trimethoprim has been researched along with pyrimethamine in 168 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (51.19) | 18.7374 |
| 1990's | 29 (17.26) | 18.2507 |
| 2000's | 25 (14.88) | 29.6817 |
| 2010's | 24 (14.29) | 24.3611 |
| 2020's | 4 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Elslager, EF; Jacob, P; Johnson, J; Rane, L; Werbel, LM; Worth, DF | 1 |
| Elslager, EF; Hutt, MP; Jacob, P; Johnson, J; Rane, L; Temporelli, B; Werbel, LM; Worth, DF | 1 |
| Genther, CS; Smith, CS | 1 |
| Doweyko, AM | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Queener, SF | 1 |
| Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL | 1 |
| Mota, CE; Queener, SF; Rosowsky, A; Wright, JE | 1 |
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Borotz, SE; Carter, RL; Hosmer, CA; Johnson, CA; Krauth, CA; Pfefferkorn, ER; Piper, JR; Queener, SF | 1 |
| Papoulis, AT; Queener, SF; Rosowsky, A | 2 |
| Forsch, RA; Papoulis, AT; Queener, SF; Rosowsky, A | 1 |
| Brun, R; Chowdhury, SF; Croft, SL; Gilbert, IH; Goodman, JM; Guerrero, RH; Leal, I; Maes, L; Pacanowska, DG; Ruiz-Perez, LM; Villamor, VB | 1 |
| Intaraudom, C; Kamchonwongpaisan, S; Phupong, W; Sirawaraporn, W; Sirichaiwat, C; Tarnchompoo, B; Thebtaranonth, Y; Vanichtanankul, J; Yuthavong, Y | 1 |
| Anderson, AC; Atom Yee, W; Chan, DC; Fillingham, YA; Popov, VM; Wright, DL | 1 |
| Anderson, AC; Joska, TM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Gangjee, A; Jain, HD; Kisliuk, RL; Queener, SF | 1 |
| Aboge, GO; Fujisaki, K; Goo, YK; Igarashi, I; Jia, H; Namikawa, K; Nishikawa, Y; Sunaga, F; Suzuki, H; Terkawi, MA; Tsuji, N; Xuan, X | 1 |
| Borrmann, S; Kiara, SM; Masseno, V; Mwai, L; Nzila, A; Ochola, I; Okombo, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bailey-Downs, LC; Gangjee, A; Ihnat, MA; Kisliuk, RL; Thorpe, JE; Zhao, Y | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Cody, V; Gangjee, A; Kisliuk, RL; Namjoshi, OA; Queener, SF; Raghavan, S | 1 |
| Blundell, TL; Dias, MV; Domingues, RR; Paes Leme, AF; Tyrakis, P | 1 |
| Correa-Basurto, J; Flores-Alamo, M; Galindo-Sevilla, N; Hernández-Luis, F; Hernández-Pineda, J; Mendoza-Martínez, C; Padierna-Mota, C; Rodríguez-Delgado, RG; Ugalde-Saldivar, VM | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cichero, E; Espinoza, S; Gainetdinov, RR; Tonelli, M | 1 |
| Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW | 1 |
| Chudasama, CJ; Dixit, BC; Dixit, RB; Patel, BD; Patel, TS; Patel, UH; Vanparia, SF | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
| Bhatt, JD; Chudasama, CJ; Dixit, BC; Dixit, RB; Patel, BD; Patel, TS; Patel, UH; Vanparia, SF | 1 |
| Barks, J; Brockman, A; Gould, J; Hopper, AT; Radke, JB; Sibley, LD; Thomas, S; Wise, A; Zou, Y | 1 |
| Bera, S; Mondal, D | 1 |
| Bhatt, JD; Chudasama, CJ; Dixit, BC; Dixit, RB; Patel, BD; Patel, TS | 1 |
| Kashihara, M; Mizuguchi, M; Yokoyama, T | 1 |
| Henkens, RW; Kitchell, BB | 1 |
| Ansdell, VE; Hutchinson, DB; Wright, SG | 1 |
| Hlaing, N; Htun Nyun, R; Kyi, KK; Myint, T; Tin, F; U, T | 1 |
| Mills, J; Ryning, FW | 1 |
| Bruce-Chwatt, LJ | 2 |
| Hof, H | 1 |
| Heilmann, E | 1 |
| Nye, FJ | 1 |
| Apt, W; Atias, A; Lorca, M; Olguín, J; Thiermann, E | 1 |
| Grey, D; Hamilton-Miller, JM | 1 |
| Coradello, H; Kretschmer, S | 1 |
| Burchall, JJ; Harvey, RJ; Pattishall, KH | 1 |
| Rollo, IM | 1 |
| Davidson, DE; Hickman, RL; Johnsen, DO; Kinnamon, KE; Tanticharoenyos, P | 1 |
| Malfatti, S; Piccini, A | 1 |
| Hynes, JB; McCullough, JL; Weinstein, GD | 1 |
| Menter, MA; Morrison, JG | 1 |
| Girdwood, RH | 1 |
| Seydel, JK; Wempe, E | 1 |
| Egger, I; Werner, H | 1 |
| Seah, SK | 1 |
| Gallasch, G; Holz, FG; Tetz, M; Völcker, HE | 1 |
| Vinogradov, NA | 1 |
| Soma, K | 1 |
| Lewin, LM; Pholpramool, C; Ruchirawat, S; Verawatnapakul, V | 1 |
| Abdullah, M; Nur, MA; Teklu, B | 1 |
| Chastang, C; Derouin, F | 1 |
| Caumes, E; Feyeux, C; Garrouste, MT; Schlemmer, B; Wallach, D | 1 |
| Haberkorn, A; Harder, A | 1 |
| Jankó, M; Juhász, P; Tóth, L; Vukmirovits, G | 1 |
| Cohen, W; Cohn, JA; Holzman, RS; Jacobs, J; McMeeking, A | 1 |
| Gottlieb, MS; Young, LS | 1 |
| Johnson, WD; Pape, JW; Verdier, RI | 1 |
| Allegra, CJ; Chabner, BA; Drake, J; Kovacs, JA; Lunde, M; Masur, H; Parrillo, JE; Swan, JC | 1 |
| Kovacs, JA; Masur, H | 1 |
| Barkakaty, BN; Chakravorty, NK; Sharma, GK | 1 |
| Davis, RE | 1 |
