troglitazone has been researched along with prostaglandin d2 in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (9.45) | 18.2507 |
| 2000's | 105 (82.68) | 29.6817 |
| 2010's | 10 (7.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, M; Chatterjee, VK; Digby, JE; Holder, JC; Lazar, MA; Montague, CT; O'Rahilly, S; Prins, JB; Sanders, L; Sewter, CP; Smith, SA | 1 |
| Jiang, C; Seed, B; Ting, AT | 1 |
| Ako, J; Eto, M; Hashimoto, M; Iijima, K; Kim, S; Liang, YQ; Ouchi, Y; Sudoh, N; Sugimoto, N; Toba, K; Yoshizumi, M | 1 |
| Libby, P; Marx, N; Murphy, C; Plutzky, J; Sukhova, G | 1 |
| Lazar, MA; Libby, P; Marx, N; Plutzky, J; Schönbeck, U | 1 |
| Hara, M; Hashimoto, N; Hashimoto, Y; Isoo, N; Kimura, S; Maekawa, H; Satoh, H; Togo, M; Tsukamoto, K; Watanabe, T | 1 |
| Fleck, E; Goetze, S; Gotlibowski, T; Hsueh, WA; Kawano, H; Law, RE; Xi, XP | 1 |
| Kwon, G; Marshall, CA; McDaniel, ML; Xu, G | 1 |
| Addya, S; Boden, G; Murer, E; Sinha, D | 1 |
| Aaltonen, LA; de la Chapelle, A; Eng, C; Kum, JB; Mueller, E; Sarraf, P; Smith, WM; Spiegelman, BM; Wright, HM | 1 |
| Burris, TP; Demarest, KT; Pelton, PD; Zhou, L | 1 |
| Asano, M; Chisaki, K; Imuta, H; Iwasawa, K; Morita, T; Nakajima, T; Nakamura, F; Okuda, Y; Omata, M; Yamada, N | 1 |
| Kishimoto, T; Komoriya, K; Nakahata, T; Nonaka, T; Sugiyama, H; Tsuji, K | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Kalus, AM; Rubin, GL; Simpson, ER; Zhao, Y | 1 |
| Hla, T; Inoue, K; Kawahito, Y; Kohno, M; Kondo, M; Mukai, S; Sano, H; Tsubouchi, Y; Yamada, R | 1 |
| Asano, T; Fujishima, M; Iino, K; Iwase, M; Sonoki, K; Wakisaka, M; Yoshinari, M | 1 |
| Ikeda, U; Murakami, Y; Shimada, K; Shimpo, M | 1 |
| Corbett, JA; Heitmeier, MR; Maggi, LB; Sadeghi, H; Scarim, AL; Weigand, C | 1 |
| Bishop-Bailey, D; Hashiramoto, A; Hla, T; Inoue, K; Kawahito, Y; Kohno, M; Kondo, M; Sano, H; Tsubouchi, Y; Yamada, R | 1 |
| Batignani, G; Bonacchi, A; Caligiuri, A; Caporale, R; Efsen, E; Gentilini, P; Laffi, G; Marra, F; Pastacaldi, S; Pinzani, M; Romanelli, RG | 1 |
| Arima, S; Igarashi, K; Ikeda, Y; Ito, S; Sugawara, A; Takeuchi, K; Taniyama, Y; Uruno, A | 1 |
| Feinstein, DL; Heneka, MT; Klockgether, T | 1 |
| Funakoshi, Y; Hirano, K; Ichiki, T; Iino, N; Kanaide, H; Takeda, K; Takeshita, A; Tokunou, T | 1 |
| Carlson, MG; Levy, R; Nelson, DM; Sadovsky, Y; Schaiff, WT; Smith, SD | 1 |
| Banba, N; Hattori, Y; Hishinuma, A; Kakishita, H; Kasai, K; Matsumura, M; Motohashi, S; Sato, N | 1 |
| Cao, HJ; Kaur, K; Padilla, J; Phipps, RP; Smith, TJ | 1 |
| Harris, SG; Phipps, RP | 2 |
| Hla, T; Inoue , K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y | 1 |
| Chen, NG; Han, X | 1 |
| Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y | 1 |
| Bécuwe, P; Bianchi, A; Bordji, K; Boyault, S; Compe, E; Dauça, M; Liagre, B; Mainard, D; Netter, P; Simonin, MA; Terlain, B | 1 |
| Chlenski, A; Hattori, K; Hayashi, Y; Kita, A; Nakashiro, KI; Oyasu, R; Reddy, JK; Tamatani, T; Usuda, N | 1 |
| Arakawa, T; Fujiwara, Y; Hasuma, T; Higuchi, K; Otani, S; Takashima, T; Yano, Y | 1 |
| Ando, K; Chiba, Y; Fujita, T; Ogita, T | 1 |
| Atsumi, G; Chilton, FH; Clay, CE; Fonteh, AN; High, KP; Namen, AM; Trimboli, AJ | 1 |
| Inoue, K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y; Yoshikawa, T; Yoshimura, R | 1 |
| Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K | 1 |
| Kikuta, K; Masamune, A; Sakai, Y; Satoh, A; Satoh, M; Shimosegawa, T | 1 |
| Ichiki, T; Iino, N; Takeda, K; Takeshita, A; Tokunou, T | 1 |
| Breyer, MD; Breyer, RM; Davis, L; Guan, Y; Schneider, A; Zhang, Y | 1 |
| Bécuwe, P; Bianchi, A; Bordji, K; Boyault, S; Dauça, M; Gouze, E; Netter, P; Simonin, MA; Terlain, B | 1 |
| Garmey, JC; Schoppee, PD; Veldhuis, JD | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Laurora, S; Pizzimenti, S | 1 |
| Masamune, A; Sakai, Y; Satoh, A; Satoh, K; Shimosegawa, T; Yoshida, M | 1 |
| Dixon, C; Doseff, AI; Hilbelink, T; Kotur, M; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Hiraishi, H; Kojima, K; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Hiraishi, H; Kojima, K; Mitobe, Y; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Marx, N | 1 |
| Hiwada, K; Kitami, Y; Nakamura, M; Okura, T; Takata, Y; Yang, ZH | 1 |
| Füzesi, L; Krüger, U; Middel, P; Mössner, R; Neumann, C; Reich, K; Schinner, S; Schulz, U | 1 |
| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Georgiou, HM; Lappas, M; Permezel, M; Rice, GE | 1 |
