improves glycaemic control in Type 2 diabetic patients inadequately controlled by sulphonylurea therapy alone. Troglitazone Study Group.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone's effect on lipoprotein(a) levels.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Middle Aged; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes.
Topics: Abdomen; Adipose Tissue; Adult; Aged; Body Weight; Calibration; Chromans; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Magnetic Resonance Imaging; Male; Middle Aged; Placebos; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone directly increases HDL cholesterol levels.
Topics: Blood Glucose; Cholesterol, HDL; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone has no effect on red cell mass or other erythropoietic parameters.
Topics: Adult; Chromans; Double-Blind Method; Erythrocyte Count; Erythrocyte Indices; Erythrocyte Volume; Erythrocytes; Erythropoiesis; Hematocrit; Hemoglobins; Humans; Hypoglycemic Agents; Male; Reticulocytes; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Effect of troglitazone on body fat distribution in type 2 diabetic patients.
Topics: Abdomen; Adipose Tissue; Blood Glucose; Blood Pressure; Body Mass Index; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Skin; Thiazoles; Thiazolidinediones; Tomography, X-Ray Computed; Troglitazone; Viscera | 1999 |
Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus.
Topics: Adult; Blood Pressure; Chromans; Diabetes Mellitus, Type 2; Female; Glyburide; Hemodynamics; Humans; Hypoglycemic Agents; Male; Middle Aged; Reference Values; Rest; Stress, Psychological; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation | 1999 |
Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes.
Topics: Adipose Tissue; Adult; Blood Glucose; Blood Pressure; Body Mass Index; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Male; Middle Aged; Thiazoles; Thiazolidinediones; Tomography, X-Ray Computed; Troglitazone | 1999 |
Effects of troglitazone on atherogenic lipoprotein phenotype in coronary patients with insulin resistance.
Topics: Aged; Chromans; Coronary Disease; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Phenotype; Probability; Reference Values; Thiazoles; Thiazolidinediones; Treatment Outcome; Triglycerides; Troglitazone | 1999 |
Effect of troglitazone on lipoprotein(a) levels in obese subjects.
Topics: Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Hypoglycemic Agents; Insulin Resistance; Lipoprotein(a); Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients.
Topics: Blood Glucose; Body Weight; C-Peptide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Circadian Rhythm; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Fructosamine; Humans; Hypoglycemic Agents; Insulin; Insulin Infusion Systems; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1999 |
Troglitazone reduces hyperglycaemia and selectively acute-phase serum proteins in patients with Type II diabetes.
Topics: Acute-Phase Proteins; Aged; Blood Glucose; Body Mass Index; C-Reactive Protein; Chromans; Complement C3; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Middle Aged; Orosomucoid; Placebos; Serum Amyloid A Protein; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Economic assessment of troglitazone as an adjunct to sulfonylurea therapy in the treatment of type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Chromans; Cohort Studies; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drug Costs; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Models, Economic; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2000 |
Effects of troglitazone on insulin sensitivity in HIV-infected patients with protease inhibitor-associated diabetes mellitus.
Topics: Adipose Tissue; Adult; Anti-HIV Agents; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus; HIV Infections; Humans; Hypoglycemic Agents; Insulin Resistance; Lipids; Male; Middle Aged; Pilot Projects; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation.
Topics: Adult; Animals; Antineoplastic Agents; Cell Differentiation; Chromans; DNA Primers; Female; Humans; Keratinocytes; Ligands; Male; Mice; Mice, SCID; Psoriasis; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Diseases; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Improvement by the insulin-sensitizing agent, troglitazone, of abnormal fibrinolysis in type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Female; Fibrinolysis; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
A comparison in a clinical setting of the efficacy and side effects of three thiazolidinediones.
Topics: Body Weight; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Edema; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Long-term effects of troglitazone: open-label extension studies in type 2 diabetic patients.
Topics: Blood Glucose; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Lipoproteins, HDL; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Repaglinide/troglitazone combination therapy: improved glycemic control in type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Chromans; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.
Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Pregnancy; Risk Factors; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone | 2000 |
Troglitazone decreases serum uric acid concentrations in type II diabetic patients and non-diabetics.
Topics: Blood Glucose; Chromans; Creatinine; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone; Uric Acid | 2000 |
Troglitazone or metformin in combination with sulfonylureas for patients with type 2 diabetes?
Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glipizide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes.
Topics: Adipose Tissue; Adult; Aged; Body Composition; Chemical and Drug Induced Liver Injury; Child; Chromans; Drug Administration Schedule; Fatty Acids, Nonesterified; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipodystrophy; Liver; Male; Middle Aged; Prospective Studies; Respiratory Function Tests; Statistics, Nonparametric; Syndrome; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Efficacy of troglitazone on body fat distribution in type 2 diabetes.
Topics: Adipose Tissue; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Obesity; Sex Characteristics; Thiazoles; Thiazolidinediones; Tomography, X-Ray Computed; Troglitazone; Viscera; Weight Gain | 2000 |
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Cell Division; Chromans; Humans; Ligands; Male; Middle Aged; Mutation; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study.
Topics: Cell Division; Chromans; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Stents; Thiazoles; Thiazolidinediones; Troglitazone; Tunica Intima; Ultrasonography, Interventional | 2000 |
Effects of troglitazone in patients with type 2 diabetes mellitus not adequately controlled by sulfonylureas.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Sulfonylurea Compounds; Thailand; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2001 |
Troglitazone prevents the rise in visceral adiposity and improves fatty liver associated with sulfonylurea therapy--a randomized controlled trial.
Topics: Adipose Tissue; Aged; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fatty Liver; Female; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Obesity; Pilot Projects; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial.
Topics: Adult; Androgens; Blood Glucose; Chromans; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gonadotropins; Hirsutism; Humans; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens.
Topics: Chromans; Clomiphene; Estrogens; Feedback, Physiological; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypoglycemic Agents; Insulin Resistance; Menopause; Metformin; Middle Aged; Obesity; Pregnancy; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Failure; Triglycerides; Troglitazone | 2001 |
Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Chromans; Confidence Intervals; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Female; Headache; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Simvastatin; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus.
Topics: Adenosine Triphosphate; Aged; Blood Glucose; Case-Control Studies; Chromans; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Thallium Radioisotopes; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2001 |
Effect of troglitazone on urinary albumin excretion and serum type IV collagen concentrations in Type 2 diabetic patients with microalbuminuria or macroalbuminuria.
Topics: Albuminuria; Animals; Blood Pressure; Chromans; Collagen; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?
Topics: Adult; Anti-Inflammatory Agents; Blood Glucose; C-Reactive Protein; Chemokine CCL2; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; I-kappa B Proteins; Insulin; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Linoleic Acid; Linoleic Acids; Linoleic Acids, Conjugated; Male; Middle Aged; NADPH Oxidases; Neutrophils; NF-kappa B; Obesity; Phenylalanine; Phosphoproteins; Plasminogen Activator Inhibitor 1; Reactive Oxygen Species; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Tyrosine | 2001 |
Serum leptin level as an indicator to predict the clinical efficacy of troglitazone in patients with type 2 diabetes mellitus.
Topics: Biomarkers; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fasting; Female; Glycated Hemoglobin; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Male; Middle Aged; Models, Biological; Predictive Value of Tests; Regression Analysis; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2001 |
Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial.
Topics: Adipose Tissue; Blood Glucose; Blood Pressure; Body Composition; Cholesterol; Chromans; Double-Blind Method; Female; Glucose Intolerance; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin; Male; Middle Aged; Risk Factors; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2001 |
Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control.
Topics: Analysis of Variance; Arteriosclerosis; Blood Coagulation; Blood Coagulation Tests; Chromans; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diet, Diabetic; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Predictive Value of Tests; Thiazoles; Thiazolidinediones; Thrombosis; Troglitazone | 2001 |
Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects.
Topics: Adipocytes; Adipose Tissue; Adult; Aged; Body Composition; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Further insight on the hypoglycemic and nonhypoglycemic effects of troglitazone 400 or 600 mg/d: effects on the very-low-density and high-density lipoprotein particle distribution.
Topics: Aged; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Fibrinogen; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Lipoproteins; Lipoproteins, HDL; Lipoproteins, VLDL; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Impact of troglitazone on coronary stent implantation using small stents in patients with type 2 diabetes mellitus.
Topics: Aged; Angioplasty, Balloon, Coronary; Chromans; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Stents; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects.
Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Isoenzymes; Male; Metformin; Middle Aged; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes.
Topics: Blood Glucose; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Lipoproteins, LDL; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Cardiac hypertrophy in diabetes patients with and without hypertension: effects of troglitazone, a novel antidiabetic drug, on diastolic function.
Topics: Cardiomegaly; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diastole; Female; Humans; Hypertension; Hypoglycemic Agents; Male; Middle Aged; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function, Left | 2001 |
A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone.
Topics: Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2002 |
High glucose concentrations abolish the superoxide dismutase response of leukocytes to ascorbic acid or troglitazone in type 2 diabetes mellitus.
Topics: Aged; Albuminuria; Antioxidants; Ascorbic Acid; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Female; Glucose; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Leukocytes; Male; Middle Aged; Superoxide Dismutase; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adult; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin; Male; Muscle, Skeletal; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reference Values; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women.
Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Double-Blind Method; Female; Glucose Tolerance Test; Hispanic or Latino; Humans; Incidence; Insulin; Insulin Resistance; Islets of Langerhans; Medical Records; Pregnancy; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin.
Topics: Adult; Chromans; Dexamethasone; Drug Interactions; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucocorticoids; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Leptin; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes.
Topics: Adult; Age of Onset; Aged; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Lipoproteins; Male; Metformin; Middle Aged; Racial Groups; Texas; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone improves cardiac function in patients with congestive heart failure.
Topics: Blood Pressure; Cardiac Output; Catecholamines; Chromans; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Stroke Volume; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Vasodilator Agents; Ventricular Function, Left | 2002 |
Troglitazone therapy improves endothelial function to near normal levels in women with polycystic ovary syndrome.
Topics: Blood Glucose; Blood Pressure; Chromans; Endothelium, Vascular; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Obesity; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Regional Blood Flow; Testosterone; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation | 2003 |
The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial.
Topics: Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Fasting; Female; Follow-Up Studies; Humans; Insulin; Male; Middle Aged; Placebos; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2003 |
Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy.
Topics: Adipocytes; Adiponectin; Adipose Tissue; Adult; Aged; Biopsy; Chromans; Culture Media, Conditioned; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Male; Metformin; Middle Aged; Molecular Weight; Obesity; Proteins; Thiazoles; Thiazolidinediones; Tissue Distribution; Troglitazone | 2003 |
Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy.
Topics: Adult; Blood Glucose; C-Peptide; Chromans; Circadian Rhythm; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Food; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Kinetics; Lipolysis; Male; Metformin; Middle Aged; Placebos; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Usefulness of troglitazone administration to obese hyperglycaemic patients with near-normoglycaemia.
Topics: Adult; Aged; Blood Glucose; Chromans; Deoxyglucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic individuals with insulin resistance: double blind, prospective randomized study.
Topics: Adult; Aorta; Blood Flow Velocity; Blood Pressure; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Lipids; Male; Middle Aged; Prospective Studies; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones.
Topics: Acute Disease; Adult; Aged; Arteriosclerosis; Body Mass Index; CD40 Ligand; Chromans; Chronic Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Longitudinal Studies; Male; Metformin; Pilot Projects; Receptors, Cytoplasmic and Nuclear; Reference Values; Risk Factors; Solubility; Spain; Thiazoles; Thiazolidinediones; Transcription Factors; Treatment Outcome; Troglitazone | 2003 |
Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome.
Topics: Adrenal Glands; Adult; Blood Glucose; Chromans; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glucose Tolerance Test; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Prospective Studies; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal.
Topics: Adult; Aged; Biopsy; Capillaries; Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Histocytochemistry; Humans; Hypoglycemic Agents; Lipid Metabolism; Male; Metformin; Microscopy, Electron; Middle Aged; Muscle Fibers, Skeletal; Muscle, Skeletal; Regional Blood Flow; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
The Diabetes Prevention Program.
Topics: Adult; Cardiovascular Diseases; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hypoglycemic Agents; Incidence; Life Style; Metformin; Morbidity; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Chromans; Disease Progression; Female; Humans; Liver; Middle Aged; Neoplasm Invasiveness; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2003 |
The impact of an insulin sensitizer, troglitazone, on glucose metabolism in African Americans at risk for type 2 diabetes mellitus: a placebo-controlled, 24-month randomized study.
Topics: Adult; Black People; Blood Glucose; Body Constitution; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Genetic Predisposition to Disease; Glucose Intolerance; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Placebos; Skinfold Thickness; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
709 other study(ies) available for troglitazone and thiazoles
| Article | Year |
|---|---|
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.
Topics: Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucagon; Gluconeogenesis; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Liver; Male; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1992 |
Studies on hindered phenols and analogues. V. Synthesis, identification, and antidiabetic activity of the glucuronide of CS-045.
Topics: Animals; Biotransformation; Chromans; Diabetes Mellitus, Experimental; Glucuronates; Hypoglycemic Agents; Macaca fascicularis; Mice; Mice, Inbred Strains; Thiazoles; Thiazolidinediones; Troglitazone | 1991 |
Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice.
Topics: Administration, Oral; Animals; Blood Glucose; Chromans; Diabetes Mellitus; Glucagon; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Pancreas; Thiazoles; Thiazolidinediones; Troglitazone | 1991 |
In vitro studies on the action of CS-045, a new antidiabetic agent.
Topics: Biological Transport; Cell Survival; Cells, Cultured; Chromans; Gluconeogenesis; Glucose; Glycogen Synthase; Humans; Hypoglycemic Agents; Insulin; Liver; Muscles; Thiazoles; Thiazolidinediones; Troglitazone | 1990 |
Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats.
Topics: Adipose Tissue; Animals; Benzopyrans; Blood Glucose; Chromans; Deoxyglucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Insulin Resistance; Ketone Bodies; Lactates; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Rats; Rats, Inbred Strains; Rats, Zucker; Receptor, Insulin; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1988 |
Metabolic effects of troglitazone on fat-induced insulin resistance in the rat.
Topics: Animals; Blood Pressure; Body Weight; Chromans; Dietary Fats; Eating; Glucose; Glucose Clamp Technique; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Liver; Male; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Actins; Adipose Tissue; Animals; Biomarkers; Carrier Proteins; Cell Differentiation; Cell Division; Chromans; Clone Cells; Creatine Kinase; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids, Nonesterified; Gene Expression; Glycerolphosphate Dehydrogenase; Hypoglycemic Agents; Linoleic Acid; Linoleic Acids; Mice; Muscles; Myelin P2 Protein; Myogenin; Neoplasm Proteins; Nerve Tissue Proteins; Palmitic Acid; Palmitic Acids; Phenotype; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 1994 |
New directions in treating insulin resistance.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
The new oral hypoglycemic agent, CS-045, inhibits the lipid peroxidation of human plasma low density lipoprotein in vitro.
Topics: Administration, Oral; Amidines; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lipoproteins, LDL; Thiazoles; Thiazolidinediones; Thiobarbituric Acid Reactive Substances; Time Factors; Troglitazone; Vitamin E | 1995 |
Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents.
Topics: Animals; Biological Transport; Blotting, Western; Cell Line; Cell Membrane; Chromans; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1995 |
Acute effects of troglitazone on in vivo insulin action in normal rats.
Topics: Animals; Blood Glucose; Chromans; Glucose; Glucose Clamp Technique; Insulin; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Suppression of hepatic gluconeogenesis in long-term Troglitazone treated diabetic KK and C57BL/KsJ-db/db mice.
Topics: Animals; Chromans; Diabetes Mellitus; Fructose-Bisphosphatase; Fructosediphosphates; Gluconeogenesis; Glycolysis; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phosphofructokinase-1; Reference Values; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1995 |
Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Cell Line; Cells, Cultured; Chromans; Cricetinae; Glucose; Glucose Transporter Type 2; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Monosaccharide Transport Proteins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
High-performance frontal analysis for the study of protein binding of troglitazone (CS-045) in albumin solution and in human plasma.
Topics: Chromans; Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Protein Binding; Serum Albumin; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Lack of effect of CS-045, a new antidiabetic agent, on insulin secretion in the remnant pancreas after 90% pancreatectomy in rats.
Topics: Animals; Blood Glucose; Chromans; Fibrosis; Glucose Tolerance Test; Hypoglycemic Agents; In Vitro Techniques; Infusions, Parenteral; Insulin; Insulin Infusion Systems; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Pancreatectomy; Perfusion; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Thiazolidinediones (AD-4833 and CS-045) improve hepatic insulin resistance in streptozotocin-induced diabetic rats.
Topics: Animals; Chromans; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Glucose Clamp Technique; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Pioglitazone; Rats; Rats, Wistar; Streptozocin; Thiazoles; Thiazolidinediones; Troglitazone | 1993 |
Insulin resistance and the prevention of diabetes mellitus.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1994 |
Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.
Topics: 3T3 Cells; Adipocytes; Animals; Blood Glucose; Cell Differentiation; Chromans; Cytokines; Drug Interactions; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Insulin; Interleukin-1; Interleukin-6; Lymphokines; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transforming Growth Factor beta; Troglitazone; Tumor Necrosis Factor-alpha | 1994 |
Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.
Topics: Animals; Blood Glucose; Blood Pressure; Chromans; Fructose; Glucose Clamp Technique; Hypoglycemic Agents; Insulin; Insulin Resistance; Kinetics; Male; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1994 |
Increased insulin responsiveness after CS-045 treatment in diabetes associated with Werner's syndrome.
Topics: Adult; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone; Werner Syndrome | 1994 |
CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes.
Topics: Animals; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Fructosediphosphates; Glucagon; Liver; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone | 1994 |
Evidence against a role of insulin in hypertension in spontaneously hypertensive rats. CS-045 does not lower blood pressure despite improvement of insulin resistance.
Topics: Animals; Blood Glucose; Blood Pressure; Chromans; Glucose; Homeostasis; Hypertension; Insulin; Insulin Resistance; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1994 |
Antihypertensive effects of CS-045 treatment in obese Zucker rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Chromans; Diuresis; Female; Hypoglycemic Agents; Insulin Resistance; Lipids; Male; Obesity; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 1993 |
A potential solution for the shortage of donors in islet transplantation using a novel oral antidiabetic agent, troglitazone.
Topics: Administration, Oral; Animals; Blood Glucose; Cell Count; Chromans; Combined Modality Therapy; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Islets of Langerhans Transplantation; Rats; Rats, Inbred Lew; Thiazoles; Thiazolidinediones; Transplantation, Isogeneic; Troglitazone | 1995 |
A study of effect of CS-045, a new antidiabetic drug, on hypertension in spontaneously hypertensive rat.
Topics: Animals; Blood Glucose; Blood Pressure; Chromans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance.
Topics: Aging; Animals; Blood Glucose; Body Weight; Chromans; Fructose; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
Photooxidation of troglitazone, a new antidiabetic drug.
Topics: Chromans; Drug Stability; Hypoglycemic Agents; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Oxygen; Photochemistry; Quinones; Singlet Oxygen; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.
Topics: Administration, Oral; Animals; Chromans; Dogs; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Macaca; Male; Mice; Mice, Inbred Strains; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.
Topics: Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Benzopyrans; Chromans; DNA, Complementary; Fatty Acids; Humans; Mice; Molecular Sequence Data; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1996 |
Effect of troglitazone on leptin production. Studies in vitro and in human subjects.
Topics: Adipocytes; Adult; Animals; Blood Glucose; Cells, Cultured; Chromans; Fasting; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Leptin; Male; Middle Aged; Obesity; Protein Biosynthesis; Proteins; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus, Experimental; Heart; Heart Function Tests; Hypoglycemic Agents; Male; Microscopy, Electron; Myocardial Ischemia; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1996 |
Inhibition of oxidation of low density lipoprotein by troglitazone.
Topics: Antioxidants; Ascorbic Acid; Benzhydryl Compounds; Chromans; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lipoproteins, LDL; Oxidation-Reduction; Thiazoles; Thiazolidinediones; Thiobarbituric Acid Reactive Substances; Troglitazone; Vitamin E | 1996 |
Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and beta-oxidation in fructose-fed rats.
Topics: Animals; Bezafibrate; Blood Glucose; Body Weight; Chromans; Diet; Drug Tolerance; Fatty Acids, Nonesterified; Fructose; Glucose; Glycogen Synthase; Hypoglycemic Agents; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Potassium Cyanide; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1995 |
Acute and chronic effects of troglitazone (CS-045) on isolated rat ventricular cardiomyocytes.
Topics: 3-O-Methylglucose; Animals; Cells, Cultured; Chromans; Cytosol; Dose-Response Relationship, Drug; Glucose Transporter Type 1; Glucose Transporter Type 4; Heart Ventricles; Hypoglycemic Agents; Immune Sera; Immunoblotting; Isoenzymes; Lactic Acid; Male; Membrane Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1996 |
Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats.
Topics: Animals; Caprylates; Carnitine O-Palmitoyltransferase; Cells, Cultured; Chromans; Coenzyme A Ligases; Fasting; Gluconeogenesis; Hypoglycemic Agents; Ketone Bodies; Kinetics; Liver; Male; Microsomes, Liver; Oleic Acid; Oxidation-Reduction; Phospholipids; Pioglitazone; Rats; Rats, Wistar; Repressor Proteins; Saccharomyces cerevisiae Proteins; Starvation; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1996 |
Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.
Topics: Animals; Arteriosclerosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Movement; Cells, Cultured; Chromans; DNA; Fibroblast Growth Factor 2; Genes, fos; Hyperplasia; Hypoglycemic Agents; Male; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Biological Transport; Cell Differentiation; Chromans; Dactinomycin; Deoxyglucose; Glucose; Glucose Transporter Type 1; Humans; Hypoglycemic Agents; Insulin; Mice; Monosaccharide Transport Proteins; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Transcription, Genetic; Troglitazone | 1996 |
Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.