| Felmingham, D; Mumtaz, G; Ridgway, GL | 1 |
| Booth, RG; Hansch, C; Neal, RA; Santi, DV; Sertsrivanich, R; Sirawaraporn, W | 1 |
| Cushion, MT; Foy, JM; Kim, CK; Linke, MJ; Walzer, PD | 1 |
| Perlman, DC; Sherman, J; Tanowitz, H; Weiss, LM; Wittner, M | 1 |
| Petersen, E | 1 |
| Morrison, JF; Stone, SR | 1 |
| Chen, GX; Mueller, C; Wendlinger, M; Zolg, JW | 1 |
| Rosenberg, IH; Selhub, J; Zimmerman, J | 1 |
| Deinhardt, F; Schierz, G; Szabados, A | 1 |
| Mojon, M | 1 |
| Catterall, JR; Potasman, I; Remington, JS | 1 |
| Harper, JS; London, WT; Sever, JL | 1 |
| Dickmeiss, H; Fleming, AF; Warrell, DA | 1 |
| Sirotnak, FM | 1 |
| Vischer, WA | 1 |
| Bowman, JE; Carson, PE; Frischer, H; Kass, L; Richard, L; Rieckmann, KH; Willerson, D | 1 |
| Dawkins, AT; Stahler, N; Terzian, LA | 1 |
| Jaffe, JJ; McCormack, JJ; Meymarian, E | 1 |
| Robenberg, IH | 1 |
| Borgstein, A; Tozer, RA | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Geiman, QM; Schnell, JV; Siddiqui, WA | 1 |
| Colwell, EJ | 1 |
| Bear, DM; Chin, W; Colwell, EJ; Kosakal, S | 1 |
| Hall, DH; Johnson, JR | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Morrison, NE | 1 |
| Botelho, A | 1 |
| Botha, D | 1 |
| Conno, L | 1 |
| Laing, AB | 1 |
| Terragna, A | 1 |
| Freisheim, JH; Smith, CC | 1 |
| Hitchings, GH | 1 |
| Freisheim, JH; Guzy, PM; Smith, CC | 1 |
| Reusser, P | 1 |
| Blakley, RL; Cocco, L; London, RE; Montgomery, JA; Roth, B; Temple, C | 1 |
| Deroń, Z; Jabłkowski, M | 1 |
| Scott, JM; Weir, DG | 1 |
| Garin, JP; Paillard, B | 1 |
| Calva-Mercado, MP; Lejeune, J; Maunoury, C; Rethoré, MO | 1 |
| Nguyen, BT; Stadtsbaeder, S | 1 |
| Dunn, SM; King, RW | 1 |
| Hughes, WT | 1 |
| Anguita, T | 1 |
| Bygbjerg, IC | 1 |
| Dankert, W; Hartman, PG; Mehlhorn, H; Then, RL | 1 |
| Gorrod, JW; Watkins, PJ | 1 |
| Hughes, WT; Killmar, JT; Oz, HS | 1 |
| Horii, T; Morimatsu, K; Sano, G | 1 |
| Mittelviefhaus, H | 1 |
| Bagnara, AS; Nott, SE | 1 |
| Assaraf, YG; Slotky, JI | 1 |
| Edman, U; Gamarro, F; Greene, PJ; Santi, D; Yu, PL; Zhao, J | 1 |
| Donald, RG; Greene, PJ; Roos, DS; Santi, DV; Trujillo, M | 1 |
| Blagburn, BL; Butler, JM; Lindsay, DS; Rippey, NS | 1 |
| Camps, W; Galama, JM; Koopmans, PP; Melchers, WJ; Schoondermark-van de Ven, EM; van der Meer, JW; van der Ven, AJ | 1 |
| Brun-Pascaud, M; Chau, F; Derouin, F; Garry, L; Girard, PM; Jacobus, D | 1 |
| Basco, LK; Le Bras, J | 1 |
| Feeney, J | 1 |
| Dubey, JP; Lindsay, DS | 1 |
| Andreev, E; Arisz, L; Koopman, M | 1 |
| Gabriëls, G; Greven, J; Stockem, E | 1 |
| Blagburn, BL; Dillon, AR; Kane, CW; Lindsay, DS; Macintire, DK; Vincent-Johnson, NA | 1 |
| Asencio Marchante, R; Lissen Otero, E | 1 |
| Gray, LC; Madigan, JE; Magdesian, KG; Sturges, BK | 1 |
| Cortese, JF; Iyer, JK; Kublin, JG; Milhous, WK; Plowe, CV | 1 |
| Nishikawa, M; Ogino, T; Ohta, T; Ono-Ogata, T; Yamagata, H | 1 |
| Derouin, F | 1 |
| Afeltra, J; Meis, JF; Mouton, JW; Verweij, PE; Vitale, RG | 1 |
| Jia, Q; Kovacs, JA; Ma, L | 1 |
| Alifrangis, M; Bygbjerg, IC; Gabar, HA; Khalil, I; Rønn, AM; Satti, GM | 1 |
| Brennan, JD; Brook, MA; Chen, Y; Hodgson, RJ; Long, H; Organ, M; Tleugabulova, D; Zhang, Z; Zhao, X | 1 |
| Kamchonwongpaisan, S; Tarnchompoo, B; Taweechai, S; Vanichtanankul, J; Yuthavong, Y; Yuvaniyama, J | 1 |
| Diallo, TO; Doui-Doumgba, K; Flori, P; Garraud, O; Gbagba, FE; Nambei, WS; Ndadjimbaye, V; Ndémanga, J; Perraut, R | 1 |
| Brennan, JD; Brook, MA; Covey, T; Hodgson, RJ; Kovarik, P | 1 |
| Vincent-Johnson, N | 1 |
| Anderson, AC; Chan, DC | 1 |
| Cui, ZF; Tirlapur, UK; Trainor, N; Triffitt, JT; Urban, JP; Xu, X | 1 |
| Androudi, S; Bhaila, I; Fiore, T; Iaccheri, B; Janjua, S; Papadaki, T; Stephen Foster, C | 1 |
| Bag, S; Degani, MS; Goswami, K; Reddy, MV; Sharma, R; Tawari, NR | 1 |
| Schott, HC; Stack, A | 1 |
| Hannongbua, S; Khamsemanan, N; Lawtrakul, L; Nattee, C; Toochinda, P | 1 |
| Gauye, F; Greub, G; Hauser, PM; Mueller, L | 1 |
| Perdih, F; Swinton Darious, R; Thomas Muthiah, P | 1 |
| Baptista, JA; Canotilho, J; Castro, RAE; Eusébio, MES; Évora, AOL; Maria, TMR; Ramos Silva, M; Rosado, MTS | 1 |
| Dallmann, R; Fromm, MF; Lehr, T; Müller, F; Selzer, D; Türk, D | 1 |
| Bekier, A; Dzitko, K; Kaproń, B; Paneth, A; Plech, T; Trotsko, N; Węglińska, L | 1 |
18 review(s) available for trimethoprim and pyrimethamine
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
[Drug-induced megaloblastic anemia].
