Page last updated: 2024-08-16

trimethoprim and probenecid

trimethoprim has been researched along with probenecid in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (47.22)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (22.22)	29.6817
2010's	10 (27.78)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Ruskin, J; Sattler, FR	1
Bresher, JT; Duncan, WC; Eakins, W; Knox, JM; Nelson, M	1
Duncan, WC; Jackson, TH; Knox, JM	1
From, E; Kristensen, JK	1
Cacini, W	1
Caranasos, GJ; Cluff, LE; Stewart, RB	1
Cacini, W; Myre, SA	1
Freyens, P; Meheus, AZ; Ngamije, E	1
Wilkinson, AE	1
Rodin, P; Seth, AD	1
Austin, TW; Bethel, M; Brooks, GF; Holmes, KK; Roberts, FL; Turck, M	1
Kristensen, JK	1
Sim, SK	1
Nicol, CS	1
Guinan, ME; Holmes, KK; Johnson, C; McCormack, WM; Stamm, WE; Starcher, T	1
Bjerk, O; Csángó, PA; Gundersen, T; Jagars, G; Salveson, A	1
Williams, RA	1
Hanada, K; Kato, T; Kinami, J; Ogata, H; Takubo, T	1

Reviews

2 review(s) available for trimethoprim and probenecid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinically desirable drug interactions. Annual review of pharmacology and toxicology, 1985, Volume: 25 Topics: Aminoglycosides; Amoxicillin; Ampicillin; Antacids; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Carbidopa; Diuretics; Drug Combinations; Drug Interactions; Drug Synergism; Humans; Hydroxamic Acids; Hypokalemia; Levodopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease; Penicillins; Probenecid; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1985

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Clinically desirable drug interactions.

Annual review of pharmacology and toxicology, 1985, Volume: 25

Topics: Aminoglycosides; Amoxicillin; Ampicillin; Antacids; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Carbidopa; Diuretics; Drug Combinations; Drug Interactions; Drug Synergism; Humans; Hydroxamic Acids; Hypokalemia; Levodopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease; Penicillins; Probenecid; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1985

Trials

5 trial(s) available for trimethoprim and probenecid

Article	Year
Therapy of gonorrhea. Comparison of trimethoprim-sulfamethoxazole and ampicillin. JAMA, 1978, Nov-17, Volume: 240, Issue:21 Topics: Ampicillin; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin Resistance; Penicillinase; Probenecid; Sulfamethoxazole; Trimethoprim	1978
Comparison of trimethoprim-sulfamethoxazole with penicillin and tetracycline in the treatment of uncomplicated gonorrhea in women. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Middle Aged; Neisseria gonorrhoeae; Penicillin G Procaine; Probenecid; Sulfamethoxazole; Tetracycline; Trimethoprim	1975
Gonorrhea. Trimethoprim-sulfamethoxazole in the treatment of gonococcal urethritis: clinical and laboratory correlates. The Journal of infectious diseases, 1973, Volume: 128 Topics: Drug Combinations; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Penicillin G Procaine; Probenecid; Sulfamethoxazole; Tetracycline; Trimethoprim; United States; Urethritis	1973
Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. The New England journal of medicine, 1984, Mar-01, Volume: 310, Issue:9 Topics: Adolescent; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Female; Gonorrhea; Humans; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Probenecid; Random Allocation; Sex Factors; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis; Uterine Cervicitis	1984
Treatment of acute gonococcal urethritis in men with simultaneous infection with Chlamydia trachomatis. The British journal of venereal diseases, 1984, Volume: 60, Issue:2 Topics: Acute Disease; Ampicillin; Anti-Infective Agents, Urinary; Chlamydia Infections; Chlamydia trachomatis; Clinical Trials as Topic; Drug Combinations; Drug Therapy, Combination; Gonorrhea; Humans; Male; Probenecid; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis	1984