| Abe, M; Furukawa, Y; Hasegawa, K; Hirai, M; Kawamura, T; Kita, T; Morimoto, T; Wada, H; Yanazume, T | 1 |
| Inoue, H; Miwa, Y; Miyagi, M; Morimoto, S; Sasaguri, T; Taba, Y; Takahashi-Yanaga, F | 1 |
| Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL | 1 |
| Abe, A; Emi, N; Kanbe, E; Kawabe, T; Saito, H; Towatari, M | 1 |
| Ashton, S; Cook, J; Gilkeson, G; Guyton, K; Halushka, P; Reilly, C; Tempel, G; Teti, G; Zingarelli, B | 1 |
| Burgermeister, E; Liscovitch, M; Tencer, L | 1 |
| Agarwal, N; Aoun, P; Simpkins, JW | 1 |
| Aoun, P; Simpkins, JW; Watson, DG | 1 |
| LaPointe, MC; Mendez, M | 1 |
| Evers, BM; Farrow, B; Hashimoto, K; Iwamura, T; O'Connor, KL | 1 |
| Azuma, Y; Date, M; Fukuchi, K; Ohura, K; Shinohara, M; Takahashi, H | 1 |
| Asada, K; Chida, K; Nakamura, H; Sasaki, S; Suda, T | 1 |
| Hase, T; Kawahito, Y; Kuratsukuri, K; Matsuyama, M; Nakatani, T; Sano, H; Segawa, Y; Tsuchida, K; Yoshimura, R | 1 |
| Baek, SJ; DiAugustine, RP; Eling, TE; Kim, JS; Nixon, JB | 1 |
| Asami-Miyagishi, R; Iseki, S; Kubo, H; Morita, I; Uchida, K; Usui, M | 1 |
| Afif, H; Cheng, S; Fahmi, H; Farrajota, K; Lavigne, M; Li, X; Martel-Pelletier, J; Pelletier, JP | 1 |
| Alba, G; Alvarez-Maqueda, M; Bedoya, FJ; Chacón, P; El Bekay, R; Martín-Nieto, J; Monteseirín, J; Pintado, E; Sobrino, F; Vega, A | 1 |
| Albanese, N; Chatterjee, VK; Gamble, JR; Hahn, C; Vadas, MA; Verrier, E; Wadham, C; Wang, L; Xia, P | 1 |
| Fisher, PB; Han, S; Roman, J; Sidell, N | 1 |
| Brunskill, NJ; Chana, RS; Lewington, AJ | 1 |
| Ikeda, M; Kakei, M; Matsumoto, S; Mori, M; Okada, S; Shimizu, H; Shimomura, K | 1 |
| Atkins, KB; Brosius, FC; Northcott, CA; Watts, SW | 1 |
| Adachi, S; Akao, M; Ehara, N; Hasegawa, K; Iwai-Kanai, E; Kawamura, T; Kita, T; Morimoto, T; Ono, K | 1 |
| Bedford, DF; Bouck, N; Campbell, SC; Henkin, J; Huang, H; Nelius, T; Schneider, A; Shroff, EH; Veliceasa, D; Volpert, OV | 1 |
| Corbett, L; Knox, AJ; Nie, M; Pang, L | 1 |
| Chen, J; Chen, Q; Jiang, H; Shen, J; Shen, X; Sun, T | 1 |
| Chen, F; Hou, M; Huang, RW; Lin, DJ; Lin, Q; Liu, JJ; Pan, XL; Peng, J; Song, YQ; Wu, XY; Zhang, MH | 1 |
| Hahn, JH; Kim, DJ; Kim, HA; Kim, PH; Lee, HS; Lee, KJ; Ma, KR; Park, JH | 1 |
| Arai, H; Chun, TH; Doi, K; Fukunaga, Y; Inoue, M; Itoh, H; Masatsugu, K; Nakao, K; Saito, T; Sakaguchi, S; Sawada, N; Tanaka, T; Yamashita, J | 1 |
| Arakawa, T; Fujiwara, Y; Hamaguchi, M; Higuchi, K; Oshitani, N; Sasaki, E; Takashima, T; Tominaga, K; Watanabe, T | 1 |
| Chen, F; Hou, M; Huang, R; Lin, D; Lin, Q; Liu, J; Lu, H; Pan, X; Peng, J; Song, Y; Wu, X; Zhang, M; Zheng, J | 1 |
| Ackerman, WE; Kniss, DA; Rovin, BH; Zhang, XL | 1 |
| Artwohl, M; Baumgartner-Parzer, SM; Freudenthaler, A; Fürnsinn, C; Hölzenbein, T; Huttary, N; Waldhäusl, WK | 1 |
| Maeda, N; Magota, K; Murakami, R; Okumura, K; Osanai, T; Sasaki, S; Toki, T; Tomita, H; Yasujima, M | 1 |
| Chakravarty, P; Patel, KM; Ward, SG; Watson, ML; Whittaker, P; Wright, KL | 1 |
| Cheon, H; Choi, SJ; Ji, JD; Kim, HJ; Lee, YH; Rho, YH; Sohn, J; Song, GG; Um, JW | 1 |
| Appel, S; Bringmann, A; Brossart, P; Grünebach, F; Mirakaj, V; Weck, MM | 1 |
| Berenbrinker, D; Mani, O; Popov, A; Schultze, JL; Smola-Hess, S; Sos, ML; Thomas, RK; Wolf, J; Zander, T | 1 |
| Arnold, R; König, W | 2 |
| Choi, YM; Kang, HY; Lee, JS; Lee, JY | 1 |
| Coyle, AT; Kinsella, BT | 1 |
| Chaffer, CL; Thomas, DM; Thompson, EW; Williams, ED | 1 |
| Chen, N; Liu, F; Wang, WM | 1 |
| Jang, KY; Jang, YB; Kang, KP; Kim, DH; Kim, W; Lee, JE; Lee, S; Moon, SO; Park, SK; Sung, MJ | 1 |
| Blero, D; Bruyns, C; Caspers, L; De Graef, C; Driessens, G; Dulku, S; Gonzalez, NS; Willermain, F | 1 |
| Jang, Y; Lee, EJ; Lee, KS; Lee, S; Lim, HJ; Park, HY; Park, JH | 1 |
| He, Y; Huang, M; Huang, RW; Li, XD; Lin, DJ; Liu, JJ; Liu, PQ; Xiao, RZ | 1 |
| Kim, HS; Kim, HY | 1 |
| Buechler, C; Neumeier, M; Schäffler, A; Schölmerich, J; Weigert, J | 1 |
| Akula, SM; Chintalgattu, V; Harris, GS; Katwa, LC | 1 |
| Arnold, R; König, W; Neumann, M | 1 |
| Li, QL; Li, SJ; Li, SY; Shang, T | 1 |
| Farrar, WL; Wang, LH; Yang, XY; Zhang, X | 1 |
| Chang, ZQ; Li, J; Li, QL; Li, SJ; Li, SY; Rui, GH; Shang, T | 1 |
| Jang, SK; Kim, JH; Kim, WJ | 1 |
| Kim, H; Kim, KH; Yu, JH | 1 |
| Chan, KW; Dai, Y; Ebert, MP; Gu, Q; Lan, HY; Ma, J; Qiao, L; Rocken, C; Wong, BC; Zou, B | 1 |
| Keshamouni, VG; Milam, JE; Narala, VR; Newstead, MW; Reddy, RC; Standiford, TJ | 1 |