Topics: Age Factors; Animals; Body Weight; Chromans; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Hyperglycemia; Insulin; Islets of Langerhans; Male; Metformin; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1996 |
Amelioration of hyperglycemia in streptozotocin-induced diabetic rats receiving a marginal mass of islet grafts by troglitazone, an oral antidiabetic agent.
Topics: Animals; Blood Glucose; Chromans; Cytoplasmic Granules; Diabetes Mellitus, Experimental; Endoplasmic Reticulum, Rough; Glucose Tolerance Test; Hypoglycemic Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred Lew; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
Inhibition of KATP channel activity by troglitazone in CRI-G1 insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone | 1996 |
Troglitazone attenuates high-glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes.
Topics: Animals; Biomechanical Phenomena; Calcium; Cells, Cultured; Chromans; Culture Media; Glucose; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Myocardial Contraction; Myocardium; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function | 1996 |
A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Blood Pressure; Captopril; Chromans; Diet; Fructose; Hypoglycemic Agents; Insulin Resistance; Male; Monosaccharide Transport Proteins; Rats; Rats, Wistar; Tetrazoles; Thiazoles; Thiazolidinediones; Troglitazone | 1996 |
"Glitazones", a prospect for non-insulin-dependent diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Chromans; DNA; Enzyme Activation; Hypoglycemic Agents; Muscle, Smooth, Vascular; Rats; Thiazoles; Thiazolidinediones; Troglitazone; Vasoconstrictor Agents | 1997 |
Metabolic effects of troglitazone in the Goto-Kakizaki rat, a non-obese and normolipidemic rodent model of non-insulin-dependent diabetes mellitus.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hypoglycemic Agents; Injections, Intravenous; Insulin Resistance; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Warner Lambert/Sankyo diabetes drug nears market.
Topics: Blood Glucose; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Industry; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1997 |
Effects of troglitazone on in vitro oxidation of LDL and HDL induced by copper ions and endothelial cells.
Topics: Arteriosclerosis; Cells, Cultured; Chromans; Copper; Diabetes Mellitus; Endothelium; Humans; Hypoglycemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Oxidation-Reduction; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 1997 |
Quantification of the effects of troglitazone on insulin sensitivity and beta-cell function in Watanabe heritable hyperlipidemic rabbits: a minimal model analysis.
Topics: Animals; Blood Glucose; Chromans; Disease Models, Animal; Fasting; Female; Glucose Tolerance Test; Hypercholesterolemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Models, Biological; Rabbits; Random Allocation; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1997 |
Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data.
Topics: Animals; Bile; Chromans; Cytosol; Glucuronates; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Rats; Rats, Wistar; Species Specificity; Stereoisomerism; Sulfates; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
New diabetes drug targets insulin resistance.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone reduces contraction by inhibition of vascular smooth muscle cell Ca2+ currents and not endothelial nitric oxide production.
Topics: Analysis of Variance; Animals; Arteries; Calcium Channels; Chromans; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Glitazones and NIDDM.
Topics: Animals; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone inhibits type 2KATP channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus.
Topics: Adenosine Triphosphate; Animals; Chromans; Hypoglycemic Agents; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Tolbutamide; Troglitazone; Ventromedial Hypothalamic Nucleus | 1997 |
Determination of protein binding of troglitazone stereoisomers by fluorometric titration.
Topics: Animals; Binding Sites; Binding, Competitive; Chromans; Dansyl Compounds; Fluorescent Dyes; Humans; Hypoglycemic Agents; Male; Mice; Protein Binding; Rats; Sarcosine; Serum Albumin; Species Specificity; Spectrometry, Fluorescence; Stereoisomerism; Thiazoles; Thiazolidinediones; Titrimetry; Troglitazone | 1997 |
Effects of thiazolidinediones on growth and differentiation of human aorta and coronary myocytes.
Topics: Aorta; Cell Division; Cells, Cultured; Chromans; Coronary Vessels; Humans; Hypoglycemic Agents; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs.
Topics: Administration, Oral; Animals; Biotransformation; Chromans; Chromatography, Thin Layer; Dogs; Feces; Female; Humans; Hypoglycemic Agents; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Protein Binding; Rats; Rats, Inbred F344; Sex Characteristics; Thiazoles; Thiazolidinediones; Tissue Distribution; Troglitazone | 1997 |
Pharmacokinetic stereoselectivity of troglitazone, an antidiabetic agent, in the KK mouse.
Topics: Animals; Blood Proteins; Chromans; Hypoglycemic Agents; Intestinal Mucosa; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Stereoisomerism; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone for non-insulin-dependent diabetes mellitus.
Topics: Administration, Oral; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hypercholesterolemia; Hypoglycemic Agents; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Acute effect of troglitazone on glucose metabolism in the absence or presence of insulin in perfused rat hindlimb.
Topics: Animals; Biological Transport; Chromans; Fructosediphosphates; Glucose; Glycogen; Hindlimb; Hypoglycemic Agents; Insulin; Kinetics; Lactates; Male; Muscle, Skeletal; Oxygen Consumption; Perfusion; Pyruvates; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1997 |
Troglitazone has a scavenging effect on reactive oxygen species.
Topics: Antioxidants; Chromans; Cytochrome c Group; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron; Molecular Structure; Neutrophils; Pioglitazone; Reactive Oxygen Species; Spin Labels; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.
Topics: Adult; Androgens; Chromans; Female; Fibrinolysis; Glucose; Glucose Tolerance Test; Gonadotropins; Humans; Insulin; Insulin Resistance; Leuprolide; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Is troglitazone a real indication for obese subjects with impaired glucose tolerance?
Topics: Chromans; Diabetes Mellitus, Type 2; Glucose Intolerance; Humans; Hypoglycemic Agents; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone: a new class of oral antihyperglycemic for the treatment of type II diabetes.
Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone ameliorates insulin resistance in patients with Werner's syndrome.
Topics: Adult; Blood Glucose; Chromans; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Kinetics; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone; Werner Syndrome | 1997 |
Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.
Topics: Animals; Chromans; Hypoglycemic Agents; In Vitro Techniques; Ion Channels; Islets of Langerhans; Male; Membrane Transport Proteins; Mitochondrial Proteins; Obesity; Proteins; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Uncoupling Protein 2; Up-Regulation | 1997 |
Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats.
Topics: Albuminuria; Animals; Chromans; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.
Topics: Animals; Cell Survival; Cells, Cultured; Chromans; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Gene Transfer Techniques; Interleukin-1; Islets of Langerhans; Leptin; Lipids; Nitric Oxide; Obesity; Proteins; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1997 |
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
Topics: 3T3 Cells; Adipocytes; Animals; Chromans; Drug Interactions; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Ligands; Mice; NF-kappa B; Phosphoproteins; Phosphorylation; Pioglitazone; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1997 |
Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits.
Topics: Animals; Blood Pressure; Chromans; Female; Heart Rate; Hyperlipidemias; Insulin; Insulin Resistance; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Competitive particle concentration fluorescence immunoassays for measuring anti-diabetic drug levels in mouse plasma.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antibody Specificity; Biological Availability; Chromans; Drug Monitoring; Fluorescence; Glucose; Hypoglycemic Agents; Immunoassay; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Molecular Structure; Phycoerythrin; Thiazoles; Thiazolidinediones; Troglitazone; Tuberculin | 1997 |
Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.
Topics: Animals; Biological Transport; Chromans; Glucose; Hypoglycemic Agents; Lactic Acid; Lipid Metabolism; Metformin; Mice; Mice, Inbred C3H; Mitochondria; Palmitoyl Coenzyme A; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1997 |
American Diabetes Association Annual Meeting, 1997. Type 2 diabetes.
Topics: Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Homeostasis; Humans; Hypoglycemic Agents; Societies, Medical; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1997 |
TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Chromans; Fatty Acids, Nonesterified; Glucose Clamp Technique; Hyperinsulinism; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 1997 |
High glucose-induced growth factor resistance in human fibroblasts can be reversed by antioxidants and protein kinase C-inhibitors.
Topics: Antioxidants; Cell Division; Cells, Cultured; Chromans; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Protein Kinase C; Protein Tyrosine Phosphatases; Thiazoles; Thiazolidinediones; Troglitazone; Wound Healing | 1997 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Chemical and Drug Induced Liver Injury; Chromans; Drug Labeling; Fenfluramine; Heart Diseases; Humans; Hypoglycemic Agents; Mammography; Quality Control; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1997 |
Troglitazone action is independent of adipose tissue.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Eating; Fatty Acids; Glycogen; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Leptin; Lipoproteins, LDL; Lipoproteins, VLDL; Mice; Mice, Transgenic; Organ Size; Proteins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1997 |
Effect of troglitazone on blood insulin levels after pancreas transplantation with systemic venous drainage in rats.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus, Type 1; Drainage; Glucose Tolerance Test; Hypoglycemic Agents; Injections; Insulin; Male; Pancreas; Pancreas Transplantation; Rats; Rats, Inbred Lew; Streptozocin; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Veins; Weight Loss | 1997 |
Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Blotting, Northern; Chromans; DNA Probes; Fatty Acids; Gene Expression Regulation; Hypoglycemic Agents; Mice; Pioglitazone; RNA, Messenger; Stearoyl-CoA Desaturase; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromans; Humans; Mice; Microbodies; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1997 |
Mechanisms of action of troglitazone in the prevention of high glucose-induced migration and proliferation of cultured coronary smooth muscle cells.
Topics: Animals; Cell Division; Cell Movement; Cells, Cultured; Chromans; Coronary Vessels; Deoxyglucose; Flow Cytometry; Glucose; Hypoglycemic Agents; Insulin; Male; Muscle, Smooth, Vascular; Phospholipase D; Protein Kinase C; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
A miracle of salamization: positive divided by two equals negative.
Topics: Chromans; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Monoclonal antibodies as surrogate receptors in a high throughput screen for compounds that enhance insulin sensitivity.
Topics: Animals; Antibodies, Monoclonal; Chromans; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred BALB C; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1997 |
Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro.
Topics: Animals; Chromans; Drug Synergism; Glucose; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Insulin; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Rats, Zucker; Serum Albumin, Bovine; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Chromans; Cricetinae; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mesocricetus; Nifedipine; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle.
Topics: Adipose Tissue; Animals; Cell Line; Chromans; Gene Expression Regulation; Hypoglycemic Agents; Insulin Resistance; Ion Channels; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscle, Skeletal; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Uncoupling Protein 2 | 1998 |
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromans; Cytokines; Humans; Inflammation Mediators; Leukocytes, Mononuclear; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1998 |
From the Food and Drug Administration.
Topics: Animals; Antioxidants; Chromans; Computer Communication Networks; Drug Labeling; Drug Monitoring; Female; Food Irradiation; Humans; Information Services; Meat; Obstetric Labor, Premature; Pregnancy; Research; Terbutaline; Thiazoles; Thiazolidinediones; Tocolytic Agents; Troglitazone; United States; United States Food and Drug Administration | 1998 |
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Topics: Animals; Benzopyrans; Benzoxazoles; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Male; Mice; Obesity; Pioglitazone; Rosiglitazone; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Thiazolidinediones and their effects on glucose transporters.
Topics: Animals; Chromans; Gene Expression Regulation; Glucose; Hypoglycemic Agents; Insulin Resistance; Monosaccharide Transport Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1997 |
Diabetes drug withdrawn after reports of hepatic events.
Topics: Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Legislation, Drug; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1997 |
New treatment for adult-onset diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats.
Topics: Adipose Tissue; Animals; Chromans; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Chromans; Coenzyme A Ligases; Diabetes Mellitus; Diabetes Mellitus, Type 2; DNA Fragmentation; Enzyme Induction; Enzyme Inhibitors; Fatty Acids, Nonesterified; Guanidines; Homozygote; Humans; Hypoglycemic Agents; Islets of Langerhans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Obesity; Palmitic Acid; Prediabetic State; Rats; Rats, Zucker; Repressor Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Thiazoles; Thiazolidinediones; Transcription, Genetic; Triazenes; Troglitazone | 1998 |
Troglitazone: monotherapy indication.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Chromans; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hypertension; Hypoglycemic Agents; Lipids; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effect of troglitazone (Rezulin) on fructose 2,6-bisphosphate concentration and glucose metabolism in isolated rat hepatocytes.
Topics: Animals; Chromans; Fructosediphosphates; Gluconeogenesis; Glucose; Glycolysis; Hypoglycemic Agents; In Vitro Techniques; Liver; Male; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone increases system A amino acid transport in 3T3-L1 cells.
Topics: 3T3 Cells; Adipocytes; Amino Acid Transport Systems; Amino Acids; Aminoisobutyric Acids; Animals; Carrier Proteins; Cell Differentiation; Chromans; Hypoglycemic Agents; Insulin; Mice; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effects of troglitazone on dexamethasone-induced insulin resistance in rats.
Topics: Animals; Blood Glucose; Chromans; Dexamethasone; Glucocorticoids; Glucose; Glucose Clamp Technique; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
Topics: Adipocytes; Adipose Tissue; Animals; Apoptosis; Blood Glucose; Blotting, Northern; Body Weight; Chromans; DNA; DNA, Complementary; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Male; Mesentery; Polymerase Chain Reaction; Proteins; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Retroperitoneal Space; RNA; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone; Tumor Necrosis Factor-alpha | 1998 |
Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study.
Topics: Adult; Aged; Analysis of Variance; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Another potential use of troglitazone in noninsulin-dependent diabetes mellitus.
Topics: Carotid Artery, Common; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone; Ultrasonography | 1998 |
A novel antidiabetic drug, troglitazone--reason for hope and concern.
Topics: Administration, Oral; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Hepatic dysfunction associated with troglitazone.
Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus; Female; Humans; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.
Topics: Administration, Oral; Animals; Blood Glucose; Chromans; Cohort Studies; Glucosamine; Glucose Clamp Technique; Hormone Antagonists; Hypoglycemic Agents; Infusion Pumps; Insulin Resistance; Male; Rats; Rats, Sprague-Dawley; Somatostatin; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Alkaline Phosphatase; Animals; Apolipoproteins; Bone Diseases, Metabolic; Calcitriol; Carrier Proteins; Cell Division; Cell Line; Cells, Cultured; Chromans; Cytokines; Dexamethasone; Enzyme Induction; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Glucocorticoids; Humans; Hypoglycemic Agents; Lipoprotein Lipase; Mice; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Osteoblasts; Osteocalcin; Phosphodiesterase Inhibitors; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Suppressor Proteins | 1998 |
Surgical and chemical approaches to regulate hyperinsulinemia after pancreas transplantation in rats.
Topics: Animals; Chromans; Diabetes Mellitus, Experimental; Drainage; Hyperinsulinism; Hypoglycemic Agents; Male; Pancreas Transplantation; Portal System; Rats; Rats, Inbred Lew; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats.
Topics: Animals; Catheterization; Cell Division; Cells, Cultured; Chromans; DNA; Endothelium, Vascular; Insulin Resistance; Male; Muscle, Smooth, Vascular; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone; Tunica Intima | 1998 |
Troglitazone enhances glucose uptake and inhibits mitogen-activated protein kinase in human aortic smooth muscle cells.
Topics: Aorta; Arteriosclerosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromans; DNA Replication; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effect of troglitazone on steady-state pharmacokinetics of digoxin.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Antioxidants; Cardiotonic Agents; Chromans; Digoxin; Humans; Metabolic Clearance Rate; Middle Aged; Radioimmunoassay; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects.
Topics: Adult; Cells, Cultured; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose; Glucose Transporter Type 1; Glycogen Synthase; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Monosaccharide Transport Proteins; Muscle, Skeletal; Obesity; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Update in endocrinology.
Topics: Chromans; Humans; Hypoglycemic Agents; Liver Failure; Neutropenia; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1998 |
Possible troglitazone-warfarin interaction.
Topics: Anticoagulants; Blood Coagulation; Chromans; Diabetes Mellitus; Drug Interactions; Humans; Hypoglycemic Agents; International Normalized Ratio; Male; Middle Aged; Thiazoles; Thiazolidinediones; Thromboembolism; Troglitazone; Warfarin | 1998 |
International Diabetes Federation meeting, 1997. Issues in the treatment of type 2 diabetes; sulfonylureas, metformin, and troglitazone.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Cost of Troglitazone therapy.
Topics: Chromans; Cost-Benefit Analysis; Diabetes Mellitus; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1998 |
An assay method for evaluating chemical selectivity of agonists for insulin signaling pathways based on agonist-induced phosphorylation of a target peptide.
Topics: Amino Acids; Antibodies, Monoclonal; Avidin; Biotinylation; Chromans; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Hypoglycemic Agents; Insulin; Nitriles; Phosphorylation; Phosphotyrosine; Placenta; Receptor, Insulin; Spectrometry, Fluorescence; Thiazoles; Thiazolidinediones; Troglitazone; Tyrphostins | 1998 |
Potential interaction of troglitazone and cyclosporine.
Topics: Acute Disease; Chromans; Cyclosporine; Drug Interactions; Female; Graft Rejection; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Middle Aged; Osmolar Concentration; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effects of troglitazone and pioglitazone on cytokine-mediated endothelial cell proliferation in vitro.
Topics: Animals; Cell Division; Chromans; Endothelium, Vascular; Fibroblast Growth Factor 2; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred BALB C; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells.
Topics: Animals; Base Sequence; Cells, Cultured; Chromans; Gene Expression; Hypoglycemic Agents; Ligands; Molecular Sequence Data; Muscle, Smooth, Vascular; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1998 |
Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists.
Topics: Adipocytes; Adrenergic beta-Agonists; Base Sequence; Cells, Cultured; Chromans; DNA Primers; Energy Metabolism; Humans; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Spectrophotometry, Infrared; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Uncoupling Protein 2 | 1998 |
Insulin-sensitising agents in polycystic-ovary syndrome.
Topics: Chromans; Controlled Clinical Trials as Topic; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1998 |
Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone-induced hepatic failure leading to liver transplantation. A case report.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver Failure; Liver Transplantation; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro.
Topics: Arteriosclerosis; Blotting, Northern; Blotting, Western; Cell Line; Cells, Cultured; Chromans; Collagenases; Humans; Immunoenzyme Techniques; Macrophages; Matrix Metalloproteinase 9; Monocytes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Effects of troglitazone on hepatic and peripheral insulin resistance induced by growth hormone excess in rats.
Topics: Administration, Oral; Animals; Chromans; Glucose; Glucose Clamp Technique; Human Growth Hormone; Hypoglycemic Agents; Injections, Subcutaneous; Insulin Resistance; Liver; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone and small low-density lipoprotein in type 2 diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Lipoproteins, LDL; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Breast; Breast Neoplasms; Cell Differentiation; Chromans; Genes, bcl-2; Humans; Hypoglycemic Agents; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 1998 |
Pharmacological and pharmacokinetic studies of the newly synthesized thiazolidinedione derivative 5-(4-(1-phenyl-1-cyclopropanecarbonylamino)benzyl)-thiazolidine-2 ,4-dio ne.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chromans; Deoxyglucose; Enzyme Inhibitors; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred Strains; Microtubules; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Fatty acid cycling in human hepatoma cells and the effects of troglitazone.
Topics: Carcinoma, Hepatocellular; Chromans; Fatty Acids; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Oxidation-Reduction; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 1998 |
Effect of troglitazone in type 2 diabetes mellitus.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effect of troglitazone in type 2 diabetes mellitus.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; Weight Gain | 1998 |
Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Differentiation; Chromans; Drug Synergism; Humans; Ligands; Male; Mice; Mice, Nude; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Troglitazone; Tumor Cells, Cultured | 1998 |
Effect of troglitazone on cyclosporine whole blood levels.
Topics: Chromans; Cyclosporine; Drug Interactions; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Kidney Transplantation; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone upregulates LDL receptor activity in HepG2 cells.
Topics: Chromans; Cyclosporine; Humans; Hypoglycemic Agents; Insulin; Lipoproteins, LDL; Liver; Receptors, LDL; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Up-Regulation | 1998 |
Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma.
Topics: Adult; Carrier Proteins; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Gene Expression; Gene Expression Regulation; Humans; Hypoglycemic Agents; Middle Aged; Muscle, Skeletal; Myelin P2 Protein; Neoplasm Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins; Up-Regulation | 1998 |
Ways of changing sensitivity to insulin.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Differential effect of the antidiabetic thiazolidinediones troglitazone and pioglitazone on human platelet aggregation mechanism.
Topics: Adenosine Diphosphate; Blood Platelets; Blood Proteins; Chromans; Collagen; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hypoglycemic Agents; In Vitro Techniques; Isoenzymes; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Pioglitazone; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Thiazoles; Thiazolidinediones; Thrombin; Troglitazone; Vitamin E | 1998 |
PPAR--the good news and the bad.
Topics: Adenomatous Polyposis Coli; Animals; Chromans; Humans; Hypoglycemic Agents; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
PPARgamma and colorectal carcinoma: conflicts in a nuclear family.
Topics: Adenomatous Polyposis Coli; Animals; Chromans; Colorectal Neoplasms; Humans; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Differentiation and reversal of malignant changes in colon cancer through PPARgamma.
Topics: Adenocarcinoma; Animals; Cell Differentiation; Cell Division; Chromans; Colonic Neoplasms; Gene Expression; Humans; Ligands; Mice; Mice, Nude; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 1998 |
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.
Topics: Adenocarcinoma; Animals; beta Catenin; Chromans; Colorectal Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; HT29 Cells; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 1998 |
Activators of the nuclear receptor PPARgamma enhance colon polyp formation.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Chromans; Diet; Humans; Ligands; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Thiazolidinediones inhibit lipoprotein lipase activity in adipocytes.
