tris(2-pyridylmethyl)amine and pifithrin

tris(2-pyridylmethyl)amine has been researched along with pifithrin* in 1 studies

Other Studies

1 other study(ies) available for tris(2-pyridylmethyl)amine and pifithrin

Article	Year
Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells. FEBS letters, 2012, Nov-30, Volume: 586, Issue:23 Our recent studies suggest a unique role of p53 during the early stage of cancer development. However, how p53 activation is regulated during TPA treatment remains elusive. We used murine skin epidermal JB6 promotion-sensitive (P+) and promotion resistant (P-) cells to observe differential expression of PTEN during TPA-induced p53 activation. Total PTEN expression was decreased in only P+ cells. Nuclear expression of PTEN increased and complex formation between PTEN and p53 occurred in P+ cells treated with TPA. Knocking down PTEN expression via siRNA inhibited TPA-induced Bax expression. Similar effects were seen with the p53 inhibitor, pifithrin-alpha. Cells that were transfected with siRNA to PTEN exhibited enhanced tumorigenicity. Our findings suggest PTEN mediates TPA-induced p53 activation. Topics: Animals; bcl-2-Associated X Protein; Benzothiazoles; Mice; Protein Binding; PTEN Phosphohydrolase; Pyridines; RNA, Small Interfering; Skin; Toluene; Tumor Suppressor Protein p53	2012

Article

Year

Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells.

FEBS letters, 2012, Nov-30, Volume: 586, Issue:23

Our recent studies suggest a unique role of p53 during the early stage of cancer development. However, how p53 activation is regulated during TPA treatment remains elusive. We used murine skin epidermal JB6 promotion-sensitive (P+) and promotion resistant (P-) cells to observe differential expression of PTEN during TPA-induced p53 activation. Total PTEN expression was decreased in only P+ cells. Nuclear expression of PTEN increased and complex formation between PTEN and p53 occurred in P+ cells treated with TPA. Knocking down PTEN expression via siRNA inhibited TPA-induced Bax expression. Similar effects were seen with the p53 inhibitor, pifithrin-alpha. Cells that were transfected with siRNA to PTEN exhibited enhanced tumorigenicity. Our findings suggest PTEN mediates TPA-induced p53 activation.

Topics: Animals; bcl-2-Associated X Protein; Benzothiazoles; Mice; Protein Binding; PTEN Phosphohydrolase; Pyridines; RNA, Small Interfering; Skin; Toluene; Tumor Suppressor Protein p53

2012