troglitazone has been researched along with ciglitazone in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.10) | 18.7374 |
| 1990's | 8 (8.79) | 18.2507 |
| 2000's | 63 (69.23) | 29.6817 |
| 2010's | 17 (18.68) | 24.3611 |
| 2020's | 2 (2.20) | 2.80 |
| Authors | Studies |
|---|---|
| Aizawa, Y; Fujita, T; Hasegawa, K; Horikoshi, H; Kanai, T; Kurumada, T; Yoshioka, T | 1 |
| Cantello, BC; Cawthorne, MA; Cottam, GP; Duff, PT; Haigh, D; Hindley, RM; Lister, CA; Smith, SA; Thurlby, PL | 1 |
| Blanchard, SG; Brackeen, MF; Brown, KK; Cobb, JE; Collins, JL; Harrington, WW; Hashim, MA; Henke, BR; Hull-Ryde, EA; Kaldor, I; Kliewer, SA; Lake, DH; Leesnitzer, LM; Lehmann, JM; Lenhard, JM; Miller, JF; Mook, RA; Noble, SA; Oliver, W; Orband-Miller, LA; Parks, DJ; Plunket, KD; Szewczyk, JR; Willson, TM | 1 |
| Dietrich, A; Katz, A; Li, Z; Moxham, C; Sawicki, DR; Seestaller, L; Sredy, J; Sullivan, D; Tio, C; Wrobel, J; Wu, L; Zhang, ZY | 1 |
| Flam, BR; Gunawan, I; Malamas, MS; Mihan, B; Sawicki, DR; Seestaller, L; Sredy, J; Sullivan, D | 1 |
| Aktas, H; Chen, H; Christ, W; Fan, YH; Guo, Y; Halperin, JA; Harbinski, F; Iyasere, J; Natarajan, A | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Chen, CS; Kulp, SK; Wang, DS; Wang, YC; Wei, S; Yang, J | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Carroll, RT; Darvesh, AS; Funk, MO; Geldenhuys, WJ; Van der Schyf, CJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Auld, DS; Austin, CP; Huang, R; Moeller, TA; Sakamuru, S; Shinn, P; Shukla, SJ; Vanleer, D; Xia, M | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Adams, WJ; Artman, GD; Colca, JR; Gadwood, RC; Kletzien, RF; Larsen, SD; Lee, PH; McDonald, WG; Parker, TT; Tanis, SP; Zeller, JB | 1 |
| Chen, S; Chen, Y; Fu, L; Zhang, L | 1 |
| Aamir Javed, M; Ikram, M; Jadoon, R; Mahnashi, MH; Rashid, U; Sadiq, A; Saeed Jan, M; Shahid, M | 1 |
| Umeda, F | 1 |
| Lambe, KG; Tugwood, JD | 1 |
| Connell, J; Petrie, J; Small, M | 1 |
| Benson, SC; Kurtz, TW; Morikang, E; Pershadsingh, HA | 1 |
| Akatsuka, H; Arakawa, K; Homma, K; Iijima, I; Inamasu, M; Kawanami, S; Matsumoto, M; Okumura, K; Ozeki, M; Saiga, Y; Watanabe, A; Yasuda, K | 1 |
| Kuzuya, T | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, RM; Vázquez, M | 1 |
| Cao, HJ; Kaur, K; Padilla, J; Phipps, RP; Smith, TJ | 1 |
| Harris, SG; Phipps, RP | 1 |
| Marra, F; Pastacaldi, S | 1 |
| Dixon, C; Doseff, AI; Hilbelink, T; Kotur, M; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Breyer, B; Cheng, H; Feng, T; Haydon, RC; He, TC; Ishikawa, A; Jiang, W; Montag, A; Peabody, T; Simon, MA; Zhou, L | 1 |
| Baik, EJ; Kim, EJ; Kwon, KJ; Lee, SH; Moon, CH; Park, JY | 1 |
| Blaschke, F; Bungenstock, A; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Stawowy, P | 1 |
| Battarbee, H; Coates, G; Nissim, I; Welbourne, T | 1 |
| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Bungenstock, A; Czupalla, C; Eilers, F; Fleck, E; Goetze, S; Graf, K; Gräfe, M; Kintscher, U; Law, RE; Nürnberg, B; Spencer-Hänsch, C; Stawowy, P | 1 |
| Chen, YE; Fu, M; Lin, Y; Mao, Z; Zhang, J; Zhu, X | 1 |
| Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL | 1 |
| Burgermeister, E; Liscovitch, M; Tencer, L | 1 |
| Dai, J; Remick, DG; Wang, X; Zeng, X | 1 |
| Chen, YE; Fu, M; Lin, Y; McLntee, FL; Xiao, H; Zhang, J; Zhu, X | 1 |
| Beauregard, C; Brandt, PC | 1 |
| Alba, G; Alvarez-Maqueda, M; Bedoya, FJ; Chacón, P; El Bekay, R; Martín-Nieto, J; Monteseirín, J; Pintado, E; Sobrino, F; Vega, A | 1 |
| Bode, C; Ernst, S; Leugers, A; Lohrmann, J; Nordt, TK; Sobel, BE; Zirlik, A | 1 |
| Albanese, N; Chatterjee, VK; Gamble, JR; Hahn, C; Vadas, MA; Verrier, E; Wadham, C; Wang, L; Xia, P | 1 |
| Fisher, PB; Han, S; Roman, J; Sidell, N | 1 |
| Brunskill, NJ; Chana, RS; Lewington, AJ | 1 |
| Chen, CS; Gardner, OS; Graves, LM; Shiau, CW | 1 |
| Brueggemeier, RW; Chen, CS; Chen, KF; Huang, JW; Kulp, SK; Shapiro, CL; Shiau, CW; Yang, YT | 1 |
| Lapotko, DO; Lukianova, EY | 1 |
| Hahn, JH; Kim, DJ; Kim, HA; Kim, PH; Lee, HS; Lee, KJ; Ma, KR; Park, JH | 1 |
| Cheon, H; Choi, SJ; Ji, JD; Kim, HJ; Lee, YH; Rho, YH; Sohn, J; Song, GG; Um, JW | 1 |
| Arnold, R; König, W | 2 |
| Choi, YM; Kang, HY; Lee, JS; Lee, JY | 1 |
| Brunskill, NJ; Chana, RS | 1 |
| Hausman, GJ; Poulos, SP | 1 |
| Kim, HT; Kim, SH; Kim, YK; Kwon, CH; Park, JY; Yoo, CI | 1 |
| Chen, N; Liu, F; Wang, WM | 1 |
| Araki, E; Ishii, N; Kawada, T; Kukidome, D; Matsumura, T; Matsuo, T; Motoshima, H; Nishikawa, T; Sakai, M; Senokuchi, T; Sonoda, K; Taguchi, T; Yano, M | 1 |
| Jang, KY; Jang, YB; Kang, KP; Kim, DH; Kim, W; Lee, JE; Lee, S; Moon, SO; Park, SK; Sung, MJ | 1 |
| Blann, E; Dial, S; Dragan, YP; Guo, L; Muskhelishvili, L; Schroth, G; Shi, L; Sun, Y; Zhang, L | 1 |
| Moseley, RH; Snow, KL | 1 |
| Kim, HS; Kim, HY | 1 |
| Brandt, U; Brüne, B; Dröse, S; Soller, M; von Knethen, A | 1 |
| Arnold, R; König, W; Neumann, M | 1 |
| Han, MJ; Han, MK; Kim, EK; Koo, BS; Kwon, KB; Park, BH; Park, JW; Ryu, DG; Song, EK; Song, MY | 1 |
| Au, AL; Chan, SW; Kwan, YW; Lam, TY; Leung, GP; Ngai, SM; Seto, SW | 1 |
| Ball, SG; Mughal, RS; O'Regan, DJ; Porter, KE; Turner, NA; Warburton, P | 1 |
| Giaginis, C; Theocharis, S; Tsantili-Kakoulidou, A | 1 |
| Chen, CS; Dewar, BJ; Earp, HS; Gardner, OS; Graves, LM; Samet, JM | 1 |
| Jang, SK; Kim, JH; Kim, WJ | 1 |
| Kim, YK; Kwon, CH; Yoon, CS | 1 |
| Akar, N; Aktas, H; Ozel Demiralp, D | 1 |
| Gangireddy, SR; Hogaboam, CM; Hu, B; Keshamouni, VG; Milam, JE; Phan, SH; Reddy, RC; Standiford, TJ; Thannickal, VJ | 1 |
| Panzer, U; Paust, HJ; Peters, A; Schneider, A; Stahl, RA; Steinmetz, OM; Turner, JE; Wienberg, U; Wolf, G; Zahner, G | 1 |
| Chen, CS; Kulp, SK; Lee, SL; Wei, S; Yang, J | 1 |
| Bianco, AC; Grozovsky, R; Huang, SA; Kim, BW; Mulcahey, MA; Patti, ME; Ribich, S; Rosene, ML | 1 |
