troglitazone has been researched along with fenofibrate in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 16 (45.71) | 29.6817 |
| 2010's | 18 (51.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, PJ; Henke, BR; Sternbach, DD; Willson, TM | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Altieri, F; Azzariti, A; Cervoni, L; Crestani, M; Di Giovanni, C; Fracchiolla, G; Gilardi, F; Giudici, M; Guerrini, U; Laghezza, A; Lavecchia, A; Loiodice, F; Mitro, N; Montanari, R; Paradiso, A; Piemontese, L; Pochetti, G; Porcelli, L; Simone, GM; Tortorella, P | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Bakmiwewa, SM; Ball, HJ; Fatokun, AA; Hunt, NH; Payne, RJ; Tran, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Amemiya-Kudo, M; Gotoda, T; Harada, K; Hasty, AH; Iizuka, Y; Ishibashi, S; Nagai, R; Ohashi, K; Okazaki, H; Osuga, J; Shimano, H; Shionoiri, F; Tamura, Y; Yahagi, N; Yamada, N | 1 |
| Kimura, H; Momose, Y; Moriyama, S; Odaka, H; Sakamoto, J; Sawada, H; Sugiyama, Y | 1 |
| Hombach, V; Marx, N | 1 |
| Blaschke, F; Bungenstock, A; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Stawowy, P | 1 |
| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Alegret, M; Cabrero, A; Carrera, MV; Cubero, M; Jové, M; Laguna, JC; Llaverías, G; Planavila, A; Sánchez, R | 1 |
| Ikeda, M; Kakei, M; Matsumoto, S; Mori, M; Okada, S; Shimizu, H; Shimomura, K | 1 |
| Haas, C; Häring, HU; Kaltenbach, S; Machicao, F; Staiger, H; Stumvoll, M; Weisser, M | 1 |
| Buechler, C; Kirchner, S; Laberer, S; Neumeier, M; Schäffler, A; Schölmerich, J; Weigert, J; Weiss, T | 1 |
| Al-Makdissy, N; Becuwe, P; Chedotal, A; Collet, P; Dauça, M; Devignes, MD; Domenjoud, L; Donner, M; Huin-Schohn, C; Kerjan, G; Murad, H; Schohn, H | 1 |
| Buechler, C; Neumeier, M; Schäffler, A; Schölmerich, J; Weigert, J | 1 |
| Binder, BR; Blüml, S; Bochkov, VN; Exner, M; Fürnkranz, A; Ikonomu, E; Kadl, A; Krönke, G; Leitinger, N; Sarembock, IJ | 1 |
| de Dios, ST; Evanko, SP; Ivey, ME; Little, PJ; Nigro, J; Potter-Perigo, S; Wight, TN | 1 |
| Chopra, B; Georgopoulos, NT; Hinley, J; Nicholl, A; Oleksiewicz, MB; Southgate, J | 1 |
| Boise, LH; Kurtoglu, M; Lampidis, TJ; Liu, H; Philips, K | 1 |
| Anderson, HD; Huang, Y; Kopilas, MA; Netticadan, T; O'Hara, KA; Shao, Z; Yu, L; Zhang, H | 1 |
| Arnett, TR; Butters, OR; Patel, JJ | 1 |
| Aubry, M; Guillouzo, A; Hewitt, P; Jiang, X; Jossé, R; Kopp-Schneider, A; Savary, CC | 1 |
| Baradaran, B; Majidinia, M; Rameshknia, V; Samadi, N; Shafiei-Irannejad, V; Targhaze, N; Yousefi, B; Zarghami, N | 1 |
| Mitterberger, MC; Zwerschke, W | 1 |
3 review(s) available for troglitazone and fenofibrate
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Peroxisome proliferator-activated receptors (PPARs) in the vessel wall: new regulators of gene expression in vascular cells].
Topics: Animals; Arteriosclerosis; Chromans; Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Female; Fenofibrate; Gemfibrozil; Gene Expression Regulation; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Ligands; Male; Mice; Muscle, Smooth, Vascular; Peroxisome Proliferators; Rats; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
32 other study(ies) available for troglitazone and fenofibrate
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Partial Agonism; Drug Screening Assays, Antitumor; Fibric Acids; Fibroblasts; Gene Expression Profiling; Humans; Insulin Resistance; Intra-Abdominal Fat; Liver; Mice; Mice, Inbred C57BL; Models, Molecular; PPAR alpha; PPAR gamma; Propionates; Stereoisomerism; Structure-Activity Relationship; Urea | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Substrate Specificity | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
Topics: Animal Feed; Animals; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Chromans; Diet; Dietary Carbohydrates; Dietary Fats, Unsaturated; Dietary Proteins; DNA-Binding Proteins; Fenofibrate; Gene Expression Regulation, Enzymologic; Glycolysis; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Rats; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 1999 |
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
Topics: Animals; Apolipoprotein A-I; Bezafibrate; Chlorocebus aethiops; Chromans; COS Cells; Fenofibrate; Gene Expression Regulation; Humans; Hypoglycemic Agents; Kinetics; Pioglitazone; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Troglitazone; Tumor Cells, Cultured | 2000 |
PPAR activators inhibit endothelial cell migration by targeting Akt.
