trimethoprim has been researched along with metioprim in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richards, WG; So, SS | 1 |
| Hansch, C; Li, RL; Poe, M; Selassie, CD | 1 |
| Debnath, G; Fang, ZX; Hansch, C; Kaufman, BT; Klein, TE; Langridge, R; Li, RL; Selassie, CD | 1 |
| Fang, ZX; Hansch, C; Kaufman, BT; Klein, T; Langridge, R; Li, RL; Selassie, CD | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Loukas, YL | 1 |
| Gyrd-Hansen, N; Nielsen, P; Olsen, CE; Xia, WJ | 1 |
| Rosenfeld, M; Seydel, JK; Wempe, EG | 1 |
| Armengaud, H; Bishop-Freudling, GB; Foing, N; Szelenyi, I; van Tho, T; Vergin, H | 1 |
| Bishop-Freudling, GB; Kaiser, W; Köhler, M; Reutter, FW; Strobel, K; Vergin, H | 1 |
| Iversen, P; Madsen, PO; Vergin, H | 1 |
| Schwarzenbach, J; Wüst, J | 1 |
| Bergan, T; Bredesen, JE; Bruun, JN; Lunde, PK; Ostby, N | 1 |
| Bishop-Freudling, GB; Merk, K; Szelenyi, I; Vergin, H | 1 |
| Iversen, P; Madsen, PO | 1 |
| SLOTNICK, IJ; SPEARS, AW; TIECKELMANN, H | 1 |
16 other study(ies) available for trimethoprim and metioprim
| Article | Year |
|---|---|
Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
Topics: Drug Design; Folic Acid Antagonists; Neural Networks, Computer; Pyrimidines; Regression Analysis; Structure-Activity Relationship | 1992 |
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Topics: Diamines; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Molecular Structure; Protein Binding; Pyrimidines; Structure-Activity Relationship | 1991 |
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Drug Design; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Topics: Animals; Chickens; Crystallography; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Mathematics; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1986 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Adaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Topics: Algorithms; Folic Acid Antagonists; Multivariate Analysis; Pyrimidines; Quantitative Structure-Activity Relationship; Regression Analysis; Tetrahydrofolate Dehydrogenase | 2001 |
Pharmacokinetics and metabolism of metioprim in pigs and goats.
Topics: Animals; Anti-Infective Agents; Blood Proteins; Goats; Lipids; Male; Protein Binding; Solubility; Swine; Trimethoprim | 1987 |
Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI).
Topics: Anti-Bacterial Agents; Dapsone; Drug Synergism; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Mycobacterium; Sulfamerazine; Trimethoprim | 1983 |
Diffusion of metioprim, tetroxoprim and sulphadiazine in the cerebrospinal fluid of dogs with healthy meninges and dogs with experimental meningitis.
Topics: Animals; Anti-Infective Agents; Blood-Brain Barrier; Dogs; Female; Half-Life; Infusions, Parenteral; Injections, Intravenous; Kinetics; Male; Meningitis; Pyrimidines; Staphylococcal Infections; Sulfadiazine; Trimethoprim | 1984 |
Pharmacokinetics of metioprim in normal subjects and patients with impaired renal function.
Topics: Adult; Age Factors; Aged; Anti-Infective Agents; Creatinine; Female; Folic Acid Antagonists; Humans; Kidney Diseases; Kinetics; Male; Trimethoprim | 1983 |
Renal handling and lymph concentration of tetroxoprim and metioprim: an experimental study in dogs.
Topics: Animals; Anti-Infective Agents; Dogs; Glomerular Filtration Rate; Kidney; Lymph; Male; Pyrimidines; Trimethoprim | 1984 |
Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacteria; Drug Combinations; Microbial Sensitivity Tests; Sulfonamides; Trimethoprim | 1983 |
Pharmacokinetics of methioprim in human volunteers.
Topics: Blister; Body Fluids; Humans; Kinetics; Models, Biological; Trimethoprim | 1983 |
Pancreatic secretion of benzylpyrimidines. Experimental studies in dogs.
Topics: Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Dogs; Female; Hydrogen-Ion Concentration; Male; Pancreas; Pyrimidines; Time Factors; Trimethoprim | 1982 |
Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone.
Topics: Animals; Bone and Bones; Dogs; Male; Pyrimidines; Trimethoprim | 1982 |
Metabolic alteration of 2-methylthio-4-amino-5-hydroxymethylpyrimidine (methioprim).
Topics: Biochemical Phenomena; Humans; Pyrimidines; Trimethoprim | 1959 |