Page last updated: 2024-08-16

trimethoprim and nadp

trimethoprim has been researched along with nadp in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (46.15)	18.7374
1990's	13 (25.00)	18.2507
2000's	12 (23.08)	29.6817
2010's	2 (3.85)	24.3611
2020's	1 (1.92)	2.80

Authors

Authors	Studies
Crosby, LK; Hall, DH; Kozloff, LM; Lute, M	1
Acar, J; Burchall, JJ; Goldstein, FW; Harvey, RJ; Pattishall, KH	1
Henkens, RW; Kitchell, BB	1
Bayley, PM; Hood, K; Roberts, GC	1
Aschhoff, HS; Vergin, H	1
Birdsall, B; Burgen, AS; Feeney, J; Roberts, GC; Way, JL	1
Gelbaum, L; Huang, FY; Huang, TH; Kuyper, LF; Yang, QX	1
Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ	1
Absil, J; Pictet, R; Stone, SR; Thillet, J	1
Beddell, CR; Champness, JN; Stammers, DK	1
Birdsall, B; Cheung, HT; Feeney, J; Hammond, SJ; Kompis, I; Roberts, GC; Searle, MS	1
Birdsall, B; Cheung, HT; Feeney, J; Forster, MJ; Geddes, AJ; Kompis, I; Roberts, GC; Searle, MS	1
Morrison, JF; Stone, SR	1
Chen, GX; Mueller, C; Wendlinger, M; Zolg, JW	1
Beddell, CR; Champness, JN; Dann, JG; Eliopoulos, E; Geddes, AJ; North, AC; Ogg, D; Stammers, DK	1
Sirotnak, FM	1
Jaffe, JJ; McCormack, JJ; Meymarian, E	1
Bevan, AW; Birdsall, B; Clore, GM; Feeney, J; Gronenborn, A; Pascual, C; Roberts, GC	1
Dunn, SM; King, RW	1
Birdsall, B; Burgen, AS; Feeney, J; Gronenborn, A; Kaptein, R; Roberts, GC	1
Birdsall, B; Burgen, A; Feeney, J; Gronenborn, A; Hyde, E; Roberts, G	1
Baccanari, DP; Daluge, S; King, RW	1
Cayley, PJ; Dunn, SM; King, RW	1
Baccanari, DP; Joyner, SS	1
Bush, K; Freudenberger, JS; Meyers, E; Slusarchyk, DS; Sykes, RB	1
Dimarco, AA; Fernandez, J; Harayama, S; Ornston, LN	1
Howell, EE; Matthews, DA; Narayana, N; Nguyen-huu, X	1
Briand, C; Gilli, R; Makarov, A; Protasevich, I; Sasso, S	1
Achari, A; Ballantine, SP; Bryant, PK; Champness, JN; Delves, CJ; Stammers, DK	1
Briand, CM; Gilli, RM; Rimet, OS; Sari, JC; Sasso, SP	1
Baccanari, DP; Kuyper, LF	1
Briand, C; Gilli, R; Lopez, C; Sari, JC; Sasso, S	1
Achari, A; Ballantine, S; Bryant, PK; Champness, JN; Delves, C; Jones, EY; Stammers, DK; Stuart, DI	1
Gelbaum, L; Howell, EE; Huang, FY; Huang, TH; Lin, TH; Yang, QX	1
Broger, C; D'Arcy, A; Dale, GE; DeHoogt, R; Hartman, PG; Jolidon, S; Kompis, I; Labhardt, AM; Langen, H; Locher, H; Oefner, C; Page, MG; Stüber, D; Then, RL; Wipf, B	1
Altmann, S; Labhardt, AM; Senn, H; Wüthrich, K	1
Birdsall, B; Feeney, J; Polshakov, VI	2
Chan, D; Cody, V; Galitsky, N; Laughton, CA; Luft, JR; Pangborn, W; Queener, SF; Rak, D; Stevens, MF	1
Birdsall, B; Feeney, J; Kelly, G; Polshakov, VI; Smirnov, EG	1
Feller, G; Gerday, C; Glansdorff, N; Xu, Y	1
Birdsall, B; Bradbury, AF; Feeney, J; Frenkiel, T; Kovalevskaya, NV; Polshakov, VI; Smurnyy, YD	1
Chisum, K; Cody, V; Pace, J; Rosowsky, A	1
Divya, N; Grifith, E; Narayana, N	1
DeRose, EF; Howell, EE; Jackson, MR; Krahn, JM; London, RE	1
Chopra, S; Dooling, RM; Horner, CG; Howell, EE	1
Anderson, AC; Bolstad, DB; Frey, KM; Liu, J; Lombardo, MN; Wright, DL	1
Barreiro, G; Chang, J; Fahnoe, K; Harris, M; Heaslet, H; Miller, JR; Putz, H; Sarver, R; Subramanyam, C	1
Dale, GE; Lociuro, S; Oefner, C; Parisi, S; Schulz, H	1
Birdsall, B; Feeney, J; Kovalevskaya, NV; Navarro Peran, EM; Polshakov, VI; Smurnyy, YD	1
Cheng, YS; Sacchettini, JC	1
Donald, BR; Fowler, VG; Frenkel, MS; Gainza, P; Holt, GT; Keshipeddy, S; Ojewole, AA; Reeve, SM; Wang, S; Wright, DL	1