| Bianchi, A; Jouzeau, JY; Koufany, M; Moulin, D; Netter, P; Sebillaud, S | 1 |
| Ha, ES; Hahn, JH; Jeoung, D; Kang, D; Kim, BC; Kim, DJ; Kim, HD; Kim, MK; Kim, YK; Lee, KJ; Lee, SH; Park, JH; Park, KH; Suh, JS | 1 |
| Cheon, CW; Cho, YH; Kim, DH; Kim, JH | 1 |
| Fantus, IG; Goldberg, HJ; Munk, S; Wang, H; Whiteside, C; Xia, L | 1 |
| Chopra, B; Georgopoulos, NT; Hinley, J; Nicholl, A; Oleksiewicz, MB; Southgate, J | 1 |
| Arnason, TG; Davies, GF; Harkness, TA; Juurlink, BH; Ross, AR | 1 |
| Kawabata, A; Maeda, Y; Nishikawa, H; Sekiguchi, F; Shigi, H; Takaoka, K | 1 |
| Andreesen, R; Gottfried, E; Hartmannsgruber, G; Kreutz, M; Kunz-Schughart, LA; Peter, K; Peuker, A; Reichle, A; Rogenhofer, S; Waibel, H; Wehrstein, M | 1 |
| Arnold, N; Bauerschlag, DO; Biernath-Wüpping, J; Bräutigam, K; Jonat, W; Maass, N; Meinhold-Heerlein, I; von Kaisenberg, CS | 1 |
| Al-Alem, L; Curry, TE; Kilgore, MW; Southard, RC | 1 |
| Andersen, OS; Greathouse, DV; Hemmings, HC; Herold, KF; Rusinova, R; Sanford, RL | 1 |
| Li, C; Li, L; Liu, X; Yang, L; Yu, H | 1 |
| Gerner, C; Gruber, S; Haudek-Prinz, V; Hofstätter, E; Jonak, C; Klepeisz, P; Kunstfeld, R; Paulitschke, V; Pehamberger, H; Petzelbauer, P; Schicher, N | 1 |
| Furumura, M; Hashimoto, T; Karashima, T; Numata, S; Ohyama, B; Tanida, N; Teye, K; Yan, Y | 1 |
| Chae, JJ; Chang, HK; Kim, DS; Kim, M; Lee, KH; Lee, MW; Myong, JP; Park, TC | 1 |
6 review(s) available for troglitazone and ciglitazone
| Article | Year |
|---|---|
Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential.
Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Interferons; Liver Neoplasms; Nucleotides; Organic Anion Transporters, Sodium-Dependent; Symporters; Virus Internalization | 2022 |
Potential role of thiazolidinediones in older diabetic patients.
Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin Resistance; Japan; Mice; Pioglitazone; Randomized Controlled Trials as Topic; Rats; Thiazoles; Thiazolidinediones; Troglitazone | 1995 |
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Mice; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
[Thiazolidinediones and PPARgamma system in repair of liver damage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arteriosclerosis; Chromans; Diabetes Mellitus, Type 2; Eicosanoids; Fatty Acids; Forecasting; Humans; Hypoglycemic Agents; In Vitro Techniques; Inflammation; Liver Cirrhosis; Neoplasms; Obesity; Receptors, Cytoplasmic and Nuclear; Research; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
PPARgamma-independent antitumor effects of thiazolidinediones.
Topics: Animals; Antineoplastic Agents; bcl-X Protein; Chromans; Humans; PPAR gamma; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Signal Transduction; Sp1 Transcription Factor; Thiazolidinediones; Troglitazone | 2009 |
[Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists].
