Page last updated: 2024-08-16

troglitazone and acetaminophen

troglitazone has been researched along with acetaminophen in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.70)	18.2507
2000's	11 (40.74)	29.6817
2010's	14 (51.85)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
Chang, TK; Ensom, MH; Kiang, TK	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Eastmond, R; Lettis, S; Young, MA	1
Galchev, V; Kindt, E; Kostrubsky, VE; Ramachandran, V; Rose, K; Sinclair, JF; Sinz, M; Strom, SC; Venkataramanan, R; Wen, YH	1
Kaneko, T; Li, J; Qin, LQ; Sato, A; Wang, PY; Wang, Y	1
Kagayama, A; Naritomi, Y; Sugiyama, Y; Terashita, S	1
Maddrey, WC	1
Ikeda, T	1
Murata, Y; Onji, M	1
Ando, Y; Arakawa, S; Fujimoto, K; Ito, K; Kumagai, K; Manabe, S; Oda, S; Yamoto, T	1
Boerma, JS; Commandeur, JN; Vermeulen, NP	1
Gunness, P; Heinzle, E; Ingelman-Sundberg, M; Mueller, D; Noor, F; Shevchenko, V	1
Deguchi, J; Funabashi, H; Goto, S; Nishio, N; Nomura, N	1
Dai, R; Dai, T; Deng, J; Huang, L; Jia, Y; Jiang, J; Xie, S; Zou, S	1
Goda, K; Kobayashi, A; Kuno, H; Shoda, T; Sugai, S; Takahashi, T	1
Li, AP; Wei, H	1

Reviews

5 review(s) available for troglitazone and acetaminophen

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced hepatotoxicity: 2005. Journal of clinical gastroenterology, 2005, Volume: 39, Issue:4 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chromans; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoniazid; Kava; Liver; Male; Minocycline; Polymorphism, Genetic; Risk Assessment; Risk Factors; Thiazolidinediones; Troglitazone; Vitamin A	2005
[Drug-induced liver injury]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 127, Issue:6 Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP2E1; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Predisposition to Disease; Humans; Hypoglycemic Agents; Imines; NADP; Pharmacogenetics; Thiazolidinediones; Troglitazone	2006
[Abnormality of liver functional test in patients with drug-induced liver injury]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Acetaminophen; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Chemical and Drug Induced Liver Injury; Chromans; Contraceptives, Oral, Hormonal; Gastrointestinal Agents; Humans; Liver Diseases; Liver Function Tests; Psychotropic Drugs; Thiazolidinediones; Time Factors; Troglitazone	2007

Trials

1 trial(s) available for troglitazone and acetaminophen

Article	Year
Coadministration of acetaminophen and troglitazone: pharmacokinetics and safety. Journal of clinical pharmacology, 1998, Volume: 38, Issue:9 Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Chromans; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Humans; Hypoglycemic Agents; Male; Thiazoles; Thiazolidinediones; Troglitazone	1998

Other Studies

21 other study(ies) available for troglitazone and acetaminophen

Article	Year
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Acetaminophen; Animals; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Hepatocytes; Humans; Nitrophenols; Pentachlorophenol; Phenobarbital; Protein Biosynthesis; Proteins; Swine; Thiazoles; Thiazolidinediones; Troglitazone	2000
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. Toxicology, 2002, Jul-01, Volume: 176, Issue:1-2 Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone	2002
Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Acetaminophen; Animals; Benzodiazepinones; Chromans; Cryopreservation; Diazepam; Diltiazem; Hepatocytes; Humans; Imidazoles; In Vitro Techniques; Indoles; Metabolic Clearance Rate; Predictive Value of Tests; Quinolizines; Rats; Reproducibility of Results; Species Specificity; Tetrazoles; Thiazolidinediones; Time Factors; Troglitazone; Zidovudine	2003
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Toxicologic pathology, 2009, Volume: 37, Issue:2 Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Knockout Techniques; Hepatocytes; Heterozygote; L-Lactate Dehydrogenase; Liver; Mice; Mice, Knockout; Mitochondria, Liver; Models, Animal; Necrosis; Sensitivity and Specificity; Superoxide Dismutase; Thiazolidinediones; Time Factors; Troglitazone	2009
Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites. Chemical research in toxicology, 2011, Aug-15, Volume: 24, Issue:8 Topics: Acetaminophen; Bacterial Proteins; Chromans; Chromatography, High Pressure Liquid; Clozapine; Cysteine; Cytochrome P-450 Enzyme System; Glutathione Transferase; Humans; Inactivation, Metabolic; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Peptides; Protein Binding; Recombinant Fusion Proteins; Tandem Mass Spectrometry; Thiazolidinediones; Troglitazone; Trypsin	2011
3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 133, Issue:1 Topics: Acetaminophen; Albumins; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Cell Culture Techniques; Cell Line, Tumor; Chromans; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Hepatocytes; High-Throughput Screening Assays; Humans; Liver; Multidrug Resistance-Associated Protein 2; Rosiglitazone; Spheroids, Cellular; Thiazolidinediones; Toxicity Tests, Acute; Troglitazone; Urea	2013
Hepatotoxicants induce cytokine imbalance in response to innate immune system. The Journal of toxicological sciences, 2015, Volume: 40, Issue:3 Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokines; Chromans; Cytokines; Down-Regulation; Fluoroquinolones; Immunity, Innate; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Kupffer Cells; Male; Naphthyridines; Nitric Oxide; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiazolidinediones; Troglitazone; Up-Regulation	2015
Development of an optimized cytotoxicity assay system for CYP3A4-mediated metabolic activation via modified piggyBac transposition. Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 32 Topics: Acetaminophen; Activation, Metabolic; Biological Assay; Cell Survival; Chromans; Citric Acid; Cytochrome P-450 CYP3A; DNA Transposable Elements; Galactosamine; Hep G2 Cells; Humans; Nerve Tissue Proteins; Thiazolidinediones; Troglitazone	2016
Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury. The Journal of toxicological sciences, 2016, Volume: 41, Issue:5 Topics: Acetaminophen; Apoptosis; Biological Assay; Biomarkers; Caspase 3; Caspase 7; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Diclofenac; Dose-Response Relationship, Drug; Ethanol; Hepatocytes; Humans; Isoxazoles; Leflunomide; Liver; Mitochondria, Liver; Oxygen Consumption; Primary Cell Culture; Ranitidine; Risk Assessment; Thiazolidinediones; Time Factors; Toxicity Tests; Troglitazone	2016
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results w Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:2 Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytochrome P-450 Enzyme System; Glutathione; HEK293 Cells; Hepatocytes; Humans; Ketoconazole; Piperazines; Triazoles; Troglitazone	2022