| Panzer, U; Paust, HJ; Peters, A; Schneider, A; Stahl, RA; Steinmetz, OM; Turner, JE; Wienberg, U; Wolf, G; Zahner, G | 1 |
| Chan, KW; Dai, Y; Gu, Q; Lan, HY; Ma, J; Qiao, L; Wang, J; Wong, BC; Zou, B | 1 |
| Ando, R; Kohri, K; Nagata, D; Nakanishi, M; Naruyama, H; Okada, S; Tozawa, K; Yoshihiro, H | 1 |
| Chen, N; Jin, YM; Wang, WM; Zhang, HD; Zhu, BB | 1 |
| Liao, K; Xiao, Y; Yao, W; Yuan, T | 1 |
| Arnold, N; Bauerschlag, DO; Biernath-Wüpping, J; Bräutigam, K; Jonat, W; Maass, N; Meinhold-Heerlein, I; von Kaisenberg, CS | 1 |
| Chowdhury, AA; Ishikawa, T; Jisaka, M; Nagaya, T; Nishimura, K; Rahman, MS; Shono, F; Yokota, K | 1 |
| Li, C; Li, L; Liu, X; Yang, L; Yu, H | 1 |
| Fujimori, K; Kamauchi, S; Maruyama, T; Urade, Y | 1 |
| Gerner, C; Gruber, S; Haudek-Prinz, V; Hofstätter, E; Jonak, C; Klepeisz, P; Kunstfeld, R; Paulitschke, V; Pehamberger, H; Petzelbauer, P; Schicher, N | 1 |
| Choi, YJ; Ham, SA; Hwang, JS; Kang, ES; Kang, KR; Kim, GH; Lee, JH; Lee, WJ; Paek, KS; Park, MH; Seo, HG; Yoo, T | 1 |
| Hindman, HB; Huxlin, KR; Jeon, KI; Kulkarni, A; Phipps, RP; Sime, PJ; Woeller, CF | 1 |
| Huxlin, KR; Jeon, KI; Phipps, RP; Sime, PJ | 2 |
127 other study(ies) available for troglitazone and prostaglandin d2
| Article | Year |
|---|---|
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromans; Humans; Mice; Microbodies; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1997 |
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromans; Cytokines; Humans; Inflammation Mediators; Leukocytes, Mononuclear; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1998 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells.
Topics: Animals; Base Sequence; Cells, Cultured; Chromans; Gene Expression; Hypoglycemic Agents; Ligands; Molecular Sequence Data; Muscle, Smooth, Vascular; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1998 |
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro.
Topics: Arteriosclerosis; Blotting, Northern; Blotting, Western; Cell Line; Cells, Cultured; Chromans; Collagenases; Humans; Immunoenzyme Techniques; Macrophages; Matrix Metalloproteinase 9; Monocytes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells.
Topics: Becaplermin; Cell Movement; Cells, Cultured; Chromans; Collagenases; Dinoprost; Gelatin; Gene Expression; Humans; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogene Proteins c-sis; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Topics: Animals; Cattle; Cells, Cultured; Chromans; Endothelin-1; Endothelium, Vascular; Hypoglycemic Agents; Insulin; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Chemotactic Factors; Chromans; Cycloheximide; Dactinomycin; Enzyme Activation; Insulin-Like Growth Factor I; Ligands; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Thrombin; Transcription Factors; Troglitazone | 1999 |
Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and in
Topics: Animals; Chromans; Guanidines; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Ribosomal Protein S6 Kinases; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1999 |
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Indomethacin; Leptin; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Obesity; Prostaglandin D2; Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Topics: Amino Acid Substitution; Binding Sites; Chromans; Colorectal Neoplasms; Dimerization; DNA-Binding Proteins; Exons; Genes, Tumor Suppressor; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Linoleic Acids, Conjugated; Mutation; Prostaglandin D2; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1999 |
PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
Topics: Adipocytes; Carrier Proteins; Cell Differentiation; Cell Line; Cells, Cultured; Chromans; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Gene Expression; Humans; Kinetics; Monocytes; Myelin P2 Protein; Neoplasm Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins | 1999 |
Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Division; Cell Line; Chromans; Hypoglycemic Agents; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Platelet-Derived Growth Factor; Prostaglandin D2; Rats; Thiazoles; Thiazolidinediones; Troglitazone; Vasopressins | 1999 |
Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chromans; Cytokines; Female; Histamine Release; Ligands; Mast Cells; Mice; Mice, Inbred BALB C; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy.
