Page last updated: 2024-08-16

troglitazone and cyclosporine

troglitazone has been researched along with cyclosporine in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (18.52)	18.2507
2000's	6 (22.22)	29.6817
2010's	15 (55.56)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Chang, TK; Ensom, MH; Kiang, TK	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Norman, BH	1
Bonomini, L; DeFranco, P; Friedman, G; Jacobs, M; Kaplan, B; Lyman, N; Mulgaonkar, SP; Viscuso, R	1
Brennan, DC; Burgess, SJ; Singer, GG	1
Al Rayyes, O; Florén, CH	1
Frantz, RP; Nguyen, TT	1
Haug, MT; Park, MH; Pelegrin, D; Young, JB	1
Davies, T; Kostrubsky, VE; Lodola, A; Rahbari, R	1
Herédi-Szabó, K; Ioja, E; Kis, E; Krajcsi, P; Nagy, T; Szente, L	1
Baranyai, Z; Jakab, F; Jemnitz, K; Szabo, M; Veres, Z	1
Chibout, SD; Germano, D; Pognan, F; Uteng, M; Wolf, A	1

Reviews

3 review(s) available for troglitazone and cyclosporine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies. Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20 Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Liver; Mitochondria, Liver; Pharmaceutical Preparations; Risk Assessment; Tissue Distribution	2020

Other Studies

24 other study(ies) available for troglitazone and cyclosporine

Article	Year
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Potential interaction of troglitazone and cyclosporine. Transplantation, 1998, May-27, Volume: 65, Issue:10 Topics: Acute Disease; Chromans; Cyclosporine; Drug Interactions; Female; Graft Rejection; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Middle Aged; Osmolar Concentration; Thiazoles; Thiazolidinediones; Troglitazone	1998
Effect of troglitazone on cyclosporine whole blood levels. Transplantation, 1998, Jul-27, Volume: 66, Issue:2 Topics: Chromans; Cyclosporine; Drug Interactions; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Kidney Transplantation; Thiazoles; Thiazolidinediones; Troglitazone	1998
Troglitazone upregulates LDL receptor activity in HepG2 cells. Diabetes, 1998, Volume: 47, Issue:8 Topics: Chromans; Cyclosporine; Humans; Hypoglycemic Agents; Insulin; Lipoproteins, LDL; Liver; Receptors, LDL; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured; Up-Regulation	1998
Rezulin (troglitazone) greatly increases cyclosporine metabolism. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:10 Topics: Chromans; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Heart Transplantation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Metabolic Clearance Rate; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone	1998
Troglitazone, a new antidiabetic agent, decreases cyclosporine level. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:11 Topics: Aged; Chromans; Cyclosporine; Diabetes Mellitus, Type 1; Drug Interactions; Heart Transplantation; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Male; Middle Aged; Thiazoles; Thiazolidinediones; Troglitazone	1998
Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 71, Issue:2 Topics: Apoptosis; Cell Survival; Chromans; Cyclosporine; Dose-Response Relationship, Drug; Drug Antagonism; Hepatocytes; Humans; Hypoglycemic Agents; Mitochondria, Liver; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured	2003
Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:9 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Biological Transport, Active; Blotting, Western; Cell Line; Cell Membrane; Cholesterol; Chromans; Cyclosporine; Electrophoresis, Polyacrylamide Gel; Glyburide; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Insecta; Kinetics; Mice; Rats; Species Specificity; Substrate Specificity; Thiazolidinediones; Troglitazone; Vesicular Transport Proteins	2009
Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity. PloS one, 2013, Volume: 8, Issue:3 Topics: Animals; Biological Transport; Bosentan; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Chromans; Cyclosporine; Hepatocytes; Humans; Rats; Sulfobromophthalein; Sulfonamides; Taurocholic Acid; Thiazolidinediones; Troglitazone	2013
Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Dec-25, Volume: 30, Issue:1 Pt A Topics: Amiodarone; Animals; Cells, Cultured; Chlorpromazine; Chromans; Culture Techniques; Cyclosporine; Dopamine Antagonists; Gene Expression Regulation; Hepatocytes; Hypoglycemic Agents; Immunosuppressive Agents; Male; Potassium Channel Blockers; Rats; Rats, Wistar; Thiazolidinediones; Troglitazone	2015