Topics: Alcoholism; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; Anticonvulsants; Antimetabolites, Antineoplastic; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Folic Acid Antagonists; Humans; Malabsorption Syndromes; Pyrimethamine; Triamterene; Trimethoprim; Vitamin B 12 | 1979 |
[Diagnosis and treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Diagnosis, Differential; Humans; Pneumonia, Pneumocystis; Prognosis; Pyrimethamine; Respiration, Artificial; Sulfanilamides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1991 |
Pneumocystis carinii pneumonia: therapy and prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Quinazolines; Recurrence; Sulfadiazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate | 1988 |
Prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Aerosols; Dapsone; Drug Combinations; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Recurrence; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
[Pneumocystis carinii pneumonia].
Topics: Adult; Animals; Antibodies; Antimalarials; Child; Drug Combinations; Drug Therapy, Combination; Humans; Lung; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; Radiography; Rats; Sulfadiazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
[Pneumocystis carinii infections].
Topics: Animals; Child; Drug Combinations; France; History, 20th Century; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Rats; Sulfadiazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
A review of the drug sensitivity of Plasmodium falciparum in Thailand.
Topics: Chloroquine; Drug Resistance; Geography; Humans; Malaria; Methylamines; Naphthacenes; Plasmodium falciparum; Pyrazines; Pyrimethamine; Pyrimidines; Quinine; Sulfamethoxazole; Sulfonamides; Tetracycline; Thailand; Trimethoprim | 1972 |
Antifolic combinations in the treatment of malaria.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Folic Acid Antagonists; Humans; Immunity; Infant; Infant, Newborn; Malaria; Middle Aged; Oxidoreductases; Plasmodium falciparum; Pyrimethamine; Sulfonamides; Trimethoprim | 1974 |
Folate antagonists as antibacterial and antiprotozoal agents.
Topics: Anti-Bacterial Agents; Antimalarials; Antiprotozoal Agents; Escherichia coli; Folic Acid Antagonists; Gastrointestinal Diseases; Gonorrhea; Humans; Lacticaseibacillus casei; Malaria; Pediococcus; Plasmodium; Pyrimethamine; Respiratory Tract Infections; Skin Diseases, Infectious; Sulfamethoxazole; Trimethoprim; Trypanosoma; Urinary Tract Infections | 1971 |
Drug-induced megaloblastic change.
Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim | 1980 |
[Treatment of ocular toxoplasmosis. Part 1: Basic principles and diagnosis].
Topics: Clindamycin; Humans; Infant; Infant, Newborn; Pyrimethamine; Toxoplasmosis, Congenital; Toxoplasmosis, Ocular; Trimethoprim | 1993 |
A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?
Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Benzeneacetamides; Cimetidine; Creatinine; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Histamine H2 Antagonists; Humans; Pyrimethamine; Renal Insufficiency; Salicylates; Trimethoprim; Urea; Vitamin D | 1999 |
Anti-toxoplasmosis drugs.
Topics: Animals; Anti-Bacterial Agents; Drug Combinations; Folic Acid Antagonists; Humans; Macrolides; Pyrimethamine; Sulfonamides; Tetrahydrofolate Dehydrogenase; Toxoplasmosis; Trimethoprim | 2001 |
Towards species-specific antifolates.
Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Design; Folic Acid Antagonists; Humans; Molecular Sequence Data; Plasmodium falciparum; Pneumocystis carinii; Pteridines; Pyrimethamine; Pyrimidines; Sequence Alignment; Species Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimetrexate | 2006 |
5 trial(s) available for trimethoprim and pyrimethamine
| Article | Year |
|---|---|
Chloroquine-resistant malaria in Burma.
Topics: Chloroquine; Clinical Trials as Topic; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Myanmar; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine; Sulfamethoxypyridazine; Trimethoprim | 1975 |
Treatment and prophylaxis of Isospora belli infection in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Chronic Disease; Coccidiosis; Drug Administration Schedule; Drug Therapy, Combination; Humans; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Sulfanilamides; Trimethoprim | 1989 |
Pneumocystis carinii pneumonia in the patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Bronchoscopy; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Eflornithine; Humans; Male; Ornithine; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Therapeutic Irrigation; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Combinations of 4-aminobenzoic acid competitors and dihydrofolate dehydrogenase inhibitors in the chemotherapy of malaria. A commentary.
Topics: Africa; Antimalarials; Asia; Chloroquine; Clinical Trials as Topic; Dapsone; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Malaria; Pyrimethamine; Trimethoprim | 1974 |
Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Central African Republic; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Parasitemia; Parasitic Sensitivity Tests; Patient Compliance; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome; Trimethoprim | 2005 |
145 other study(ies) available for trimethoprim and pyrimethamine
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Aotus trivirgatus; Bacteria; Chickens; Folic Acid Antagonists; Haplorhini; Malaria; Male; Mice; Microbial Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship | 1978 |
Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.
Topics: Animals; Antimalarials; Bacteria; Chemical Phenomena; Chemistry; Chickens; Drug Resistance; Folic Acid Antagonists; Haplorhini; Malaria; Mice; Plasmodium; Quinazolines | 1979 |
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Triazines | 1977 |
The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Lactoylglutathione Lyase; Lyases; Microcomputers; Models, Chemical; Models, Molecular; Molecular Conformation; Saccharomyces cerevisiae; Structure-Activity Relationship; Thermodynamics | 1988 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate | 1995 |
2,4-Diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: synthesis and antifolate activity.
