Page last updated: 2024-08-16

troglitazone and metformin

troglitazone has been researched along with metformin in 119 studies

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	37 (31.09)	18.2507
2000's	67 (56.30)	29.6817
2010's	15 (12.61)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Boyce, RS; Brown, SP; Bussiere, DE; Fang, E; Goff, D; Harrison, SD; Jansen, JM; Johnson, KW; Le, VP; Levine, BH; Ng, SC; Ni, ZJ; Nuss, JM; Pfister, KB; Ramurthy, S; Renhowe, PA; Ring, DB; Shafer, CM; Shu, W; Subramanian, S; Wagman, AS; Zhou, XA	1
Burant, CF; Polonsky, KS; Pugh, W; Sreenan, S; Sturis, J	1
Kawamori, R; Yoshii, H	1
Bressler, R; Johnson, DG	1
Nestler, JE	1
Flórez, H	1
Linday, LA	1
Katayama, S	1
Kliewer, SA; Lehmann, JM; Lenhard, JM; Paulik, MA; Plunket, KD; Weiel, JE	1
Hirsch, IB; Purnell, JQ	1
Hompes, PG; Lambalk, CB; van Hooff, MH; van Montfrans, JM	1
Inzucchi, SE; Maggs, DG; Page, SL; Rife, FS; Shulman, GI; Spollett, GR; Walton, V	1
Bloomgarden, ZT	1
Cooper, ME; Gilbert, RE; Krum, H	1
Greer, IA; Hopkinson, ZE; Sattar, N	1
Casanova, P; Flórez, H	1
Arai, K; Hori, M; Imano, E; Kajimoto, Y; Kanda, T; Motomura, M; Nakatani, Y; Nishida, T; Yamasaki, Y	1
Ehrmann, DA	2
Fonseca, VA; Granberry, MC	1
Awata, T; Chen, S; Katayama, S; Kosegawa, I; Negishi, K	1
Blonde, L; Guthrie, RD; Sandberg, MI	1
Davies, GF; Khandelwal, RL; Roesler, WJ	1
DeFronzo, RA	1
Andres, E; Blicklé, JF; Brogard, JM; Neyrolles, N	1
Lefèbvre, PJ; Scheen, AJ	1
Krentz, AJ	1
Feinglos, MN; Hughes, AT; Luna, B	1
Buse, JB	1
Ginsberg, H; Plutzky, J; Sobel, BE	1
Collier, G; Zimmet, P	1
Kruszynska, YT; Mulford, MI; Olefsky, JM; Yu, JG	1
Smits, P; Tack, CJ	1
Brillon, D; Brown, DL	1
Mozersky, RP	1
Larmore, SS	1
Diamanti-Kandarakis, E; Zapanti, E	1
McCarty, MF	1
Kirk, JK; Michielutte, R; Pearce, KA; Summerson, JH	1
Brindley, DN; Davidge, ST; Delrat, P; Jochemsen, R; Kelly, SE; O'Brien, SF; Pégorier, JP; Ravel, D; Russell, JC	1
Carlton, FB	1
Iuorno, MJ; Nestler, JE	1
Garber, AJ	1
Moses, R	2
Arlt, W; Auchus, RJ; Miller, WL	1
Fajardo, ME; Malacara, JM; Nava, LE	1
Foyt, HL; Ghazzi, MN; Owens-Grillo, JK; Valiquett, TR; Whitcomb, RW; Yale, JF	1
Chang, CT; Chen, CC; Chen, RH; Sheen, LY; Shih, HC; Wang, HJ; Wang, TY	1
Chaudhry, MU; Simmons, DL	1
Marcus, AO	1
Boccuzzi, SJ; Fox, J; Kim, J; Shah, AB; Sung, JC; Wogen, J	1
Baxi, S; Caulfield, M; Chu, NV; Ciaraldi, TP; Henry, RR; Kim, DD; Kong, AP; Loviscach, M; Mudaliar, S; Plodkowski, R; Reitz, R	1
Inzucchi, SE	1
Chu, N; Ciaraldi, TP; Henry, RR; Kahn, BB; Kim, D; Kim, YB; Kong, A; Mohideen, P; Mudaliar, S	1
Armstrong, D; Baxi, S; Caulfield, M; Chu, NV; Deutsch, R; Henry, RR; Kim, DD; Kong, AP; Mudaliar, SR; Reaven, PD; Reitz, R	1
Khan, MA; St Peter, JV; Xue, JL	1
Laboureau-Soares Barbosa, S; Rodien, P; Rohmer, V	1
Bonnefont-Rousselot, D	1
Abourjaily, HM; Alsheikh-Ali, AA; Karas, RH	1
Avilés-Santa, ML; Raskin, P; Strowig, SM	1
Noda, M	1
Chen, J; Chen, M; Hu, R; Li, F; Tang, J; Yang, Y; Yin, J	1
Sakura, H	1
Solignac, M	1
Iida, KT; Iwama, Y; Kamata, K; Kawakami, Y; Mokuno, H; Shimada, K; Shimano, H; Sone, H; Suzuki, M; Toyoshima, H; Watanabe, Y; Yamada, N	1
Aroda, V; Bandukwala, R; Baxi, S; Carter, L; Ciaraldi, TP; Henry, RR; Kong, AP; Mudaliar, SR; Phillips, SA	1
Grellner, WJ; Harris, WS; Isley, WL; Klein, S; Miles, JM; Windsor, S; Wooldridge, D	1
Ackerson, L; Chan, KA; Everhart, JE; Gurwitz, JH; Hurley, JS; Martinson, B; Moseley, RH; Platt, R; Selby, JV; Terrault, N; Truman, A	1
Bruun, JM; He, G; Lihn, AS; Pedersen, SB; Richelsen, B	1
Bouche, C; Goldfine, AB	1
Bernal, MR; Calle-Pascual, AL; Fernández-Cruz, A; Goldfine, A; Horton, E; Jarolim, P; Libby, P; Nuzzo, R; Schönbeck, U; Varo, JJ; Varo, N; Veves, A; Vicent, D	1
Chu, N; Ciaraldi, TP; Cui, L; Henry, RR; Ju, Y; Kim, D; Kong, A; Mathieu-Costello, O; Mudaliar, S	1
Aneja, A; El-Atat, F; McFarlane, SI; Muniyappa, R	1
Pugeat, M	1
Baillargeon, JP; Iuorno, MJ; Nestler, JE	1
Flight, IH; Lord, JM; Norman, RJ	1
Abd el-Aal, G; Abdel-Kareem, O; Amin, M; Maruo, T; Moriyama, T; Takekida, S	1
Ishibashi, S; Ishikawa, SE; Kusaka, I; Nagasaka, S; Nakamura, T; Yatagai, T; Yoshitaka, A	1
Diedrich, K; Ortmann, O; Schröder, AK; Tauchert, S; Weiss, JM	1
Schernthaner, G	1
Anderson, DC	1
Bruun, JM; Lihn, AS; Pedersen, SB; Richelsen, B	1
Fonseca, VA; Jawa, AA	1
Fugate, SE; Stout, DL	1
Barrett-Connor, E; Edelstein, SL; Ehrmann, DA; Fowler, SE; Hamman, RF; Kahn, SE; Knowler, WC; Nathan, DM; Walker, EA	1
Moreno Sánchez, D	1
Abramowicz, M; Zuccotti, G	1
Huypens, P; Pipeleers, D; Quartier, E; Van de Casteele, M	1
Chen, Q; Qiu, Z; Xia, Y	1
El Beltagy, K; Honda, K; Ishiko, O; Misugi, T; Ozaki, K; Tokuyama, O	1
Grant, RW; Meigs, JB	1
Baxi, S; Christiansen, L; Ciaraldi, TP; Henry, RR; Kong, AP; Mudaliar, S; Nikoulina, SE; Oh, DK	1
Hanusch-Enserer, U; Kautzky-Willer, A; Ludvik, B; Pacini, G; Prager, R; Tura, A; Wagner, OF; Winzer, C	1
Altshuler, D; Bayley, N; Florez, JC; Hamman, RF; Jablonski, KA; Kahn, SE; Knowler, WC; Nathan, DM; Shamoon, H; Sun, MW	1
Altshuler, D; Delahanty, L; Florez, JC; Franks, PW; Hanson, RL; Jablonski, KA; Kahn, SE; Knowler, WC	1
Elasy, T; Stafford, JM	1
Chalasani, N; Khashab, M	1
Asai, M; Hashimoto, K; Iwasaki, Y; Kambayashi, M; Nishiyama, M; Taguchi, T; Takayasu, S; Tsugita, M; Yoshida, M	1
Erkkola, R; Gao, L; Hou, L; Qu, J; Wang, Y; Wu, X	1
Bray, GA; Carrion-Petersen, ML; Delahanty, LM; Edelstein, SL; Hamman, RF; Hoskin, MA; Knowler, WC; Ma, Y; Venditti, EM	1
