trk-820 and octane

trk-820 has been researched along with octane* in 1 studies

Other Studies

1 other study(ies) available for trk-820 and octane

Article	Year
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 A novel opioid ligand possessing a stable and cyclic imine 16 and its derivatives with an azabicyclo[2.2.2]octane skeleton were synthesized. The imine 16 showed higher affinity for the μ receptor than compound 21 with an oxabicyclo[2.2.2]octane skeleton. Azabicyclo[2.2.2]octane derivative 18d with a cyclopropylmethyl group on the 8-nitrogen showed the highest affinity for the μ receptor among the synthesized derivatives. Topics: Analgesics, Opioid; Aza Compounds; Bridged Bicyclo Compounds; Drug Design; Ligands; Molecular Structure; Morphinans; Octanes; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Spiro Compounds; Structure-Activity Relationship	2012

Article

Year

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.

Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

A novel opioid ligand possessing a stable and cyclic imine 16 and its derivatives with an azabicyclo[2.2.2]octane skeleton were synthesized. The imine 16 showed higher affinity for the μ receptor than compound 21 with an oxabicyclo[2.2.2]octane skeleton. Azabicyclo[2.2.2]octane derivative 18d with a cyclopropylmethyl group on the 8-nitrogen showed the highest affinity for the μ receptor among the synthesized derivatives.

Topics: Analgesics, Opioid; Aza Compounds; Bridged Bicyclo Compounds; Drug Design; Ligands; Molecular Structure; Morphinans; Octanes; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Spiro Compounds; Structure-Activity Relationship

2012