Topics: Animals; Folic Acid Antagonists; Humans; Pyrimidines; Rats; Structure-Activity Relationship; Trimetrexate | 1994 |
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneumonia, Pneumocystis; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis; Trimetrexate | 1996 |
2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Thiophenes; Toxoplasma | 1997 |
2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Folic Acid Antagonists; Liver; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma; Trimethoprim | 1998 |
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Liver; Lung; Mice; Pneumocystis; Pyrimidines; Quinazolines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Tumor Cells, Cultured | 1999 |
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Topics: Animals; Drug Design; Folic Acid Antagonists; Humans; In Vitro Techniques; Leishmania infantum; Leishmania major; Macrophages, Peritoneal; Mice; Models, Molecular; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 1999 |
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Binding, Competitive; Chlorocebus aethiops; Folic Acid Antagonists; Humans; KB Cells; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Vero Cells | 2002 |
Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.
Topics: Animals; Binding Sites; Chemistry, Pharmaceutical; Cryptosporidium; Drug Design; Inhibitory Concentration 50; Ligands; Models, Chemical; Models, Molecular; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2006 |
Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads.
Topics: 4-Aminopyridine; Amino Acid Sequence; Anti-Bacterial Agents; Bacillus anthracis; Bacillus cereus; Binding Sites; Drug Design; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Models, Molecular; Sequence Alignment; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Topics: Alkylation; Anti-Infective Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2008 |
Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Babesia; Base Sequence; Cloning, Molecular; DNA Primers; DNA, Protozoan; Escherichia coli; Folic Acid Antagonists; Gene Expression; Genes, Protozoan; Molecular Sequence Data; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2008 |
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Genotype; Inhibitory Concentration 50; Kenya; Methotrexate; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Drug Screening Assays, Antitumor; Humans; Indenes; Melanoma, Experimental; Mice; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Topics: Amination; Aniline Compounds; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pyridines; Pyrimidines; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2013 |
Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs.
Topics: Bacterial Proteins; Calorimetry; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Proguanil; Protein Conformation; Pyrimethamine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 2014 |
Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies.
Topics: Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Electrochemical Techniques; Leishmania mexicana; Macrophages; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Parasitic Sensitivity Tests; Solubility; Structure-Activity Relationship | 2015 |
Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
Topics: Absorption, Physicochemical; Animals; Biguanides; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2017 |
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries | 2017 |
Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition.
Topics: Amino Acids; Antimalarials; Biological Availability; Enzyme Inhibitors; Folic Acid Antagonists; Plasmodium falciparum; Quinazolines; Sulfonamides; Tetrahydrofolate Dehydrogenase | 2017 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Ionic liquid mediated stereoselective synthesis of alanine linked hybrid quinazoline-4(3H)-one derivatives perturbing the malarial reductase activity in folate pathway.
Topics: Alanine; Animals; Antimalarials; Caco-2 Cells; Catalysis; Chlorocebus aethiops; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Humans; Ionic Liquids; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinazolinones; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Vero Cells | 2017 |
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.
Topics: Animals; Antiparasitic Agents; Dogs; Female; Folic Acid Antagonists; Humans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Mice; Molecular Structure; Piperazines; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis | 2019 |
Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway.
Topics: Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Molecular Structure; Phenylalanine; Quantitative Structure-Activity Relationship; Sulfonamides | 2019 |
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Topics: Amyloid Neuropathies, Familial; Anthelmintics; Bithionol; Crystallography, X-Ray; Drug Repositioning; Humans; Prealbumin; Thermodynamics; Triclabendazole | 2021 |
Effect of temperature on fluorescence and circular dichroism of Escherichia coli dihydrofolate reductase and its complexes.
Topics: Circular Dichroism; Escherichia coli; Ligands; Methotrexate; NADP; Protein Conformation; Pyrimethamine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1978 |
Megaloblastic anaemia associated with combined pyrimethamine and co-trimoxazole administration.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Drug Therapy, Combination; Female; Fever; Humans; Malaria; Pyrimethamine; Sulfamethoxazole; Trimethoprim | 1976 |
Pneumocystis carinii, Toxoplasma gondii, Cytomegalovirus and the compromised host.
Topics: Adolescent; Adult; Animals; Cats; Child; Child, Preschool; Cytomegalovirus Infections; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Rats; Stilbamidines; Sulfamethoxazole; Sulfanilamides; Toxoplasmosis; Trimethoprim | 1979 |
Prevention and treatment of malaria.
Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Quinine; Trimethoprim | 1977 |
[Toxoplasma gondii. Infection and its prevention].
Topics: Animals; Antibody Formation; Cats; Chorioretinitis; Chronic Disease; Complement Fixation Tests; Disease Vectors; Drug Synergism; Female; Fluorescent Antibody Technique; Humans; Hydrocephalus; Immunity, Cellular; Intellectual Disability; Jaundice; Lactation; Leucomycins; Macrophages; Mice; Pregnancy; Pyrimethamine; Spleen; Sulfonamides; T-Lymphocytes; Toxoplasmosis; Trimethoprim; Virulence | 1978 |
Treating toxoplasmosis.
Topics: Drug Therapy, Combination; Humans; Leucomycins; Pyrimethamine; Sulfonamides; Tetracyclines; Toxoplasmosis; Trimethoprim | 1979 |
A comparative study of some combined treatment regimens in acute toxoplasmosis in mice.
Topics: Acute Disease; Animals; Clindamycin; Drug Therapy, Combination; Humans; Leucomycins; Mice; Pyrimethamine; Sulfamethoxazole; Sulfamethoxypyridazine; Toxoplasmosis, Animal; Trimethoprim | 1978 |
Trimethoprim-resistant bacteria: cross-resistance patterns.
Topics: Aspartic Acid; Bacteria; Bacterial Infections; Cross Reactions; Drug Resistance, Microbial; Humans; Methotrexate; Proguanil; Pyrimethamine; R Factors; Species Specificity; Trimethoprim; Urine | 1977 |
[A comparison of Ultrax, Diazil, Bactrim and Spiramycin in experimental toxoplasmosis in mice (author's transl)].