Topics: Adipocytes; Animals; Biological Transport; Cell Differentiation; CHO Cells; Chromans; Cricetinae; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Insulin; Insulin Resistance; Lipids; Lipoprotein Lipase; Mice; Protein Biosynthesis; Rats; RNA, Messenger; Rosiglitazone; Stem Cells; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Troglitazone, an insulin sensitizer, increases forearm blood flow in humans.
Topics: Adult; Chromans; Forearm; Humans; Hypoglycemic Agents; Male; Regional Blood Flow; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiotonic Agents; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hypoglycemic Agents; Oxidoreductases, N-Demethylating; Sensitivity and Specificity; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
[Changes in clinical intervention studies: when the wellbeing of the patients takes precedence].
Topics: Antihypertensive Agents; Chromans; Clinical Trials as Topic; Diabetes Complications; Enalapril; Ethics, Medical; Hypertension; Hypoglycemic Agents; Metformin; Multicenter Studies as Topic; Nisoldipine; Prediabetic State; Prospective Studies; Thiazoles; Thiazolidinediones; Treatment Failure; Troglitazone | 1998 |
Targeted glycemic control in type 2 diabetes.
Topics: Aged; Algorithms; Anti-Obesity Agents; Biguanides; Blood Glucose; Blood Glucose Self-Monitoring; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Baseline factors affecting the efficacy of troglitazone on plasma glucose in Japanese patients with non-insulin-dependent diabetes mellitus.
Topics: Aged; Blood Glucose; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Hypoglycemic Agents; Japan; Lipids; Male; Middle Aged; Regression Analysis; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1998 |
Comment: troglitazone drug interactions.
Topics: Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hypoglycemic Agents; Mixed Function Oxygenases; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Comment: troglitazone.
Topics: Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Mixed Function Oxygenases; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone prevents insulin dependent diabetes in the non-obese diabetic mouse.
Topics: Age Factors; Animals; Chromans; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Female; Insulin; Mice; Mice, Inbred NOD; Pancreas; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Effects of troglitazone and pioglitazone on the action potentials and membrane currents of rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Chromans; Heart Ventricles; In Vitro Techniques; Male; Membrane Potentials; Pioglitazone; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Treatment of psoriasis with troglitazone therapy.
Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Middle Aged; Platelet Aggregation Inhibitors; Psoriasis; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone interferes with gemfibrozil's lipid-lowering action.
Topics: Chromans; Diabetes Mellitus; Drug Interactions; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Retrospective Studies; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1998 |
Troglitazone reduces free fatty acid-induced insulin resistance in perfused rat hindquarter.
Topics: Animals; Chromans; Fatty Acids, Nonesterified; Hindlimb; Hypoglycemic Agents; Insulin; Insulin Resistance; Palmitic Acid; Perfusion; Rats; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1998 |
Rezulin (troglitazone) greatly increases cyclosporine metabolism.
Topics: Chromans; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Heart Transplantation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metabolic Clearance Rate; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Synergistic actions of insulin and troglitazone on contractility in endothelium-denuded rat aortic rings.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Calcium; Chromans; Endothelium, Vascular; Hypoglycemic Agents; In Vitro Techniques; Insulin; Isometric Contraction; Male; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1998 |
Effects of troglitazone on the growth and differentiation of hematopoietic cell lines.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line; Chromans; G1 Phase; Hematopoietic Stem Cells; HL-60 Cells; Humans; Hypoglycemic Agents; Mice; Monocytes; Phosphorylation; Retinoblastoma Protein; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 1998 |
Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells.
Topics: Becaplermin; Cell Movement; Cells, Cultured; Chromans; Collagenases; Dinoprost; Gelatin; Gene Expression; Humans; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogene Proteins c-sis; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Troglitazone inhibits progesterone production in porcine granulosa cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Chromans; Colforsin; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Progesterone; Steroids; Swine; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1998 |
Mechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Calcium; Chromans; Coronary Vessels; Cytosol; Histamine; Hypoglycemic Agents; In Vitro Techniques; Isometric Contraction; Potassium; Swine; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation; Vasodilator Agents | 1998 |
Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Lipid Peroxidation; Lipid Peroxides; Male; Motor Neurons; Neural Conduction; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Tibial Nerve; Troglitazone | 1998 |
An autopsy case of troglitazone-induced fulminant hepatitis.
Topics: Alanine Transaminase; Autopsy; Bilirubin; Chromans; Diabetes Mellitus, Type 2; Fatal Outcome; Hepatic Encephalopathy; Humans; Hypoglycemic Agents; Liver; Male; Middle Aged; Prothrombin Time; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1998 |
LDL cholesterol and troglitazone therapy.
Topics: Cardiovascular Diseases; Cholesterol, LDL; Chromans; Coronary Disease; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypoglycemic Agents; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone, a new antidiabetic agent possessing radical scavenging ability, improved decreased skin blood flow in diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Chromans; Diabetes Mellitus, Experimental; Dinoprostone; Epoprostenol; Fibroblasts; Free Radical Scavengers; Guinea Pigs; Hindlimb; Hypoglycemic Agents; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Regional Blood Flow; Skin; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation; Vitamin E | 1998 |
Pleuropulmonary disease in a man with diabetes who was treated with troglitazone.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lung Diseases, Interstitial; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
From fat-free mice, the skinny on diabetes.
Topics: Adipose Tissue; Animals; Chromans; Diabetes Mellitus, Type 2; Fatty Acids; Humans; Hypoglycemic Agents; Lipodystrophy; Mice; Mice, Transgenic; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1998 |
Insulin action enhancement normalizes brachial artery vasoactivity in patients with peripheral vascular disease and occult diabetes.
Topics: Aged; Blood Flow Velocity; Brachial Artery; Chromans; Fasting; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peripheral Vascular Diseases; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Troglitazone, a new antidiabetic agent, decreases cyclosporine level.
Topics: Aged; Chromans; Cyclosporine; Diabetes Mellitus, Type 1; Drug Interactions; Heart Transplantation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Fatal hepatotoxicity associated with troglitazone.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Male; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Synthesis and biological activity of novel thiazolidinediones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Butanones; Chromans; Edema; Female; Hypoglycemic Agents; Male; Mice; Nabumetone; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
Significant weight gain with rezulin therapy.
Topics: Chromans; Diabetes Mellitus, Type 2; Edema; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone; Weight Gain | 1999 |
Relationships between apolipoprotein(a) phenotype and increase of lipoprotein(a) by troglitazone.
Topics: Adult; Aged; Apolipoproteins; Apoprotein(a); Chromans; Female; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Middle Aged; Phenotype; Protein Isoforms; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone and vascular reactivity: role of glucose and calcium.
Topics: Animals; Calcium; Chromans; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin-Like Growth Factor I; Male; Nitroprusside; Potassium Chloride; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Vasoconstriction; Vasodilator Agents | 1999 |
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Topics: Animals; Cattle; Cells, Cultured; Chromans; Endothelin-1; Endothelium, Vascular; Hypoglycemic Agents; Insulin; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Troglitazone ameliorates insulin resistance in a diabetic patient with Prader-Willi syndrome.
Topics: Adolescent; Blood Glucose; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 1; Glucose Intolerance; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Prader-Willi Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 1998 |
NIH opens conflict-of-interest investigation.
Topics: Biomedical Research; Chromans; Clinical Trials as Topic; Conflict of Interest; Diabetes Mellitus, Type 2; Disclosure; Federal Government; Humans; Hypoglycemic Agents; National Institutes of Health (U.S.); Research Support as Topic; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1999 |
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Topics: 3T3 Cells; Administration, Oral; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1999 |
Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene.
Topics: 3T3 Cells; Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Chromans; Dimerization; DNA; DNA-Binding Proteins; Fatty Acid Transport Proteins; Membrane Proteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Oleic Acid; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Tretinoin; Troglitazone; Up-Regulation | 1999 |
Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors.
Topics: Animals; Antioxidants; Base Sequence; Cell Differentiation; Chromans; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; Gene Expression; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sebum; Sequence Homology, Nucleic Acid; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Reduction of vascular tone by introduction of troglitazone to the canine coronary artery.
Topics: Animals; Chromans; Coronary Vessels; Depression, Chemical; Dinoprost; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1999 |
Combination treatment with troglitazone, an insulin action enhancer, and pravastatin, an inhibitor of HMG-CoA reductase, shows a synergistic effect on atherosclerosis of WHHL rabbits.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Blood Glucose; Cholesterol, LDL; Chromans; Coronary Vessels; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Glucose Tolerance Test; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperinsulinism; Hyperlipoproteinemia Type II; Hypoglycemic Agents; Insulin Resistance; Male; Pravastatin; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone; Xanthomatosis | 1999 |
Inhibition of galactose-induced cataractogenesis by troglitazone, a new antidiabetic drug with an antioxidant property, in rat lens culture.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cataract; Chromans; Galactitol; Galactose; Glutathione Peroxidase; Glutathione Reductase; Hypoglycemic Agents; Lens, Crystalline; Lipid Peroxides; NADP; Organ Culture Techniques; Organ Size; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone; Vacuoles | 1999 |
Acute troglitazone action in isolated perfused rat liver.
Topics: Animals; Bile; Cattle; Chromans; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Liver; Male; Perfusion; Portal Pressure; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Topics: Adipocytes; Animals; Chromans; Chromium; Fatty Acids, Nonesterified; Fish Oils; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Liver; Muscle, Skeletal; Protein Kinase C; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Vanadium; Vitamin E | 1998 |
Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.
Topics: Animals; Chromans; Gene Expression Regulation, Enzymologic; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Hexosamines; Hypoglycemic Agents; Insulin Resistance; Liver; Mice; Mice, Transgenic; Monosaccharide Transport Proteins; Muscle Proteins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Severe hepatotoxicity associated with troglitazone.
Topics: Cholestasis; Chromans; Diabetes Mellitus, Type 1; Fatal Outcome; Female; Humans; Hypoglycemic Agents; Jaundice; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone-associated hepatic failure.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells.
Topics: Calcium-Binding Proteins; Carrier Proteins; Cell Differentiation; Cell Division; Chromans; Colonic Neoplasms; Genes, Reporter; Humans; Luciferases; Microfilament Proteins; Nuclear Proteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Troglitazone; Tumor Cells, Cultured | 1999 |
A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation.
Topics: Adipocytes; Animals; Base Sequence; Carrier Proteins; Cells, Cultured; Chromans; Diabetes Mellitus; DNA Probes; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Gene Expression Regulation; Genetic Techniques; Humans; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Sequence Data; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tretinoin; Troglitazone; Tumor Suppressor Proteins | 1999 |
Troglitazone exhibits immunomodulatory activity on the cytokine production of activated human lymphocytes.
Topics: Chromans; Cytokines; Humans; Hypoglycemic Agents; Lymphocyte Activation; Lymphocytes; Monocytes; Phytohemagglutinins; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 1999 |
Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts.
Topics: Animals; Blood Pressure; Calcium Channels; Chromans; Coronary Circulation; Heart Rate; Hemodynamics; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Nifedipine; Nitroprusside; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function, Left | 1999 |
FDA drug-review, surveillance processes under scrutiny.
Topics: Chromans; Drug Approval; Humans; Hypoglycemic Agents; Liver Failure; Product Surveillance, Postmarketing; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1999 |
Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes.
Topics: Animals; Aorta, Thoracic; Chromans; Electric Stimulation; Hypoglycemic Agents; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pulmonary Artery; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Inhibition of LDL oxidation in vitro but not ex vivo by troglitazone.
Topics: Antioxidants; Chromans; Copper; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Lipoproteins, LDL; Macrophages; Oxidation-Reduction; Probucol; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
p53 is not inactivated in B6C3F1 mouse vascular tumors arising spontaneously or associated with long-term administration of the thiazolidinedione troglitazone.
Topics: Animals; Antioxidants; Chromans; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Hemangioma; Hemangiosarcoma; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Sequence Analysis, DNA; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Neoplasms | 1999 |
Troglitazone not only reduced insulin resistance but also improved myotonia in a patient with myotonic dystrophy.
Topics: Adult; Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Myotonic Dystrophy; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1999 |
Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; Interleukin-1; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 1999 |
PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Base Sequence; Cell Differentiation; Chromans; DNA; Down-Regulation; Hypoglycemic Agents; Mice; Oligonucleotide Probes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 1999 |
Troglitazone, an euglycemic antidiabetic drug.
Topics: Chromans; Crystallography, X-Ray; Hydrogen Bonding; Hypoglycemic Agents; Models, Molecular; Molecular Structure; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats.
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Chromans; Diabetes Mellitus, Type 2; Glucose Transporter Type 4; Glyburide; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Metformin; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Chemotactic Factors; Chromans; Cycloheximide; Dactinomycin; Enzyme Activation; Insulin-Like Growth Factor I; Ligands; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Thrombin; Transcription Factors; Troglitazone | 1999 |
Pregnancy after treatment with the insulin-sensitizing agent troglitazone in an obese woman with the hyperandrogenic, insulin-resistant acanthosis nigricans syndrome.
Topics: Acanthosis Nigricans; Adult; Blood Glucose; Chromans; Female; Gonadal Steroid Hormones; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Obesity; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Effect of troglitazone on plasma lipid metabolism and lipoprotein lipase.
Topics: 3T3 Cells; Adipocytes; Aged; Animals; Blood Glucose; Blotting, Northern; Chromans; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Hypoglycemic Agents; Lipids; Lipoprotein Lipase; Liver; Male; Mice; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARgamma in endothelial function.
Topics: Base Sequence; Cells, Cultured; Chromans; DNA Primers; Down-Regulation; Endothelium, Vascular; Humans; Pioglitazone; Plasminogen Activator Inhibitor 1; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1999 |
On the need for outcome trials in preventive pharmacology. Lessons from the recent experience with adverse drug reactions.
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 1999 |
Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.
Topics: 3T3 Cells; Animals; Anticholesteremic Agents; Cell Line; CHO Cells; Cholesterol; Chromans; Cricetinae; Cycloheximide; Dactinomycin; Hypoglycemic Agents; Mice; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Receptors, Cytoplasmic and Nuclear; RNA; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Advisory panel hears contradictory evidence, backs keeping troglitazone on market.
Topics: Chromans; Consultants; Drug Monitoring; Humans; Hypoglycemic Agents; Liver Failure; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1999 |
Troglitazone inhibits voltage-dependent calcium currents in guinea pig cardiac myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiotonic Agents; Chromans; Cyclic AMP; Electric Conductivity; Guinea Pigs; Hypoglycemic Agents; Isoproterenol; Kinetics; Myocardium; Nifedipine; Thiazoles; Thiazolidinediones; Troglitazone; Verapamil | 1999 |
Effects of troglitazone on substrate storage and utilization in insulin-resistant rats.
Topics: Animals; Body Weight; Chromans; Eating; Glucose; Glycogen; In Vitro Techniques; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Lipoprotein Lipase; Muscle, Skeletal; Palmitates; Pyruvate Dehydrogenase Complex; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1999 |
Inhibition of tumor necrosis factor-alpha with anti-diabetic agents.
Topics: Animals; Biological Assay; Cells, Cultured; Chromans; Enzyme-Linked Immunosorbent Assay; Female; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Interleukin-1; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
Switching insulin-sensitizing agents in patients with type 2 diabetes who require insulin.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and in
Topics: Animals; Chromans; Guanidines; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Ribosomal Protein S6 Kinases; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1999 |
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Indomethacin; Leptin; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Obesity; Prostaglandin D2; Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Endrin inhibits adipocyte differentiation by selectively altering expression pattern of CCAAT/enhancer binding protein-alpha in 3T3-L1 cells.
Topics: 3T3 Cells; Adipocytes; Animals; Antioxidants; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Chromans; Dieldrin; DNA-Binding Proteins; Drug Interactions; Endrin; Insecticides; Mice; NF-kappa B; Nuclear Proteins; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 1999 |
Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Chromans; Cytoplasm; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 1999 |
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Topics: Animals; Benzophenones; Chromans; Clone Cells; Diabetes Mellitus, Experimental; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Immunohistochemistry; Logistic Models; Obesity; Phenotype; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tyrosine | 1999 |
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Topics: Amino Acid Substitution; Binding Sites; Chromans; Colorectal Neoplasms; Dimerization; DNA-Binding Proteins; Exons; Genes, Tumor Suppressor; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Linoleic Acids, Conjugated; Mutation; Prostaglandin D2; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1999 |
Effects of troglitazone on frequency of coronary vasospastic-induced angina pectoris in patients with diabetes mellitus.
Topics: Angina Pectoris, Variant; Chromans; Diabetic Angiopathies; Endothelium, Vascular; Humans; Insulin Resistance; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Vasodilator Agents | 1999 |
Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium Channel Blockers; Cells, Cultured; Chromans; Diltiazem; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Swine; Thapsigargin; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Vasodilator Agents | 1999 |
Troglitazone inhibits alpha1-adrenoceptor-induced DNA synthesis in vascular smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Chromans; DNA; DNA-Binding Proteins; Genes, fos; Hypoglycemic Agents; Muscle, Smooth, Vascular; Nuclear Proteins; Oligonucleotides, Antisense; Phenylephrine; Rats; Receptors, Adrenergic, alpha-1; Response Elements; Serum Response Factor; Thiazoles; Thiazolidinediones; Transcriptional Activation; Troglitazone; Type C Phospholipases | 1999 |
PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
Topics: Adipocytes; Carrier Proteins; Cell Differentiation; Cell Line; Cells, Cultured; Chromans; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Gene Expression; Humans; Kinetics; Monocytes; Myelin P2 Protein; Neoplasm Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins | 1999 |
Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.
Topics: Androstenedione; Animals; Blood Glucose; Body Composition; Chromans; Dehydroepiandrosterone; Diabetes Mellitus; Eating; Fructose-Bisphosphatase; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; Enzyme Inhibitors; Flow Cytometry; Gene Expression; Humans; Hypereosinophilic Syndrome; Leukemia, Myeloid; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 1999 |
Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism.
Topics: Animals; Cells, Cultured; Chromans; Gene Expression Regulation; Gluconeogenesis; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Liver; Male; Metformin; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone inhibits bicarbonate secretion in rat and human duodenum.
Topics: Animals; Bicarbonates; Biological Transport; Chromans; Cyclic AMP; Duodenum; Humans; Hypoglycemic Agents; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Water | 1999 |
Elimination of hyperinsulinemia after pancreas transplantation in rats.
Topics: Animals; Chromans; Hyperinsulinism; Hypoglycemic Agents; Male; Pancreas Transplantation; Portal System; Postoperative Complications; Rats; Rats, Inbred Lew; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Steady-state pharmacokinetics and dose proportionality of troglitazone and its metabolites.
Topics: Adolescent; Adult; Aged; Chromans; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Middle Aged; Quinones; Statistics as Topic; Sulfuric Acid Esters; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro.
Topics: Adipocytes; Alternative Splicing; Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Differentiation; Cell Line; Chromans; Humans; Hybridomas; Hypoglycemic Agents; In Vitro Techniques; Mice; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Rosiglitazone; Species Specificity; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
A Japanese case of liver dysfunction after 19 months of troglitazone treatment.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Female; Humans; Hypoglycemic Agents; Japan; Middle Aged; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Ascorbic Acid; Biological Transport; Chromans; Glucose; Glucose Oxidase; Glucose Transporter Type 4; Glutathione; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Oxidative Stress; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Thiazoles; Thiazolidinediones; Thioctic Acid; Troglitazone; Vitamin E | 1999 |
Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Hypoglycemic Agents; Liver; Oxidoreductases, N-Demethylating; Rifampin; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Avoiding hepatic injury from drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Diseases; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus; Eating; Hypoglycemic Agents; Islets of Langerhans; Lipids; Mitochondria; Obesity; Rats; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 1999 |
Scientist denies role in conflict investigation.
Topics: Biomedical Research; Biotechnology; Chromans; Clinical Trials as Topic; Conflict of Interest; Drug Industry; Federal Government; Government Regulation; Hypoglycemic Agents; National Institutes of Health (U.S.); Patents as Topic; Thiazoles; Thiazolidinediones; Troglitazone; United States | 1999 |
Troglitazone can prevent development of type 1 diabetes induced by multiple low-dose streptozotocin in mice.
Topics: Animals; Blood Glucose; Chromans; Cricetinae; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radical Scavengers; Hypoglycemic Agents; Insulin; Islets of Langerhans; Mice; Mice, Inbred DBA; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Streptozocin; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 1999 |
PPARgamma agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expression.
Topics: Antioxidants; Cell Adhesion; Cell Line, Transformed; Chromans; DNA-Binding Proteins; Endothelium, Vascular; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Linoleic Acids; Linoleic Acids, Conjugated; Lipopolysaccharides; Lipoproteins, LDL; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Necrosis Factor-alpha; Umbilical Veins | 1999 |
Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Division; Cell Line; Chromans; Hypoglycemic Agents; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Platelet-Derived Growth Factor; Prostaglandin D2; Rats; Thiazoles; Thiazolidinediones; Troglitazone; Vasopressins | 1999 |
Non-alcoholic steatohepatitis.
Topics: Chromans; Contraindications; Diabetes Mellitus, Type 2; Fatty Liver; Hepatitis; Humans; Hypoglycemic Agents; Metformin; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Spontaneous and thiazolidinedione-induced B6C3F1 mouse hemangiosarcomas exhibit low ras oncogene mutation frequencies.
Topics: Animals; Carcinogens; Chromans; DNA, Neoplasm; Evolution, Molecular; Female; Genes, ras; Hemangiosarcoma; Male; Mice; Mice, Inbred Strains; Mutation; Polymerase Chain Reaction; Sequence Analysis; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Neoplasms | 1999 |
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Chromans; COS Cells; Diazoxide; Electrophysiology; Glyburide; Membrane Potentials; Pinacidil; Pioglitazone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Recombinant Fusion Proteins; Rubidium Radioisotopes; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Transfection; Troglitazone | 1999 |
Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes.
Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Chromans; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Quinones; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
Topics: Alitretinoin; Antineoplastic Agents; Antioxidants; Cell Cycle; Cell Differentiation; Cell Division; Chromans; DNA-Binding Proteins; HL-60 Cells; Humans; Leukemia, Myeloid; Receptors, Cytoplasmic and Nuclear; Superoxides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Troglitazone; Tumor Cells, Cultured; U937 Cells | 1999 |
Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro.
Topics: Acid Phosphatase; Adipocytes; Animals; Bone Marrow Cells; Bone Resorption; Calcitriol; Cell Differentiation; Cells, Cultured; Chromans; Hypoglycemic Agents; Interleukin-11; Isoenzymes; Mice; Mice, Inbred ICR; Osteoclasts; Parathyroid Hormone; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Tartrate-Resistant Acid Phosphatase; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Rezulin pulled in the UK.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Drug and Narcotic Control; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; United Kingdom | 1998 |
Thiazolidinedione induces apoptosis and monocytic differentiation in the promyelocytic leukemia cell line HL60.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Chromans; Drug Synergism; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Monocytes; Nicotinic Acids; Proto-Oncogene Proteins; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Diabetes drug Rezulin: take it, but take precautions.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Liver Failure; Liver Function Tests; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome.
Topics: Adult; Body Temperature; Chromans; Clomiphene; Drug Resistance; Female; Humans; Infertility, Female; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Progesterone; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
PPARgamma inhibits the expression of c-MET in human gastric cancer cells through the suppression of Ets.
Topics: Cell Division; Chromans; Gene Expression; Humans; Promoter Regions, Genetic; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins c-met; Receptors, Cytoplasmic and Nuclear; Stomach Neoplasms; Suppression, Genetic; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured | 1999 |
Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L6 myotubes.
Topics: Alitretinoin; Animals; Carrier Proteins; Cells, Cultured; Chromans; Dimerization; Drug Synergism; Epoprostenol; Gene Expression Regulation; Ion Channels; Mitochondrial Proteins; Muscle, Skeletal; Oleic Acid; Palmitates; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Triiodothyronine; Troglitazone; Uncoupling Protein 3 | 1999 |
The effect of insulin sensitizer, troglitazone, on lipoprotein lipase mass in preheparin serum.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Chromans; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Glycated Hemoglobin; Heparin; Humans; Hypoglycemic Agents; Insulin; Lipoprotein Lipase; Male; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Differential effects of troglitazone and D-chiroinositol on glucosamine-induced insulin resistance in vivo in rats.
Topics: Animals; Chromans; Glucosamine; Glucose Clamp Technique; Hypoglycemic Agents; Inositol; Insulin Resistance; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium.
Topics: Alitretinoin; Animals; Carcinogens; Chromans; Drug Implants; Estradiol; Female; Guinea Pigs; Humans; Leiomyomatosis; Menstrual Cycle; Myometrium; Neoplasm Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Troglitazone; Uterine Neoplasms | 1999 |
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
Topics: Animal Feed; Animals; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Chromans; Diet; Dietary Carbohydrates; Dietary Fats, Unsaturated; Dietary Proteins; DNA-Binding Proteins; Fenofibrate; Gene Expression Regulation, Enzymologic; Glycolysis; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Rats; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 1999 |
Troglitazone efficacy in a subject with glucocorticoid-induced diabetes.
Topics: Aged; C-Peptide; Chromans; Diabetes Mellitus; Female; Glucocorticoids; Humans; Hypoglycemic Agents; Polymyositis; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
A drug interaction between troglitazone and simvastatin.
Topics: Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Retrospective Studies; Simvastatin; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Differential block by troglitazone and rosiglitazone of glibenclamide-sensitive K(+) current in rat aorta myocytes.
Topics: Animals; Aorta, Thoracic; Chromans; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channel Blockers; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
A short synthesis of troglitazone: an antidiabetic drug for treating insulin resistance.
Topics: Chromans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity.
Topics: Antioxidants; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; NF-kappa B; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Vitamin E | 1999 |
Effects of troglitazone on collagen accumulation and distensibility of aortic wall in prestage of non-insulin-dependent diabetes mellitus of Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Aorta, Thoracic; Body Weight; Chromans; Collagen; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hemodynamics; Hydroxyproline; Hypoglycemic Agents; Male; Muscle, Smooth, Vascular; Observer Variation; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Deterioration of rheumatoid arthritis with troglitazone: a rare and unexpected adverse effect.
Topics: Arthritis, Rheumatoid; Chromans; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Hypoglycemic Agents; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain; Cell Differentiation; Chromans; Cyclooxygenase 2; Dinoprost; Genes, Reporter; Humans; Inflammation; Interleukin-6; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Microbodies; Microglia; Monocytes; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data.
Topics: Adamantane; Anti-Bacterial Agents; Antimalarials; Atovaquone; Biopharmaceutics; Chemical Phenomena; Chemistry, Physical; Chromans; Chromatography, High Pressure Liquid; Food-Drug Interactions; Lactams; Naphthoquinones; Phenylurea Compounds; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prodrugs; Solubility; Solvents; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators.
Topics: Animals; Arteriosclerosis; Cell Movement; Cells, Cultured; Chromans; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Macrophages; Mice; Monocytes; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vascular Cell Adhesion Molecule-1; Vasculitis | 2000 |
Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS.
Topics: Adult; Carbon Isotopes; Chromans; Glucose; Glucose Clamp Technique; Glycogen; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Magnetic Resonance Spectroscopy; Male; Middle Aged; Muscle, Skeletal; Obesity; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Pharmacologic management of diabetes mellitus.
Topics: Carbamates; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone.
Topics: Chromans; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hypoglycemic Agents; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Oxidation-Reduction; Pioglitazone; Recombinant Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Xenobiotics | 2000 |
Troglitazone improves insulin-stimulated glucose utilization associated with an increased muscle glycogen content in obese Zucker rats.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Animals; Blood Glucose; Body Weight; Chromans; Eating; Glucose Clamp Technique; Glucose Transporter Type 4; Glycogen; Hypoglycemic Agents; Insulin; Male; Metabolic Clearance Rate; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Obesity; Pyruvate Dehydrogenase Complex; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.
Topics: Base Sequence; Cell Line; Chromans; DNA Probes; DNA-Binding Proteins; Humans; Interleukin-2; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chromans; Cytokines; Female; Histamine Release; Ligands; Mast Cells; Mice; Mice, Inbred BALB C; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Lipotoxic heart disease in obese rats: implications for human obesity.
Topics: Age Factors; Animals; Apoptosis; Blood Glucose; Body Weight; Chromans; DNA Fragmentation; Echocardiography; Heart Diseases; Humans; Insulin; Lipid Metabolism; Male; Microscopy, Electron; Myocardium; Obesity; Organ Size; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone.
Topics: Blotting, Northern; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chemotaxis; Chromans; Coronary Vessels; DNA; DNA-Binding Proteins; Genes, fos; Humans; Muscle, Smooth, Vascular; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vasodilator Agents | 2000 |
Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination.
Topics: Chromans; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Humans; Hypoglycemic Agents; Liver Failure; Middle Aged; Necrosis; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone-associated hepatic failure.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Hepatic Encephalopathy; Humans; Hyperlipidemias; Hypoglycemic Agents; Liver; Liver Failure; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells.
Topics: Blotting, Northern; Cell Count; Cell Survival; Cells, Cultured; Chemokine CCL2; Chromans; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hypoglycemic Agents; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha; Vitamin E | 2000 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Carcinogens; Chromans; Estradiol; Female; Ligands; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Precancerous Conditions; Progesterone; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoid X Receptors; Retinoids; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Troglitazone | 2000 |
Antidiabetic activity of white skinned sweet potato (Ipomoea batatas L.) in obese Zucker fatty rats.
Topics: Animals; Blood Glucose; Chromans; Fatty Acids, Nonesterified; Glucose Tolerance Test; Hyperinsulinism; Hypoglycemic Agents; Insulin; Islets of Langerhans; Lactic Acid; Male; Plant Extracts; Rats; Rats, Zucker; Solanaceae; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Weight Gain | 2000 |
Troglitazone does not initiate hypertrophy but can sensitise cardiomyocytes to growth effects of serum.
Topics: Animals; Cattle; Cell Differentiation; Cell Survival; Chromans; Culture Media; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Fetal Blood; Glucose; Heart Ventricles; Hydrogen-Ion Concentration; Hypertrophy; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Male; Myocardium; Norepinephrine; Phenylalanine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone improves recovery of left ventricular function after regional ischemia in pigs.
Topics: Animals; Blood Pressure; Chromans; Hypoglycemic Agents; Insulin Resistance; Myocardial Ischemia; Oxygen Consumption; Swine; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function, Left | 2000 |
Short-term treatment with troglitazone decreases bone turnover in patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Blood Glucose; Bone and Bones; Bone Remodeling; Bone Resorption; Chromans; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1999 |
Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cells, Cultured; Chromans; Deoxyglucose; Gene Expression Regulation; Glomerular Mesangium; Glucose; Glucose Transporter Type 1; Glycolysis; Hypoglycemic Agents; Methylglucosides; Monosaccharide Transport Proteins; Phlorhizin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Thiazoles; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2000 |
The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice.
Topics: 3T3 Cells; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Type 2; Hyperglycemia; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Oxadiazoles; Pioglitazone; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Weight Gain | 2000 |
Managing type 2 diabetes. A look at the newer agents.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Troglitazone-induced pulmonary edema.
Topics: Antioxidants; Chromans; Humans; Hypoglycemic Agents; Pulmonary Edema; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Drugs and disease.
Topics: Chromans; Cisapride; Diabetes Mellitus, Type 2; Drug and Narcotic Control; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy.
Topics: Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Breast; Breast Neoplasms; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Estrogens; Female; Gene Expression Regulation, Enzymologic; Humans; Ligands; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group.
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver; Liver Failure; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Chromans; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glucocorticoids; Humans; Hypoglycemic Agents; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Steroid Hydroxylases; Substrate Specificity; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis.
Topics: Apoptosis; Base Sequence; Cell Division; Chromans; DNA Primers; Humans; Lung Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
The role of antioxidants in the long-term glycation of low density lipoprotein and its Cu2+-catalyzed oxidation.
Topics: Antioxidants; Aspirin; Chromans; Copper; Edetic Acid; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycosylation; Humans; Lipoproteins, LDL; Oxidation-Reduction; Spectrometry, Fluorescence; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2000 |
Rapid-onset subfulminant liver failure associated with troglitazone.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes.
Topics: Adipocytes; Adult; Cell Differentiation; Cells, Cultured; Chromans; Culture Media; Female; Humans; Middle Aged; Obesity; Omentum; Osmolar Concentration; Plasminogen Activator Inhibitor 1; Reference Values; RNA, Messenger; Skin; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells.
Topics: Aorta; Carcinoma, Hepatocellular; Cells, Cultured; Chromans; Culture Media, Conditioned; Endothelium, Vascular; Humans; Hypoglycemic Agents; Kinetics; Liver; Liver Neoplasms; Muscle, Smooth, Vascular; Plasminogen Activator Inhibitor 1; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Umbilical Veins; Urokinase-Type Plasminogen Activator | 2000 |
Troglitazone directly inhibits CO(2) production from glucose and palmitate in isolated rat skeletal muscle.
Topics: Animals; Carbon Dioxide; Chromans; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle, Skeletal; Palmitates; Rats; Rats, Sprague-Dawley; Solvents; Stimulation, Chemical; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats.
Topics: Administration, Oral; Animals; Chromans; Diabetes Mellitus; Fatty Acids; Hypoglycemic Agents; Liver; Male; Muscle, Skeletal; Obesity; Oxidation-Reduction; Palmitic Acid; Rats; Rats, Zucker; Reference Values; Substrate Specificity; Thiazoles; Thiazolidinediones; Thiazolidines; Triglycerides; Troglitazone | 2000 |
Severe but reversible hepatitis induced by troglitazone.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Liver; Liver Function Tests; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone in progesterone derivative-induced impairment of glucose tolerance.
Topics: Aged; Antineoplastic Agents, Hormonal; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Hypoglycemic Agents; Medroxyprogesterone Acetate; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells.
Topics: Cells, Cultured; Chemokine CCL2; Chromans; Endothelium, Vascular; Humans; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha; Umbilical Veins | 2000 |
Substituting for troglitazone (Rezulin).
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
From the Food and Drug Administration.
Topics: Anti-Infective Agents, Local; Bacterial Vaccines; Bandages; Chromans; Cisapride; Drug and Narcotic Control; Drug Approval; Equipment Contamination; Gastrointestinal Agents; Heptavalent Pneumococcal Conjugate Vaccine; Humans; Hypoglycemic Agents; Infant; Meningococcal Vaccines; Pneumococcal Vaccines; Streptococcus pneumoniae; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration; Vaccines, Conjugate | 2000 |
Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes.
Topics: 3T3 Cells; Abortifacient Agents, Steroidal; Adipocytes; Animals; Binding Sites; Chromans; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Glucocorticoids; Glycogen; Hypoglycemic Agents; Insulin; Insulin Resistance; Iodine Radioisotopes; Mice; Mifepristone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regulation; Gene Expression; Hypoglycemic Agents; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Thiazolidinediones exert different effects on insulin resistance between dexamethasone-treated rats and wistar fatty rats.
Topics: Animals; Chromans; Dexamethasone; Drug Combinations; Glucocorticoids; Glucose; Glucose Clamp Technique; Homeostasis; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Obesity; Pioglitazone; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone inhibits mitogenic signaling by insulin in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; DNA; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Fibroblast Growth Factor 2; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cells.
Topics: Acetophenones; Cells, Cultured; Chromans; Endothelial Growth Factors; Gene Expression Regulation; Humans; Lymphokines; Muscle, Smooth, Vascular; Peroxisome Proliferators; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetrazoles; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2000 |
Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
Topics: Adult; Aromatase; Aromatase Inhibitors; Chromans; Dimerization; Enzyme Inhibitors; Estrogens; Female; Granulosa Cells; Humans; Nicotinic Acids; Ovary; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Insulin sensitizers and antiandrogens in the treatment of polycystic ovary syndrome.
Topics: Androgen Antagonists; Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats.
Topics: Absorptiometry, Photon; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Cataract; Chromans; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Eating; Hypoglycemic Agents; Isoxazoles; Male; Neural Conduction; Obesity; Pancreas; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 2000 |
Dietary troglitazone decreases oxidative stress in early stage type II diabetic rats.
Topics: Animals; Antioxidants; Chromans; Diabetes Mellitus, Type 2; Diet; Hypoglycemic Agents; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Long-Evans; Superoxide Dismutase; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Expression; Glomerular Mesangium; Nuclear Proteins; Oligonucleotides; Prostaglandin D2; Protein Binding; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Troglitazone withdrawn from market.
Topics: Chromans; Drug and Narcotic Control; Humans; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake.
Topics: 3T3 Cells; Adipocytes; Animals; CCAAT-Enhancer-Binding Proteins; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Hypoglycemic Agents; Interleukin 1 Receptor Antagonist Protein; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Sialoglycoproteins; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 1999 |
Drug recalls underscore safety concerns.
Topics: Arrhythmias, Cardiac; Chromans; Cisapride; Drug and Narcotic Control; Gastrointestinal Agents; Humans; Hypoglycemic Agents; Liver Failure; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit nitric oxide synthesis in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; Humans; Interleukin-1; Ligands; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Dissociation between the Ca(2+) signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Signaling; Cattle; Cell Division; Cell Survival; Cells, Cultured; Chromans; Collagen; Diltiazem; Endothelial Growth Factors; Endothelium, Vascular; Gels; Imidazoles; Lymphokines; Neovascularization, Physiologic; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Late-onset troglitazone-induced hepatic dysfunction.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Liver Function Tests; Male; Thiazoles; Thiazolidinediones; Time Factors; Treatment Refusal; Troglitazone | 2000 |
Deterioration of glycemic control after long-term treatment with troglitazone in nonobese type 2 diabetic patients.
Topics: Biomarkers; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Time Factors; Treatment Failure; Troglitazone | 2000 |
Toward practical prevention of type 2 diabetes.
Topics: alpha-Linolenic Acid; Animals; Biotin; Calcium; Chromans; Coenzymes; Diabetes Mellitus, Type 2; Ethanol; Female; Humans; Liver; Magnesium; Male; Metformin; Rats; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone; Ubiquinone | 2000 |
How should patients taking the discontinued diabetes drug troglitazone be managed?
Topics: Alanine Transaminase; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Liver; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats.
Topics: Albuminuria; Animals; Chromans; Diabetes Mellitus, Experimental; Diglycerides; Extracellular Matrix Proteins; Hemodynamics; Insulin; Kidney Glomerulus; Male; Mitogen-Activated Protein Kinases; Pioglitazone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Renal Circulation; RNA, Messenger; Thiazoles; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2000 |
Acute rhabdomyolysis associated with troglitazone.
Topics: Chromans; Creatine Kinase; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Isoenzymes; Middle Aged; Rhabdomyolysis; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromans; Cytokines; Hot Temperature; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Shock; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.
Topics: 3T3 Cells; Animals; Cell Line; Chromans; Electrophoresis, Gel, Two-Dimensional; Epithelial Cells; Gene Expression Regulation; Humans; Hypoglycemic Agents; Kidney; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Trypsin | 2000 |
Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects.
Topics: Adult; Arteriosclerosis; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Female; Fibrinolysis; Glucose Clamp Technique; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Plasminogen Activator Inhibitor 1; Thiazoles; Thiazolidinediones; Tissue Plasminogen Activator; Troglitazone | 2000 |
Inhibitory action of troglitazone, an insulin-sensitizing agent, on the calcium current in cardiac ventricular cells of guinea pig.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Chromans; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Hypoglycemic Agents; Male; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Troglitazone, an insulin action enhancer--a drug of precision to treat adult-onset diabetes].
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization.
Topics: Animals; Blotting, Western; Cell Division; Cell Movement; Choroid; Choroidal Neovascularization; Chromans; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Fluorescein Angiography; Humans; Injections; Laser Coagulation; Ligands; Lymphokines; Macaca fascicularis; Male; Pigment Epithelium of Eye; Rats; Rats, Inbred BN; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
All that glitters in glitazones.
Topics: Antiviral Agents; Chromans; Drug Approval; Drug Prescriptions; Europe; Guanidines; Humans; Hypoglycemic Agents; National Health Programs; Pyrans; Rosiglitazone; Sialic Acids; Sri Lanka; Thiazoles; Thiazolidinediones; Troglitazone; United Kingdom; United States; United States Food and Drug Administration; Zanamivir | 1999 |
Pharmacokinetics of the insulin-sensitizing agent troglitazone in cats.
Topics: Administration, Oral; Animals; Area Under Curve; Cats; Chromans; Chromatography, High Pressure Liquid; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Half-Life; Hypoglycemic Agents; Injections, Intravenous; Random Allocation; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets.
Topics: Adenoviridae; Animals; CCAAT-Enhancer-Binding Proteins; Chromans; DNA-Binding Proteins; Genetic Vectors; Hyperinsulinism; Hypolipidemic Agents; Islets of Langerhans; Leptin; Liver; Male; Nuclear Proteins; Obesity; Rats; Rats, Sprague-Dawley; Rats, Zucker; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2000 |
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chromans; Female; Humans; Ligands; Osteoarthritis; Prostaglandin D2; Rats; Rats, Inbred Lew; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Tissue Distribution; Transcription Factors; Troglitazone | 2000 |
Mechanism of troglitazone action in type 2 diabetes.
Topics: Body Composition; Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Glucose-6-Phosphate; Glycogen; Hormones; Humans; Hypoglycemic Agents; Intracellular Membranes; Male; Middle Aged; Muscle, Skeletal; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
The FDA: protector or puppet?
Topics: Chromans; Cisapride; Drug and Narcotic Control; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Tobacco Industry; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Troglitazone decreases collagen accumulation in prediabetic stage of a type II diabetic rat model.
Topics: Animals; Chromans; Collagen; Diabetes Mellitus, Type 2; Heart Diseases; Hypoglycemic Agents; Male; Rats; Rats, Long-Evans; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Topics: Animals; Anticholesteremic Agents; Bezafibrate; Carrier Proteins; Chromans; Female; Gene Expression Regulation; Hypoglycemic Agents; Hypolipidemic Agents; Ion Channels; Lactation; Litter Size; Mice; Microbodies; Mitochondria, Muscle; Mitochondrial Proteins; Muscle, Skeletal; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Uncoupling Agents; Uncoupling Protein 3; Weaning | 2000 |
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts.
Topics: Animals; Chromans; Dose-Response Relationship, Drug; Hemodynamics; Hypoglycemic Agents; Indomethacin; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Pioglitazone; Prostaglandins; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2000 |
Thiazolidinediones for type 2 diabetes. New agents reduce insulin resistance but need long term clinical trials.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Contraindications; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[A 75-year-old type 2 diabetes mellitus case responding strikingly troglitazone: possible mechanism of insulin resistance induced by insulin antibody].
Topics: Aged; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin Antibodies; Insulin Resistance; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
The effect of activation of peroxisome proliferator-activated receptor gamma (PPARgamma) on human monocyte function: PPARgamma ligands do not inhibit tumor necrosis factor-alpha release in human monocytic cell line THP-1.
Topics: Antineoplastic Agents; Carcinogens; Cell Survival; Cells, Cultured; Chromans; Humans; Hypoglycemic Agents; Ligands; Monocytes; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Lipoatrophy, lipodystrophy, and insulin resistance.