Arakaki, RF; Florez, JC; Goldstein, BJ; Hanson, RL; Jablonski, KA; Kahn, SE; Kitabchi, AE; Knowler, WC; Mason, CC; McAteer, JB; Moore, AF	1
Banerjee, A; Flynt, L; Ghosh, S; Mellema, M; Panettieri, RA; Shore, SA; Williams, E; Zhu, M	1
Florez, JC; Goldberg, RB; Jablonski, KA; Kahn, SE; Majithia, AR; Mather, KJ; McAteer, JB	1
Cho, NH; Cho, YM; Choi, SH; Jang, HC; Jung, HS; Kim, K; Kim, SY; Kwak, SH; Lim, S; Park, KS	1
Arnett, TR; Butters, OR; Patel, JJ	1
Adams, LA; Bedwell, DW; Calvert, NA; Cassidy, KC; Cramer, JW; Mohutsky, MA; Moulton, RD; Rougée, LR; Ruterbories, KJ; Yumibe, NP; Zhou, X	1
DeBoer, MD; Filipp, SL; Gurka, MJ	1

Reviews

46 review(s) available for troglitazone and metformin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Drug therapy in subjects with impaired glucose tolerance]. Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:10 Topics: Acarbose; Biguanides; Chromans; Diabetes Mellitus, Type 2; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Metformin; Pioglitazone; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1996
Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Archives of internal medicine, 1997, Apr-28, Volume: 157, Issue:8 Topics: Acarbose; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1997
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications. Seminars in reproductive endocrinology, 1997, Volume: 15, Issue:2 Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Ovary; Polycystic Ovary Syndrome; Steroid 17-alpha-Hydroxylase; Thiazoles; Thiazolidinediones; Troglitazone	1997
[Steps toward the primary prevention of type II diabetes mellitus. Various epidemiological considerations]. Investigacion clinica, 1997, Volume: 38, Issue:1 Topics: Adult; Aged; Chromans; Comorbidity; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Diet, Reducing; Exercise; Female; Glucose Tolerance Test; Humans; Hypertension; Hypoglycemic Agents; Life Style; Male; Metformin; Middle Aged; National Institutes of Health (U.S.); Obesity; Prediabetic State; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone; United States	1997
[Treatment of hypertension associated with diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:8 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cerebrovascular Disorders; Chromans; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Metformin; Obesity; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone	1997
New oral therapies for type 2 diabetes. American family physician, 1997, Nov-01, Volume: 56, Issue:7 Topics: Acarbose; Administration, Oral; Algorithms; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1997
Treatment of hyperinsulinaemia in polycystic ovary syndrome? Human reproduction (Oxford, England), 1998, Volume: 13, Issue:1 Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone	1998
Drug administration in patients with diabetes mellitus. Safety considerations. Drug safety, 1998, Volume: 18, Issue:6 Topics: Acarbose; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Chromans; Diabetes Complications; Diabetes Mellitus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypoglycemic Agents; Insulin; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1998
Attenuation of hyperinsulinemia in polycystic ovary syndrome: what are the options? Journal of endocrinological investigation, 1998, Volume: 21, Issue:9 Topics: Chromans; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone	1998
Insulin resistance syndrome: options for treatment. Southern medical journal, 1999, Volume: 92, Issue:1 Topics: Arteriosclerosis; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Microvascular Angina; Obesity; Thiazoles; Thiazolidinediones; Troglitazone	1999
Pharmacologic therapy for type 2 diabetes mellitus. Annals of internal medicine, 1999, Aug-17, Volume: 131, Issue:4 Topics: Acarbose; Administration, Oral; Algorithms; Carbamates; Chromans; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Insulin; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone	1999
[Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs]. La Revue de medecine interne, 1999, Volume: 20 Suppl 3 Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exercise; Fenfluramine; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Lactones; Lipase; Metformin; Orlistat; Peroxisome Proliferators; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone	1999
Troglitazone: antihyperglycemic activity and potential role in the treatment of type 2 diabetes. Diabetes care, 1999, Volume: 22, Issue:9 Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
The use of insulin secretagogues in the treatment of type 2 diabetes. Primary care, 1999, Volume: 26, Issue:4 Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Piperidines; Protein Precursors; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
The use of insulin alone and in combination with oral agents in type 2 diabetes. Primary care, 1999, Volume: 26, Issue:4 Topics: Acarbose; Blood Glucose; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Self Care; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
A review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering. Journal of cardiovascular risk, 1999, Volume: 6, Issue:5 Topics: Antioxidants; Blood Coagulation; Cardiovascular Diseases; Cardiovascular System; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Metformin; Thiazoles; Thiazolidinediones; Troglitazone	1999