Topics: Animals; Injections, Subcutaneous; Leucomycins; Mice; Pyrimethamine; Sulfameter; Sulfamethazine; Sulfamethoxazole; Sulfanilamides; Toxoplasmosis, Animal; Trimethoprim | 1978 |
Interconvertible forms of Escherichia coli dihydrofolate reductase with different affinities for analogs of dihydrofolate.
Topics: Binding Sites; Escherichia coli; Isoenzymes; Kinetics; Mathematics; Pronase; Protein Binding; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1976 |
Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Lacticaseibacillus casei; Leucovorin; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Pyrimidines; Sulfalene; Sulfonamides; Trimethoprim | 1975 |
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
Topics: Amodiaquine; Animals; Antimalarials; Dapsone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Tolerance; Haplorhini; Macaca mulatta; Malaria; Phenanthrenes; Primaquine; Prodigiosin; Pyrimethamine; Quinine; Sulfadiazine; Sulfadimethoxine; Sulfalene; Trimethoprim | 1976 |
[Pancytopenic megaloblastic anaemia following administration of pyrimethamine, trimethoprim and sulphamethoxazole (author's transl)].
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Synergism; Folic Acid Antagonists; Humans; Male; Pyrimethamine; Sulfamethoxazole; Trimethoprim | 1976 |
In vitro screening of biochemical activity of folic acid antagonists in skin.
Topics: Animals; Animals, Newborn; Chlorobenzenes; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Psoriasis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Skin; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1977 |
Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nékam): a manifestation of acquired adult toxoplasmosis.
Topics: Adult; Drug Combinations; Female; Humans; Kaposi Varicelliform Eruption; Male; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1976 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12 | 1976 |
Kinetics and mechanisms of action of 'folate synthesis inhibitors', alone or in combination, on Escherichia coli. III. Pyrimethamine, trimethoprim and sulfamethoxazole.
Topics: Cell Count; Cell Division; Depression, Chemical; Drug Interactions; Escherichia coli; Folic Acid Antagonists; Kinetics; Pyrimethamine; Sulfamethoxazole; Trimethoprim | 1975 |
[Comparative Chemotherapeutical studies on the effect of Bactrim and other combined preparations on the proliferative and cystforming phase of Toxoplasma gondii in NMRI mice. A contribution to experimental chemotherapy of toxoplasmosis (author's transl)].
Topics: Acute Disease; Animals; Chronic Disease; Drug Combinations; Drug Evaluation; Drug Synergism; Female; Mice; Pyrimethamine; Sulfamethoxazole; Sulfonamides; Time Factors; Toxoplasmosis; Trimethoprim | 1975 |
Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations.
Topics: Animals; Drug Combinations; Drug Evaluation; Female; Mice; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Toxoplasmosis, Animal; Trimethoprim | 1975 |
[Segmental retinal arteritis and retinochorioiditis].
Topics: Adult; Arteritis; Chorioretinitis; Drug Therapy, Combination; Fluorescein Angiography; Humans; Male; Prednisolone; Pyrimethamine; Retinal Diseases; Sulfamethoxazole; Toxoplasmosis, Ocular; Trimethoprim; Visual Acuity; Visual Field Tests | 1992 |
[Diagnosis and therapy of parasitic lung diseases].
Topics: Humans; Lung Diseases, Parasitic; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; Spiramycin; Strongyloidiasis; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1991 |
Mode of action of the antifertility sulphonamides: lack of effects on folate metabolism.
Topics: Animals; Dimethyl Sulfoxide; Drug Combinations; Epididymis; Fertility; Folic Acid; Liver; Male; Prostate; Pyrimethamine; Rats; Rats, Inbred F344; Seminal Vesicles; Sulfacetamide; Sulfamerazine; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Sulfonamides; Trimethoprim | 1990 |
Two fevers with a common etiology.
Topics: Adult; Aged; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Female; Fever of Unknown Origin; Humans; Pyrimethamine; Sulfamethoxazole; Toxoplasmosis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1989 |
In vitro effects of folate inhibitors on Toxoplasma gondii.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Pyrimidines; Quinazolines; Sulfamethoxazole; Sulfisoxazole; Toxoplasma; Trimethoprim; Trimetrexate | 1989 |
[Bullous toxic skin disease with fatal outcome in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Johnson Syndrome; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Zidovudine | 1989 |
Possible mode of action of toltrazuril: studies on two Eimeria species and mammalian and Ascaris suum enzymes.
Topics: Animals; Ascaris; Chickens; Coccidiosis; Coccidiostats; Dihydroorotate Dehydrogenase; Drug Synergism; Drug Therapy, Combination; Eimeria; Folic Acid Antagonists; Mice; Mitochondria, Liver; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimethamine; Succinate Cytochrome c Oxidoreductase; Succinate Dehydrogenase; Sulfamethazine; Triazines; Trimethoprim | 1989 |
Acute monosymptomatic aseptic meningitis caused by Toxoplasma gondii.
Topics: Acute Disease; Child, Preschool; Drug Combinations; Folic Acid; Humans; Male; Meningitis; Meningitis, Aseptic; Pyrimethamine; Staining and Labeling; Sulfamethoxazole; Toxoplasmosis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Evaluation of the policy of empiric treatment of suspected Toxoplasma encephalitis in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain; Clindamycin; Encephalitis; Female; Humans; Male; Middle Aged; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Tomography, X-Ray Computed; Toxoplasmosis; Trimethoprim | 1989 |
Adverse reactions to pyrimethamine-sulfadoxine in context of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Drug Hypersensitivity; Humans; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Sulfanilamides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Folic Acid Antagonists; Macrophages; Mice; Mice, Inbred BALB C; Pentamidine; Pyrimethamine; Quinazolines; Sulfadiazine; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim; Trimetrexate | 1987 |
Studies on efficacy of treatment with sulfamethoxazole + trimethoprim and sulfalene + pyrimethamine combinations in Plasmodium falciparum malaria of known and unknown resistant status.
Topics: Animals; Drug Evaluation; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Pyrimethamine; Sulfalene; Sulfamethoxazole; Sulfanilamides; Trimethoprim | 1988 |
In vitro activity of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine against Chlamydia trachomatis SA2f in McCoy cell culture.