Topics: Body Composition; Chromans; Diabetes Mellitus, Lipoatrophic; Humans; Hypoglycemic Agents; Insulin Resistance; Lipodystrophy; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.
Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CCL2; Chromans; Cytotoxins; Gene Expression; Hepatitis; Humans; Interleukin-1; Ligands; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogenes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tyrosine; Wound Healing | 2000 |
Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.
Topics: Animals; Base Sequence; Binding Sites; Chromans; Cloning, Molecular; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Leucine Zippers; Macrophages; Molecular Sequence Data; NF-E2-Related Factor 2; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Thromboxane-A Synthase; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
[Effect of antioxidants on radical-initiated peroxidation of retinal homogenate].
Topics: Animals; Antioxidants; Cattle; Chromans; In Vitro Techniques; Lipid Peroxidation; Oxidative Stress; Quercetin; Retina; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Carcinoma, Transitional Cell; Carrier Proteins; Cell Death; Chromans; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; G1 Phase; Humans; Immunoblotting; In Situ Hybridization; Ligands; Luciferases; Myelin P2 Protein; Neoplasm Proteins; Nicotinic Acids; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Ribonucleases; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Tretinoin; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins; Urinary Bladder Neoplasms | 1999 |
Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Cell Movement; Chemokine CCL2; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Monocytes; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
Troglitazone has a reducing effect on thromboxane production.
Topics: Arachidonic Acid; Blood Platelets; Chromans; Diabetes Mellitus, Type 2; Fibrinolytic Agents; Gas Chromatography-Mass Spectrometry; Humans; Leukemia, Erythroblastic, Acute; Rosiglitazone; Thiazoles; Thiazolidinediones; Thromboxane A2; Troglitazone; Tumor Cells, Cultured; Vitamin E | 2000 |
Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators.
Topics: Animals; Carrier Proteins; Chromans; COS Cells; Histone Acetyltransferases; Ligands; Mediator Complex Subunit 1; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivator 2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 2000 |
Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromans; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; Insulin; Isoenzymes; Lipids; Male; Mice; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stearoyl-CoA Desaturase; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender.
Topics: Adipocytes; Cells, Cultured; Chromans; Dexamethasone; Female; Gene Expression Regulation; Humans; Leptin; Male; Obesity, Morbid; Omentum; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Thiazoles; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2000 |
Intestinal absorption and excretion of troglitazone sulphate, a major biliary metabolite of troglitazone.
Topics: Animals; Bile; Biotransformation; Cecum; Chromans; Chromatography, Thin Layer; Enterohepatic Circulation; Feces; Hypoglycemic Agents; In Vitro Techniques; Intestinal Absorption; Male; Rats; Rats, Inbred F344; Sulfates; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Information on thiazolidinediones.
Topics: Chromans; Drug Industry; Humans; Hypoglycemic Agents; Internet; Ligands; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter.
Topics: Alitretinoin; Animals; Base Sequence; Cell Line; Cells, Cultured; Chromans; Consensus Sequence; Dimerization; DNA-Binding Proteins; Gene Expression Regulation; Glucose Transporter Type 2; Hypoglycemic Agents; Islets of Langerhans; Male; Monosaccharide Transport Proteins; Promoter Regions, Genetic; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Recombinant Proteins; Retinoid X Receptors; Sequence Alignment; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Tretinoin; Troglitazone | 2000 |
Potential interaction between troglitazone and atorvastatin.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Chromans; Diabetes Mellitus; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hyperlipidemias; Hypoglycemic Agents; Male; Middle Aged; Pyrroles; Retrospective Studies; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
The rise and fall of troglitazone.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects.
Topics: Adult; Antioxidants; Brachial Artery; Chromans; Female; Humans; Hypertension; Ischemia; Leukocytes, Mononuclear; Lipid Peroxidation; Male; Middle Aged; Neutrophils; Nitroglycerin; Reactive Oxygen Species; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation; Vasodilator Agents | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Cerebellum; Chromans; Cyclooxygenase Inhibitors; Down-Regulation; Ibuprofen; Immunohistochemistry; In Situ Nick-End Labeling; Interferon-gamma; Ligands; Lipopolysaccharides; Male; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures.
Topics: Acetaminophen; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Hepatocytes; Humans; Nitrophenols; Pentachlorophenol; Phenobarbital; Protein Biosynthesis; Proteins; Swine; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Drug Interactions; Gemfibrozil; Hypoglycemic Agents; Lipopolysaccharides; Myocardium; NF-kappa B; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Diabetes recall. Though Rezulin's withdrawal is a blow for some patients, there are ways to cope. Here's how.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Approval; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes.
Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Eating; Fasting; Fatty Acids, Nonesterified; Glucose Tolerance Test; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Obesity; Organ Size; Pancreas; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Chromans; Down-Regulation; Gene Expression Regulation; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages.
Topics: Blotting, Northern; CD36 Antigens; Cell Line; Cells, Cultured; Chromans; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Foam Cells; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Immunohistochemistry; Macrophages; Membrane Proteins; Microscopy, Fluorescence; Monocytes; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, LDL; Receptors, Lipoprotein; Receptors, Oxidized LDL; Receptors, Scavenger; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class A; Scavenger Receptors, Class B; Scavenger Receptors, Class E; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Troglitazone; Tumor Necrosis Factor-alpha; Ultraviolet Rays; Up-Regulation | 2000 |
Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.
Topics: Adenocarcinoma; Androgen Antagonists; Antineoplastic Agents; Blotting, Western; Chromans; Dihydrotestosterone; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Ligands; Male; Middle Aged; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Cytoplasmic and Nuclear; Response Elements; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2000 |
Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27KiP1 in human. Pancreatic carcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Blotting, Northern; Cell Cycle Proteins; Cell Division; Chromans; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Growth Inhibitors; Humans; Immunohistochemistry; Luciferases; Microtubule-Associated Proteins; Oligonucleotides, Antisense; Pancreatic Neoplasms; Peroxisome Proliferators; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
[New development in diabetes therapy. 35th Annual Meeting of the German Diabetes Society, Munich, May 5-June 3, 2000].
Topics: Chromans; Diabetes Mellitus, Type 2; Germany; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone as an anti-inflammatory agent.
Topics: Anti-Inflammatory Agents; Antioxidants; Arthritis, Rheumatoid; Chromans; Humans; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Eating; Fluorenes; Gene Expression; Glucose Tolerance Test; Glucose-6-Phosphatase; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Resistance; Lactic Acid; Lipids; Liver; Male; Mesenteric Arteries; Metformin; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphoenolpyruvate Carboxylase; Rats; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Resistance | 2000 |
[Insulin sensitizer. A new therapy option for type 2 diabetic patients].
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Topics: Acyl-CoA Dehydrogenase; Animals; Atorvastatin; Bezafibrate; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Cholesterol; Chromans; Down-Regulation; Fatty Acid Desaturases; Heptanoic Acids; Hypoglycemic Agents; Ion Channels; Ligands; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscles; Oleic Acid; Peroxisome Proliferators; Proteins; Pyrimidines; Pyrroles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triazenes; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2000 |
Effects of a low-energy diet and an insulin-sensitizing agent on ambulatory blood pressure in overweight hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Chromans; Diet, Reducing; Female; Humans; Hypertension; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Obesity; Thiazoles; Thiazolidinediones; Troglitazone; Weight Loss | 2000 |
Glucose modifies the cross-talk between insulin and the beta-adrenergic signalling system in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoproterenol; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoproteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone inhibits the expression of inducible nitric oxide synthase in adipocytes in vitro and in vivo study in 3T3-L1 cells and Otsuka Long-Evans Tokushima Fatty rats.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Chromans; Escherichia coli; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Interferon-gamma; Lipopolysaccharides; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Obesity; Rats; Rats, Long-Evans; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cells, Cultured; Chorionic Gonadotropin; Chromans; Densitometry; Fluorescent Antibody Technique; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Trophoblasts | 2000 |
Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromans; GADD45 Proteins; Gene Expression; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Pioglitazone; Platelet Aggregation Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Protein p53 | 2000 |
Troglitazone-associated hepatotoxicity treated successfully with steroids.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Chromans; Humans; Prednisone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Effect of troglitazone on exocrine pancreas in rats with streptozotocin-induced diabetes mellitus.
Topics: Animals; Cholecystokinin; Chromans; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Male; Pancreas; Rats; Rats, Wistar; Streptozocin; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Topics: Anticholesteremic Agents; Arsenites; Bucladesine; Cells, Cultured; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoglycemic Agents; Ligands; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sodium Compounds; Thiazoles; Thiazolidinediones; Thyroglobulin; Thyroid Gland; Thyrotropin; Transcription Factors; Troglitazone | 2000 |
Troglitazone (CS-045) normalizes hypertriglyceridemia and restores the altered patterns of glucose-stimulated insulin secretion in dyslipidemic rats.
Topics: Animals; Body Weight; Chromans; Dietary Sucrose; Fatty Acids, Nonesterified; Glucose; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Liver; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Renal protective effect of troglitazone in Wistar fatty rats.
Topics: Animals; Blood Pressure; Body Weight; Chromans; Female; Hypoglycemic Agents; Insulin Resistance; Kidney; Proteinuria; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy.
Topics: Antineoplastic Agents; Cell Survival; Chromans; Chromones; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Humans; Morpholines; Pancreatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Starvation; Stomach Neoplasms; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2000 |
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.
Topics: Adipose Tissue; Animals; Blood Glucose; Chromans; Diabetes Mellitus, Lipoatrophic; Disease Models, Animal; Female; Hypoglycemic Agents; Insulin; Ligands; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Cytoplasmic and Nuclear; Respiratory Function Tests; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 2000 |
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the li
Topics: Adipose Tissue; Animals; Blotting, Northern; Chromans; Diabetes Mellitus; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Regulation of leptin release by troglitazone in human adipose tissue.
Topics: Adipose Tissue; Adult; Aged; Chromans; Culture Techniques; Dexamethasone; Female; Humans; Hypoglycemic Agents; Insulin; Leptin; Male; Middle Aged; Prostaglandins; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
Topics: Animals; Apolipoprotein A-I; Bezafibrate; Chlorocebus aethiops; Chromans; COS Cells; Fenofibrate; Gene Expression Regulation; Humans; Hypoglycemic Agents; Kinetics; Pioglitazone; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Troglitazone; Tumor Cells, Cultured | 2000 |
Role of glucose and insulin in thiazolidinedione-induced alterations in hepatic gluconeogenesis.
Topics: Animals; Chromans; Gluconeogenesis; Glucose; Hepatocytes; Hypoglycemic Agents; Insulin; Lactic Acid; Liver; Male; Phosphofructokinase-1; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Unraveling the mechanism of action of thiazolidinediones.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone prevents fatty changes of the liver in obese diabetic rats.
Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Cholesterol; Chromans; Colon; Colonic Polyps; Data Interpretation, Statistical; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Hyperlipidemias; Hypoglycemic Agents; Insulin; Liver; Male; Organ Size; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides; Troglitazone | 2000 |
Plaintiff's attorney actively seeking out patients who have used various FDA approved medications and who "may be entitled to compensation for damages caused by these medications".
Topics: Chromans; Cisapride; Gastrointestinal Agents; Humans; Hypoglycemic Agents; Liability, Legal; Malpractice; Mississippi; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion.
Topics: Animals; Anticarcinogenic Agents; Bezafibrate; Blotting, Western; Cell Differentiation; Cell Line; Chromans; Female; Keratinocytes; Linoleic Acid; Mice; Mice, Inbred SENCAR; Papilloma; Peroxisome Proliferators; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Skin; Skin Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2000 |
Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures.
Topics: Adipocytes; Animals; Antineoplastic Agents; Bone and Bones; Bone Marrow Cells; Calcitriol; Calcium Channel Agonists; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chromans; Gene Expression; Hemostatics; Male; Membrane Glycoproteins; Mice; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vitamin K; Vitamin K 2 | 2000 |
Aging and the neuroendocrine regulation of reproduction and body weight.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Chromans; Eating; Gene Expression Regulation, Developmental; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Humans; Hypoglycemic Agents; Insulin; Leptin; Male; Models, Animal; Neuropeptide Y; Neurosecretory Systems; Pituitary Gland; Rats; Rats, Inbred BN; Reproduction; RNA, Messenger; Testis; Thiazoles; Thiazolidinediones; Troglitazone; Weight Gain | 2000 |
Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion.
Topics: Animals; Basement Membrane; Body Weight; Chondroitin Sulfate Proteoglycans; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fibrosis; Glomerular Mesangium; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Islets of Langerhans; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.
Topics: Adipocytes; Animals; Chromans; Dogs; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glucose Clamp Technique; Glycogen; Hypoglycemic Agents; Insulin; Lipids; Liver; Male; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
Topics: 3T3 Cells; Adrenergic beta-Agonists; Animals; Carrier Proteins; Cell Line; Chromans; Dioxoles; Drug Combinations; Half-Life; Ion Channels; Membrane Proteins; Mice; Mitochondrial Proteins; Norepinephrine; Propranolol; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Uncoupling Protein 1 | 2000 |
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
Topics: Animals; Chromans; Female; Glucose Clamp Technique; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Monosaccharide Transport Proteins; Motor Activity; Muscle Proteins; Obesity; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Zucker; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats.
Topics: Animals; Antioxidants; Body Weight; Carbon Dioxide; Carrier Proteins; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glucose; Insulin Resistance; Ion Channels; Mitochondrial Proteins; Muscle, Skeletal; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Uncoupling Protein 3 | 2000 |
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Lineage; Cells, Cultured; Chromans; Dinoprost; Hypoglycemic Agents; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones.
Topics: Adipocytes; Animals; Blood Glucose; Body Weight; Chromans; Diabetes Mellitus, Experimental; Female; Gene Expression; Gene Expression Profiling; Hypoglycemic Agents; Liver; Mice; Muscles; Pioglitazone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Method development and validation for the HPLC potency assay of troglitazone tablets.
Topics: Chromans; Chromatography, High Pressure Liquid; Drug Stability; Hypoglycemic Agents; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tablets; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Effects of fructose and troglitazone on phospholipid fatty acid composition in rat skeletal muscle.
Topics: Animals; Blood Glucose; Chromans; Fatty Acids; Fructose; Hypoglycemic Agents; Male; Muscle, Skeletal; Phosphatidylethanolamines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Dietary fat-induced increase in blood pressure and insulin resistance in rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Blood Pressure; Body Weight; Chromans; Dietary Carbohydrates; Dietary Fats; Dietary Fats, Unsaturated; Fatty Acids, Nonesterified; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Obesity; Rats; Rats, Wistar; Sucrose; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients.
Topics: Blood Flow Velocity; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chromans; Diabetes Mellitus, Type 2; Echocardiography, Doppler; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Hypoglycemic Agents; Insulin; Middle Aged; Myocardial Contraction; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone amplifies counterregulatory responses to hypoglycemia in nondiabetic subjects.
Topics: Adult; Blood Glucose; Chromans; Epinephrine; Female; Glucagon; Glucose Clamp Technique; Homeostasis; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Norepinephrine; Reference Values; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2001 |
Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells.
Topics: Adipocytes; Base Sequence; Biomarkers; Cell Differentiation; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; DNA Primers; Gene Expression; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Glycogen; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Topics: Animals; Bile; Biotransformation; Catalysis; Chromans; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hypoglycemic Agents; Isoenzymes; Ketoconazole; Kinetics; Mass Spectrometry; Microsomes, Liver; NADP; Rats; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Carboxy-Lyases; Chromans; Constriction; Diabetes Mellitus, Experimental; Dietary Fats; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Food; Gene Expression Regulation, Enzymologic; Heart; Male; Muscle, Skeletal; Myocardium; Organ Size; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
The transcription factor Fos-related antigen 1 is induced by thiazolidinediones during differentiation of 3T3-L1 cells.
Topics: 3T3 Cells; Animals; Cell Differentiation; Cell Nucleus; Chromans; Dimerization; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypoglycemic Agents; Mice; Pioglitazone; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Troglitazone; Up-Regulation | 2001 |
Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Bile Canaliculi; Binding, Competitive; Biological Transport; Cholagogues and Choleretics; Chromans; Hypoglycemic Agents; Liver; Male; Rats; Rats, Wistar; Taurocholic Acid; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms.
Topics: Amino Acid Sequence; Animals; Arylsulfotransferase; Catecholamines; Chromans; Cytosol; Humans; Immunoblotting; Isoenzymes; Mefenamic Acid; Melatonin; Mice; Mice, Inbred Strains; Molecular Sequence Data; Phenols; Phylogeny; Rabbits; Rats; Rats, Inbred Strains; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Species Specificity; Substrate Specificity; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Failure to develop hepatic injury from rosiglitazone in a patient with a history of troglitazone-induced hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Pulmonary edema associated with rosiglitazone and troglitazone.
Topics: Aged; Chromans; Diabetes Mellitus, Type 2; Humans; Male; Pulmonary Edema; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2001 |
Troglitazone has no effect on K(ATP) channel opener induced-relaxations in rat aorta and in human saphenous veins from patients with type 2 diabetes.
Topics: Animals; Aorta; Chromans; Cromakalim; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Rats; Rats, Wistar; Reference Values; Saphenous Vein; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation | 2000 |
Effect of troglitazone on the liver of a Gunn rat model of genetic enzyme polymorphism.
Topics: Animals; Chromans; Female; Glucuronosyltransferase; Hypoglycemic Agents; Liver; Male; Polymorphism, Genetic; Rats; Rats, Gunn; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans.
Topics: Animals; Bilirubin; Chromans; Glucuronides; Glucuronosyltransferase; Humans; Hypoglycemic Agents; Isoenzymes; Male; Microsomes, Liver; Polymorphism, Genetic; Rats; Rats, Gunn; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone stimulates acetyl-CoA carboxylase activity through a post-translational mechanism.
Topics: Acetyl-CoA Carboxylase; Animals; Body Weight; Chromans; Eating; Hypoglycemic Agents; Indicators and Reagents; Liver; Male; Nuclease Protection Assays; Phosphates; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; RNA, Messenger; Stimulation, Chemical; Subcellular Fractions; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Improvement of left ventricular diastolic dynamics in prediabetic stage of a type II diabetic rat model after troglitazone treatment.
Topics: Animals; Blood Pressure; Chromans; Diastole; Disease Models, Animal; Echocardiography, Doppler; Heart Rate; Hypoglycemic Agents; Male; Prediabetic State; Random Allocation; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function, Left | 2001 |
Survival activity of troglitazone in rat motoneurones.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Chromans; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Hippocampus; Insulin-Like Growth Factor I; Motor Neurons; Neurons, Afferent; Phosphoinositide-3 Kinase Inhibitors; Pioglitazone; Rats; Receptors, Cytoplasmic and Nuclear; Septum of Brain; Spinal Cord; Sympathetic Nervous System; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Does pioglitazone, like troglitazone, increase serum levels of lipoprotein(a) in diabetic patients?
Topics: Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Middle Aged; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway.
Topics: Animals; Apoptosis; Cells, Cultured; Chromans; Fibrinolytic Agents; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Inbred WKY; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
FDA reviews troglitazone.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Liver Diseases; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 1999 |
Troglitazone reduces plasma levels of tumour necrosis factor-alpha in obese patients with type 2 diabetes.
Topics: Blood Glucose; C-Peptide; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Obesity; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone.
Topics: Adipocytes; Adipose Tissue; Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cells, Cultured; Chromans; Dexamethasone; Drug Synergism; Enhancer Elements, Genetic; Glucocorticoids; Immunochemistry; Morphogenesis; Receptors, Cytoplasmic and Nuclear; Sugar Alcohol Dehydrogenases; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Dehydroepiandrosterone suppresses elevated hepatic glucose-6-phosphatase mRNA level in C57BL/KsJ-db/db mice: comparison with troglitazone.
Topics: Animals; Blood Glucose; Blotting, Northern; Body Weight; Chromans; Dehydroepiandrosterone; Diabetes Mellitus; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Troglitazone protects human erythrocytes from oxidant damage.
Topics: Antioxidants; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Erythrocyte Membrane; Erythrocytes; Free Radicals; Humans; Lipid Peroxides; Liposomes; Oxidative Stress; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Vitamin E | 2000 |
Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Cytoplasm; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Fibrinolysin; Glomerular Mesangium; Matrix Metalloproteinase Inhibitors; Plasminogen Activator Inhibitor 1; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Antiatherogenic effects of thiazolidinediones?
Topics: Animals; Arteriosclerosis; Cell Movement; Chromans; Diabetes Mellitus, Type 2; Dietary Fats; Humans; Monocytes; Receptors, LDL; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2001 |
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Arteriosclerosis; Blood Glucose; Body Weight; Cell Movement; Cells, Cultured; Chemokine CCL2; Chromans; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Endothelium, Vascular; Flavonoids; Fructose; Humans; Insulin; Lipids; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Receptors, LDL; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Vasodilator Agents | 2001 |
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Blood Glucose; Blotting, Northern; Body Weight; CD36 Antigens; Cells, Cultured; Chromans; Fatty Acids, Nonesterified; Female; Gene Expression Regulation; Hypoglycemic Agents; Insulin; Lipids; Lipoprotein Lipase; Lipoproteins; Lipoproteins, HDL; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 2001 |
Insulin resistance and nonalcoholic steatohepatitis: fat or fiction?
Topics: Chromans; Fatty Liver; Humans; Hypoglycemic Agents; Insulin Resistance; Lipolysis; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis.
Topics: Adult; Alanine Transaminase; Chromans; Fatty Liver; Female; Humans; Hypoglycemic Agents; Obesity; Pilot Projects; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone and liver function abnormalities: lessons from a prescription event monitoring study and spontaneous reporting.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; England; Fatigue; Female; Humans; Hypoglycemic Agents; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Nausea; Product Surveillance, Postmarketing; Thiazoles; Thiazolidinediones; Troglitazone; Vomiting | 2001 |
Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese.