Topics: Animals; Arthritis, Rheumatoid; Chromans; Dimerization; Extracellular Matrix; Humans; Hypoglycemic Agents; Joint Diseases; Osteoarthritis; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR-beta; Rosiglitazone; Thiazolidinediones; Troglitazone | 2008 |
85 other study(ies) available for troglitazone and ciglitazone
| Article | Year |
|---|---|
Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation.
Topics: Animals; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Phenols; Rats; Structure-Activity Relationship | 1989 |
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hemoglobins; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Structure-Activity Relationship; Thiazoles | 1994 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Topics: Administration, Oral; Aminopyridines; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Lipids; Male; Mice; Oxazoles; Propionates; Radioligand Assay; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Stereoisomerism; Structure-Activity Relationship; Transcription Factors; Transfection; Tyrosine | 1998 |
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
Topics: Animals; Enzyme Inhibitors; Furans; Humans; Hypoglycemic Agents; Mice; Mice, Obese; Models, Molecular; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Thiophenes | 1999 |
New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Topics: 4-Nitrophenylphosphatase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Liver; Male; Membrane Proteins; Mice; Mice, Obese; Oxazoles; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Structure-Activity Relationship | 2000 |
Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.
Topics: Antineoplastic Agents; Calcium; Cell Line, Tumor; Cell Proliferation; Chromans; Eukaryotic Initiation Factor-2; Humans; Phosphorylation; Protein Biosynthesis; Structure-Activity Relationship; Thiazolidinediones; Troglitazone | 2004 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Pharmacological exploitation of the peroxisome proliferator-activated receptor gamma agonist ciglitazone to develop a novel class of androgen receptor-ablative agents.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; PPAR gamma; Receptors, Androgen; RNA, Messenger; Structure-Activity Relationship; Thiazolidinediones | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Topics: Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Identification of clinically used drugs that activate pregnane X receptors.
Topics: Animals; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Interactions; Hep G2 Cells; Hepatocytes; Humans; Pharmaceutical Preparations; Pregnane X Receptor; Rats; Receptors, Steroid; Small Molecule Libraries; Species Specificity; Structure-Activity Relationship; Xenobiotics | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Insulin Resistance; Molecular Structure; PPAR gamma; Structure-Activity Relationship; Thiazolidinediones | 2018 |
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.
Topics: Hydrazones; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship; Thiazolidines | 2022 |
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs.
Topics: Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Benzopyrans; Chromans; DNA, Complementary; Fatty Acids; Humans; Mice; Molecular Sequence Data; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1996 |
"Glitazones", a prospect for non-insulin-dependent diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Effects of thiazolidinediones on growth and differentiation of human aorta and coronary myocytes.
Topics: Aorta; Cell Division; Cells, Cultured; Chromans; Coronary Vessels; Humans; Hypoglycemic Agents; Muscle, Smooth, Vascular; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Topics: Animals; Benzopyrans; Benzoxazoles; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Male; Mice; Obesity; Pioglitazone; Rosiglitazone; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Topics: Acyl-CoA Dehydrogenase; Animals; Atorvastatin; Bezafibrate; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Cholesterol; Chromans; Down-Regulation; Fatty Acid Desaturases; Heptanoic Acids; Hypoglycemic Agents; Ion Channels; Ligands; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscles; Oleic Acid; Peroxisome Proliferators; Proteins; Pyrimidines; Pyrroles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triazenes; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2000 |
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Lineage; Cells, Cultured; Chromans; Dinoprost; Hypoglycemic Agents; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Topics: Animals; Antigen Presentation; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chromans; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ionomycin; Ligands; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Death; Cell Division; Cells, Cultured; Chromans; Chromones; Enzyme Inhibitors; Glomerular Mesangium; Humans; Morpholines; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Osteosarcoma; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Neoplasm; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Tretinoin; Troglitazone; Tumor Cells, Cultured | 2002 |
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Topics: Animals; Cell Culture Techniques; Cell Death; Chromans; Clofibrate; Cyclooxygenase 2; Dinoprostone; Electrophoretic Mobility Shift Assay; Escherichia coli; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred ICR; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxisome Proliferators; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
PPAR activators inhibit endothelial cell migration by targeting Akt.