Topics: Cell Line; Chlamydia trachomatis; Culture Media; Drug Combinations; Humans; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Sulfanilamides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Leishmania tropica; Proguanil; Pyrimethamine; Pyrimidines; Triazines; Trimethoprim | 1988 |
Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia.
Topics: Animals; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Male; Pneumonia, Pneumocystis; Pyrimethamine; Pyrimidines; Rats; Rats, Inbred Strains; Sulfadiazine; Sulfadoxine; Sulfamethoxazole; Trimethoprim | 1988 |
Isospora belli infection: treatment with pyrimethamine.
Topics: Adult; Coccidiosis; Diarrhea; Drug Combinations; HIV Seropositivity; Humans; Intestinal Diseases, Parasitic; Male; Middle Aged; Pyrimethamine; Recurrence; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
In vitro susceptibility of Plasmodium falciparum malaria to pyrimethamine, sulfadoxine, trimethoprim and sulfamethoxazole, singly and in combination.
Topics: Animals; Antimalarials; Drug Combinations; Drug Synergism; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Sulfanilamides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1987 |
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1986 |
Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum.
Topics: Chromatography, Affinity; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Malaria; Methotrexate; NADP; Plasmodium falciparum; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1987 |
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.
Topics: Animals; Binding Sites; Biological Transport; Folic Acid; Folic Acid Antagonists; Intestinal Absorption; Intestine, Small; Jejunum; Kinetics; Male; Pyrimethamine; Rats; Rats, Inbred Strains; Trimethoprim | 1987 |
Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.
Topics: Animals; Clindamycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucomycins; Liver; Pregnancy; Pyrimethamine; Saimiri; Spleen; Sulfadiazine; Sulfamethoxazole; Toxoplasma; Toxoplasmosis; Toxoplasmosis, Animal; Trimethoprim | 1985 |
Letter: Co-trimoxazole and the blood.
Topics: Administration, Oral; Adult; Anemia, Macrocytic; Blood Cell Count; Drug Therapy, Combination; Female; Humans; Malaria; Pyrimethamine; Self Medication; Sulfamethoxazole; Trimethoprim | 1974 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
[Comparative study on the effect of some clinically used sulfanilamide derivatives against toxoplasmosis in the mouse].
Topics: Aminobenzoates; Animals; Dapsone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Placebos; Pyrimethamine; Structure-Activity Relationship; Sulfamerazine; Sulfamethoxazole; Sulfonamides; Time Factors; Toxoplasmosis, Animal; Trimethoprim | 1973 |
Chemotherapeutic results in a multi-drug resistant strain of Plasmodium falciparum malaria from Vietnam.
Topics: Adult; Alanine Transaminase; Anopheles; Antimalarials; Aspartate Aminotransferases; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Malaria; Male; Methylamines; Military Medicine; Phenanthrenes; Plasmodium falciparum; Pyrazines; Pyrimethamine; Quinine; Sulfanilamides; Trimethoprim; Vietnam | 1974 |
Differences in drug response of the sporogonous cycles of three strains of Plasmodium falciparum in Anopheles stephensi.
Topics: Animals; Anti-Infective Agents; Antimalarials; Culicidae; Drug Resistance, Microbial; Folic Acid Antagonists; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Pyrimidines; Triazines; Trimethoprim | 1970 |
Comparative properties of schistosomal and filarial dihydrofolate reductases.
Topics: Anthelmintics; Chromatography, Gel; Eukaryota; Filarioidea; Folic Acid Antagonists; Molecular Weight; NADP; Pyrimethamine; Quinazolines; Schistosoma mansoni; Structure-Activity Relationship; Suramin; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1972 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim | 1972 |
Infectious mononucleosis and megaloblastic anaemia associated with daraprim and bactrim.
Topics: Adolescent; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Deficiency; Hemorrhage; Humans; Infectious Mononucleosis; Pyrimethamine; Sulfamethoxazole; Trimethoprim; Vitamin B 12 | 1974 |
Effect of lipid-soluble esters of methotrexate on DNA synthesis in human skin.
Topics: Aminopterin; Depression, Chemical; DNA; Esters; Humans; Lipids; Methotrexate; Pyrimethamine; Skin; Solubility; Temperature; Time Factors; Trimethoprim; Tritium; Uridine | 1974 |
A model in vitro system to test the susceptibility of human malarial parasites to antimalarial drugs.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Microbial Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Quinine; Trimethoprim | 1972 |
A comparative evaluation of sulfalene-trimethoprim and sulphormethoxine-pyrimethamine against falciparum malaria in Thailand.
Topics: Adolescent; Adult; Anti-Infective Agents; Antibodies; Antimalarials; Drug Combinations; Evaluation Studies as Topic; Fluorescent Antibody Technique; Folic Acid Antagonists; Glucosephosphate Dehydrogenase Deficiency; Hematocrit; Humans; Leukocyte Count; Malaria; Male; Middle Aged; Plasmodium falciparum; Pyrimethamine; Pyrimidines; Sulfonamides; Thailand; Trimethoprim | 1973 |
Isolation and characterization of mutants of bacteriophage T4 resistant to folate analogs.
Topics: Coliphages; Culture Media; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Hot Temperature; Mutation; Osmotic Fragility; Phenotype; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1973 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein Binding; Pteridines; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1974 |
Considerations on the use of sulphones and sulphonamides with a pyrimidine derivative.
Topics: Adult; Amodiaquine; Child; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Mozambique; Plasmodium falciparum; Plasmodium malariae; Primaquine; Pyrimethamine; Sulfonamides; Trimethoprim | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfonamides; Trimethoprim | 1974 |
[Lymph-node toxoplasmosis: recent clinical, diagnostic and therapeutic acquisitions].
Topics: Anti-Infective Agents; Diagnosis, Differential; Folic Acid Antagonists; Humans; Infectious Mononucleosis; Lymph Nodes; Lymphatic Diseases; Lymphoma; Pyrimethamine; Pyrimidines; Sulfamethoxazole; Sulfonamides; Toxoplasmosis; Trimethoprim | 1972 |
Levels of dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to substituted pyrimidines, triazines and MTX.