Topics: Adult; Anti-Inflammatory Agents; Arteriosclerosis; Blood Glucose; C-Reactive Protein; Cell Nucleus; Chemokine CCL2; Chromans; Female; Humans; I-kappa B Proteins; Insulin; Intercellular Adhesion Molecule-1; Interleukin-10; Leukocytes, Mononuclear; Male; Middle Aged; NADPH Oxidases; NF-kappa B; Obesity; Phosphoproteins; Plasminogen Activator Inhibitor 1; Reactive Oxygen Species; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Effects of type-2 diabetes and troglitazone on the expression patterns of small intestinal sugar transporters and PPAR-gamma in the Zucker diabetic fatty rat.
Topics: Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Chromans; Diabetes Mellitus, Type 2; Glucose Transporter Type 2; Glucose Transporter Type 5; Hypoglycemic Agents; Immunoenzyme Techniques; Intestinal Mucosa; Membrane Glycoproteins; Monosaccharide Transport Proteins; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sodium-Glucose Transporter 1; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.
Topics: Adipose Tissue, Brown; Animals; Bezafibrate; Carrier Proteins; Chromans; Dietary Fats; Female; Gene Expression Regulation; Ion Channels; Lactation; Litter Size; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Pregnancy; Proteins; Pyrimidines; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2001 |
Troglitazone is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme in the ovary.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Animals; Binding, Competitive; Cells, Cultured; Chromans; Enzyme Inhibitors; Female; Granulosa Cells; Humans; Hypoglycemic Agents; Kinetics; Ovary; Swine; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Company played down drug's risks, report says.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Deception; Diabetes Mellitus, Type 2; Drug Industry; Government Regulation; Humans; Hypoglycemic Agents; Legislation, Drug; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2001 |
Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.
Topics: Animals; Apoptosis; Chromans; Diabetes Mellitus, Type 2; Fatty Acids; Hypoglycemic Agents; Islets of Langerhans; Lipid Metabolism; Obesity; Oxidation-Reduction; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor-gamma activation inhibits interleukin-1beta -mediated platelet-derived growth factor-alpha receptor gene expression via CCAAT/enhancer-binding protein-delta in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; Dinoprost; Gene Expression Regulation; Humans; Interleukin-1; Male; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Biguanides; Chromans; Cloning, Molecular; Humans; Kinetics; Metformin; Pioglitazone; Recombinant Proteins; Saccharomyces cerevisiae; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin.
Topics: Aged; Anticholesteremic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Disease Progression; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypoglycemic Agents; Liver Cirrhosis; Myositis; Simvastatin; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats.
Topics: Acetylcholine; Animals; Blood Glucose; Body Weight; Chromans; Diet; Dose-Response Relationship, Drug; Endothelium, Vascular; Energy Metabolism; Fatty Acids, Nonesterified; Female; Hypoglycemic Agents; In Vitro Techniques; Insulin; Leptin; Mesenteric Arteries; Nitroprusside; Norepinephrine; Obesity; Potassium Chloride; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Chromans; Humans; Hypertension; Hypoglycemic Agents; Insulin Resistance; Kidney; Kidney Failure, Chronic; Male; Proteinuria; Rats; Rats, Inbred SHR; Thiazepines; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bezafibrate; Cell Division; Chromans; Colitis; Colonic Neoplasms; Dextran Sulfate; Growth Substances; Intestinal Mucosa; Ligands; Male; Mucins; Muscle Proteins; Neuropeptides; Nucleolus Organizer Region; Peptides; Precancerous Conditions; Proteins; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Silver Staining; Thiazoles; Thiazolidinediones; Transcription Factors; Trefoil Factor-2; Trefoil Factor-3; Troglitazone | 2001 |
Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in hepG2 cells.
Topics: Bezafibrate; Blotting, Northern; Carcinoma, Hepatocellular; Chromans; Culture Media, Conditioned; Dose-Response Relationship, Drug; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Humans; Insulin; Liver Neoplasms; Oleic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Up-Regulation | 2001 |
Toxic effect of troglitazone on cultured rat hepatocytes.
Topics: Animals; Cell Nucleus; Cell Survival; Cells, Cultured; Chromans; DNA Fragmentation; Dose-Response Relationship, Drug; Hepatocytes; Hypoglycemic Agents; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats.
Topics: Aging; Amylases; Animals; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fibrosis; Homeostasis; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipase; Male; Pancreas; Rats; Rats, Inbred OLETF; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone; Trypsin | 2001 |
Other novel agents: Rationale and current status as chemopreventive agents.
Topics: Anticarcinogenic Agents; Atrasentan; Chromans; Humans; Male; Prostatic Neoplasms; Pyrrolidines; Receptors, Endothelin; Somatomedins; Thiazoles; Thiazolidinediones; Troglitazone; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors | 2001 |
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Topics: Animals; Antigen Presentation; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chromans; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ionomycin; Ligands; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.
Topics: Animals; Cell Division; Chromans; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation Mediators; Mice; Mice, Inbred C57BL; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Receptors, Cytoplasmic and Nuclear; Reference Values; RNA, Messenger; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Administration of troglitazone, but not pioglitazone, reduces insulin resistance caused by short-term dexamethasone (DXM) treatment by accelerating the metabolism of DXM.
Topics: Administration, Oral; Blood Glucose; Chromans; Dexamethasone; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metabolic Clearance Rate; Pioglitazone; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Inhibitory effect of troglitazone on glucuronidation catalyzed by human uridine diphosphate-glucuronosyltransferase 1A6.
Topics: Chromans; Glucuronosyltransferase; Humans; Hypoglycemic Agents; Naphthols; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats.
Topics: Animals; Antihypertensive Agents; Base Sequence; Chromans; Disease Models, Animal; DNA Primers; Glomerulosclerosis, Focal Segmental; Hypoglycemic Agents; Insulin Resistance; Kidney; Lipids; Macrophages; Male; Nephrectomy; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transforming Growth Factor beta; Troglitazone | 2001 |
Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Chromans; Coenzyme A Ligases; Dietary Sucrose; Ethylmaleimide; Fasting; Intracellular Membranes; Liver; Mitochondrial Proteins; Molecular Sequence Data; Rats; Subcellular Fractions; Thiazoles; Thiazolidinediones; Triazenes; Triglycerides; Troglitazone | 2001 |
Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue.
Topics: Adipose Tissue; Animals; Blood Glucose; Blotting, Western; Body Weight; Chromans; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Kidney; Male; Obesity; Organ Size; Rats; Rats, Inbred OLETF; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Troglitazone induces GLUT4 translocation in L6 myotubes.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromans; Cycloheximide; Deoxyglucose; Gene Expression Regulation; Glucose Transporter Type 1; Glucose Transporter Type 3; Glucose Transporter Type 4; Insulin; Kinetics; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Protein Transport; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2001 |
Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Chromans; Endothelial Growth Factors; Female; Humans; Hypoglycemic Agents; Insulin; Lymphokines; Male; Mice; Middle Aged; RNA, Messenger; Sex Characteristics; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors; Transcription, Genetic; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules.
Topics: Acidosis; Animals; Bicarbonates; Cell Membrane; Cell Polarity; Chromans; Dose-Response Relationship, Drug; Electrophysiology; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Male; Membrane Potentials; Perfusion; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Nucleus; Chromans; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Humans; Ligands; Liver Neoplasms; Microtubule-Associated Proteins; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Retinoblastoma Protein; RNA, Messenger; Thiazoles; Thiazolidinediones; Tissue Distribution; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Antidiabetic treatment for NASH?
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Chromans; Diabetes Mellitus; DNA-Binding Proteins; Fatty Liver; Hepatitis; Hypoglycemic Agents; Islets of Langerhans; Leptin; Liver; Obesity; Rats; Rats, Sprague-Dawley; Rats, Zucker; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Northern; Carcinoma, Papillary; Cell Division; Chromans; Humans; Male; Mice; Mice, Inbred BALB C; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Thymidine; Thyroid Neoplasms; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Response of experimental retinal neovascularization to thiazolidinediones.
Topics: Animals; Blotting, Western; Cattle; Cell Division; Cell Movement; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Fluorescein Angiography; Hypoglycemic Agents; Immunoenzyme Techniques; Injections; Lymphokines; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Animal; Phosphorylation; Retinal Ganglion Cells; Retinal Neovascularization; Retinal Vessels; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Biogenic Polyamines; Carcinogens; Chromans; Colitis; Colonic Neoplasms; Dextran Sulfate; Intestinal Mucosa; Ligands; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedback; Humans; Isoenzymes; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Efficacy and safety of troglitazone for lipodystrophy syndromes.
Topics: Adipocytes; Chemical and Drug Induced Liver Injury; Chromans; Hepatocytes; Humans; Lipodystrophy; Mitochondria; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.
Topics: CD36 Antigens; Chromans; Drug Synergism; Female; Glucose; Glycogen Synthase; Humans; Lipid Metabolism; Male; Middle Aged; Muscle, Skeletal; Nicotinic Acids; Oxidation-Reduction; Palmitic Acid; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Combined effects of troglitazone and muscle contraction on insulin sensitization in Balb-c mouse muscle.
Topics: Animals; Antimetabolites; Chromans; Deoxyglucose; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Glycogen; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Muscles; Physical Conditioning, Animal; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2001 |
Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Chromans; Diabetes Mellitus, Type 1; Fatty Liver; Female; Hepatitis; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chromans; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Glucocorticoids; Hepatocytes; Humans; Insecta; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats.
Topics: Animals; Chromans; Fatty Acids, Nonesterified; Fructose; Hypoglycemic Agents; Insulin Resistance; Leptin; Male; Metformin; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium.
Topics: Base Sequence; Cell Line, Transformed; Chromans; DNA Primers; Endothelium, Vascular; Enzyme Activation; Gene Expression; Genes, fos; Humans; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes.
Topics: alpha-Tocopherol; Animals; Cells, Cultured; Chromans; Gene Expression; Hypoglycemic Agents; Muscle, Smooth, Vascular; Pioglitazone; Promoter Regions, Genetic; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; Receptors, Thromboxane; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2001 |
Treatment of lipodystrophy with troglitazone.
Topics: Adipose Tissue; Antioxidants; Chromans; Humans; Lipodystrophy; Respiration; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells.
Topics: Base Sequence; Cell Differentiation; Cells, Cultured; Chromans; Gene Expression Regulation; Humans; Ligands; Luciferases; Macrophages; Molecular Sequence Data; Monocytes; Osteopontin; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients.
Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Muscle, Skeletal; Radiopharmaceuticals; Thiazoles; Thiazolidinediones; Tomography, Emission-Computed; Troglitazone | 2001 |
Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration.
Topics: Adamantane; Administration, Oral; Algorithms; Anti-Bacterial Agents; Antifungal Agents; Atovaquone; Chemical Phenomena; Chemistry, Physical; Chromans; Humans; Hypoglycemic Agents; Lactams; Lipids; Models, Chemical; Naphthoquinones; Pharmaceutical Preparations; Pharmacokinetics; Phenylurea Compounds; Solubility; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects.
Topics: Adult; Antioxidants; Blood Glucose; Blotting, Western; Chromans; Female; Humans; Insulin; Leukocytes, Mononuclear; Linoleic Acids; Linoleic Acids, Conjugated; Lipids; Male; Middle Aged; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.
Topics: Acute Kidney Injury; Chromans; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Liver Failure, Acute; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone and rosiglitazone inhibit the low density lipoprotein-induced vascular smooth muscle cell growth.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cell Division; Chromans; DNA; Enzyme Activation; Hypoglycemic Agents; JNK Mitogen-Activated Protein Kinases; Kinetics; Lipoproteins, LDL; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Inbred WKY; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Effects of troglitazone and voluntary running on insulin resistance induced high fat diet in the rat.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Dietary Fats; Female; Glucose; Glucose Clamp Technique; Glycogen; Hypoglycemic Agents; Insulin; Insulin Resistance; Muscle, Skeletal; Rats; Rats, Wistar; Running; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Nucleus; Cells, Cultured; Chondrocytes; Chromans; Cyclooxygenase 2; DNA; Enzyme Induction; Gene Expression Regulation; Humans; Interleukin-1; Isoenzymes; Ligands; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Binding; Proteoglycans; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone | 2001 |
Rezulin to be withdrawn from the market.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Liver; Safety; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2000 |
Warner-Lambert voluntarily withdraws Rezulin.
Topics: Chromans; Consumer Product Safety; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2000 |
Actos (pioglitazone HCL) provides a safe, effective alternative for patients formerly taking Rezulin.
Topics: Chromans; Clinical Trials as Topic; Consumer Product Safety; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2000 |
Avandia, a leading alternative for Rezulin patients, prescribed to more than 700,000 patients.
Topics: Chromans; Consumer Product Safety; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Liver; Liver Function Tests; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2000 |
Utilization of oral hypoglycemic agents in a drug-insured U.S. population.
Topics: Carbamates; Chromans; Cohort Studies; Databases as Topic; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insurance, Pharmaceutical Services; Longitudinal Studies; Managed Care Programs; Metformin; Piperidines; Retrospective Studies; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; United States | 2001 |
Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells.
Topics: Aromatase; Cell Division; Chromans; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Induction; Estrone; Female; Granulosa Cell Tumor; Humans; Ligands; Nicotinic Acids; Ovary; Promoter Regions, Genetic; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Receptors, FSH; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2001 |
The glutamine/glutamate couplet and cellular function.
Topics: Acidosis; Animals; Cell Physiological Phenomena; Chromans; Cytosol; Glutamic Acid; Glutamine; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Troglitazone improves endothelial dysfunction in patients with insulin resistance.
Topics: Adult; Arteriosclerosis; Brachial Artery; Case-Control Studies; Chromans; Endothelium, Vascular; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation | 2000 |
New labeling and use changes for Rezulin.
Topics: Chromans; Consumer Product Safety; Diabetes Mellitus, Type 2; Drug Labeling; Humans; Hypoglycemic Agents; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells.
Topics: Aged; Blotting, Western; Cell Division; Cell Line; Chromans; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Ligands; Male; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urothelium | 2001 |
PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Chromans; DNA Primers; Esophageal Neoplasms; Flow Cytometry; Humans; Immunologic Factors; Ligands; Ornithine Decarboxylase; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones.
Topics: Animals; Chromans; Diabetes Mellitus; Fatty Liver; Gene Expression; Hypoglycemic Agents; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Obesity; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2001 |
Liver enzyme monitoring in patients treated with troglitazone.
Topics: Chromans; Drug Labeling; Humans; Hypoglycemic Agents; Liver; Liver Failure, Acute; Liver Function Tests; Risk Management; Thiazoles; Thiazolidinediones; Transaminases; Troglitazone; United States; United States Food and Drug Administration | 2001 |
Ca(2+)-sensitizing effect is involved in the positive inotropic effect of troglitazone.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cardiotonic Agents; Chromans; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Heart Ventricles; Isoproterenol; Male; Patch-Clamp Techniques; Rats; Rats, Wistar; Ryanodine; Sarcoplasmic Reticulum; Thapsigargin; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Pressure | 2001 |
Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides.
Topics: Animals; Arteriosclerosis; Carotid Arteries; Cattle; Cell Division; Cells, Cultured; Chromans; Coronary Vessels; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Gene Expression; Humans; Hypoglycemic Agents; Natriuretic Peptide, C-Type; Pioglitazone; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Vasodilator Agents; Vasomotor System | 2001 |
PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.
Topics: Animals; Arteriosclerosis; Cattle; Cells, Cultured; Chromans; Drug Antagonism; Endothelium; Immunohistochemistry; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Receptors, Oxidized LDL; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Glucocorticoids; Hepatocytes; Hypoglycemic Agents; Oxidoreductases, N-Demethylating; Quinones; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
PPARgamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease.
Topics: Animals; Anti-Inflammatory Agents; Chromans; Colitis, Ulcerative; Crohn Disease; Disease Models, Animal; Inflammation; Intestines; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
A comparison of the effects of troglitazone and vitamin E on the fatty acid composition of serum phospholipids in an experimental model of insulin resistance.
Topics: Animals; Antioxidants; Blood Glucose; Blood Pressure; Chromans; Disease Models, Animal; Fatty Acids; Female; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistance; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2001 |
Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s).
Topics: Animals; Autoradiography; Carcinoma, Hepatocellular; Chromans; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin Resistance; Ligands; Liver Neoplasms; Rats; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chromans; Female; Humans; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured | 2001 |
Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Separation; Cell Survival; Chromans; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Ethanol; Flow Cytometry; G1 Phase; Humans; Ligands; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; Retinoblastoma Protein; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 2001 |
Troglitazone enhances glucose uptake induced by alpha-adrenoceptor stimulation via phosphatidylinositol 3-kinase in rat heart.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Androstadienes; Animals; Catecholamines; Chromans; Glucose; Heart; Hemodynamics; Humans; In Vitro Techniques; Insulin; Isoproterenol; Male; Myocardium; Phentolamine; Phenylephrine; Phosphates; Phosphatidylinositol 3-Kinases; Phosphocreatine; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sugar Phosphates; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Wortmannin | 2001 |
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biliary Tract; Biological Transport, Active; Cholestasis, Intrahepatic; Chromans; Cytosol; Female; Glyburide; Hypoglycemic Agents; Liver; Male; Rats; Rats, Wistar; Sex Factors; Sulfates; Taurocholic Acid; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists.
Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Renal Cell; Cell Division; Chromans; Coloring Agents; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Immunohistochemistry; Immunologic Factors; Kidney Neoplasms; Ligands; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Up-Regulation | 2001 |
Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes.
Topics: Adipocytes; Animals; Biological Transport; Chromans; Epitopes; Glucose Transporter Type 1; Glucose Transporter Type 4; Hemagglutinins; Insulin; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression.
Topics: Animals; Chromans; Cycloheximide; Dactinomycin; Drug Interactions; Energy Metabolism; Gene Expression; In Vitro Techniques; Insulin Resistance; Ligands; Male; Muscle, Skeletal; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone | 2001 |
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.
Topics: Animals; CD36 Antigens; Chromans; Emulsions; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Glucose; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lecithins; Ligands; Liver; Male; Membrane Glycoproteins; Muscle, Skeletal; Organic Anion Transporters; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Safflower Oil; Soybean Oil; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tyrosine | 2001 |
Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diacylglycerol Kinase; Disease Progression; Enzyme Activation; Glomerular Mesangium; Isoenzymes; Mice; Mitogen-Activated Protein Kinases; Pioglitazone; Plant Proteins; Protein Kinase C; Protein Kinase C beta; Rats; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism.
Topics: Animals; Antioxidants; Chromans; Gene Expression; Hepatocytes; Male; Oxidative Stress; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
Topics: Acetophenones; Adenoviridae; Animals; Aorta, Thoracic; Apoptosis; Benzopyrans; Blotting, Western; Carbazoles; Cell Division; Cells, Cultured; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Hydroquinones; Indoles; Insulin; Isoenzymes; Kinetics; Ligands; Mice; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine; Up-Regulation; Vanadates | 2001 |
Troglitazone use in polycystic ovary syndrome.
Topics: Chromans; Clinical Trials as Topic; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Antineoplastic and anti-inflammatory effects of PPAR ligands in colitis.
Topics: Animals; Antioxidants; Bezafibrate; Chromans; Colitis; Colon; DNA-Binding Proteins; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells.
Topics: Actins; Animals; Cells, Cultured; Chemokine CCL2; Chromans; Collagen Type I; G1 Phase; Ligands; NF-kappa B; Pancreas; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice.
Topics: Adipocytes; Adipose Tissue; Animals; Bone Development; Bone Marrow Cells; Chromans; Diet; Image Processing, Computer-Assisted; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Thiazoles; Thiazolidinediones; Tibia; Troglitazone | 2001 |
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Cells, Cultured; Chromans; Enzyme Activation; Enzyme Inhibitors; Immunologic Factors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pioglitazone; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Wortmannin | 2001 |
Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Blood Glucose; Blotting, Western; Chromans; Cyclic Nucleotide Phosphodiesterases, Type 3; Fatty Acids, Nonesterified; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; RNA, Messenger; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; Cell Survival; Cells, Cultured; Chromans; Cloning, Molecular; Endothelium, Vascular; Fatty Acid-Binding Proteins; Glomerular Mesangium; Hypoglycemic Agents; Kidney Glomerulus; Molecular Sequence Data; Neoplasm Proteins; Prostaglandin D2; Rabbits; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2001 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration.
Topics: Animals; Aortic Diseases; Cell Adhesion; Cell Movement; Cell Nucleus; Cells, Cultured; Chromans; Cytosol; Enzyme Inhibitors; Graft Occlusion, Vascular; Ligands; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2001 |
Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Chromans; Drug Synergism; Epoprostenol; Male; Protein Isoforms; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Sebaceous Glands; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats.
Topics: Animals; Animals, Genetically Modified; Area Under Curve; Bile; Bile Acids and Salts; Bilirubin; Biotransformation; Cholestasis; Chromans; Glucuronides; Hypoglycemic Agents; Male; Organic Anion Transporters; Quinones; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Tissue Distribution; Troglitazone | 2001 |
Troglitazone selectively inhibits glyoxalase I gene expression.
Topics: Animals; Antioxidants; Astrocytoma; Cell Culture Techniques; Cells, Cultured; Chromans; Gene Expression Regulation, Enzymologic; Glutathione; Hepatocytes; Humans; Hydroquinones; Hypoglycemic Agents; Kinetics; Lactoylglutathione Lyase; Liver; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Thiolester Hydrolases; Time Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Troglitazone inhibits glutamine metabolism in rat mesangial cells.