Topics: Apoptosis; Blotting, Western; Cell Movement; Cells, Cultured; Chromans; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fenofibrate; Flavonoids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; In Situ Nick-End Labeling; Lipid Metabolism; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peroxisome Proliferators; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2002 |
Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
Topics: Acidosis; Alanine Transaminase; Animals; Cell Line; Chromans; Epithelial Cells; Glutamine; Hydrogen-Ion Concentration; Hypoglycemic Agents; Kidney; L-Lactate Dehydrogenase; Nitrogen; Nitrogen Isotopes; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
Topics: Androstadienes; Cell Line; Cell Movement; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Leptin; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins; Wortmannin | 2002 |
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Topics: Anilides; Aorta; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hypoglycemic Agents; Inhibitor of Differentiation Protein 2; Muscle, Smooth, Vascular; Oxazoles; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine | 2003 |
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligands; Prostaglandin D2; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Uterine Neoplasms | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells.
Topics: Adenoviridae; Animals; Aorta; Apoptosis; Cells, Cultured; Chlorocebus aethiops; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Interferon Regulatory Factor-1; Ligands; Muscle, Smooth, Vascular; Oxazoles; Phosphoproteins; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine; Up-Regulation | 2004 |
Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.
Topics: Animals; Cell Line, Transformed; Chromans; Clofibrate; Dexamethasone; Gene Expression; Humans; Interleukin-1; Lacrimal Apparatus; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PPAR alpha; PPAR gamma; Pterins; Pyrimidines; Rabbits; Thiazolidinediones; Troglitazone | 2003 |
15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.
Topics: Acetylcysteine; Allopurinol; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Chromans; Cyclic N-Oxides; Cyclopentanes; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ions; Lymphocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthrolines; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Temperature; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Xanthine Oxidase | 2004 |
Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones.
Topics: Adipocytes; Adipose Tissue; Cells, Cultured; Chromans; Humans; Hypoglycemic Agents; Insulin Resistance; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; Rosiglitazone; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2004 |
PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.
Topics: Animals; Aorta; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chromans; Diabetic Angiopathies; Diacylglycerol Kinase; Diglycerides; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Glucose; Humans; PPAR gamma; Prostaglandin D2; Protein Kinase C; Protein Kinase C beta; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Thiazolidinediones; Transfection; Troglitazone; U937 Cells; Umbilical Veins; Vasculitis | 2004 |
Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression.
Topics: Antineoplastic Agents; Apoptosis; Chromans; Cyclin D1; Humans; Lung Neoplasms; Prostaglandin D2; Proto-Oncogene Proteins p21(ras); Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazolidinediones; Transcription Factors; Troglitazone | 2004 |
Differential effects of peroxisome proliferator activated receptor-gamma (PPAR gamma) ligands in proximal tubular cells: thiazolidinediones are partial PPAR gamma agonists.
Topics: Animals; Cells, Cultured; Chromans; Extracellular Signal-Regulated MAP Kinases; Kidney Tubules, Proximal; Ligands; Opossums; PPAR gamma; Prostaglandin D2; Thiazolidinediones; Transcriptional Activation; Transfection; Troglitazone | 2004 |
Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Topics: Animals; Antineoplastic Agents; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromans; Culture Media, Serum-Free; eIF-2 Kinase; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Activation; Epithelial Cells; Immunoblotting; Immunoprecipitation; Ligands; Liver; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Models, Biological; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR gamma; Protein Binding; Rats; Signal Transduction; Sulfonamides; Thiazolidinediones; Time Factors; Troglitazone | 2005 |
Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Chromans; Cyclin D1; Down-Regulation; Female; Humans; PPAR gamma; Proteasome Endopeptidase Complex; Thiazolidinediones; Troglitazone | 2005 |
Influence of physiological conditions on laser damage thresholds for blood, heart, and liver cells.
Topics: Animals; Cell Culture Techniques; Chromans; Erythrocytes; Hepatocytes; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lasers; Male; Myocytes, Cardiac; Oxygen; Rats; Rats, Wistar; Temperature; Thiazolidinediones; Troglitazone | 2005 |
Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g.
Topics: Antibodies, Blocking; CD36 Antigens; Cells, Cultured; Chromans; Humans; Lipoproteins, LDL; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Monocytes; NF-kappa B; PPAR gamma; Prostaglandin D2; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2004 |
15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes.