Reviews

1 review(s) available for trimethoprim and nadp

Article	Year
Basis of selectivity of antibacterial diaminopyrimidines. Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:6 Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Humans; Mice; NADP; Protein Conformation; Pyrimidines; Sensitivity and Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	1993

Other Studies

51 other study(ies) available for trimethoprim and nadp

Article	Year
Bacteriophage T4 baseplate components. II. Binding and location of bacteriophage-induced dihydrofolate reductase. Journal of virology, 1975, Volume: 16, Issue:6 Topics: Adenine Nucleotides; Coliphages; DNA Viruses; Drug Resistance, Microbial; Escherichia coli; Morphogenesis; Mutation; NAD; NADP; Protein Conformation; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim; Viral Proteins	1975
Two distinct types of trimethoprim-resistant dihydrofolate reductase specified by R-plasmids of different compatibility groups. The Journal of biological chemistry, 1977, Apr-10, Volume: 252, Issue:7 Topics: Chromosomes, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Phenotype; Plasmids; Protein Biosynthesis; Species Specificity; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Trimethoprim	1977
Effect of temperature on fluorescence and circular dichroism of Escherichia coli dihydrofolate reductase and its complexes. Biochimica et biophysica acta, 1978, May-24, Volume: 534, Issue:1 Topics: Circular Dichroism; Escherichia coli; Ligands; Methotrexate; NADP; Protein Conformation; Pyrimethamine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim	1978
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R. The Biochemical journal, 1979, Feb-01, Volume: 177, Issue:2 Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim	1979
Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase. The Journal of antimicrobial chemotherapy, 1979, Volume: 5, Issue:B Topics: Animals; Anti-Bacterial Agents; Cattle; Escherichia coli; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; NADP; Pyrimidines; Trimethoprim	1979
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase. Biochemistry, 1975, Jul-29, Volume: 14, Issue:15 Topics: Amides; Aminopterin; Binding Sites; Carbon Isotopes; Carboxylic Acids; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1975
The conformations of trimethoprim/E. coli dihydrofolate reductase complexes. A 15N and 31P NMR study. FEBS letters, 1991, May-20, Volume: 283, Issue:1 Topics: Escherichia coli; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; NADP; Nitrogen Isotopes; Phosphorus Isotopes; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1991
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase. Biochemistry, 1989, May-30, Volume: 28, Issue:11 Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1989
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim. The Journal of biological chemistry, 1988, Sep-05, Volume: 263, Issue:25 Topics: Amino Acid Sequence; Animals; Binding Sites; DNA; DNA, Recombinant; Drug Resistance; Drug Stability; Escherichia coli; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mice; Molecular Sequence Data; Mutation; NADP; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	1988
Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase. FEBS letters, 1986, Apr-07, Volume: 199, Issue:1 Topics: Binding Sites; Escherichia coli; Lacticaseibacillus casei; Models, Molecular; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1986
Trimethoprim binding to Lactobacillus casei dihydrofolate reductase: a 13C NMR study using selectively 13C-enriched trimethoprim. Biochemistry, 1986, Apr-22, Volume: 25, Issue:8 Topics: Binding Sites; Carbon Isotopes; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim	1986
Dynamics of trimethoprim bound to dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:11 Topics: Binding Sites; Folic Acid Antagonists; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Motion; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1988
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues. Biochimica et biophysica acta, 1986, Feb-14, Volume: 869, Issue:3 Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim	1986
Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum. Molecular pharmacology, 1987, Volume: 31, Issue:4 Topics: Chromatography, Affinity; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Malaria; Methotrexate; NADP; Plasmodium falciparum; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Trimethoprim	1987
The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme. FEBS letters, 1987, Jun-22, Volume: 218, Issue:1 Topics: Animals; Binding Sites; Humans; Leukemia L1210; Mice; Models, Molecular; NADP; Neoplasm Proteins; Protein Binding; Protein Conformation; Species Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1987
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase. Biochimica et biophysica acta, 1973, Mar-15, Volume: 302, Issue:1 Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	1973
Comparative properties of schistosomal and filarial dihydrofolate reductases. Biochemical pharmacology, 1972, Mar-01, Volume: 21, Issue:5 Topics: Anthelmintics; Chromatography, Gel; Eukaryota; Filarioidea; Folic Acid Antagonists; Molecular Weight; NADP; Pyrimethamine; Quinazolines; Schistosoma mansoni; Structure-Activity Relationship; Suramin; Tetrahydrofolate Dehydrogenase; Trimethoprim	1972
Multinuclear NMR characterization of two coexisting conformational states of the Lactobacillus casei dihydrofolate reductase-trimethoprim-NADP+ complex. Biochemistry, 1984, Sep-25, Volume: 23, Issue:20 Topics: Carbon Isotopes; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; NADP; Nitrogen Isotopes; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1984
Kinetics of ternary complex formation between dihydrofolate reductase, coenzyme, and inhibitors. Biochemistry, 1980, Feb-19, Volume: 19, Issue:4 Topics: Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Methotrexate; NADP; Protein Binding; Pyrimethamine; Pyrimidines; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	1980
Photo-CIDNP studies of the influence of ligand binding on the surface accessibility of aromatic residues in dihydrofolate reductase. Biochemistry, 1980, May-27, Volume: 19, Issue:11 Topics: Folic Acid; Histidine; Lacticaseibacillus casei; Lasers; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Photochemistry; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1980
1H and 31P NMR characterization of two conformations of the trimethoprim-NADP+-dihydrofolate reductase complex. Molecular pharmacology, 1981, Volume: 20, Issue:1 Topics: In Vitro Techniques; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Molecular Conformation; NADP; Tetrahydrofolate Dehydrogenase; Trimethoprim	1981
Inhibition of dihydrofolate reductase: effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminobenzylpyrimidines. Biochemistry, 1982, Sep-28, Volume: 21, Issue:20 Topics: Anti-Bacterial Agents; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Lymphoma; NADP; Structure-Activity Relationship; Substrate Specificity; Trimethoprim	1982
Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase. Biochemistry, 1981, Feb-17, Volume: 20, Issue:4 Topics: Escherichia coli; Fluorescence; Folic Acid; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase; Trimethoprim	1981
Dihydrofolate reductase hysteresis and its effect of inhibitor binding analyses. Biochemistry, 1981, Mar-31, Volume: 20, Issue:7 Topics: Binding Sites; Escherichia coli; Isoenzymes; Kinetics; Methotrexate; NADP; Oxidation-Reduction; Protein Binding; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim	1981
Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans. Experientia, 1982, Apr-15, Volume: 38, Issue:4 Topics: Aminopterin; Animals; Candida albicans; Cattle; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; NADP; Trimethoprim	1982
Purification and characterization of Acinetobacter calcoaceticus 4-hydroxybenzoate 3-hydroxylase after its overexpression in Escherichia coli. Journal of biochemistry, 1995, Volume: 117, Issue:6 Topics: 4-Hydroxybenzoate-3-Monooxygenase; Acinetobacter calcoaceticus; Amino Acid Sequence; Enzyme Inhibitors; Folic Acid Antagonists; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; NADP; Recombinant Proteins; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim	1995