Topics: Alanine; Alanine Transaminase; Animals; Cells, Cultured; Chromans; Collagen; Deamination; Dose-Response Relationship, Drug; Glomerular Mesangium; Glutamic Acid; Glutamine; Glycosaminoglycans; Male; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Growth inhibition and differentiation of pancreatic cancer cell lines by PPAR gamma ligand troglitazone.
Topics: Adenocarcinoma; Cell Differentiation; Cell Division; Chromans; Dose-Response Relationship, Drug; Flow Cytometry; Ligands; Pancreatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chromans; Cyclooxygenase 2; Fibroblasts; Gene Expression; Interleukin-1; Isoenzymes; Ligands; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
PPARgamma agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cell Line, Transformed; Cell Nucleus; Chromans; Cyclin D1; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Flow Cytometry; Humans; Hypoglycemic Agents; Intestines; Ligands; Luciferases; Plasmids; Promoter Regions, Genetic; ras Proteins; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Troglitazone | 2001 |
Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo.
Topics: Adipocytes; Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Humans; Immunohistochemistry; Kinetics; Ligands; Luciferases; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenotype; Prognosis; Receptors, Cytoplasmic and Nuclear; RNA; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebellum; Chromans; Chromones; Enzyme Inhibitors; Glutamic Acid; Morpholines; Neurons; Neuroprotective Agents; Peroxisomes; Potassium; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2002 |
Increased lymphatic lipid transport in genetically diabetic obese rats.
Topics: Animals; Bile Acids and Salts; Body Weight; Carrier Proteins; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Intake; Fistula; Hypoglycemic Agents; Lymphatic System; Male; Obesity; Phosphatidylcholines; Physical Conditioning, Animal; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2002 |
Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells.
Topics: Androgens; Animals; Blotting, Western; Cells, Cultured; Chromans; DNA; Female; Fluorescent Dyes; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Organic Chemicals; Ovary; Progesterone; Prostaglandin D2; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Steroid 17-alpha-Hydroxylase; Swine; Theca Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Thiazolidinediones influence plasma steroids of male obese Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Chromans; Glucose; Hormones; Insulin; Male; Muscle, Skeletal; Obesity; Rats; Rats, Zucker; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes.
Topics: Animals; Blotting, Northern; Blotting, Western; Chromans; Hepatocytes; Humans; Hypoglycemic Agents; Ligands; Male; Mice; Mice, Inbred C57BL; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Up-Regulation; Vitamin E | 2002 |
Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors.
Topics: Animals; Arteriosclerosis; Chromans; Endothelium, Vascular; Glucuronidase; Hypertension; Kidney; Klotho Proteins; Male; Membrane Proteins; Metabolic Diseases; Obesity; Rats; Rats, Inbred OLETF; Risk Factors; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2001 |
Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.
Topics: Antineoplastic Agents; Benzoquinones; Cell Survival; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epoxy Compounds; Growth Inhibitors; Hepatocytes; Humans; Indicators and Reagents; Mixed Function Oxygenases; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2002 |
Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Chromans; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Pioglitazone; Rosiglitazone; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2001 |
Biphasic vasodilator action of troglitazone on the renal microcirculation.
Topics: Angiotensin II; Animals; Arterioles; Calcium Channel Blockers; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Male; Microcirculation; Rabbits; Renal Circulation; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
Beneficial hepatic effect of troglitazone in a patient with antimitochondrial antibody-negative primary biliary cirrhosis.
Topics: Autoantibodies; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Liver Cirrhosis, Biliary; Middle Aged; Mitochondria; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells | 2002 |
Thiazolidinediones enhance insulin-mediated suppression of fatty acid flux in type 2 diabetes mellitus.
Topics: Adipose Tissue; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucose; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Cyclin E; Dose-Response Relationship, Drug; Gene Expression Regulation; Histamine; Humans; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; U937 Cells | 2002 |
Effect of troglitazone on endothelial function in type 2 diabetic patients.
Topics: Aged; Antioxidants; Blood Glucose; Blood Pressure; Chromans; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glycated Hemoglobin; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Lipids; Lysophosphatidylcholines; Male; Middle Aged; Nitric Oxide; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cell Survival; Cells, Cultured; Chromans; Humans; Hydantoins; In Situ Nick-End Labeling; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Regulation of aromatase by nuclear receptors.
Topics: Aromatase; Benzoates; Breast Neoplasms; Cholecalciferol; Chromans; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Granulosa Cells; Humans; Ligands; Nicotinic Acids; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; RNA, Neoplasm; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Line; Chromans; Clusterin; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Gene Expression; Glycoproteins; I-kappa B Proteins; Immunologic Factors; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Molecular Chaperones; NF-KappaB Inhibitor alpha; Oligopeptides; Pancreas; Pancreatitis-Associated Proteins; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis.
Topics: Amylases; Animals; Antineoplastic Agents; Blood Glucose; Chromans; Chronic Disease; Disease Models, Animal; DNA; Gene Expression; Hypoglycemic Agents; Insulin; Interleukin-8; Macrophages, Peritoneal; Male; Organ Size; Pancreatitis; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
PPARgamma ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells.
Topics: Animals; AT Rich Sequence; Cell Line; Chromans; COS Cells; Gene Expression; Gene Expression Regulation; Genes, Reporter; Humans; Hypoglycemic Agents; Ligands; Monocytes; Mutagenesis, Site-Directed; Nuclear Proteins; Osteopontin; Promoter Regions, Genetic; Protein Binding; Rabbits; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone | 2002 |
A treatment for Mr WP: thiazolidinediones after troglitazone.
Topics: Aged; Animals; Body Mass Index; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Mice, Knockout; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adipocytes; Animals; Blotting, Western; Chromans; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Enzyme Inhibitors; Insulin; Insulin Resistance; Isoquinolines; Lipolysis; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.
Topics: Animals; Cell Line; Chromans; Dimerization; DNA; Enzyme Activation; Gene Expression; Glucokinase; Hypoglycemic Agents; Islets of Langerhans; Mice; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Troglitazone | 2002 |
Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
Topics: Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Nucleus; Chromans; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; HT29 Cells; Humans; Luciferases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.
Topics: Actins; Angiotensin II; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Cell Size; Cells, Cultured; Chromans; Disease Models, Animal; Gene Expression; Heart; Heterozygote; Hypoglycemic Agents; Ligands; Mice; Mice, Knockout; Myocardium; Organ Size; Pioglitazone; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Division; Chromans; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro.
Topics: Androgens; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Drug Combinations; Female; Gene Expression; Insulin; Luteinizing Hormone; Phosphorylation; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Swine; Theca Cells; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
Topics: Animals; Base Sequence; Cell Division; Cell Survival; Chromans; DNA Primers; Fatty Acids, Nonesterified; Insulin; Insulin Secretion; Insulinoma; Kinetics; Linoleic Acid; Oleic Acid; Palmitic Acid; Pancreatic Neoplasms; Peroxisomes; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Troglitazone stimulates pancreatic growth in normal rats.
Topics: Aging; Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Cholecystokinin; Chromans; Diet; DNA; Eating; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Organ Size; Pancreas; Proteins; Rats; Rats, Long-Evans; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1.
Topics: Alitretinoin; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Carcinoma; Cell Division; Chromans; Cyclin D1; Dose-Response Relationship, Drug; Drug Synergism; G1 Phase; Humans; Pancreatic Neoplasms; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Tretinoin; Troglitazone; Tumor Cells, Cultured | 2002 |
Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression.
Topics: Aging; Animals; Body Composition; Chromans; Eating; Fasting; Gene Expression; Hypoglycemic Agents; Hypothalamus; In Situ Hybridization; Insulin; Leptin; Male; Neuropeptide Y; Protein Precursors; Rats; Rats, Inbred BN; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Weight Gain | 2002 |
Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Blood Pressure; Body Weight; Chromans; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hemodynamics; Hypoglycemic Agents; Kidney Glomerulus; Male; Rats; Rats, Inbred SHR; Reference Values; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Chronic toxicity in monkeys with the thiazolidinedione antidiabetic agent troglitazone.
Topics: Administration, Oral; Anemia; Animals; Area Under Curve; Bile Ducts, Intrahepatic; Cholesterol; Chromans; Dose-Response Relationship, Drug; Erythrocyte Count; Female; Hyperplasia; Hypoglycemic Agents; Liver; Macaca fascicularis; Male; Organ Size; Thiazoles; Thiazolidinediones; Toxicity Tests; Troglitazone | 2002 |
Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures.
Topics: Adult; Cells, Cultured; Cholesterol Esters; Chromans; Dose-Response Relationship, Drug; Fatty Acid Desaturases; Female; Gene Amplification; Gene Expression Regulation, Enzymologic; Humans; Hypoglycemic Agents; Kinetics; Linoleoyl-CoA Desaturase; Male; Methylation; Muscle, Skeletal; Receptors, Cytoplasmic and Nuclear; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2002 |
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Death; Cell Division; Cells, Cultured; Chromans; Chromones; Enzyme Inhibitors; Glomerular Mesangium; Humans; Morpholines; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro.
Topics: Animals; Cells, Cultured; Chromans; Clofibrate; Collagen Type I; Extracellular Matrix Proteins; Glomerular Mesangium; Hyperglycemia; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Chromans; Dose-Response Relationship, Drug; Fatty Acid Synthases; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hypoglycemic Agents; Insulin; Mice; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Troglitazione affects survival of human osteosarcoma cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Count; Cell Division; Cell Survival; Chromans; Humans; Osteosarcoma; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
[Diabetic dyslipoproteinemia: physiopathological bases and treatment prospects].
Topics: Anticholesteremic Agents; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Chromans; Clinical Trials as Topic; Coronary Disease; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Hyperlipoproteinemias; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Male; Risk Factors; Simvastatin; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Pioglitazone-induced hepatic injury in a patient previously receiving troglitazone with success.
Topics: Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liver; Middle Aged; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus.
Topics: Adipose Tissue; Animals; Blood Glucose; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Male; Monosaccharide Transport Proteins; Muscle Proteins; Obesity; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Reference Values; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2002 |
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells.
Topics: Apoptosis; Cell Division; Cell Survival; Chromans; Colonic Neoplasms; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Ligands; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.
Topics: Animals; Chromans; Drug Interactions; Fatty Acids, Nonesterified; Hypoglycemic Agents; In Vitro Techniques; Islets of Langerhans; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Effect of PPARgamma ligands on the viability of gastric epithelial cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Chromans; DNA, Complementary; Dose-Response Relationship, Drug; Epithelial Cells; Gastric Mucosa; Gene Expression Regulation; Humans; Immunologic Factors; Ligands; Microscopy, Phase-Contrast; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Chromans; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Gene Expression; HL-60 Cells; Humans; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; TCF Transcription Factors; Thiazoles; Thiazolidinediones; Transcription Factor 7-Like 2 Protein; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Crystal structure of an antidiabetic agent, (+/-)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazollidine, troglitazone dihydrate.
Topics: Chromans; Crystallization; Crystallography, X-Ray; Hypoglycemic Agents; Stereoisomerism; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Osteosarcoma; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Neoplasm; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Tretinoin; Troglitazone; Tumor Cells, Cultured | 2002 |
Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells.
Topics: Acid-Base Equilibrium; Acids; Alanine; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Glomerular Mesangium; Hydrogen-Ion Concentration; Hypoglycemic Agents; Intracellular Fluid; Lactic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Adhesion; Cell Division; Chromans; Collagen Type I; Colonic Neoplasms; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix Proteins; Fibronectins; Flow Cytometry; Humans; Integrins; Laminin; Matrix Metalloproteinase 7; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Topics: Animals; Cell Culture Techniques; Cell Death; Chromans; Clofibrate; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Escherichia coli; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred ICR; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxisome Proliferators; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).
Topics: Acarbose; Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Atorvastatin; Chromans; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrroles; Simvastatin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
Topics: 3T3 Cells; Adipocytes; Adipose Tissue; Animals; Chromans; Dexamethasone; Epididymis; Epinephrine; Gene Expression; Glucocorticoids; Glucose; Hormones, Ectopic; Human Growth Hormone; Hypoglycemic Agents; Insulin; Intercellular Signaling Peptides and Proteins; Male; Mice; Nerve Growth Factor; Proteins; Resistin; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats.
Topics: Animals; Chromans; Cystathionine beta-Synthase; Erythrocytes; Female; Homocysteine; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Zucker; S-Adenosylhomocysteine; S-Adenosylmethionine; Thiazoles; Thiazolidinediones; Thinness; Troglitazone | 2002 |
PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages.
Topics: Cell Differentiation; Cell Line; Cholesterol; Chromans; Coenzyme A Ligases; DNA, Antisense; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Macrophages; Oligonucleotides; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Response Elements; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2002 |
Troglitazone inhibits growth and improves insulin signaling by suppression of angiotensin II action in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Arteriosclerosis; Cell Division; Cells, Cultured; Chromans; Depression, Chemical; DNA; Growth Substances; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 2002 |
Pharmacological treatments for GH-induced insulin resistance.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Chromans; Drug Interactions; Human Growth Hormone; Hypoglycemic Agents; Inositol; Insulin; Insulin Resistance; Male; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
PPAR activators inhibit endothelial cell migration by targeting Akt.
Topics: Apoptosis; Blotting, Western; Cell Movement; Cells, Cultured; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fenofibrate; Flavonoids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipid Metabolism; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2002 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.
Topics: Adipose Tissue, Brown; Administration, Oral; Animals; Area Under Curve; Bone Marrow; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Chromans; Dose-Response Relationship, Drug; Heart; Hemangiosarcoma; Hypoglycemic Agents; Liver; Liver Neoplasms; Longevity; Mice; Myocardium; Rats; Rats, Wistar; Species Specificity; Survival Analysis; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription.
Topics: Active Transport, Cell Nucleus; Adipocytes; Animals; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chromans; COS Cells; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Humans; Keratinocytes; Ligands; Mice; Neoplasm Proteins; Nerve Tissue Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Troglitazone; Tumor Suppressor Proteins | 2002 |
Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Blotting, Northern; Brain Neoplasms; Cell Division; Chromans; DNA; DNA Fragmentation; DNA, Complementary; Flow Cytometry; Glioblastoma; Humans; In Situ Nick-End Labeling; Ligands; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands.
Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Chromans; DNA Replication; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Ligands; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2002 |
Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer.
Topics: Antineoplastic Agents; Cell Division; Chromans; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Humans; Pancreatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis.
Topics: Animals; Cell Movement; Chemokine CCL2; Chromans; Gene Expression; Glomerulonephritis; Hypoglycemic Agents; Macrophages; Male; Monocytes; NF-kappa B; Nuclear Proteins; Rats; Rats, Wistar; Receptors, CCR2; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone | 2002 |
Enhanced inhibition of L-type calcium currents by troglitazone in streptozotocin-induced diabetic rat cardiac ventricular myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chromans; Diabetes Mellitus, Experimental; Heart Ventricles; Hypoglycemic Agents; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver.
Topics: Animals; Arylsulfotransferase; Cell Line; Chromans; Cytosol; Enzyme Activation; Female; Humans; Hypoglycemic Agents; Isoenzymes; Liver; Polymorphism, Genetic; Rabbits; Substrate Specificity; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose.
Topics: Adipose Tissue; Aromatase; Base Sequence; Chromans; Colforsin; Female; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Tetradecanoylphorbol Acetate; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone.
Topics: Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Cholestasis; Chromans; Female; Humans; Hypoglycemic Agents; Liver Function Tests; Middle Aged; Rosiglitazone; Thiazoles; Thiazolidinediones; Transaminases; Troglitazone | 2002 |
Troglitazone improves blood flow by inhibiting neointimal formation after balloon injury in Otsuka Long-Evans Tokushima fatty rats.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Carotid Arteries; Catheterization; Cell Division; Chromans; Hyperplasia; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle, Smooth, Vascular; Rats; Rats, Long-Evans; Systole; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane.
Topics: Animals; Butyrates; Chromans; Coenzyme A Ligases; Endoplasmic Reticulum; Female; Gemfibrozil; Hypoglycemic Agents; Hypolipidemic Agents; Intracellular Membranes; Isoenzymes; Ligands; Liver; Mitochondria; Mitochondrial Proteins; Peroxisomes; Phenylurea Compounds; Potassium Chloride; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Subcellular Fractions; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation | 2002 |
Troglitazone induces G1 arrest by p27(Kip1) induction that is mediated by inhibition of proteasome in human gastric cancer cells.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Division; Chromans; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Humans; Ligands; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins p21(ras); Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Stomach Neoplasms; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Body Weight; Caloric Restriction; Chromans; Data Interpretation, Statistical; Female; Glucose Tolerance Test; Humans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Thiazoles; Thiazolidinediones; Troglitazone; Uric Acid | 2002 |
Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor gamma-mediated signalling pathway.
Topics: Adipocytes; Arthritis, Rheumatoid; Cell Differentiation; Cells, Cultured; Chromans; DNA; Fibroblasts; Gelatinases; Humans; In Vitro Techniques; Interleukin-6; Interleukin-8; Ligands; Matrix Metalloproteinase Inhibitors; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Peroxisome proliferator-activated receptor-gamma activators inhibit endothelin-1-related cardiac hypertrophy in rats.
Topics: Analysis of Variance; Animals; Cardiomegaly; Chromans; Endothelin-1; Endothelins; Male; Natriuretic Peptide, Brain; Pioglitazone; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stimulation, Chemical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Effective use of thiazolidinediones for the treatment of glucocorticoid-induced diabetes.
Topics: Administration, Oral; Adult; Biomarkers; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Fructosamine; Glucocorticoids; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Leptin; Middle Aged; Prednisone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
PPARgamma and vascular inflammation: adding another piece to the puzzle.
Topics: Animals; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Luciferases; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 2002 |
Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma.
Topics: Animals; Carotid Arteries; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Interleukin-6; Luciferases; Male; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2002 |
Effects of troglitazone on HepG2 viability and mitochondrial function.
Topics: Adenosine Triphosphate; Cell Death; Cell Survival; Chromans; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Microscopy, Confocal; Microscopy, Electron; Mitochondria, Liver; Permeability; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
Topics: Acidosis; Alanine Transaminase; Animals; Cell Line; Chromans; Epithelial Cells; Glutamine; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kidney; L-Lactate Dehydrogenase; Nitrogen; Nitrogen Isotopes; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Melanoma; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Skin Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Pretreatment with troglitazone decreases lethality during endotoxemia in mice.
Topics: Administration, Oral; Animals; Chromans; Diet; Disease Models, Animal; Drug Interactions; Endotoxemia; Female; Hypoglycemic Agents; Interleukin-6; Lethal Dose 50; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Butadienes; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Chromans; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Insulin; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Dinoprostone; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Humans; Immunohistochemistry; Ligands; Male; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Testicular Neoplasms; Testis; Thiazoles; Thiazolidinediones; Thiazolidines; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Biochemical correlates of thiazolidinedione-induced adipocyte differentiation by high-resolution magic angle spinning NMR spectroscopy.
Topics: 3T3 Cells; Adipocytes; Animals; Antineoplastic Agents; Cell Differentiation; Cells, Cultured; Chromans; Flow Cytometry; Humans; Ligands; Liposarcoma; Magnetic Resonance Spectroscopy; Mice; Phosphatidylcholines; Phosphorylcholine; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
PPAR alpha stimulates the rat gastrin-producing cell.
Topics: Animals; Chromans; Clofibric Acid; Female; Fibric Acids; Gastric Mucosa; Gastrins; Ligands; Parietal Cells, Gastric; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone.
Topics: Amnion; Chorion; Chromans; Culture Techniques; Decidua; DNA; Female; Humans; Interleukin-6; Interleukin-8; L-Lactate Dehydrogenase; Ligands; NF-kappa B; Placenta; Pregnancy; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
Topics: Adipose Tissue; Animals; Cell Fractionation; Chromans; Diabetes Mellitus; Disease Models, Animal; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Direct chiral separation of troglitazone stereoisomers using reversed-phase high-performance liquid chromatography.
Topics: Chemistry, Pharmaceutical; Chromans; Chromatography, High Pressure Liquid; Reproducibility of Results; Stereoisomerism; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase.
Topics: Adenoviridae; Animals; Antioxidants; Chromans; Dietary Fats; DNA, Complementary; Down-Regulation; Fats; Leptin; Linear Models; Liver; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Stearoyl-CoA Desaturase; Thiazoles; Thiazolidinediones; Troglitazone; Up-Regulation | 2002 |
Activation of peroxisome proliferator-activated receptor-gamma inhibits apoptosis induced by serum deprivation in LLC-PK1 cells.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Chromans; Culture Media, Serum-Free; Enzyme Inhibitors; LLC-PK1 Cells; Receptors, Cytoplasmic and Nuclear; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Wortmannin | 2002 |
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
Topics: Aging; Animals; Base Sequence; Bone Development; Bone Marrow Cells; Bone Morphogenetic Proteins; Bone Resorption; Cells, Cultured; Chromans; DNA Primers; Humans; Interleukin-11; Male; Mice; Mice, Transgenic; Recombinant Proteins; Thiazoles; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2002 |
Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors.
Topics: Adenosine Triphosphate; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Chromans; Coloring Agents; Female; Formazans; Glutathione; Hepatocytes; Humans; Hypoglycemic Agents; Infant; Liver Diseases; Male; Middle Aged; Neutral Red; Oxazines; Rosiglitazone; Sex Factors; Smoking; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone; Xanthenes | 2002 |
Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes.
Topics: Adenosine Triphosphate; Arylsulfotransferase; Chromans; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Hepatocytes; Humans; Hypoglycemic Agents; Isoenzymes; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Identification of glutathione conjugates of troglitazone in human hepatocytes.