Topics: Arthritis, Rheumatoid; Chromans; Cycloheximide; Dactinomycin; DNA-Binding Proteins; Gene Expression Regulation; Humans; Hypoglycemic Agents; Interleukin-6; Jurkat Cells; Lymphocytes; NF-kappa B; Phosphorylation; PPAR gamma; Prostaglandin D2; Protein Synthesis Inhibitors; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Thiazolidinediones; Trans-Activators; Troglitazone | 2005 |
Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells.
Topics: Cell Line, Tumor; Chemokine CCL5; Chemokines, CC; Chromans; Cytokines; Epithelial Cells; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-1; Interleukin-6; Interleukin-8; NF-kappa B; PPAR gamma; Prostaglandin D2; Respiratory Syncytial Viruses; RNA, Messenger; Thiazolidinediones; Transcription Factor AP-1; Troglitazone; Tumor Necrosis Factor-alpha | 2006 |
Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Proliferation; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Male; Melanocytes; PPAR gamma; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Thiazolidinediones; Troglitazone | 2006 |
Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma.
Topics: Albumins; Anilides; Animals; Cells, Cultured; Cholesterol; Chromans; Farnesol; Kidney Tubules, Proximal; Ligands; Mevalonic Acid; Opossums; Polyisoprenyl Phosphates; PPAR gamma; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Troglitazone | 2006 |
A comparison of thiazolidinedione-induced adipogenesis and myogenesis in stromal-vascular cells from subcutaneous adipose tissue or semitendinosus muscle of postnatal pigs.
Topics: Adipogenesis; Adipose Tissue; Animals; Cells, Cultured; Chromans; Hypoglycemic Agents; Muscle, Skeletal; Stromal Cells; Swine; Thiazolidinediones; Troglitazone | 2006 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells.
Topics: Chromans; Humans; Lung; PPAR gamma; Prostaglandin D2; Respiratory Mucosa; Respiratory Syncytial Viruses; Thiazolidinediones; Troglitazone; Virus Replication | 2006 |
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.
Topics: 3T3 Cells; Anilides; Animals; Antioxidants; Apoptosis; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Enzyme Inhibitors; Fibric Acids; Hypoglycemic Agents; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Reactive Oxygen Species; Thiazolidinediones; Troglitazone | 2006 |
[Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts].
Topics: Animals; Blotting, Far-Western; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Kidney; Peroxisome Proliferator-Activated Receptors; Prostaglandin D2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad Proteins; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2006 |
Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: impact of the suppression of nuclear translocation of ERK1/2.
Topics: Animals; Cell Proliferation; Chromans; Granulocyte-Macrophage Colony-Stimulating Factor; Hypoglycemic Agents; Lipoproteins, LDL; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Thiazolidinediones; Troglitazone | 2007 |
Rosiglitazone ameliorates cisplatin-induced renal injury in mice.
Topics: Anilides; Animals; Apoptosis; C-Peptide; Cell Line; Chromans; Cisplatin; Drug Evaluation, Preclinical; Glioma; Humans; Hypoglycemic Agents; Inflammation; Insulin; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; PPAR gamma; Prostaglandin D2; Protein Transport; Rosiglitazone; Thiazolidinediones; Transcription Factor RelA; Troglitazone; Tumor Necrosis Factor-alpha | 2006 |
Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Chromans; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Humans; Hypoglycemic Agents; Liver Neoplasms; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Transcription, Genetic; Troglitazone | 2006 |
Effect of thiazolidinediones on bile acid transport in rat liver.
Topics: Animals; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Cell Membrane; Cholestasis, Intrahepatic; Chromans; Dose-Response Relationship, Drug; Hypoglycemic Agents; Liver; Male; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Transport Vesicles; Troglitazone | 2007 |
Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages.
Topics: Animals; Cells, Cultured; Chemokine CXCL2; Chemokines; Chemokines, CXC; Chromans; Dose-Response Relationship, Drug; Immunologic Factors; Ligands; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; PPAR gamma; Prostaglandin D2; Prostaglandins A; RNA, Messenger; Thiazolidinediones; Troglitazone; Up-Regulation | 2007 |
Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.