A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nature structural biology, 1995, Volume: 2, Issue:11 Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Folic Acid Antagonists; Models, Molecular; Molecular Sequence Data; NADP; Plasmids; Protein Conformation; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance	1995
Thermal denaturation of bacterial and bovine dihydrofolate reductases and their complexes with NADPH, trimethoprim and methotrexate. Journal of biomolecular structure & dynamics, 1995, Volume: 12, Issue:5 Topics: Animals; Calorimetry, Differential Scanning; Cattle; Escherichia coli; Hot Temperature; Isoelectric Point; Liver; Methotrexate; NADP; Osmolar Concentration; Protein Denaturation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1995
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. Structure (London, England : 1993), 1994, Oct-15, Volume: 2, Issue:10 Topics: Amino Acid Sequence; Animals; Binding Sites; Escherichia coli; Folic Acid Antagonists; Humans; Leukemia L1210; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; NADP; Pneumocystis; Protein Conformation; Protein Folding; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Trimethoprim	1994
Thermodynamic study of dihydrofolate reductase inhibitor selectivity. Biochimica et biophysica acta, 1994, Jul-20, Volume: 1207, Issue:1 Topics: Animals; Escherichia coli; Folic Acid Antagonists; Methotrexate; Mice; NADP; Protein Folding; Temperature; Thermodynamics; Trimethoprim; Trimetrexate	1994
Thermodynamic study of folate analogue binding to dihydrofolate reductases from different species. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Calorimetry; Cattle; Escherichia coli; Folic Acid Antagonists; Liver; Methotrexate; NADP; Oxidation-Reduction; Species Specificity; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim; Trimetrexate	1993
Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase. Journal of molecular biology, 1993, Mar-20, Volume: 230, Issue:2 Topics: AIDS-Related Opportunistic Infections; Genes, Bacterial; Humans; NADP; Pneumocystis; Protein Binding; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1993
Dynamics of trimethoprim bound to dihydrofolate reductase--a deuterium NMR study. Solid state nuclear magnetic resonance, 1996, Volume: 7, Issue:3 Topics: Deuterium; Escherichia coli; Folic Acid Antagonists; Magnetic Resonance Spectroscopy; NADP; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	1996
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance. Journal of molecular biology, 1997, Feb-14, Volume: 266, Issue:1 Topics: Binding Sites; Chromosomes, Bacterial; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Conformation; NADP; Phenylalanine; Point Mutation; Protein Conformation; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance; Tyrosine	1997
Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH. Journal of biomolecular NMR, 1997, Volume: 9, Issue:4 Topics: Folic Acid Antagonists; Magnetic Resonance Spectroscopy; Mutation; NADP; Protein Conformation; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance	1997
Characterization of rates of ring-flipping in trimethoprim in its ternary complexes with Lactobacillus casei dihydrofolate reductase and coenzyme analogues. Biochemistry, 1999, Nov-30, Volume: 38, Issue:48 Topics: Binding Sites; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Models, Molecular; NADP; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	1999
Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Biochemistry, 2000, Apr-04, Volume: 39, Issue:13 Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Folic Acid Antagonists; Models, Molecular; NADP; Pneumocystis; Protein Conformation; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazenes; Trimethoprim	2000
NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH. Journal of biomolecular NMR, 2002, Volume: 24, Issue:1 Topics: Binding Sites; Lacticaseibacillus casei; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	2002
Moritella cold-active dihydrofolate reductase: are there natural limits to optimization of catalytic efficiency at low temperature? Journal of bacteriology, 2003, Volume: 185, Issue:18 Topics: Amino Acid Sequence; Catalysis; Cloning, Molecular; Cold Temperature; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Kinetics; Methotrexate; Molecular Sequence Data; Molecular Weight; Moritella; NADP; Protein Conformation; Protein Denaturation; Sequence Homology, Amino Acid; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim	2003
Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH. Journal of biomolecular NMR, 2005, Volume: 33, Issue:1 Topics: Binding Sites; Crystallization; Crystallography, X-Ray; Folic Acid Antagonists; Humans; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	2005
Effects of co-operative ligand binding on protein amide NH hydrogen exchange. Journal of molecular biology, 2006, Mar-03, Volume: 356, Issue:4 Topics: Amides; Bacterial Proteins; Deuterium; Folic Acid; Hydrogen; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Ligands; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	2006
New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring s Proteins, 2006, Dec-01, Volume: 65, Issue:4 Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Folic Acid Antagonists; Mice; Models, Molecular; Molecular Sequence Data; NADP; Pneumocystis carinii; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	2006
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode. Protein science : a publication of the Protein Society, 2007, Volume: 16, Issue:6 Topics: Amino Acid Substitution; Binding Sites; Computer Simulation; Crystallography, X-Ray; Models, Molecular; NADP; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	2007
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 2007, Dec-25, Volume: 46, Issue:51 Topics: Catalysis; Crystallography, X-Ray; Folic Acid; Ligands; Models, Molecular; NADP; Protein Structure, Tertiary; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim	2007
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase. The Journal of biological chemistry, 2008, Feb-22, Volume: 283, Issue:8 Topics: Binding Sites; Catalysis; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Folic Acid; Folic Acid Antagonists; NADP; Osmosis; Oxidation-Reduction; Protein Structure, Quaternary; Sorbitol; Sweetening Agents; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water	2008
Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. Journal of molecular biology, 2009, Apr-17, Volume: 387, Issue:5 Topics: Amino Acid Sequence; Amino Acid Substitution; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Methicillin-Resistant Staphylococcus aureus; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NADP; Sequence Homology, Amino Acid; Static Electricity; Tetrahydrofolate Dehydrogenase; Trimethoprim	2009
Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim. Proteins, 2009, Aug-15, Volume: 76, Issue:3 Topics: Crystallography, X-Ray; Hydrogen Bonding; Mutation; NADP; Protein Binding; Protein Folding; Protein Structure, Secondary; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	2009
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta crystallographica. Section D, Biological crystallography, 2009, Volume: 65, Issue:Pt 8 Topics: Anti-Bacterial Agents; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Isomerism; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Multienzyme Complexes; Mutant Proteins; NADP; Protein Structure, Tertiary; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trimethoprim	2009
NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions. Biochemistry, 2011, May-10, Volume: 50, Issue:18 Topics: Binding Sites; Calorimetry; Escherichia coli; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; NADP; Protein Binding; Protein Structure, Secondary; Solvents; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	2011
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 2016, Feb-23, Volume: 55, Issue:7 Topics: Aminosalicylic Acid; Antitubercular Agents; Bacterial Proteins; Catalytic Domain; Drug Resistance, Bacterial; Enzyme Inhibitors; Folic Acid Antagonists; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; NADP; Nucleotide Deaminases; Phylogeny; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim; Trimetrexate	2016
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus. PLoS computational biology, 2022, Volume: 18, Issue:2 Topics: Drug Resistance, Bacterial; Folic Acid Antagonists; Humans; NADP; Staphylococcal Infections; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Trimethoprim	2022