Topics: Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Breast; Breast Neoplasms; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Estrogens; Female; Gene Expression Regulation, Enzymologic; Humans; Ligands; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis.
Topics: Apoptosis; Base Sequence; Cell Division; Chromans; DNA Primers; Humans; Lung Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Expression; Glomerular Mesangium; Nuclear Proteins; Oligonucleotides; Prostaglandin D2; Protein Binding; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit nitric oxide synthesis in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; Humans; Interleukin-1; Ligands; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromans; Cytokines; Hot Temperature; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Shock; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chromans; Female; Humans; Ligands; Osteoarthritis; Prostaglandin D2; Rats; Rats, Inbred Lew; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Tissue Distribution; Transcription Factors; Troglitazone | 2000 |
Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.
Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CCL2; Chromans; Cytotoxins; Gene Expression; Hepatitis; Humans; Interleukin-1; Ligands; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogenes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tyrosine; Wound Healing | 2000 |
Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.
Topics: Animals; Base Sequence; Binding Sites; Chromans; Cloning, Molecular; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Leucine Zippers; Macrophages; Molecular Sequence Data; NF-E2-Related Factor 2; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Thromboxane-A Synthase; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Cerebellum; Chromans; Cyclooxygenase Inhibitors; Down-Regulation; Ibuprofen; Immunohistochemistry; In Situ Nick-End Labeling; Interferon-gamma; Ligands; Lipopolysaccharides; Male; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Chromans; Down-Regulation; Gene Expression Regulation; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cells, Cultured; Chorionic Gonadotropin; Chromans; Densitometry; Fluorescent Antibody Technique; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Trophoblasts | 2000 |
15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Topics: Anticholesteremic Agents; Arsenites; Bucladesine; Cells, Cultured; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoglycemic Agents; Ligands; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sodium Compounds; Thiazoles; Thiazolidinediones; Thyroglobulin; Thyroid Gland; Thyrotropin; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Lineage; Cells, Cultured; Chromans; Dinoprost; Hypoglycemic Agents; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Topics: Animals; Antigen Presentation; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chromans; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ionomycin; Ligands; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedback; Humans; Isoenzymes; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium.
Topics: Base Sequence; Cell Line, Transformed; Chromans; DNA Primers; Endothelium, Vascular; Enzyme Activation; Gene Expression; Genes, fos; Humans; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Nucleus; Cells, Cultured; Chondrocytes; Chromans; Cyclooxygenase 2; DNA; Enzyme Induction; Gene Expression Regulation; Humans; Interleukin-1; Isoenzymes; Ligands; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Binding; Proteoglycans; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone | 2001 |
Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells.
Topics: Aged; Blotting, Western; Cell Division; Cell Line; Chromans; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Ligands; Male; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urothelium | 2001 |
PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Chromans; DNA Primers; Esophageal Neoplasms; Flow Cytometry; Humans; Immunologic Factors; Ligands; Ornithine Decarboxylase; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.
Topics: Animals; Arteriosclerosis; Cattle; Cells, Cultured; Chromans; Drug Antagonism; Endothelium; Immunohistochemistry; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Receptors, Oxidized LDL; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chromans; Female; Humans; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured | 2001 |
Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists.
Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Renal Cell; Cell Division; Chromans; Coloring Agents; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Immunohistochemistry; Immunologic Factors; Kidney Neoplasms; Ligands; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Up-Regulation | 2001 |
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells.
Topics: Actins; Animals; Cells, Cultured; Chemokine CCL2; Chromans; Collagen Type I; G1 Phase; Ligands; NF-kappa B; Pancreas; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Cells, Cultured; Chromans; Enzyme Activation; Enzyme Inhibitors; Immunologic Factors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pioglitazone; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Wortmannin | 2001 |
Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; Cell Survival; Cells, Cultured; Chromans; Cloning, Molecular; Endothelium, Vascular; Fatty Acid-Binding Proteins; Glomerular Mesangium; Hypoglycemic Agents; Kidney Glomerulus; Molecular Sequence Data; Neoplasm Proteins; Prostaglandin D2; Rabbits; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2001 |
PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chromans; Cyclooxygenase 2; Fibroblasts; Gene Expression; Interleukin-1; Isoenzymes; Ligands; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells.
Topics: Androgens; Animals; Blotting, Western; Cells, Cultured; Chromans; DNA; Female; Fluorescent Dyes; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Organic Chemicals; Ovary; Progesterone; Prostaglandin D2; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Steroid 17-alpha-Hydroxylase; Swine; Theca Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells | 2002 |
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cell Survival; Cells, Cultured; Chromans; Humans; Hydantoins; In Situ Nick-End Labeling; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Line; Chromans; Clusterin; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Gene Expression; Glycoproteins; I-kappa B Proteins; Immunologic Factors; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Molecular Chaperones; NF-KappaB Inhibitor alpha; Oligopeptides; Pancreas; Pancreatitis-Associated Proteins; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Death; Cell Division; Cells, Cultured; Chromans; Chromones; Enzyme Inhibitors; Glomerular Mesangium; Humans; Morpholines; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells.
Topics: Apoptosis; Cell Division; Cell Survival; Chromans; Colonic Neoplasms; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Ligands; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Effect of PPARgamma ligands on the viability of gastric epithelial cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Chromans; DNA, Complementary; Dose-Response Relationship, Drug; Epithelial Cells; Gastric Mucosa; Gene Expression Regulation; Humans; Immunologic Factors; Ligands; Microscopy, Phase-Contrast; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
PPARgamma and vascular inflammation: adding another piece to the puzzle.
