trimethoprim has been researched along with proguanil in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Cichero, E; Espinoza, S; Gainetdinov, RR; Tonelli, M | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
| Grey, D; Hamilton-Miller, JM | 1 |
| Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P | 1 |
| Booth, RG; Hansch, C; Neal, RA; Santi, DV; Sertsrivanich, R; Sirawaraporn, W | 1 |
| Botha, D | 1 |
| Rollo, IM | 1 |
| Freisheim, JH; Guzy, PM; Smith, CC | 1 |
| Bruce-Chwatt, LJ | 1 |
| Lantz, CH; Van Dyke, K | 1 |
| Hughes, WT; Killmar, JT; Oz, HS | 1 |
| Brun-Pascaud, M; Chau, F; Derouin, F; Garry, L; Girard, PM; Jacobus, D | 1 |
| Basco, LK; Le Bras, J | 1 |
| Binh, TQ; de Vries, PJ; Giao, PT; Hung, le Q; Kager, PA; Nam, NV | 1 |
| Kamchonwongpaisan, S; Tarnchompoo, B; Taweechai, S; Vanichtanankul, J; Yuthavong, Y; Yuvaniyama, J | 1 |
| Borrmann, S; Kiara, SM; Masseno, V; Mwai, L; Nzila, A; Ochola, I; Okombo, J | 1 |
| Blundell, TL; Dias, MV; Domingues, RR; Paes Leme, AF; Tyrakis, P | 1 |
| Gauye, F; Greub, G; Hauser, PM; Mueller, L | 1 |
1 review(s) available for trimethoprim and proguanil
| Article | Year |
|---|---|
Dihydrofolate reductase inhibitors as antimicrobial agents and their potentiation by sulfonamides.
Topics: Anti-Bacterial Agents; Antimalarials; Antiprotozoal Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Drug Combinations; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kidney; Lactobacillus; Proguanil; Pyrimidines; Sulfamethoxazole; Sulfonamides; Trimethoprim | 1970 |
1 trial(s) available for trimethoprim and proguanil
| Article | Year |
|---|---|
CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Atovaquone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Naphthoquinones; Parasitemia; Plasmodium falciparum; Primaquine; Proguanil; Quinolines; Sesquiterpenes; Treatment Outcome; Trimethoprim; Vietnam | 2004 |
18 other study(ies) available for trimethoprim and proguanil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
Topics: Absorption, Physicochemical; Animals; Biguanides; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2017 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Trimethoprim-resistant bacteria: cross-resistance patterns.
Topics: Aspartic Acid; Bacteria; Bacterial Infections; Cross Reactions; Drug Resistance, Microbial; Humans; Methotrexate; Proguanil; Pyrimethamine; R Factors; Species Specificity; Trimethoprim; Urine | 1977 |
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
Topics: Acute Disease; Adult; Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Malaria; Male; Middle Aged; Neutropenia; Proguanil; Retrospective Studies; Sulfaguanidine; Sulfamethoxazole; Travel; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Leishmania tropica; Proguanil; Pyrimethamine; Pyrimidines; Triazines; Trimethoprim | 1988 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfonamides; Trimethoprim | 1974 |
Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Folic Acid Antagonists; Genetics, Microbial; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Methyltransferases; Mutation; Proguanil; Pyrimethamine; Streptococcus; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Recurrence; Sulfonamides; Sulfones; Trimethoprim | 1972 |
Studies concerning the mechanism of action of antimalarial drugs. II. Inhibition of the incorporation of adenosine-5'-monophosphate- 3 H into nucleic acids of erythrocyte-free malarial parasites.
Topics: Adenine Nucleotides; Adenosine; Adenosine Monophosphate; Amodiaquine; Animals; Antimalarials; Chloroquine; DNA; Erythrocytes; Methods; Naphthalenes; Phenanthridines; Plasmodium; Proguanil; Quinacrine; Quinine; Rats; RNA; Saponins; Triazines; Trimethoprim; Tritium | 1971 |
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.
Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Trials as Topic; Dapsone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Naphthoquinones; Pentamidine; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1994 |
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim | 1996 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Lethal Dose 50; Malaria, Falciparum; Nonlinear Dynamics; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1997 |
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Topics: Algorithms; Animals; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Folic Acid Antagonists; Humans; Kinetics; Mass Spectrometry; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Binding; Pyrimethamine; Recombinant Proteins; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 2005 |
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Genotype; Inhibitory Concentration 50; Kenya; Methotrexate; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2009 |
Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs.
Topics: Bacterial Proteins; Calorimetry; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Proguanil; Protein Conformation; Pyrimethamine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 2014 |
Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil.
Topics: DNA Viruses; Enzyme Activation; Folic Acid Antagonists; Humans; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim | 2017 |