Clinical efficacy of metformin against insulin resistance parameters: sinking the iceberg. Drugs, 1999, Volume: 58 Suppl 1 Topics: Animals; Blood Glucose; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Leptin; Male; Metformin; Rats; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone	1999
New drugs for diabetes. The Netherlands journal of medicine, 1999, Volume: 55, Issue:5 Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone	1999
New directions in type 2 diabetes mellitus: an update of current oral antidiabetic therapy. Journal of the National Medical Association, 1999, Volume: 91, Issue:7 Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
Recent advances in the pharmacologic management of diabetes mellitus. Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4 Topics: Acarbose; Administration, Oral; Carbamates; Chromans; Diabetes Mellitus; Drug Overdose; Emergencies; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2000
The polycystic ovary syndrome: treatment with insulin sensitizing agents. Diabetes, obesity & metabolism, 1999, Volume: 1, Issue:3 Topics: Chromans; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Obesity; Ovary; Polycystic Ovary Syndrome; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone	1999
Using dose-response characteristics of therapeutics agents for treatment decisions in type 2 diabetes. Diabetes, obesity & metabolism, 2000, Volume: 2, Issue:3 Topics: Acarbose; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2000
Combination therapy in type 2 diabetes: the role of repaglinide. The Journal of the Association of Physicians of India, 2001, Jan-25, Volume: 49 Spec No Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone	2001
Safety of drugs commonly used to treat hypertension, dyslipidemia, and Type 2 diabetes (the metabolic syndrome): part 2. Diabetes technology & therapeutics, 2000,Summer, Volume: 2, Issue:2 Topics: Acarbose; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Insulin; Metformin; Safety; Sulfonylurea Compounds; Syndrome; Thiazoles; Thiazolidinediones; Troglitazone	2000
Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA, 2002, Jan-16, Volume: 287, Issue:3 Topics: Administration, Oral; Biguanides; Blood Glucose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Diet; Drug Therapy, Combination; Enzyme Inhibitors; Exercise; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2002
[Polycystic ovary syndrome: treatment with insulin-sensitizing agents]. Annales d'endocrinologie, 2002, Volume: 63, Issue:1 Topics: Androgens; Chromans; Female; Hirsutism; Humans; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Metformin; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone	2002
[Antioxidant and anti-AGE therapeutics: evaluation and perspectives]. Journal de la Societe de biologie, 2001, Volume: 195, Issue:4 Topics: Antioxidants; Chromans; Diabetes Mellitus; Gliclazide; Glycation End Products, Advanced; Guanidines; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Thiazolidinediones; Troglitazone	2001
[Primary prevention of diabetes mellitus by pharmacological intervention]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9 Topics: Acarbose; Angiotensin-Converting Enzyme Inhibitors; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lactones; Metformin; Orlistat; Pravastatin; Primary Prevention; Ramipril; Thiazoles; Thiazolidinediones; Troglitazone	2002
[Combination therapy with biguanides]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10 Topics: Acarbose; Biguanides; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone	2002
Repaglinide in combination therapy. Diabetes, nutrition & metabolism, 2002, Volume: 15, Issue:6 Suppl Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Pioglitazone; Piperidines; Postprandial Period; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone	2002
Prevention of type 2 diabetes: are we ready? Minerva medica, 2003, Volume: 94, Issue:1 Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactones; Life Style; Lipase; Metformin; Orlistat; Thiazoles; Thiazolidinediones; Troglitazone	2003
[Treatment of PCOS without IVF: weight loss, insulin-sensitizing agents]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2003, Volume: 32, Issue:3 Pt 2 Topics: Acarbose; Chromans; Enzyme Inhibitors; Female; Glucose Intolerance; Glucosidases; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone; Weight Loss	2003
Insulin sensitizers for polycystic ovary syndrome. Clinical obstetrics and gynecology, 2003, Volume: 46, Issue:2 Topics: Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Thiazoles; Thiazolidinediones; Troglitazone	2003
Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. The Cochrane database of systematic reviews, 2003, Issue:3 Topics: Anovulation; Chromans; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Ovulation Induction; Pioglitazone; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone	2003
Minireview: Up-date management of non responder to clomiphene citrate in polycystic ovary syndrome. The Kobe journal of medical sciences, 2003, Volume: 49, Issue:3-4 Topics: Anovulation; Chromans; Clomiphene; Drug Resistance; Drug Therapy, Combination; Female; Gynecologic Surgical Procedures; Humans; Hyperinsulinism; Hypoglycemic Agents; Inositol Phosphates; Laparoscopy; Metformin; Ovary; Polycystic Ovary Syndrome; Polysaccharides; Thiazolidinediones; Treatment Failure; Troglitazone	2003