Topics: Adenosine Triphosphate; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Chromans; Humans; Jurkat Cells; Mitochondria; Necrosis; PPAR gamma; Reactive Oxygen Species; Rosiglitazone; T-Lymphocytes; Thiazolidinediones; Troglitazone | 2007 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells.
Topics: Amino Acids; Cell Adhesion; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Fluorenes; Humans; Intercellular Adhesion Molecule-1; Lung; NF-kappa B; PPAR gamma; Prostaglandin D2; Respiratory Mucosa; Respiratory Syncytial Virus Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones; Troglitazone; U937 Cells | 2007 |
Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway.
Topics: Adenoviridae; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; I-kappa B Proteins; Insulin; Insulin-Secreting Cells; Interleukin-1beta; Male; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrites; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazolidinediones; Troglitazone | 2007 |
Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.
Topics: Abdominal Fat; Adipocytes; Animals; Aorta, Thoracic; Carbohydrate Metabolism; Chromans; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Lipid Metabolism; Lipolysis; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Pioglitazone; PPAR gamma; RNA, Messenger; Thiazolidinediones; Troglitazone; Vasodilation | 2007 |
Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.
Topics: Analysis of Variance; Antibodies, Monoclonal; Cells, Cultured; Chromans; Coronary Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-1alpha; Interleukin-1beta; Interleukin-6; Interleukins; Myocytes, Cardiac; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Signal Transduction; Simvastatin; Stimulation, Chemical; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2007 |
Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity.
Topics: Chromans; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Lipids; Membranes, Artificial; Octanols; Pioglitazone; PPAR gamma; Rosiglitazone; Thiazolidinediones; Transcriptional Activation; Troglitazone; Water | 2007 |
Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones.
Topics: Animals; Calcium; Calcium Signaling; Cell Line; Chelating Agents; Chromans; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 2; Hypoglycemic Agents; Phosphorylation; PPAR gamma; Protein Tyrosine Phosphatases; Rats; src-Family Kinases; Thiazolidinediones; Transcriptional Activation; Troglitazone; Tyrosine | 2007 |
Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arsenites; Chromans; Cyclopentanes; Cytoplasmic Granules; Dinoprostone; Emetine; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4A; Gene Expression Regulation; HeLa Cells; Humans; Hypoglycemic Agents; Inflammation; Poly(A)-Binding Proteins; PPAR gamma; Prostaglandin D2; Prostaglandins A; Protein Biosynthesis; Protein Synthesis Inhibitors; Rosiglitazone; Signal Transduction; Sodium Compounds; T-Cell Intracellular Antigen-1; Thiazolidinediones; TNF Receptor-Associated Factor 2; Troglitazone; Tumor Necrosis Factor-alpha | 2007 |
Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Chromans; Clofibric Acid; Dose-Response Relationship, Drug; Epithelial Cells; Fibric Acids; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Imidazoles; Kidney Tubules; Membrane Potential, Mitochondrial; Opossums; p38 Mitogen-Activated Protein Kinases; PPAR gamma; Pyridines; Thiazolidinediones; Troglitazone | 2008 |
The effect of plasminogen activator inhibitor-1 -675 4G/5G polymorphism on PAI-1 gene expression and adipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromans; Humans; Insulin Resistance; Mice; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; PPAR gamma; Promoter Regions, Genetic; Thiazolidinediones; Troglitazone | 2008 |
PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Differentiation; Cell Division; Cells, Cultured; Chromans; Cyclin D; Cyclins; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression; Humans; Hypoglycemic Agents; Ligands; Phenotype; PPAR gamma; Promoter Regions, Genetic; Pulmonary Fibrosis; Rats; Rats, Inbred F344; Thiazolidinediones; Transforming Growth Factor beta1; Troglitazone | 2008 |
15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
Topics: Animals; Cells, Cultured; Chemokine CXCL10; Chemokine CXCL11; Chemokine CXCL9; Chromans; Gene Expression; Glomerulonephritis; Interferon-gamma; Janus Kinases; Mesangial Cells; Mice; PPAR gamma; Prostaglandin D2; Recombinant Proteins; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Thiazolidinediones; Troglitazone | 2008 |
Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
Topics: Animals; Cells, Cultured; Chromans; Enzyme Activation; Immunohistochemistry; Insulin; Iodide Peroxidase; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Fibers, Skeletal; Myoblasts; Pioglitazone; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidinediones; Troglitazone | 2009 |
CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma.