Topics: Aged; Aged, 80 and over; Chromans; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Glucuronides; Glutathione; Hepatocytes; Humans; Hypoglycemic Agents; Isoenzymes; Male; Mass Spectrometry; Middle Aged; Sulfates; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Effect of peroxisome proliferator-activated receptor gamma on thromboxane A(2) and prostaglandin E(2) production in macrophage cell lines.
Topics: Animals; Cell Line; Chromans; Dinoprostone; Humans; Ligands; Macrophages; Monocytes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Thromboxane A2; Transcription Factors; Transfection; Troglitazone | 2002 |
Effects of berberine on glucose metabolism in vitro.
Topics: Berberine; Cell Line; Chromans; Dose-Response Relationship, Drug; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Phenotype; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
Topics: Androstadienes; Cell Line; Cell Movement; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Leptin; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins; Wortmannin | 2002 |
Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Chromans; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Ligands; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Synergistic effects of troglitazone and oleate on the translatability of preproinsulin mRNA from INS-1 cells.
Topics: Animals; Cell Line; Chromans; Drug Synergism; Insulin; Insulin Secretion; Oleic Acid; Proinsulin; Protein Biosynthesis; Protein Precursors; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Physical property of troglitazone, an equal mixture of four stereoisomers.
Topics: Chemistry, Pharmaceutical; Chromans; Chromatography, High Pressure Liquid; Humidity; Solubility; Stereoisomerism; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10.
Topics: Catalysis; Chromans; Dose-Response Relationship, Drug; Glucuronides; Glucuronosyltransferase; Humans; Intestines; Metabolic Clearance Rate; Microsomes, Liver; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
[Meta-analysis shows: insulin sensitizer is safe for the liver].
Topics: Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Hypoglycemic Agents; Meta-Analysis as Topic; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Topics: Adipocytes; Animals; Cell Differentiation; Chromans; Cyclic AMP-Dependent Protein Kinases; Embryo, Mammalian; Enzyme Inhibitors; Hydrolysis; Isoproterenol; Isoquinolines; Lipase; Lipolysis; Mice; Mice, Knockout; Sterol Esterase; Sulfonamides; Thiazoles; Thiazolidinediones; Tissue Extracts; Triglycerides; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets.
Topics: Animals; Cell Line; Cell Movement; Chromans; Cytokines; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Immediate-Early Proteins; Inflammation; Leukocytes; Ligands; Lung; Male; Mice; Mice, Inbred C57BL; Phagocytes; Rats; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; RNA, Messenger; Survival Analysis; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Chromans; Colorectal Neoplasms; Dactinomycin; DNA Primers; DNA-Binding Proteins; Early Growth Response Protein 1; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; K562 Cells; Plasmids; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Cells, Cultured; Zinc Fingers | 2003 |
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis.
Topics: Acute Disease; Animals; Antibody Formation; Antioxidants; Chromans; Colitis; Cytokines; Disease Models, Animal; Hypoglycemic Agents; Ligands; Mice; Mice, Inbred C57BL; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Th2 Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Apolipoprotein A-I expression in rats is not altered by troglitazone.
Topics: Animals; Apolipoprotein A-I; Body Weight; Chromans; Gene Expression Regulation; Male; Rats; Rats, Inbred F344; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.
Topics: Adipose Tissue; Animals; Chromans; Esterification; Fasting; Fatty Acids, Nonesterified; Glycerol; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Lipolysis; Male; Obesity; Palmitic Acids; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Altered renal microvascular response in Zucker obese rats.
Topics: Acetylcholine; Animals; Arterioles; Blood Pressure; Chromans; Hydronephrosis; In Vitro Techniques; Insulin; Microcirculation; Norepinephrine; Obesity; Rats; Rats, Zucker; Reference Values; Renal Artery; Renal Circulation; Thiazoles; Thiazolidinediones; Troglitazone; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
[News on diabetes and public health perspectives].
Topics: Administration, Oral; Adult; Chromans; Clinical Trials as Topic; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Exercise; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Metformin; Obesity; Pancreas Transplantation; Patient Education as Topic; Pregnancy; Public Health; Risk Factors; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2002 |
Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes.
Topics: Acetylcysteine; Albumins; Antioxidants; Cell Line, Transformed; Cell Polarity; Chromans; Cytochrome c Group; Free Radical Scavengers; Hepatocytes; Humans; Hydrogen Peroxide; Ligands; Microscopy, Electron; Mitochondria; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
[Anti-inflammatory effect of peroxisome proliferator-activated receptor-gamma incultured human mesangial cells].
Topics: Cells, Cultured; Chromans; Glomerular Mesangium; Glomerulonephritis; Humans; Interleukin-1; Interleukin-6; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chromans; Female; Hospitalization; Humans; Hypoglycemic Agents; Incidence; Liver Failure, Acute; Male; Middle Aged; Retrospective Studies; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Carrier Proteins; Chromans; Cycloheximide; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Did this drug cause my patient's hepatitis?
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Pioglitazone; Product Surveillance, Postmarketing; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
Topics: Aging; Animals; Chromans; Dietary Fats; Heterozygote; Insulin Resistance; Metabolism, Inborn Errors; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Chromans; Colon; Colonic Neoplasms; Female; Immunohistochemistry; Ligands; Mice; Mice, Inbred BALB C; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data.
Topics: Apoptosis; Cell Survival; Chromans; Cyclosporine; Dose-Response Relationship, Drug; Drug Antagonism; Hepatocytes; Humans; Hypoglycemic Agents; Mitochondria, Liver; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2003 |
Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Endothelium, Vascular; Hypoglycemic Agents; Isometric Contraction; Lipid Peroxidation; Lipids; Male; Metformin; Muscle Contraction; Muscle Relaxation; Oxidation-Reduction; Pioglitazone; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents | 2003 |
Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide.
Topics: Animals; Brain; Cells, Cultured; Cerebrovascular Circulation; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glycation End Products, Advanced; Hepatocytes; Humans; Hyperglycemia; Hypoglycemic Agents; Lactoylglutathione Lyase; Pyruvaldehyde; Rats; tert-Butylhydroperoxide; Thiazoles; Thiazolidinediones; Thiolester Hydrolases; Troglitazone; Up-Regulation | 2002 |
The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.
Topics: 3T3 Cells; Adenoviridae; Adipocytes; Animals; Antioxidants; Cell Differentiation; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Glucuronidase; Glucuronosyltransferase; Hepatocytes; Humans; Macrophages; Mice; Microsomes, Liver; Mutagenesis, Site-Directed; Plasmids; Promoter Regions, Genetic; Protein Binding; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; UDP-Glucuronosyltransferase 1A9; Xenobiotics | 2003 |
Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.
Topics: Animals; Cell Line; Chromans; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Uncoupling Protein 2 | 2002 |
Medical monitoring for pharmaceutical injuries: tort law for the public's health?
Topics: Appetite Depressants; Chromans; Dexfenfluramine; Drug Industry; Drug Monitoring; Fenfluramine; Health Policy; Humans; Hypoglycemic Agents; Liability, Legal; Phentermine; Product Surveillance, Postmarketing; Public Health; Thiazoles; Thiazolidinediones; Troglitazone; United States | 2003 |
Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists.
Topics: Aged; Cell Division; Chromans; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Ligands; Male; Middle Aged; Neoplasm Staging; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Urinary Bladder; Urinary Bladder Neoplasms | 2003 |
Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Chromans; Cyclin A; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Rats; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade.
Topics: Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Chromans; Cytokines; Electrophoretic Mobility Shift Assay; HIV Envelope Protein gp120; MAP Kinase Kinase Kinases; Mice; NF-kappaB-Inducing Kinase; Plasmids; Precipitin Tests; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adrenal Glands; Animals; Cattle; Chromaffin Cells; Chromans; Clofibrate; Culture Media; Down-Regulation; Epoprostenol; Insulin; Insulin Receptor Substrate Proteins; Iodine Radioisotopes; Ketone Bodies; Membrane Proteins; Phosphoproteins; Phosphorylation; Receptor, Insulin; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 2003 |
Structural studies on the impurities of troglitazone.
Topics: Chromans; Chromatography, High Pressure Liquid; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiazoles; Thiazolidinediones; Troglitazone; X-Ray Diffraction | 2003 |
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Topics: Anilides; Aorta; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hypoglycemic Agents; Inhibitor of Differentiation Protein 2; Muscle, Smooth, Vascular; Oxazoles; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine | 2003 |
GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Topics: Actins; Cell Differentiation; Cells, Cultured; Chromans; Dimethyl Sulfoxide; DNA-Binding Proteins; GATA6 Transcription Factor; Humans; Immunohistochemistry; Muscle, Smooth, Vascular; Oligopeptides; Phenotype; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2003 |
15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Chromans; Cycloheximide; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Hypoglycemic Agents; Immunologic Factors; Inhibitor of Apoptosis Proteins; Intramolecular Oxidoreductases; Lipocalins; Luciferases; Microtubule-Associated Proteins; Neoplasm Proteins; Prostaglandin D2; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Survivin; Thiazoles; Thiazolidinediones; Troglitazone; Ubiquitin-Protein Ligases; Umbilical Veins | 2003 |
A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Cohort Studies; Female; Humans; Hypoglycemic Agents; Incidence; Insulin; Liver; Liver Failure; Male; Metformin; Middle Aged; Proportional Hazards Models; Severity of Illness Index; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Acute effects of troglitazone and nitric oxide on glucose uptake in L929 fibroblast cells.
Topics: Animals; Chromans; Deoxyglucose; Dose-Response Relationship, Drug; Drug Combinations; Fibroblasts; Hypoglycemic Agents; Mice; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2003 |
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligands; Prostaglandin D2; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Uterine Neoplasms | 2003 |
Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression; HL-60 Cells; Humans; Ligands; Oncogenes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Troglitazone-binding to LDL and its glycated modifications: its role in cell-catalysed and Cu-mediated LDL-oxidation.
Topics: Adult; Cell Survival; Chromans; Copper; Dinoprost; Endothelium, Vascular; Glycoproteins; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lipoproteins, LDL; Malondialdehyde; Oxidation-Reduction; Protein Binding; Thiazoles; Thiazolidinediones; Thiobarbituric Acid Reactive Substances; Troglitazone | 2000 |
Troglitazone stimulates IGF-binding protein-1 by a PPAR gamma-independent mechanism.
Topics: Carcinoma, Hepatocellular; Chromans; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Insulin-Like Growth Factor Binding Protein 1; Kinetics; Liver Neoplasms; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.
Topics: Actins; Animals; Antineoplastic Agents; Antioxidants; Cell Division; Chromans; Collagen Type I; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Fibronectins; Gene Expression; Hepatocytes; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Troglitazone reduces activity of the Na+/H+ exchanger in fructose-fed borderline hypertensive rats.
Topics: Animals; Bezafibrate; Blood Glucose; Blood Platelets; Blood Pressure; Calcium; Chromans; Diet; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Fructose; Hydrogen-Ion Concentration; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Hypolipidemic Agents; Insulin; Male; Propionates; Rats; Sodium-Hydrogen Exchangers; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Vasodilator Agents | 2003 |
Troglitazone-induced liver failure: a case study.
Topics: Age Distribution; Aged; Chemical and Drug Induced Liver Injury; Chromans; Chronic Disease; Confidence Intervals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug and Narcotic Control; Female; Humans; Liver Failure; Liver Failure, Acute; Liver Function Tests; Male; Middle Aged; Odds Ratio; Probability; Registries; Risk Assessment; Severity of Illness Index; Sex Distribution; Survival Rate; Thiazoles; Thiazolidinediones; Troglitazone; United States; United States Food and Drug Administration | 2003 |
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Topics: Antigens, Neoplasm; Apoptosis; Chromans; DNA Topoisomerases, Type II; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Etoposide; Flow Cytometry; Gene Expression; Humans; Jurkat Cells; Leukemia; Ligands; Mutagenesis; Phosphoproteins; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Topoisomerase II Inhibitors; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 2003 |
Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects.
Topics: Adult; CD36 Antigens; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Nonesterified; Female; Gene Expression; Humans; Insulin Resistance; Male; Membrane Glycoproteins; Middle Aged; Muscle, Skeletal; Organic Anion Transporters; Oxidation-Reduction; Palmitic Acid; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones.
Topics: Animals; Cells, Cultured; Chromans; Glucose; Hydrogen Peroxide; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Swine; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1; Troglitazone | 2003 |
Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Chromans; Cytokines; Diabetes Mellitus, Type 1; Female; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Islets of Langerhans; Mice; Mice, Inbred NOD; Rats; Spleen; T-Lymphocytes; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chromans; Disease Models, Animal; Gene Expression Regulation; Heart; Hypoglycemic Agents; Myocardial Ischemia; Myocardial Reperfusion Injury; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Ventricular Dysfunction, Left | 2003 |
Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromans; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Down-Regulation; Drug Resistance, Neoplasm; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Protein Binding; Protein Serine-Threonine Kinases; RNA, Messenger; S-Phase Kinase-Associated Proteins; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Adipocytes; Animals; Blotting, Western; Cell Nucleus; Chromans; DNA; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Genes, Reporter; HeLa Cells; Humans; Mice; Mutation; NF-kappa B; Oligonucleotide Array Sequence Analysis; Plasmids; Platelet Aggregation Inhibitors; Protein Binding; Proto-Oncogene Proteins c-rel; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Topics: Aged; Alanine Transaminase; Alleles; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chromans; Data Collection; Diabetes Mellitus, Type 2; DNA; DNA Primers; Female; Gene Frequency; Genotype; Glutathione Transferase; Humans; Hypoglycemic Agents; Japan; Male; Middle Aged; Polymorphism, Genetic; Sex Characteristics; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation.
Topics: Becaplermin; Cell Count; Cell Cycle; Cell Division; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Insulin; Ligands; Mammary Arteries; Mitogens; Muscle, Smooth, Vascular; Phosphorylation; Pioglitazone; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Radial Artery; Receptors, Cytoplasmic and Nuclear; Retinoblastoma Protein; Rosiglitazone; Saphenous Vein; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages.
Topics: Bezafibrate; Cholesterol; Chromans; Fenofibrate; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Monocytes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli.
Topics: Animals; Cells, Cultured; Chromans; Enzyme Activation; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; Nitric Oxide; Phosphorylation; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Staphylococcus aureus; Thiazoles; Thiazolidinediones; Thromboxane B2; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Line, Transformed; Cell Survival; Chromans; Cytoprotection; Glutamic Acid; Ligands; Neuroprotective Agents; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Retinal Ganglion Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Effects of troglitazone on intracellular cholesterol distribution and cholesterol-dependent cell functions in MA-10 Leydig tumor cells.
Topics: Cell Membrane; Cholesterol; Cholesterol Esters; Chromans; Humans; Hypoglycemic Agents; Leydig Cell Tumor; Receptors, Cytoplasmic and Nuclear; Sterol O-Acyltransferase; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways.
Topics: 3T3 Cells; Adipocytes; Animals; Blotting, Northern; Cell Differentiation; Chromans; DNA Replication; Gene Expression Regulation; Genes, Reporter; Insulin; Kinetics; Lipoprotein Lipase; MAP Kinase Signaling System; Mice; Thiazoles; Thiazolidinediones; Thioctic Acid; Thymidine; Transcription Factors; Troglitazone | 2003 |
Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test.
Topics: Adult; Anti-Inflammatory Agents; Breath Tests; Chromans; Corticosterone; Cushing Syndrome; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Diagnostic Errors; Drug Interactions; Enzyme Activation; Erythromycin; Female; Glucocorticoids; Humans; Hydrocortisone; Hypoglycemic Agents; Male; Protein Synthesis Inhibitors; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adipose Tissue; Adolescent; Adult; Aged; Body Mass Index; Cell Differentiation; Cells, Cultured; Chromans; Female; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Middle Aged; Stromal Cells; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Binding Sites; Blotting, Northern; Caspase Inhibitors; Cell Division; Cells, Cultured; Chromans; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; GADD45 Proteins; Gene Expression Regulation; Host Cell Factor C1; Humans; Intracellular Signaling Peptides and Proteins; Luciferases; Muscle, Smooth, Vascular; Mutation; Octamer Transcription Factor-1; Promoter Regions, Genetic; Protein Binding; Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2003 |
PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes.
Topics: Anilides; Animals; Cells, Cultured; Chromans; Cyclooxygenase 2; Gene Expression Regulation; Interleukin-1; Intramolecular Oxidoreductases; Isoenzymes; Myocytes, Cardiac; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Effect of troglitazone on vascular and glucose metabolic actions of insulin in high-sucrose-fed rats.
Topics: Animals; Biological Transport, Active; Blood Pressure; Blood Vessels; Body Weight; Chromans; Diet; Eating; Glucose; Glucose Clamp Technique; Heart Rate; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sucrose; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilation | 2003 |
Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.
Topics: Acyl-CoA Oxidase; Animals; Chickens; Chromans; COUP Transcription Factor II; COUP Transcription Factors; DNA-Binding Proteins; Down-Regulation; Enzyme Repression; Male; Mice; Myocardium; Oxidoreductases; Receptors, Steroid; Repressor Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway.
Topics: Adenocarcinoma; Alitretinoin; Antineoplastic Agents; Apoptosis; Biliary Tract Neoplasms; Cell Differentiation; Cell Division; Chromans; Drug Screening Assays, Antitumor; Drug Synergism; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tretinoin; Troglitazone; Tumor Cells, Cultured | 2003 |
Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
Topics: Adipocytes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Chromans; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hydrocortisone; Immunohistochemistry; Inclusion Bodies; Indomethacin; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Microscopy, Electron; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator.
Topics: Chromans; Humans; Integrins; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Pancreatic Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Tissue Plasminogen Activator; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins.
Topics: Animals; Blood Glucose; Blotting, Western; Cardiotonic Agents; Chromans; Connexin 43; Dogs; Dose-Response Relationship, Drug; Free Radical Scavengers; Hemodynamics; Insulin; Male; Microscopy, Confocal; Myocardial Infarction; Myocardium; Phosphorylation; Superoxides; Thiazoles; Thiazolidinediones; Troglitazone | 2003 |
Expression of NPM-RARalpha fusion gene in hematopoietic cells confers sensitivity to troglitazone-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Differentiation; Cell Division; Chromans; Enzyme Induction; Hematopoietic Stem Cells; Humans; Neoplasm Proteins; Oncogene Proteins, Fusion; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; U937 Cells | 2003 |
Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone.
Topics: Amino Acid Chloromethyl Ketones; Analysis of Variance; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspase Inhibitors; Caspases; Cell Survival; Chromans; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Immunologic Factors; Mouth Neoplasms; Oligopeptides; Prostaglandin D2; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Novel PPARgamma-dependent and independent effects for thiazolidinediones.
Topics: Animals; Bezafibrate; Body Weight; Chromans; Diabetes Mellitus, Type 2; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Proteins; Mice; Monocytes; Pancreas; Pioglitazone; PPAR alpha; PPAR gamma; Pregnancy Proteins; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Troglitazone; Tumor Necrosis Factor-alpha | 2003 |
An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.
Topics: Adenosine Triphosphate; Albendazole; Amitriptyline; Animals; Buthionine Sulfoximine; Carbamazepine; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Chromans; Coculture Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Enzyme Activation; Flutamide; Glutathione; Humans; Isoniazid; Microsomes; Ochratoxins; Piperazines; Quinidine; Substrate Specificity; Tamoxifen; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Toxicity Tests; Triazolam; Troglitazone; Xenobiotics | 2005 |
Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.
Topics: Chromans; Clozapine; Glutathione; Humans; Indoles; Isotope Labeling; Isotopes; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Naphthalenes; Pharmaceutical Preparations; Sensitivity and Specificity; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 2005 |
Effect of ecdysterone on glucose metabolism in vitro.
Topics: Animals; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Ecdysterone; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liver Neoplasms; Metformin; Mice; Mice, Transgenic; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2006 |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.
Topics: Albumins; Anilides; Animals; Cells, Cultured; Cholesterol; Chromans; Farnesol; Kidney Tubules, Proximal; Ligands; Mevalonic Acid; Opossums; Polyisoprenyl Phosphates; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Troglitazone | 2006 |
Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Topics: Alitretinoin; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromans; Dimerization; Fenofibrate; Gene Expression; HT29 Cells; Humans; K562 Cells; PPAR alpha; PPAR gamma; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Semaphorins; Thiazoles; Thiazolidinediones; Tretinoin; Troglitazone | 2006 |
Troglitazone, a peroxisome proliferator-activated receptor gamma ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Nucleus; Chromans; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Ligands; Models, Biological; PPAR gamma; Protein Transport; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2008 |
Stearic acid-induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone.
Topics: Animals; Cell Death; Chick Embryo; Chromans; Decanoic Acids; Lipid Metabolism; Myocytes, Cardiac; Oleic Acids; Stearic Acids; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2009 |
Role of peroxisome proliferator-activated receptor beta/delta in chicken adipogenesis.
Topics: Adipogenesis; Anilides; Animals; Cell Differentiation; Chickens; Chromans; Fatty Acid-Binding Proteins; Oleic Acid; PPAR delta; PPAR gamma; PPAR-beta; Thiazoles; Thiazolidinediones; Troglitazone | 2009 |
Peroxisome proliferator-activated receptor gamma antagonists decrease Na+ transport via the epithelial Na+ channel.
Topics: Anilides; Animals; Benzamides; Biological Transport; Cell Survival; CHO Cells; Chromans; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Epithelial Sodium Channels; Hypoglycemic Agents; Insulin; Membrane Potentials; Pioglitazone; PPAR gamma; Pyridines; Rosiglitazone; Sodium; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2009 |
Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; G1 Phase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoblotting; Male; Microscopy, Fluorescence; NF-kappa B; PPAR gamma; Prostatic Neoplasms; Resting Phase, Cell Cycle; RNA Interference; Thiazoles; Thiazolidinediones; Troglitazone; Urea | 2011 |
Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Photochemotherapy; PPAR gamma; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone | 2016 |