[Insulin resistance in polycystic ovary syndrome]. Wiener klinische Wochenschrift, 2003, Dec-15, Volume: 115, Issue:23 Topics: Adolescent; Adult; Body Mass Index; Cardiovascular Diseases; Chromans; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Infant, Newborn; Infertility, Female; Insulin Resistance; Metformin; Middle Aged; Obesity; Placebos; Polycystic Ovary Syndrome; Pregnancy; Premenopause; Prevalence; Prospective Studies; Retrospective Studies; Risk Factors; Thiazolidinediones; Troglitazone	2003
[Progress in the prevention of type 2 diabetes]. Wiener klinische Wochenschrift, 2003, Nov-28, Volume: 115, Issue:21-22 Topics: Acarbose; Adult; Alcohol Drinking; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Chromans; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Exercise; Fasting; Female; Glucose Tolerance Test; Humans; Hypertension; Hypoglycemic Agents; Insulin Resistance; Life Style; Male; Metformin; Middle Aged; Placebos; Primary Prevention; Randomized Controlled Trials as Topic; Risk Factors; Thiazolidinediones; Time Factors; Troglitazone; Weight Loss	2003
Pharmacologic prevention or delay of type 2 diabetes mellitus. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:1 Topics: Acarbose; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactones; Meta-Analysis as Topic; Metformin; Orlistat; Randomized Controlled Trials as Topic; Thiazolidinediones; Troglitazone	2005
Role of insulin secretagogues and insulin sensitizing agents in the prevention of cardiovascular disease in patients who have diabetes. Cardiology clinics, 2005, Volume: 23, Issue:2 Topics: Angioplasty, Balloon, Coronary; Animals; Biguanides; Blood Pressure; Chromans; Diabetic Angiopathies; Endothelium, Vascular; Fibrinolysis; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Postprandial Period; Risk Factors; Rosiglitazone; Sulfonylurea Compounds; Thiazolidinediones; Troglitazone	2005
Thiazolidinediones for treatment of polycystic ovary syndrome. Pharmacotherapy, 2005, Volume: 25, Issue:2 Topics: Adult; Chromans; Clinical Trials as Topic; Clomiphene; Contraceptives, Oral; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Ovulation; Pioglitazone; Polycystic Ovary Syndrome; Thiazolidinediones; Troglitazone	2005
Polycystic ovary syndrome. The New England journal of medicine, 2005, Mar-24, Volume: 352, Issue:12 Topics: Acne Vulgaris; Androgen Antagonists; Cardiovascular Diseases; Chromans; Contraceptives, Oral; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diet, Reducing; Female; Glucose Intolerance; Hirsutism; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Thiazolidinediones; Troglitazone	2005
[Medical management of primary nonalcoholic fatty liver disease]. Medicina clinica, 2005, Jun-18, Volume: 125, Issue:3 Topics: Anti-Obesity Agents; Anticholesteremic Agents; Atorvastatin; Chromans; Diabetes Mellitus, Type 2; Fatty Liver; Heptanoic Acids; Humans; Hypoglycemic Agents; Insulin Resistance; Lactones; Metabolic Syndrome; Metformin; Obesity; Orlistat; Prevalence; Pyrroles; Rosiglitazone; Thiazolidinediones; Troglitazone	2005
Management of the metabolic syndrome. Panminerva medica, 2005, Volume: 47, Issue:4 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Diseases; Chromans; Diet; Exercise; Humans; Insulin Resistance; Metabolic Syndrome; Metformin; Thiazolidinediones; Troglitazone	2005
Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes. Vascular health and risk management, 2007, Volume: 3, Issue:4 Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Rosiglitazone; Thiazolidinediones; Treatment Outcome; Troglitazone	2007
Use of insulin sensitizers in NASH. Endocrinology and metabolism clinics of North America, 2007, Volume: 36, Issue:4 Topics: Alanine Transaminase; Chromans; Fatty Liver; Humans; Insulin Resistance; Metabolic Syndrome; Metformin; Pioglitazone; Prognosis; Rosiglitazone; Thiazolidinediones; Troglitazone	2007

Trials

29 trial(s) available for troglitazone and metformin

Article	Year
Trivalent chromium and the diabetes prevention program. Medical hypotheses, 1997, Volume: 49, Issue:1 Topics: Chromans; Chromium; Clinical Protocols; Complementary Therapies; Diabetes Mellitus, Type 2; Diet; Exercise; Glucose Intolerance; Humans; Hypoglycemic Agents; Metformin; Safety; Thiazoles; Thiazolidinediones; Troglitazone	1997
Treatment of hyperinsulinaemia in polycystic ovary syndrome? Human reproduction (Oxford, England), 1998, Volume: 13, Issue:1 Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Troglitazone	1998
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. The New England journal of medicine, 1998, Mar-26, Volume: 338, Issue:13 Topics: Administration, Oral; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucose; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone	1998
Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy. Diabetes care, 1998, Volume: 21, Issue:12 Topics: Aged; Albuminuria; Blood Glucose; Blood Pressure; C-Peptide; Cholesterol; Cholesterol, HDL; Chromans; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone	1998
The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes care, 1999, Volume: 22, Issue:4 Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Intake; Exercise Therapy; Female; Glucose Tolerance Test; Health Policy; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Life Style; Liver; Male; Metformin; Middle Aged; Obesity; Outcome and Process Assessment, Health Care; Quality of Life; Research Design; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone	1999