Topics: Chromatography, Gel; Culture Media; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid Antagonists; Methotrexate; Methyltransferases; Protein Binding; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1971 |
Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Folic Acid Antagonists; Genetics, Microbial; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Methyltransferases; Mutation; Proguanil; Pyrimethamine; Streptococcus; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Recurrence; Sulfonamides; Sulfones; Trimethoprim | 1972 |
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Middle Aged; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Trimethoprim | 1980 |
Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase.
Topics: Animals; Cattle; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lacticaseibacillus casei; Liver; Magnetic Resonance Spectroscopy; Methotrexate; Protein Binding; Pyrimethamine; Streptococcus; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1983 |
[Side effects of toxoplasmosis treatment].
Topics: Adolescent; Adult; Anemia; Antiprotozoal Agents; Child; Child, Preschool; Drug Eruptions; Dyspepsia; Female; Humans; Leukopenia; Male; Middle Aged; Pyrimethamine; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1980 |
[Experimental toxoplasmosis in mice. Comparative activity of clindamycin, midecamycin, josamycin, spiramycin, pyrimethamine-sulfadoxine, and trimethoprim-sulfamethoxazole].
Topics: Animals; Clindamycin; Drug Combinations; Leucomycins; Mice; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Sulfanilamides; Toxoplasmosis, Animal; Trimethoprim | 1984 |
[Fragility of the X chromosome and inhibition of dihydrofolate reductase. Comparison of the effects of 2 antibiotics: trimethoprim and pyrimethamine].
Topics: Adult; Child; Chromosome Fragility; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Male; Pyrimethamine; Trimethoprim; X Chromosome | 1983 |
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice.
Topics: Animals; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Leucomycins; Mice; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Virulence | 1983 |
Kinetics of ternary complex formation between dihydrofolate reductase, coenzyme, and inhibitors.
Topics: Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Methotrexate; NADP; Protein Binding; Pyrimethamine; Pyrimidines; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Pneumocystis carinii pneumonitis.
Topics: Animals; Drug Combinations; Humans; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Trimethoprim | 1981 |
[Bone marrow megaloblastosis associated with the use of pyrimethamine, triamterene and trimethoprim-sulfamethoxazole].
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Drug Combinations; Female; Folic Acid Antagonists; Humans; Male; Megaloblasts; Middle Aged; Pyrimethamine; Sulfamethoxazole; Triamterene; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1982 |
Augmentation of human lymphocyte proliferative responses in vitro by pyrimethamine.
Topics: Adult; Cells, Cultured; Female; Humans; Lymphocyte Activation; Male; Middle Aged; Mitogens; Pyrimethamine; Trimethoprim | 1981 |
A pilot study on the efficacy of epiroprim against developmental stages of Toxoplasma gondii and Pneumocystis carinii in animal models.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dapsone; Drug Therapy, Combination; Female; Folic Acid Antagonists; Male; Mice; Mice, Inbred Strains; Mice, Nude; Mice, SCID; Pilot Projects; Pneumocystis; Pneumocystis Infections; Pyrimethamine; Rats; Rats, Nude; Sodium Chloride; Sulfadiazine; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim | 1995 |
Determination of isomeric N-oxide metabolites of some substituted 2,4-diaminopyrimidines by reversed-phase ion-pair high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Cricetinae; Dioctyl Sulfosuccinic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Indicators and Reagents; Isomerism; Microsomes, Liver; Oxides; Pyrimethamine; Pyrimidines; Surface-Active Agents; Trimethoprim | 1993 |
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.
Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Trials as Topic; Dapsone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Naphthoquinones; Pentamidine; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1994 |
Purification and characterization of dihydrofolate reductase of Plasmodium falciparum expressed by a synthetic gene in Escherichia coli.
Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Design; Enzyme Reactivators; Escherichia coli; Genes, Protozoan; Genes, Synthetic; Genetic Code; Inclusion Bodies; Methotrexate; Molecular Sequence Data; Plasmodium falciparum; Protein Denaturation; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1994 |
The toxicity of antifolates in Babesia bovis.
Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate | 1993 |
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
Topics: Animals; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Flow Cytometry; Folic Acid Antagonists; Leucovorin; Pyrimethamine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1993 |
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.
Topics: Amino Acid Sequence; Animals; Base Sequence; Enzyme Induction; Folic Acid Antagonists; Genes, Protozoan; Humans; Kinetics; Molecular Sequence Data; Protozoan Proteins; Pyrimethamine; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim; Trypanosoma brucei brucei; Trypanosoma cruzi | 1995 |
Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.
Topics: Animals; Base Sequence; Cloning, Molecular; DNA Primers; DNA, Protozoan; Escherichia coli; Folic Acid Antagonists; Gene Expression; Genetic Vectors; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma; Trimethoprim | 1996 |
Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine.
Topics: Animals; Anti-Infective Agents; Cell Line; Coccidiostats; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Folic Acid Antagonists; Humans; Male; Neospora; Pyrimethamine; Pyrimidines; Skin; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim | 1996 |
Anti-toxoplasma effect of pyrimethamine, trimethoprim and sulphonamides alone and in combination: implications for therapy.
Topics: Animals; Anti-Infective Agents; Enzyme Inhibitors; Folic Acid Antagonists; Microbial Sensitivity Tests; Pyrimethamine; Sulfonamides; Toxoplasma; Trimethoprim | 1996 |
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim | 1996 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Lethal Dose 50; Malaria, Falciparum; Nonlinear Dynamics; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1997 |
Diaminopyrimidines and severe cutaneous adverse reactions.
Topics: Acute Disease; Anticonvulsants; Antimalarials; Drug Eruptions; Humans; Lamotrigine; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines; Trimethoprim | 1997 |
Determination of the activity of pyrimethamine, trimethoprim, sulfonamides, and combinations of pyrimethamine and sulfonamides against Sarcocystis neurona in cell cultures.
Topics: Animals; Anti-Infective Agents; Antimetabolites; Antiprotozoal Agents; Cattle; Cells, Cultured; Drug Combinations; Encephalomyelitis; Enzyme-Linked Immunosorbent Assay; Horse Diseases; Horses; Pyrimethamine; Sarcocystis; Sarcocystosis; Sulfonamides; Trimethoprim; Turbinates | 1999 |
Potassium-sparing renal effects of trimethoprim and structural analogues.