Topics: Animals; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Luciferases; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 2002 |
Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma.
Topics: Animals; Carotid Arteries; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Interleukin-6; Luciferases; Male; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2002 |
Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Melanoma; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Skin Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone.
Topics: Amnion; Chorion; Chromans; Culture Techniques; Decidua; DNA; Female; Humans; Interleukin-6; Interleukin-8; L-Lactate Dehydrogenase; Ligands; NF-kappa B; Placenta; Pregnancy; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Topics: Actins; Cell Differentiation; Cells, Cultured; Chromans; Dimethyl Sulfoxide; DNA-Binding Proteins; GATA6 Transcription Factor; Humans; Immunohistochemistry; Muscle, Smooth, Vascular; Oligopeptides; Phenotype; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2003 |
15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Chromans; Cycloheximide; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Hypoglycemic Agents; Immunologic Factors; Inhibitor of Apoptosis Proteins; Intramolecular Oxidoreductases; Lipocalins; Luciferases; Microtubule-Associated Proteins; Neoplasm Proteins; Prostaglandin D2; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Survivin; Thiazoles; Thiazolidinediones; Troglitazone; Ubiquitin-Protein Ligases; Umbilical Veins | 2003 |
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligands; Prostaglandin D2; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Uterine Neoplasms | 2003 |
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Topics: Antigens, Neoplasm; Apoptosis; Chromans; DNA Topoisomerases, Type II; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Etoposide; Flow Cytometry; Gene Expression; Humans; Jurkat Cells; Leukemia; Ligands; Mutagenesis; Phosphoproteins; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Topoisomerase II Inhibitors; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 2003 |
Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli.
Topics: Animals; Cells, Cultured; Chromans; Enzyme Activation; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; Nitric Oxide; Phosphorylation; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Staphylococcus aureus; Thiazoles; Thiazolidinediones; Thromboxane B2; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Line, Transformed; Cell Survival; Chromans; Cytoprotection; Glutamic Acid; Ligands; Neuroprotective Agents; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Retinal Ganglion Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells.
Topics: Alitretinoin; Animals; Cell Line; Cell Survival; Chromans; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Humans; Hydrogen Peroxide; Mice; Neuroprotective Agents; Oxidation-Reduction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Time Factors; Transcription Factors; Tretinoin; Troglitazone | 2003 |
PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes.
Topics: Anilides; Animals; Cells, Cultured; Chromans; Cyclooxygenase 2; Gene Expression Regulation; Interleukin-1; Intramolecular Oxidoreductases; Isoenzymes; Myocytes, Cardiac; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator.
Topics: Chromans; Humans; Integrins; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Pancreatic Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Tissue Plasminogen Activator; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone.
Topics: Amino Acid Chloromethyl Ketones; Analysis of Variance; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspase Inhibitors; Caspases; Cell Survival; Chromans; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Immunologic Factors; Mouth Neoplasms; Oligopeptides; Prostaglandin D2; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.
Topics: Apoptosis; CD36 Antigens; Chromans; Humans; In Vitro Techniques; Inflammation; Macrophages, Alveolar; Neutrophils; Phagocytosis; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2004 |
The effect of peroxisome proliferator-activated receptor-gamma ligand on urological cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Humans; Immunologic Factors; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Troglitazone; Urologic Neoplasms | 2003 |
Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Chromans; Cytokines; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Growth Differentiation Factor 15; Humans; Immediate-Early Proteins; Ligands; Luciferases; Models, Biological; Models, Genetic; Multigene Family; Oligonucleotides; Phosphorylation; Plasmids; Promoter Regions, Genetic; Prostaglandin D2; Protein Binding; Receptors, Cytoplasmic and Nuclear; RNA; Sp1 Transcription Factor; Thiazolidinediones; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Troglitazone; Up-Regulation | 2004 |
Expression and function of PPARgamma in rat placental development.
Topics: Administration, Oral; Animals; Body Weight; Cell Differentiation; Chromans; DNA; Ear, Inner; Female; Gene Deletion; Gene Expression Regulation, Developmental; Immunohistochemistry; Ligands; Maternal Exposure; Maternal-Fetal Exchange; Microscopy, Fluorescence; Placenta; Pregnancy; Pregnancy, Animal; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Trophoblasts | 2004 |
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
Topics: Amino Acid Motifs; Anilides; Binding Sites; Blotting, Western; Cell Division; Cell Nucleus; Chromans; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Fibroblasts; Genes, Dominant; Genes, Reporter; Humans; Immediate-Early Proteins; Immunologic Factors; Inflammation; Interleukin-1; Intramolecular Oxidoreductases; Ligands; Peroxisome Proliferators; Plasmids; Promoter Regions, Genetic; Prostaglandin D2; Prostaglandin-E Synthases; Protein Binding; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; Synovial Membrane; Thiazolidinediones; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone | 2004 |
15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.
Topics: Acetylcysteine; Allopurinol; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Chromans; Cyclic N-Oxides; Cyclopentanes; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ions; Lymphocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthrolines; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Temperature; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Xanthine Oxidase | 2004 |
PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.
Topics: Animals; Aorta; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chromans; Diabetic Angiopathies; Diacylglycerol Kinase; Diglycerides; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Glucose; Humans; PPAR gamma; Prostaglandin D2; Protein Kinase C; Protein Kinase C beta; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Thiazolidinediones; Transfection; Troglitazone; U937 Cells; Umbilical Veins; Vasculitis | 2004 |
Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.
Topics: Antineoplastic Agents; Apoptosis; Chromans; Cyclin D1; Humans; Lung Neoplasms; Prostaglandin D2; Proto-Oncogene Proteins p21(ras); Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazolidinediones; Transcription Factors; Troglitazone | 2004 |
Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists.
Topics: Animals; Cells, Cultured; Chromans; Extracellular Signal-Regulated MAP Kinases; Kidney Tubules, Proximal; Ligands; Opossums; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Transcriptional Activation; Transfection; Troglitazone | 2004 |
Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.
