Compounds > troglitazone

Page last updated: 2024-08-16

troglitazone and gemfibrozil

troglitazone has been researched along with gemfibrozil in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (5.88)	18.7374
1990's	1 (5.88)	18.2507
2000's	8 (47.06)	29.6817
2010's	7 (41.18)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aizawa, Y; Fujita, T; Hasegawa, K; Horikoshi, H; Kanai, T; Kurumada, T; Yoshioka, T	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bell, DS; Ovalle, F	1
Asakawa, M; Komuro, I; Masuda, Y; Nagai, T; Oka, T; Saito, T; Takano, H; Toyozaki, T	1
Hombach, V; Marx, N	1
Coleman, RA; Krisans, SK; Lewin, TM; Van Horn, CG	1
Angulo, P	1
Brun, ME; Funk, C; Noé, J; Portmann, R	1

Reviews

3 review(s) available for troglitazone and gemfibrozil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Peroxisome proliferator-activated receptors (PPARs) in the vessel wall: new regulators of gene expression in vascular cells]. Zeitschrift fur Kardiologie, 2001, Volume: 90, Issue:7 Topics: Animals; Arteriosclerosis; Chromans; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Female; Fenofibrate; Gemfibrozil; Gene Expression Regulation; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Ligands; Male; Mice; Muscle, Smooth, Vascular; Peroxisome Proliferators; Rats; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone	2001
Current best treatment for non-alcoholic fatty liver disease. Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:5 Topics: Antioxidants; Chromans; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Fatty Liver; Gemfibrozil; Humans; Hypolipidemic Agents; Liver Transplantation; Obesity; Thiazoles; Thiazolidinediones; Troglitazone; Weight Loss	2003

Other Studies

14 other study(ies) available for troglitazone and gemfibrozil

Article	Year
Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation. Journal of medicinal chemistry, 1989, Volume: 32, Issue:2 Topics: Animals; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Phenols; Rats; Structure-Activity Relationship	1989
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Troglitazone interferes with gemfibrozil's lipid-lowering action. Diabetes care, 1998, Volume: 21, Issue:11 Topics: Chromans; Diabetes Mellitus; Drug Interactions; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Retrospective Studies; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone	1998
Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes. Circulation research, 2000, Sep-29, Volume: 87, Issue:7 Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Drug Interactions; Gemfibrozil; Hypoglycemic Agents; Lipopolysaccharides; Myocardium; NF-kappa B; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Necrosis Factor-alpha	2000
Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Archives of biochemistry and biophysics, 2002, Aug-15, Volume: 404, Issue:2 Topics: Animals; Butyrates; Chromans; Coenzyme A Ligases; Endoplasmic Reticulum; Female; Gemfibrozil; Hypoglycemic Agents; Hypolipidemic Agents; Intracellular Membranes; Isoenzymes; Ligands; Liver; Mitochondria; Mitochondrial Proteins; Peroxisomes; Phenylurea Compounds; Potassium Chloride; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Subcellular Fractions; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Up-Regulation	2002
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8 Topics: Animals; Anticholesteremic Agents; Biological Transport; Cell Line; CHO Cells; Chromans; Cricetinae; Cricetulus; Drug Interactions; Estrone; Fatty Acids, Monounsaturated; Fluvastatin; Gemfibrozil; Hepatocytes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Indoles; Kinetics; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pravastatin; Protein Binding; Recombinant Proteins; Simvastatin; Solute Carrier Organic Anion Transporter Family Member 1B3; Taurocholic Acid; Thiazolidinediones; Troglitazone	2007