Topics: Apoptosis; Blotting, Western; Cell Movement; Cells, Cultured; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fenofibrate; Flavonoids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipid Metabolism; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages.
Topics: Bezafibrate; Cholesterol; Chromans; Fenofibrate; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Monocytes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.
Topics: Animals; Chromans; Cricetinae; Fenofibrate; Immunologic Factors; Insulin; Insulin Secretion; Membrane Proteins; Potassium Channels; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2004 |
Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.
Topics: Adult; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Fatty Acid Desaturases; Female; Fenofibrate; Gene Expression Regulation; Humans; Hypoglycemic Agents; Male; Muscle Fibers, Skeletal; Peroxisome Proliferators; PPAR gamma; Pyrimidines; Receptors, Adiponectin; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Statistics, Nonparametric; Stearoyl-CoA Desaturase; Thiazolidinediones; Troglitazone | 2005 |
Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.
Topics: Adiponectin; Alitretinoin; Animals; Caco-2 Cells; Cell Line; CHO Cells; Chromans; Cricetinae; DNA-Binding Proteins; Fenofibrate; HeLa Cells; Hepatocytes; Humans; Hydroxycholesterols; Liver X Receptors; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptors; Pioglitazone; PPAR alpha; Receptors, Adiponectin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Thiazolidinediones; Tretinoin; Troglitazone; Up-Regulation | 2005 |
Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Topics: Alitretinoin; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromans; Dimerization; Fenofibrate; Gene Expression; HT29 Cells; Humans; K562 Cells; PPAR alpha; PPAR gamma; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Semaphorins; Thiazoles; Thiazolidinediones; Tretinoin; Troglitazone | 2006 |
Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin".
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Cell Differentiation; Chromans; Fenofibrate; Gene Expression Regulation; Mice; Peroxisome Proliferator-Activated Receptors; Prostaglandin D2; Proteins; Resistin; RNA, Messenger; Thiazolidinediones; Troglitazone | 2007 |
Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.
Topics: Anti-Inflammatory Agents; Cell Proliferation; Cells, Cultured; Chromans; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Heme Oxygenase-1; Humans; Membrane Proteins; Metalloporphyrins; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Polymorphism, Genetic; PPAR alpha; PPAR gamma; Promoter Regions, Genetic; Protoporphyrins; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Time Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Necrosis Factor-alpha | 2007 |
The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells.
Topics: Chromans; Culture Media; Electrophoresis, Polyacrylamide Gel; Fenofibrate; Glucose; Humans; Ligands; Muscle, Smooth, Vascular; Peroxisome Proliferator-Activated Receptors; Proteoglycans; Thiazolidinediones; Troglitazone | 2008 |
Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Topics: Apoptosis; Calcium; Calcium Channels; Caspase 3; Caspase 9; Cell Division; Cells, Cultured; Chromans; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Membrane Potential, Mitochondrial; Oxazines; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Phenylpropionates; Rosiglitazone; Thiazolidinediones; Troglitazone; Urothelium | 2009 |
High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors.
Topics: Antineoplastic Agents; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Death; Cell Line, Tumor; Cell Survival; Chromans; Endoplasmic Reticulum; Fenofibrate; Humans; Leukemia, B-Cell; Membrane Potential, Mitochondrial; Mitochondria; Multiple Myeloma; Peroxisome Proliferator-Activated Receptors; Thiazolidinediones; Transcription Factor CHOP; Troglitazone; Uncoupling Agents; Unfolded Protein Response | 2010 |
Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase zeta.
Topics: Age Factors; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Chromans; Diacylglycerol Kinase; Endothelin-1; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Myocytes, Cardiac; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazolidinediones; Troglitazone; Up-Regulation | 2011 |
PPAR agonists stimulate adipogenesis at the expense of osteoblast differentiation while inhibiting osteoclast formation and activity.
Topics: Adipogenesis; Animals; Cell Differentiation; Cells, Cultured; Chromans; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Droplets; Metformin; Mice; Osteoblasts; Osteoclasts; Osteogenesis; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Troglitazone | 2014 |
Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period.
Topics: Cell Line; Chromans; Drug Administration Schedule; Fenofibrate; Gene Expression Regulation; Hepatocytes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Microarray Analysis; Peroxisome Proliferator-Activated Receptors; Rosiglitazone; Thiazolidinediones; Transcriptome; Troglitazone | 2015 |
Differential effects of peroxisome proliferator-activated receptor agonists on doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Chromans; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fenofibrate; Gene Expression; Humans; K562 Cells; Oxazoles; Peroxisome Proliferator-Activated Receptors; Rhodamine 123; Signal Transduction; Thiazolidinediones; Thiophenes; Troglitazone | 2015 |
Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Chromans; Extracellular Signal-Regulated MAP Kinases; Fatty Acid-Binding Proteins; Gene Expression Regulation; Mice; Naphthalenes; PPAR gamma; Pyrones; Resveratrol; Stem Cells; Stilbenes; Thiazolidinediones; Troglitazone | 2013 |