Other Studies

29 other study(ies) available for trimethoprim and probenecid

Article	Year
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Trimethoprim-sulfamethoxazole in the treatment of gonorrhea: comparison with standard treatment schedules. Southern medical journal, 1975, Volume: 68, Issue:9 Topics: Ampicillin; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin G Procaine; Probenecid; Sulfamethoxazole; Tetracycline; Trimethoprim	1975
Trimethoprim-sulphamethoxazole in gonorrhoea. A comparison with privampicillin combined with probenecid. The British journal of venereal diseases, 1975, Volume: 51, Issue:1 Topics: Ampicillin; Drug Combinations; Dyspepsia; Erythema; Female; Gonorrhea; Humans; Male; Palatine Tonsil; Pivampicillin; Probenecid; Sulfamethoxazole; Trimethoprim	1975
In vivo renal tubular secretion of trimethoprim without metabolism. Biochemical pharmacology, 1987, Aug-15, Volume: 36, Issue:16 Topics: Animals; Biological Transport, Active; Chickens; Female; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Tetraethylammonium Compounds; Trimethoprim	1987
Uptake of trimethoprim by renal cortex. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Animals; Biological Transport, Active; Cold Temperature; Dinitrophenols; Energy Metabolism; Female; Kidney Cortex; Kinetics; Male; Nitrogen; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Trimethoprim; Tritium	1985
Treatment of gonorrhoea with trimethoprim-sulphamethoxazole and probenecid plus procaine penicillin in Rwanda. The British journal of venereal diseases, 1974, Volume: 50, Issue:6 Topics: Drug Combinations; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Penicillin G Procaine; Probenecid; Rwanda; Sulfamethoxazole; Trimethoprim	1974
Problems in the treatment of venereal disease: bacterial resistance: allergy. Journal of the Royal College of Physicians of London, 1972, Volume: 6, Issue:2 Topics: Drug Hypersensitivity; Gonorrhea; Humans; Kanamycin; Leucomycins; Male; Neisseria gonorrhoeae; Penicillin Resistance; Penicillins; Probenecid; Sexually Transmitted Diseases; Streptomycin; Syphilis; Treponema pallidum; Trimethoprim	1972
Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid. The British journal of venereal diseases, 1972, Volume: 48, Issue:6 Topics: Adolescent; Adult; Anti-Bacterial Agents; Drug Combinations; Folic Acid Antagonists; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillins; Probenecid; Pyrimidines; Recurrence; Sulfamethoxazole; Sulfonamides; Trimethoprim; Urethritis	1972
[Genital and extragenital gonorrhea. 1 years' material]. Ugeskrift for laeger, 1974, Apr-01, Volume: 136, Issue:14 Topics: Adolescent; Adult; Age Factors; Aged; Denmark; Epididymitis; Female; Gonorrhea; Humans; Male; Middle Aged; Palatine Tonsil; Penicillins; Probenecid; Sex Factors; Trimethoprim	1974
Chemotherapy of gonorrhea: a review of current status. Canadian Medical Association journal, 1972, Nov-18, Volume: 107, Issue:10 Topics: Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Erythromycin; Gonorrhea; Humans; Kanamycin; Penicillins; Probenecid; Rifampin; Sulfonamides; Trimethoprim	1972
[Gonorrhea in women]. Gynakologische Rundschau, 1970, Volume: 10, Issue:3 Topics: Ampicillin; Culture Media; Female; Gonorrhea; Humans; Kanamycin; Probenecid; Sulfamethoxazole; Trimethoprim; Vaginal Smears	1970
Penicillinase-producing Neisseria gonorrhoeae. American family physician, 1981, Volume: 24, Issue:6 Topics: beta-Lactamases; Communicable Disease Control; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Penicillinase; Philippines; Probenecid; Spectinomycin; Sulfamethoxazole; Trimethoprim; United States	1981
Effect of trimethoprim on the renal clearance of lamivudine in rats. The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:3 Topics: Animals; Anti-HIV Agents; Cimetidine; Drug Interactions; Glomerular Filtration Rate; Kidney; Lamivudine; Male; Metabolic Clearance Rate; Probenecid; Quinidine; Rats; Rats, Wistar; Time Factors; Trimethoprim	2000