Topics: Animals; Chromans; Cricetinae; Fenofibrate; Immunologic Factors; Insulin; Insulin Secretion; Membrane Proteins; Potassium Channels; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2004 |
Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries.
Topics: Animals; Aorta; Arteries; Biomarkers; Blood Pressure; Carotid Arteries; Chromans; Deoxyglucose; Desoxycorticosterone; Glucose Transporter Type 4; Hypertension; Ligands; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Smooth, Vascular; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rosiglitazone; Sodium Chloride; Thiazolidinediones; Troglitazone | 2005 |
Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cells, Cultured; Chromans; DNA; DNA-Binding Proteins; Endothelin-1; Myocytes, Cardiac; NFATC Transcription Factors; Nuclear Proteins; Prostaglandin D2; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Troglitazone | 2004 |
Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510.
Topics: Angiogenesis Inhibitors; CD36 Antigens; Cells, Cultured; Chromans; Drug Interactions; Endothelium, Vascular; Humans; Ligands; Microcirculation; Neoplasms; Neovascularization, Pathologic; Peptides; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Thrombospondin 1; Troglitazone; Vasodilator Agents | 2004 |
Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.
Topics: Adrenergic beta-Agonists; Albuterol; Androstadienes; Blotting, Western; Cell Line; Chemokine CCL11; Chemokine CCL2; Chemokines; Chemokines, CC; Chromans; Chromatin; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluticasone; Gene Expression Regulation; Glucocorticoids; Humans; Immunoprecipitation; Interleukin-8; Plasmids; PPAR alpha; PPAR gamma; Promoter Regions, Genetic; Prostaglandin D2; Protein Binding; Pyrimidines; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA; Salmeterol Xinafoate; Thiazolidinediones; Transcription, Genetic; Transfection; Troglitazone; Tumor Necrosis Factor-alpha | 2005 |
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist.
Topics: alpha-Galactosidase; Anilides; Cells, Cultured; Chromans; CREB-Binding Protein; Drug Evaluation, Preclinical; Genes, Reporter; Indomethacin; Ligands; Nuclear Proteins; Oxazoles; Pioglitazone; PPAR gamma; Prostaglandin D2; Protein Binding; Rosiglitazone; Thiazolidinediones; Trans-Activators; Troglitazone; Two-Hybrid System Techniques; Tyrosine; Yeasts | 2004 |
Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Chromans; Cysteine Proteinase Inhibitors; Down-Regulation; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Immunologic Factors; Inhibitor of Apoptosis Proteins; K562 Cells; Ligands; Microtubule-Associated Proteins; Neoplasm Proteins; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Thiazolidinediones; Troglitazone; Up-Regulation | 2005 |
Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g.
Topics: Antibodies, Blocking; CD36 Antigens; Cells, Cultured; Chromans; Humans; Lipoproteins, LDL; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Monocytes; NF-kappa B; PPAR gamma; Prostaglandin D2; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2004 |
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.
Topics: Alitretinoin; Angioplasty, Balloon; Animals; Aorta; Arteriosclerosis; Binding, Competitive; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CCL2; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression Regulation; Humans; Macrophages; Male; Monocytes; Pioglitazone; PPAR gamma; Prostaglandin D2; Rabbits; Receptors, CCR2; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones; Time Factors; Tretinoin; Troglitazone; Vascular Endothelial Growth Factor A; Wound Healing | 2005 |
Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma.
Topics: Antibodies, Monoclonal; Apoptosis; Barrett Esophagus; Biopsy; Bisbenzimidazole; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; Esophageal Neoplasms; G1 Phase; Humans; Immunohistochemistry; Ligands; PPAR gamma; Prostaglandin D2; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thiazolidinediones; Thymidine; Troglitazone | 2005 |
Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells.
Topics: Antineoplastic Agents; Chromans; Extracellular Matrix; Humans; Leukemia, Myeloid; Metalloproteases; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2005 |
Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells.
Topics: Amnion; Cells, Cultured; Chromans; Cyclooxygenase 2; Epithelial Cells; Gene Expression Regulation; Humans; Membrane Proteins; NF-kappa B; PPAR gamma; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2005 |
Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells.
Topics: Aorta; Apoptosis; Blotting, Western; Caspases; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Chaperonin 60; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; E2F Transcription Factors; E2F1 Transcription Factor; Endothelium, Vascular; Enzyme Activation; Humans; Hypoglycemic Agents; Ligands; Microscopy, Phase-Contrast; Mitochondria; Pioglitazone; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rosiglitazone; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; von Willebrand Factor | 2005 |
Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.
Topics: Blotting, Western; Cells, Cultured; Chromans; Endothelial Cells; Endothelium, Vascular; Gene Expression; Humans; I-kappa B Proteins; Ligands; Microscopy, Fluorescence; Mitochondrial Proton-Translocating ATPases; NF-kappa B; Oxidative Phosphorylation Coupling Factors; PPAR gamma; Prostaglandin D2; Radioimmunoassay; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Stress, Mechanical; Thiazolidinediones; Troglitazone | 2005 |
Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).
Topics: Cell Line; Chromans; Cyclooxygenase 2; Dinoprostone; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; I-kappa B Proteins; Membrane Proteins; NF-kappa B; Phosphatidylinositol 3-Kinases; PPAR gamma; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2005 |
15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes.
Topics: Arthritis, Rheumatoid; Chromans; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Gene Expression Regulation; Humans; Hypoglycemic Agents; Interleukin-6; Jurkat Cells; Lymphocytes; NF-kappa B; Phosphorylation; PPAR gamma; Prostaglandin D2; Protein Synthesis Inhibitors; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Thiazolidinediones; Trans-Activators; Troglitazone | 2005 |
PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways.
Topics: Blotting, Western; Cell Movement; Chromans; Cytokines; Dendritic Cells; Humans; Hypoglycemic Agents; Mitogen-Activated Protein Kinases; NF-kappa B; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Toll-Like Receptors; Troglitazone | 2005 |
Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies.