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients. Diabetes, 1999, Volume: 48, Issue:12 Topics: Blood Glucose; Body Weight; C-Peptide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Circadian Rhythm; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Fructosamine; Humans; Hypoglycemic Agents; Insulin; Insulin Infusion Systems; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone	1999
Troglitazone or metformin in combination with sulfonylureas for patients with type 2 diabetes? The Journal of family practice, 1999, Volume: 48, Issue:11 Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glipizide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens. Steroids, 2001, Volume: 66, Issue:7 Topics: Chromans; Clomiphene; Estrogens; Feedback, Physiological; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Hypoglycemic Agents; Insulin Resistance; Menopause; Metformin; Middle Aged; Obesity; Pregnancy; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiazoles; Thiazolidinediones; Troglitazone	2001
The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial. Annals of internal medicine, 2001, May-01, Volume: 134, Issue:9 Pt 1 Topics: Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Treatment Failure; Triglycerides; Troglitazone	2001
Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects. Diabetes, 2002, Volume: 51, Issue:1 Topics: Adipocytes; Adipose Tissue; Adult; Aged; Body Composition; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Signal Transduction; Thiazoles; Thiazolidinediones; Troglitazone	2002
Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes, 2002, Volume: 51, Issue:2 Topics: Adult; Aged; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Isoenzymes; Male; Metformin; Middle Aged; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Thiazoles; Thiazolidinediones; Troglitazone	2002
Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes. Diabetes care, 2002, Volume: 25, Issue:3 Topics: Blood Glucose; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Lipoproteins, LDL; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone	2002
A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes care, 2002, Volume: 25, Issue:4 Topics: Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone	2002
Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and troglitazone in type 2 diabetes. Diabetes care, 2002, Volume: 25, Issue:10 Topics: Adult; Age of Onset; Aged; Body Mass Index; C-Peptide; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Lipoproteins; Male; Metformin; Middle Aged; Racial Groups; Texas; Thiazoles; Thiazolidinediones; Troglitazone	2002
Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes, 2003, Volume: 52, Issue:3 Topics: Adipocytes; Adiponectin; Adipose Tissue; Adult; Aged; Biopsy; Chromans; Culture Media, Conditioned; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Male; Metformin; Middle Aged; Molecular Weight; Obesity; Proteins; Thiazoles; Thiazolidinediones; Tissue Distribution; Troglitazone	2003
Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy. Diabetes, 2003, Volume: 52, Issue:3 Topics: Adult; Blood Glucose; C-Peptide; Chromans; Circadian Rhythm; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Food; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Kinetics; Lipolysis; Male; Metformin; Middle Aged; Placebos; Thiazoles; Thiazolidinediones; Troglitazone	2003
Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones. Circulation, 2003, Jun-03, Volume: 107, Issue:21 Topics: Acute Disease; Adult; Aged; Arteriosclerosis; Body Mass Index; CD40 Ligand; Chromans; Chronic Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Longitudinal Studies; Male; Metformin; Pilot Projects; Receptors, Cytoplasmic and Nuclear; Reference Values; Risk Factors; Solubility; Spain; Thiazoles; Thiazolidinediones; Transcription Factors; Treatment Outcome; Troglitazone	2003
Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal. Metabolism: clinical and experimental, 2003, Volume: 52, Issue:5 Topics: Adult; Aged; Biopsy; Capillaries; Chromans; Diabetes Mellitus, Type 2; Female; Glucose; Histocytochemistry; Humans; Hypoglycemic Agents; Lipid Metabolism; Male; Metformin; Microscopy, Electron; Middle Aged; Muscle Fibers, Skeletal; Muscle, Skeletal; Regional Blood Flow; Thiazoles; Thiazolidinediones; Troglitazone	2003
The Diabetes Prevention Program. Current diabetes reports, 2003, Volume: 3, Issue:3 Topics: Adult; Cardiovascular Diseases; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hypoglycemic Agents; Incidence; Life Style; Metformin; Morbidity; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone	2003
Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects. Diabetes research and clinical practice, 2004, Volume: 63, Issue:1 Topics: Blood Glucose; C-Reactive Protein; Chromans; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Thiazolidinediones; Time Factors; Troglitazone	2004
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes, 2005, Volume: 54, Issue:4 Topics: Chromans; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Humans; Hypoglycemic Agents; Incidence; Insulin Resistance; Life Style; Male; Metformin; Middle Aged; Thiazolidinediones; Troglitazone	2005
Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:5 Topics: Adult; Aged; Biopsy; Blood Glucose; Caloric Restriction; Chromans; Diabetes Mellitus, Type 2; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Muscle, Skeletal; Obesity; Phosphorylation; Subcutaneous Fat; Thiazolidinediones; Troglitazone; Weight Loss	2006
Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione. Diabetes, obesity & metabolism, 2006, Volume: 8, Issue:5 Topics: Blood Glucose; Body Weight; C-Peptide; Cell Adhesion Molecules; Chromans; Diabetes Mellitus, Type 2; Drug Monitoring; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Middle Aged; Proinsulin; Thiazolidinediones; Troglitazone	2006
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:4 Topics: Amino Acid Substitution; Chromans; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Disease Progression; Genetic Variation; Genotype; Humans; Hypoglycemic Agents; Life Style; Metformin; Polymorphism, Single Nucleotide; PPAR gamma; Thiazolidinediones; Troglitazone	2007
The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia, 2007, Volume: 50, Issue:12 Topics: Adult; Alanine; Amino Acid Substitution; Body Composition; Chromans; Diabetes Mellitus, Type 2; Dietary Fats; Eating; Female; Gene Frequency; Genotype; Humans; Hypoglycemic Agents; Life Style; Male; Metformin; Middle Aged; Obesity; Placebos; PPAR gamma; Proline; Thiazolidinediones; Troglitazone	2007
First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes. International journal of obesity (2005), 2008, Volume: 32, Issue:10 Topics: Behavior Therapy; Caloric Restriction; Chromans; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Female; Humans; Hypoglycemic Agents; Life Style; Male; Metformin; Middle Aged; Obesity; Overweight; Thiazolidinediones; Troglitazone; Weight Loss	2008
The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:2 Topics: Chromans; Combined Modality Therapy; Diabetes Mellitus, Type 2; Exercise Therapy; Female; Gene Frequency; Genetic Linkage; Genetic Predisposition to Disease; Glutamic Acid; Humans; Hypoglycemic Agents; Incidence; Lysine; Male; Metformin; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases; Risk Reduction Behavior; Thiazolidinediones; Troglitazone	2009
Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program. Diabetologia, 2011, Volume: 54, Issue:10 Topics: Adult; C-Peptide; Cation Transport Proteins; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Male; Metformin; Middle Aged; Polymorphism, Genetic; Proinsulin; Thiazolidinediones; Troglitazone; Zinc Transporter 8	2011
Use of a Metabolic Syndrome Severity Diabetes care, 2018, Volume: 41, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Life Style; Male; Metabolic Syndrome; Metformin; Middle Aged; Prediabetic State; Prognosis; Program Evaluation; Research Design; Risk Factors; Risk Reduction Behavior; Severity of Illness Index; Troglitazone; Waist Circumference	2018

Other Studies

45 other study(ies) available for troglitazone and metformin

Article	Year
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. Journal of medicinal chemistry, 2017, 10-26, Volume: 60, Issue:20 Topics: Animals; CHO Cells; Chromatography, High Pressure Liquid; Cricetulus; Crystallography, X-Ray; Enzyme Inhibitors; Glycogen Synthase Kinases; Humans; Hypoglycemic Agents; Mass Spectrometry; Proton Magnetic Resonance Spectroscopy; Pyrimidines; Rats; Structure-Activity Relationship	2017
Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 1 Topics: Age Factors; Animals; Body Weight; Chromans; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Hyperglycemia; Insulin; Islets of Langerhans; Male; Metformin; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone	1996
Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways. Biochemical pharmacology, 1997, Oct-01, Volume: 54, Issue:7 Topics: Animals; Biological Transport; Chromans; Glucose; Hypoglycemic Agents; Lactic Acid; Lipid Metabolism; Metformin; Mice; Mice, Inbred C3H; Mitochondria; Palmitoyl Coenzyme A; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone	1997
International Diabetes Federation meeting, 1997. Issues in the treatment of type 2 diabetes; sulfonylureas, metformin, and troglitazone. Diabetes care, 1998, Volume: 21, Issue:6 Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1998
Insulin-sensitising agents in polycystic-ovary syndrome. Lancet (London, England), 1998, Jan-31, Volume: 351, Issue:9099 Topics: Chromans; Controlled Clinical Trials as Topic; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone	1998
[Changes in clinical intervention studies: when the wellbeing of the patients takes precedence]. Investigacion clinica, 1998, Volume: 39, Issue:3 Topics: Antihypertensive Agents; Chromans; Clinical Trials as Topic; Diabetes Complications; Enalapril; Ethics, Medical; Hypertension; Hypoglycemic Agents; Metformin; Multicenter Studies as Topic; Nisoldipine; Prediabetic State; Prospective Studies; Thiazoles; Thiazolidinediones; Treatment Failure; Troglitazone	1998
Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 1999, Volume: 21, Issue:3 Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Chromans; Diabetes Mellitus, Type 2; Glucose Transporter Type 4; Glyburide; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Metformin; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Troglitazone	1999