Topics: Animals; Anti-Infective Agents; Blood Pressure; Chlorides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glomerular Filtration Rate; Kidney; Male; Methotrexate; Potassium; Pyrimethamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium; Time Factors; Trimethoprim | 2000 |
Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998).
Topics: Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antiprotozoal Agents; Blood Glucose; Body Temperature; Body Weight; Clindamycin; Coccidia; Coccidiosis; Coccidiostats; Decoquinate; Dog Diseases; Dogs; Female; Hematocrit; Leukocyte Count; Male; Pyrimethamine; Recurrence; Retrospective Studies; Serum Albumin; Sulfadiazine; Survival Analysis; Trimethoprim | 2001 |
[Secondary prevention of opportunistic infections in HIV-infected patients].
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Antitubercular Agents; Antiviral Agents; Clarithromycin; Cytomegalovirus Infections; Drug Therapy, Combination; Ethambutol; Ganciclovir; Humans; Leucovorin; Mycobacterium avium-intracellulare Infection; Pneumonia, Pneumocystis; Pyrimethamine; Recurrence; Rifabutin; Sulfadiazine; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 2001 |
Suspected protozoal myeloencephalitis in a two-month-old colt.
Topics: Animals; Animals, Newborn; Antibodies, Protozoan; Antiprotozoal Agents; Blotting, Western; Diagnosis, Differential; Drug Combinations; Encephalomyelitis; Facial Paralysis; Horse Diseases; Horses; Male; Pyrimethamine; Sarcocystis; Sarcocystosis; Sulfadiazine; Trimethoprim | 2001 |
Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine.
Topics: Africa; Alleles; Animals; Antimalarials; Child; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2001 |
Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Drug Therapy, Combination; Escherichia coli; Mutagenicity Tests; Mutagens; Mutation; Nitrites; Primaquine; Pyrimethamine; Pyrimidines; Rats; Salmonella typhimurium; Trimethoprim | 2002 |
In vitro activities of pentamidine, pyrimethamine, trimethoprim, and sulfonamides against Aspergillus species.
Topics: Anti-Infective Agents; Antifungal Agents; Aspergillosis; Aspergillus; Culture Media; Humans; Microbial Sensitivity Tests; Pentamidine; Pyrimethamine; Sulfonamides; Trimethoprim | 2002 |
Development of a yeast assay for rapid screening of inhibitors of human-derived Pneumocystis carinii dihydrofolate reductase.
Topics: Animals; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Pneumocystis; Pneumocystis Infections; Pyrimethamine; Rats; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2002 |
Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Dihydropteroate Synthase; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Pyrimethamine; Reproducibility of Results; Sulfadoxine; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance | 2003 |
Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography.
Topics: Buffers; Chromatography, Affinity; Chromatography, Liquid; Ethylene Oxide; Folic Acid; Phase Transition; Porosity; Proteins; Pyrimethamine; Silanes; Silicon Dioxide; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim | 2004 |
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Topics: Algorithms; Animals; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Folic Acid Antagonists; Humans; Kinetics; Mass Spectrometry; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Binding; Pyrimethamine; Recombinant Proteins; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 2005 |
Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns.
Topics: Automation; Binding Sites; Buffers; Chromatography, Affinity; Coumaric Acids; Fluorescein; Folic Acid; Image Interpretation, Computer-Assisted; Osmolar Concentration; Proteins; Pyrimethamine; Sensitivity and Specificity; Silicon Dioxide; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim | 2005 |
Questions limitation in treatment of hepatozoonosis.
Topics: Animals; Clindamycin; Coccidiosis; Coccidiostats; Decoquinate; Dog Diseases; Dogs; Drug Combinations; Drug Therapy, Combination; Eucoccidiida; Pyrimethamine; Sulfadiazine; Treatment Outcome; Trimethoprim | 2005 |
Application of multiple parallel perfused microbioreactors and three-dimensional stem cell culture for toxicity testing.
Topics: Bioreactors; Bone Marrow Cells; Cell Culture Techniques; Cell Survival; Cells, Cultured; Humans; Oxazines; Pyrimethamine; Stem Cells; Tissue Culture Techniques; Toxicity Tests; Trimethoprim; Xanthenes | 2007 |
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.
Topics: Adolescent; Adult; Atovaquone; Clindamycin; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; Gastrointestinal Diseases; Humans; Male; Medical Records; Middle Aged; Pyrimethamine; Retrospective Studies; Sulfadiazine; Sulfamethoxazole; Toxoplasmosis, Ocular; Trimethoprim; Vitreous Body; Young Adult | 2008 |
In vitro biological evaluation of biguanides and dihydrotriazines against Brugia malayi and folate reversal studies.
Topics: Animals; Biguanides; Brugia malayi; Filariasis; Filaricides; Folic Acid Antagonists; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 2010 |
Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: a case series.
Topics: Animals; Anti-Bacterial Agents; Central Nervous System Diseases; Drug Overdose; Drug Therapy, Combination; Female; Horse Diseases; Horses; Male; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Sulfonamides; Trimethoprim | 2011 |
A novel prediction approach for antimalarial activities of Trimethoprim, Pyrimethamine, and Cycloguanil analogues using extremely randomized trees.
Topics: Antimalarials; Humans; Hydrophobic and Hydrophilic Interactions; Malaria; Models, Molecular; Plasmodium falciparum; Pyrimethamine; Structure-Activity Relationship; Trimethoprim | 2017 |
Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil.
Topics: DNA Viruses; Enzyme Activation; Folic Acid Antagonists; Humans; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim | 2017 |
Supramolecular hydrogen-bonding patterns in salts of the antifolate drugs trimethoprim and pyrimethamine.
Topics: Crystallography, X-Ray; Folic Acid Antagonists; Hydrogen Bonding; Pyrimethamine; Pyrimidines; Trimethoprim | 2018 |
Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening.
Topics: Crystallography, X-Ray; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2021 |
Renal Transporter-Mediated Drug-Biomarker Interactions of the Endogenous Substrates Creatinine and N
Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Organic Cation Transport Proteins; Pharmaceutical Preparations; Pyrimethamine; Trimethoprim | 2022 |
Inhibition of
Topics: Antiprotozoal Agents; Humans; Imidazoles; Pyrimethamine; Sulfadiazine; Toxoplasma; Triazoles; Trimethoprim | 2022 |