Topics: CD36 Antigens; Cell Line, Tumor; Chromans; Cycloheximide; HSP70 Heat-Shock Proteins; Humans; Lipoproteins, LDL; Monocytes; PPAR gamma; Protein Synthesis Inhibitors; Signal Transduction; Thiazolidinediones; Troglitazone | 2008 |
Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Humans; Hypoglycemic Agents; Oligonucleotide Array Sequence Analysis; PPAR gamma; Stomach Neoplasms; Thiazolidinediones; Troglitazone | 2009 |
Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chromans; Collagen Type IV; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Membranes; Mesangial Cells; NADPH Oxidases; Oxidative Stress; PPAR gamma; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Response Elements; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Transfection; Troglitazone; Vascular Endothelial Growth Factor A | 2009 |
Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Topics: Apoptosis; Calcium; Calcium Channels; Caspase 3; Caspase 9; Cell Division; Cells, Cultured; Chromans; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Membrane Potential, Mitochondrial; Oxazines; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Phenylpropionates; Rosiglitazone; Thiazolidinediones; Troglitazone; Urothelium | 2009 |
Troglitazone inhibits histone deacetylase activity in breast cancer cells.
Topics: Acetylation; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Butyrates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromans; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Methylation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Thiazolidinediones; Troglitazone | 2010 |
Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release.
Topics: Animals; Base Sequence; Cell Line; Chromans; Dinoprostone; DNA Primers; Gastric Mucosa; Phosphorylation; Polymerase Chain Reaction; Rats; Receptor, PAR-1; Signal Transduction; Thiazolidinediones; Troglitazone | 2010 |
Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids.
Topics: Cell Line, Tumor; Cell Proliferation; Chromans; Deoxyglucose; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Lactic Acid; Male; Pioglitazone; PPAR gamma; Prostatic Neoplasms; Spheroids, Cellular; Thiazolidinediones; Troglitazone | 2011 |
Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Chromans; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Ovarian Neoplasms; PPAR gamma; Prostaglandin D2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Thiazolidinediones; TNF-Related Apoptosis-Inducing Ligand; Troglitazone | 2011 |
Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromans; Female; Gene Expression; Humans; Ovarian Neoplasms; Pioglitazone; PPAR gamma; Rosiglitazone; Thiazolidinediones; Troglitazone | 2011 |
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.
Topics: Animals; Cell Line; Cell Membrane; Chromans; Drug Discovery; Gramicidin; Insulin; Ion Channels; Lipid Bilayers; Membrane Potentials; Membrane Proteins; Pioglitazone; PPAR gamma; Rats; Rosiglitazone; Sodium Channels; Thiazolidinediones; Troglitazone | 2011 |
15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.
Topics: Acetylcysteine; Anilides; Animals; Cell Line; Cell Proliferation; Chemokine CCL2; Chromans; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Monocytes; Oxidative Stress; Phagocytosis; PPAR gamma; Prostaglandin D2; Reactive Oxygen Species; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2012 |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromans; Humans; Melanoma; PPAR gamma; Prostaglandin D2; Proteome; Pyrimidines; Thiazolidinediones; Troglitazone | 2012 |
Various peroxisome proliferator-activated receptor (PPAR)-γ agonists differently induce differentiation of cultured human keratinocytes.
Topics: Anti-Inflammatory Agents; Benzimidazoles; Benzoates; Cell Differentiation; Cells, Cultured; Chromans; Filaggrin Proteins; Gene Expression Regulation; Humans; Intermediate Filament Proteins; Keratinocytes; Membrane Proteins; Microscopy, Fluorescence; Pioglitazone; PPAR gamma; RNA, Messenger; Rosiglitazone; Skin; Telmisartan; Thiazolidinediones; Troglitazone | 2015 |
Inhibition of ERK activity enhances the cytotoxic effect of peroxisome proliferator-activated receptor γ (PPARγ) agonists in HeLa cells.
Topics: Antineoplastic Agents; Apoptosis; Butadienes; Caspase 3; Cell Survival; Cervix Uteri; Chromans; Drug Synergism; Enzyme Inhibitors; Female; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; PPAR gamma; Thiazolidinediones; Troglitazone; Uterine Cervical Neoplasms | 2017 |