triolein and 1-2-cyclohexanedione

In this study we examine the effects of intravenous ethyl oleate emulsions on the metabolism of native and cyclohexanedione-modified human low density lipoprotein in rabbits. Treatment produced a highly significant fall in receptor-independent catabolism as measured by the fractional clearance rate of cyclohexanedione-modified low density lipoprotein. Receptor-dependent catabolism (the difference between the fractional clearance rates of native and cyclohexanedione-modified low density lipoprotein) was variably affected with some animals showing a decrease in receptor activity. These data suggest that the reticuloendothelial system makes a substantial contribution to receptor-independent low density lipoprotein catabolism in the rabbit.

Topics: Animals; Cyclohexanones; Emulsions; Humans; Kinetics; Lipoproteins, LDL; Mononuclear Phagocyte System; Oleic Acids; Rabbits; Receptors, Cell Surface; Receptors, LDL; Triolein