Topics: Active Transport, Cell Nucleus; Apoptosis; B-Lymphocytes; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chromans; Dose-Response Relationship, Drug; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; I-kappa B Kinase; I-kappa B Proteins; Molecular Chaperones; Mutation; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Prostaglandin D2; Signal Transduction; Thiazolidinediones; Troglitazone; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells.
Topics: Cell Line, Tumor; Chemokine CCL5; Chemokines, CC; Chromans; Cytokines; Epithelial Cells; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Interleukin-6; Interleukin-8; NF-kappa B; PPAR gamma; Prostaglandin D2; Respiratory Syncytial Viruses; RNA, Messenger; Thiazolidinediones; Transcription Factor AP-1; Troglitazone; Tumor Necrosis Factor-alpha | 2006 |
Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Proliferation; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Male; Melanocytes; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Thiazolidinediones; Troglitazone | 2006 |
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells.
Topics: Cell Line; Cell Line, Tumor; Chromans; Genes, Reporter; Humans; Leukemia, Erythroblastic, Acute; Luciferases; PPAR gamma; Promoter Regions, Genetic; Prostaglandin D2; Protein Isoforms; Receptors, Thromboxane A2, Prostaglandin H2; Retinoid X Receptor alpha; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transcription Factor AP-1; Transcription, Genetic; Troglitazone | 2006 |
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Carcinoma, Transitional Cell; Caspase 3; Caspase 7; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromans; DNA Fragmentation; Humans; Ligands; Male; PPAR gamma; Prostaglandin D2; Prostatic Neoplasms; RNA, Messenger; Thiazolidinediones; Troglitazone; Urinary Bladder Neoplasms | 2006 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells.
Topics: Chromans; Humans; Lung; PPAR gamma; Prostaglandin D2; Respiratory Mucosa; Respiratory Syncytial Viruses; Thiazolidinediones; Troglitazone; Virus Replication | 2006 |
[Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts].
Topics: Animals; Blotting, Far-Western; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Kidney; Peroxisome Proliferator-Activated Receptors; Prostaglandin D2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad Proteins; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2006 |
Rosiglitazone ameliorates cisplatin-induced renal injury in mice.
Topics: Anilides; Animals; Apoptosis; C-Peptide; Cell Line; Chromans; Cisplatin; Drug Evaluation, Preclinical; Glioma; Humans; Hypoglycemic Agents; Inflammation; Insulin; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; PPAR gamma; Prostaglandin D2; Protein Transport; Rosiglitazone; Thiazolidinediones; Transcription Factor RelA; Troglitazone; Tumor Necrosis Factor-alpha | 2006 |
15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism.
Topics: Cell Line; Cells, Cultured; Chromans; Coculture Techniques; Dinoprost; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Histocompatibility Antigens Class I; HLA-D Antigens; Humans; Immunologic Factors; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon-gamma; Nuclear Proteins; Phosphorylation; Pigment Epithelium of Eye; PPAR gamma; Prostaglandin D2; Rosiglitazone; STAT Transcription Factors; T-Lymphocytes; Thiazolidinediones; Trans-Activators; Troglitazone | 2006 |
PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs.
Topics: Actins; Adiponectin; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; CD36 Antigens; Cells, Cultured; Chromans; Complement Factor D; Fatty Acid-Binding Proteins; Foam Cells; Gene Expression; Hypoglycemic Agents; Lipid Metabolism; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; PPAR alpha; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Transfection; Troglitazone; Tropomyosin | 2006 |
Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro.
Topics: Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Chromans; Cyclooxygenase 2; DNA, Neoplasm; Flow Cytometry; Gene Expression; Humans; Leukemia; Membrane Potential, Mitochondrial; Monocytes; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Thymidine; Troglitazone; U937 Cells | 2007 |
Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.
Topics: Animals; Cells, Cultured; Chemokine CXCL2; Chemokines; Chemokines, CXC; Chromans; Dose-Response Relationship, Drug; Immunologic Factors; Ligands; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; PPAR gamma; Prostaglandin D2; Prostaglandins A; RNA, Messenger; Thiazolidinediones; Troglitazone; Up-Regulation | 2007 |
Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin".
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Cell Differentiation; Chromans; Fenofibrate; Gene Expression Regulation; Mice; Peroxisome Proliferator-Activated Receptors; Prostaglandin D2; Proteins; Resistin; RNA, Messenger; Thiazolidinediones; Troglitazone | 2007 |
PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts.
Topics: Animals; Cells, Cultured; Chromans; Collagen; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Laminin; Male; Microscopy, Fluorescence; Muscle Fibers, Skeletal; Myocardial Infarction; Myocytes, Cardiac; NF-kappa B; PPAR gamma; Prostaglandin D2; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Troglitazone; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells.
Topics: Amino Acids; Cell Adhesion; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Fluorenes; Humans; Intercellular Adhesion Molecule-1; Lung; NF-kappa B; PPAR gamma; Prostaglandin D2; Respiratory Mucosa; Respiratory Syncytial Virus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones; Troglitazone; U937 Cells | 2007 |
[Effects of peroxisome proliferator-activated receptor gamma and its ligands on cytotrophoblast invasion in first trimester of pregnancy and mechanism thereof].
Topics: Adult; Cell Movement; Cells, Cultured; Chromans; Female; Humans; Immunohistochemistry; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; PPAR gamma; Pregnancy; Pregnancy Trimester, First; Prostaglandin D2; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Troglitazone; Trophoblasts | 2007 |
Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP.
Topics: Bone Marrow; CCAAT-Enhancer-Binding Proteins; Cell Adhesion; Cell Line, Tumor; Cells, Cultured; Chromans; Humans; Multiple Myeloma; NF-kappa B; PPAR gamma; Prostaglandin D2; Receptor Cross-Talk; Stromal Cells; Thiazolidinediones; Troglitazone | 2007 |
[Effect of peroxisome proliferators-activated receptor gamma ligands on cytotrophoblast invasion in first trimester pregnancy].