Switching insulin-sensitizing agents in patients with type 2 diabetes who require insulin. Diabetes care, 1999, Volume: 22, Issue:6 Topics: Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Thiazoles; Thiazolidinediones; Troglitazone	1999
Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism. Biochimica et biophysica acta, 1999, Aug-12, Volume: 1451, Issue:1 Topics: Animals; Cells, Cultured; Chromans; Gene Expression Regulation; Gluconeogenesis; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Liver; Male; Metformin; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone	1999
Non-alcoholic steatohepatitis. Lancet (London, England), 1999, Oct-09, Volume: 354, Issue:9186 Topics: Chromans; Contraindications; Diabetes Mellitus, Type 2; Fatty Liver; Hepatitis; Humans; Hypoglycemic Agents; Metformin; Thiazoles; Thiazolidinediones; Troglitazone	1999
Pharmacologic management of diabetes mellitus. The Journal of the American Osteopathic Association, 1999, Volume: 99, Issue:12 Suppl Topics: Carbamates; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	1999
Managing type 2 diabetes. A look at the newer agents. JAAPA : official journal of the American Academy of Physician Assistants, 1999, Volume: 12, Issue:6 Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone	1999
Insulin sensitizers and antiandrogens in the treatment of polycystic ovary syndrome. Annals of the New York Academy of Sciences, 2000, Volume: 900 Topics: Androgen Antagonists; Chromans; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Pregnancy; Thiazoles; Thiazolidinediones; Troglitazone	2000
Toward practical prevention of type 2 diabetes. Medical hypotheses, 2000, Volume: 54, Issue:5 Topics: alpha-Linolenic Acid; Animals; Biotin; Calcium; Chromans; Coenzymes; Diabetes Mellitus, Type 2; Ethanol; Female; Humans; Liver; Magnesium; Male; Metformin; Rats; Risk Factors; Thiazoles; Thiazolidinediones; Troglitazone; Ubiquinone	2000
Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Animals; Blood Glucose; Body Weight; Chromans; Eating; Fluorenes; Gene Expression; Glucose Tolerance Test; Glucose-6-Phosphatase; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Resistance; Lactic Acid; Lipids; Liver; Male; Mesenteric Arteries; Metformin; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphoenolpyruvate Carboxylase; Rats; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Vascular Resistance	2000
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase. The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20 Topics: 3-Hydroxysteroid Dehydrogenases; Biguanides; Chromans; Cloning, Molecular; Humans; Kinetics; Metformin; Pioglitazone; Recombinant Proteins; Saccharomyces cerevisiae; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone	2001
Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats. Journal of the Formosan Medical Association = Taiwan yi zhi, 2001, Volume: 100, Issue:3 Topics: Animals; Chromans; Fatty Acids, Nonesterified; Fructose; Hypoglycemic Agents; Insulin Resistance; Leptin; Male; Metformin; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone	2001
Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin. The Journal of the Arkansas Medical Society, 2001, Volume: 98, Issue:1 Topics: Acute Kidney Injury; Chromans; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Liver Failure, Acute; Male; Metformin; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone	2001
Utilization of oral hypoglycemic agents in a drug-insured U.S. population. Diabetes care, 2001, Volume: 24, Issue:8 Topics: Carbamates; Chromans; Cohort Studies; Databases as Topic; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insurance, Pharmaceutical Services; Longitudinal Studies; Managed Care Programs; Metformin; Piperidines; Retrospective Studies; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; United States	2001
Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose). The American journal of cardiology, 2002, Jun-01, Volume: 89, Issue:11 Topics: Acarbose; Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Atorvastatin; Chromans; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrroles; Simvastatin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2002
Effects of berberine on glucose metabolism in vitro. Metabolism: clinical and experimental, 2002, Volume: 51, Issue:11 Topics: Berberine; Cell Line; Chromans; Dose-Response Relationship, Drug; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Metformin; Phenotype; Thiazoles; Thiazolidinediones; Troglitazone	2002
[News on diabetes and public health perspectives]. Presse medicale (Paris, France : 1983), 2002, Nov-23, Volume: 31, Issue:39 Pt 1 Topics: Administration, Oral; Adult; Chromans; Clinical Trials as Topic; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Exercise; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Metformin; Obesity; Pancreas Transplantation; Patient Education as Topic; Pregnancy; Public Health; Risk Factors; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone	2002
Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:6 Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol, LDL; Chromans; Diabetes Mellitus, Type 2; Endothelium, Vascular; Hypoglycemic Agents; Isometric Contraction; Lipid Peroxidation; Lipids; Male; Metformin; Muscle Contraction; Muscle Relaxation; Oxidation-Reduction; Pioglitazone; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Vasodilator Agents	2003
