triolein has been researched along with aniline* in 1 studies
1 other study(ies) available for triolein and aniline
| Article | Year |
|---|---|
Study of apoptosis in human lymphocytes by toxic substances implicated in toxic oil syndrome.
Toxic Oil Syndrome is a multisystemic disease that occurred in epidemic proportions in Spain in 1981 caused by the ingestion of rapeseed oil denatured with aniline. Several data implicate T cells in the pathogenesis of the disease. We evaluated the mechanisms of cytotoxicity in human lymphocytes of TOS-related products: aniline, 3-(N-phenylamino)-1,2-propanediol and its mono- and di-oleyl esters and eosinophilia myalgia-related product such as 3-(phenylamino)-L-alanine, which is chemically similar to 3-(N-phenylamino)-1,2-propanediol, and has been found in manufactured L-tryptophan. Our results show that only di-oleyl ester of 3-(N-phenylamino)-1,2-propanediol induces apoptosis in human lymphocytes, in a concentration and time-dependent way, confirmed by morphology, expression of phosphatidylserine in membrane and analysis of DNA degradation. Topics: Alanine; Aniline Compounds; Apoptosis; Brassica; Cells, Cultured; Coloring Agents; DNA; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Flow Cytometry; Foodborne Diseases; Humans; Lymphocytes; Microscopy, Fluorescence; Plant Oils; Propylene Glycols; Rapeseed Oil; Syndrome; Triolein; Trypan Blue | 1997 |