Topics: Adult; Cell Movement; Cells, Cultured; Chorionic Villi; Chromans; Female; Gene Expression Regulation, Developmental; Humans; Immunohistochemistry; Ligands; Placenta; PPAR gamma; Pregnancy; Pregnancy Trimester, First; Prostaglandin D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones; Troglitazone; Trophoblasts | 2007 |
Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arsenites; Chromans; Cyclopentanes; Cytoplasmic Granules; Dinoprostone; Emetine; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4A; Gene Expression Regulation; HeLa Cells; Humans; Hypoglycemic Agents; Inflammation; Poly(A)-Binding Proteins; PPAR gamma; Prostaglandin D2; Prostaglandins A; Protein Biosynthesis; Protein Synthesis Inhibitors; Rosiglitazone; Signal Transduction; Sodium Compounds; T-Cell Intracellular Antigen-1; Thiazolidinediones; TNF Receptor-Associated Factor 2; Troglitazone; Tumor Necrosis Factor-alpha | 2007 |
SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Ceruletide; Chromans; Enzyme-Linked Immunosorbent Assay; Interleukin-6; Janus Kinase 2; Male; Pancreas; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone | 2008 |
Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2.
Topics: Anilides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Chromans; Colonic Neoplasms; Down-Regulation; HCT116 Cells; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Troglitazone; X-Linked Inhibitor of Apoptosis Protein | 2008 |
Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}.
Topics: Actins; Anilides; Animals; Antineoplastic Agents; Cell Adhesion; Chemotaxis; Chromans; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fibrinogen; HL-60 Cells; Humans; Inflammation; Interleukin-4; Interleukin-8; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; PPAR gamma; Prostaglandin D2; Sepsis; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
Topics: Animals; Cells, Cultured; Chemokine CXCL10; Chemokine CXCL11; Chemokine CXCL9; Chromans; Gene Expression; Glomerulonephritis; Interferon-gamma; Janus Kinases; Mesangial Cells; Mice; PPAR gamma; Prostaglandin D2; Recombinant Proteins; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Thiazolidinediones; Troglitazone | 2008 |
Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Colonic Neoplasms; Down-Regulation; Humans; Ki-67 Antigen; Ligands; Poly(ADP-ribose) Polymerases; PPAR gamma; Prostaglandin D2; Proteasome Endopeptidase Complex; Thiazolidinediones; Troglitazone; Vascular Endothelial Growth Factor A; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays | 2008 |
Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromans; Flow Cytometry; Humans; Immunohistochemistry; Ligands; Male; PPAR gamma; Promoter Regions, Genetic; Prostaglandin D2; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Thiazolidinediones; Transfection; Troglitazone | 2008 |
PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells.
Topics: Animals; Cell Line; Chemokine CCL2; Chromans; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hypoglycemic Agents; Interleukin-8; Kidney Tubules, Proximal; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone | 2009 |
3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; bcl-Associated Death Protein; Caspase 3; Chromans; Male; Mice; Pioglitazone; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Zucker; Thiazolidinediones; Troglitazone | 2010 |
Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Chromans; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Ovarian Neoplasms; PPAR gamma; Prostaglandin D2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Thiazolidinediones; TNF-Related Apoptosis-Inducing Ligand; Troglitazone | 2011 |
15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Arachidonic Acid; Calcimycin; Cell Proliferation; Chromans; Dinoprost; Dinoprostone; Gene Expression; Ionophores; Isoenzymes; Lipid Metabolism; Mice; NF-kappa B; PPAR gamma; Proline; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Thiazolidinediones; Thiocarbamates; Triglycerides; Troglitazone | 2011 |
15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.
Topics: Acetylcysteine; Anilides; Animals; Cell Line; Cell Proliferation; Chemokine CCL2; Chromans; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Monocytes; Oxidative Stress; Phagocytosis; PPAR gamma; Prostaglandin D2; Reactive Oxygen Species; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2012 |
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways.
Topics: 3T3-L1 Cells; Adipogenesis; Anilides; Animals; Chromans; Gene Expression Regulation; HeLa Cells; Humans; Hypoglycemic Agents; Intramolecular Oxidoreductases; Lipocalins; Mice; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Troglitazone | 2012 |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromans; Humans; Melanoma; PPAR gamma; Prostaglandin D2; Proteome; Pyrimidines; Thiazolidinediones; Troglitazone | 2012 |
15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Antioxidant Response Elements; Base Sequence; Cells, Cultured; Chromans; Enzyme Induction; Glucose Oxidase; Male; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rosiglitazone; Signal Transduction; Thiazolidinediones; Troglitazone; Up-Regulation | 2014 |
Inhibitory effects of PPARγ ligands on TGF-β1-induced corneal myofibroblast transformation.
Topics: Actins; Animals; Cats; Cell Line, Transformed; Cell Nucleus; Chromans; Collagen Type I; Cornea; Fibronectins; Fibrosis; Humans; Ligands; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR gamma; Prostaglandin D2; Protein Kinase Inhibitors; Protein Transport; Rosiglitazone; Signal Transduction; Smad Proteins; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone; Wound Healing | 2014 |
Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts.
Topics: Actins; Animals; Blotting, Western; Cats; Cells, Cultured; Chromans; Collagen Type I; Connective Tissue Growth Factor; Corneal Keratocytes; Fibronectins; Hypoglycemic Agents; JNK Mitogen-Activated Protein Kinases; Ligands; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Prostaglandin D2; RNA, Small Interfering; Rosiglitazone; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone | 2015 |
Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin-Regulated Pathways.
Topics: Actins; Animals; beta Catenin; Cats; Chromans; Collagen Type I; Cornea; Fibroblasts; Fibronectins; Fibrosis; Glycogen Synthase Kinase 3 beta; Lithium Chloride; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR gamma; Prostaglandin D2; Pyrvinium Compounds; Receptors, Transforming Growth Factor beta; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone | 2017 |