A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. Archives of internal medicine, 2003, Mar-24, Volume: 163, Issue:6 Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Cohort Studies; Female; Humans; Hypoglycemic Agents; Incidence; Insulin; Liver; Liver Failure; Male; Metformin; Middle Aged; Proportional Hazards Models; Severity of Illness Index; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone	2003
Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:1 Topics: Adipocytes; Adipose Tissue; Adult; Cells, Cultured; Chromans; Culture Techniques; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Kinetics; Metformin; Pioglitazone; Plasminogen Activator Inhibitor 1; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Transcription Factors; Troglitazone	2003
Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:4 Topics: Adipocytes; Adipose Tissue; Chemokine CCL2; Chromans; Humans; Interleukin-1; Interleukin-8; Macrophages; Metformin; Skin; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha; Viscera	2005
Drugs for diabetes. Treatment guidelines from the Medical Letter, 2005, Volume: 3, Issue:36 Topics: Acarbose; Chromans; Diabetes Mellitus, Type 2; Exenatide; Humans; Hypoglycemic Agents; Insulin; Metformin; Peptides; Thiazolidinediones; Troglitazone; Venoms	2005
Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3 Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Northern; Blotting, Western; Chromans; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Glucose; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Metformin; Mice; Multienzyme Complexes; Phenformin; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Messenger; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha	2005
Effect of ecdysterone on glucose metabolism in vitro. Life sciences, 2006, Feb-02, Volume: 78, Issue:10 Topics: Animals; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Ecdysterone; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liver Neoplasms; Metformin; Mice; Mice, Transgenic; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Troglitazone	2006
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats. Gynecologic and obstetric investigation, 2006, Volume: 61, Issue:4 Topics: 17-Hydroxysteroid Dehydrogenases; Adjuvants, Immunologic; Animals; Chromans; Dehydroepiandrosterone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hypoglycemic Agents; Immunohistochemistry; Insulin; Metformin; Ovary; Pioglitazone; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Testosterone; Thiazolidinediones; Troglitazone	2006
Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene. Molecular and cellular endocrinology, 2008, Mar-26, Volume: 285, Issue:1-2 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Anticholesteremic Agents; Base Sequence; Cell Line; Chromans; Clofibrate; Cortisone; Cushing Syndrome; Dexamethasone; Gene Expression Regulation, Enzymologic; Glucocorticoids; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Interleukin-1beta; Liver; Metabolic Syndrome; Metformin; Molecular Sequence Data; Receptors, Glucocorticoid; Thiazolidinediones; Transcription Factor AP-1; Troglitazone; Tumor Necrosis Factor-alpha	2008
Insulin resistance directly contributes to androgenic potential within ovarian theca cells. Fertility and sterility, 2009, Volume: 91, Issue:5 Suppl Topics: Androgens; Animals; Cell Culture Techniques; Chromans; Female; Glucose Transporter Type 4; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Swine; Theca Cells; Thiazolidinediones; Troglitazone	2009
Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells. American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:1 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anilides; Anti-Inflammatory Agents; Antimetabolites; Asthma; Cells, Cultured; Chromans; Cytokines; Enzyme Activators; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Hypoglycemic Agents; Inflammation Mediators; Metformin; Myocytes, Smooth Muscle; PPAR gamma; Pyrazoles; Pyrimidines; Respiratory System; Ribonucleotides; Rosiglitazone; Thiazolidinediones; Troglitazone; Vidarabine	2011
Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score. Diabetologia, 2013, Volume: 56, Issue:12 Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Disease Progression; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Metformin; Postpartum Period; Predictive Value of Tests; Pregnancy; Prospective Studies; Republic of Korea; Risk Assessment; Risk Factors; Risk Reduction Behavior; Thiazolidinediones; Troglitazone	2013
PPAR agonists stimulate adipogenesis at the expense of osteoblast differentiation while inhibiting osteoclast formation and activity. Cell biochemistry and function, 2014, Volume: 32, Issue:4 Topics: Adipogenesis; Animals; Cell Differentiation; Cells, Cultured; Chromans; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Droplets; Metformin; Mice; Osteoblasts; Osteoclasts; Osteogenesis; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Troglitazone	2014
Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8 Topics: Administration, Intravenous; Animals; Biotransformation; Canagliflozin; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glyburide; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Male; Metformin; Rats, Sprague-Dawley; Rats, Zucker; Rosiglitazone; Species Specificity; Substrate Specificity; Sulfotransferases; Thiazolidinediones; Troglitazone	2016