trimethoprim has been researched along with methotrexate in 188 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (46.28) | 18.7374 |
| 1990's | 25 (13.30) | 18.2507 |
| 2000's | 40 (21.28) | 29.6817 |
| 2010's | 33 (17.55) | 24.3611 |
| 2020's | 3 (1.60) | 2.80 |
| Authors | Studies |
|---|---|
| Genther, CS; Smith, CS | 1 |
| Bowden, K; Harris, NV; Smith, C | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Baccanari, DP; Baker, DJ; Beddell, CR; Champness, JN; Dann, JG; Ferone, R; Kuyper, LF; Norrington, FE; Roth, B; Stammers, DK | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Crippen, GM; Ghose, AK | 2 |
| Dias, CB; Hansch, C; Khwaja, TA; Li, R; Selassie, CD | 1 |
| Queener, SF | 1 |
| Gangjee, A; Mavandadi, F; McGuire, JJ; Queener, SF | 1 |
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Baccanari, DP; Boytos, CM; Caddell, JM; Comley, JC; Friedman, HS; Hunter, RN; Jones, ML; Joyner, SS; Knick, V; Kuyper, LF; Rudolph, SK; Stables, JN; Tansik, RL; Wilson, HR | 1 |
| Gangjee, A; Kisliuk, RL; Queener, SF; Vasudevan, A | 1 |
| Gangjee, A; Mavandadi, F; Queener, SF | 1 |
| Elzein, E; Gangjee, A; McGuire, JJ; Queener, SF | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Elzein, E; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF; Vidwans, A | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gangjee, A; Kisliuk, RL; McGuire, JJ; Zeng, Y | 1 |
| Gangjee, A; Haile, WH; Kisliuk, RL; McGuire, JJ; Sobrero, G; Yu, J | 1 |
| Barrow, EW; Barrow, WW; Bourne, PC | 1 |
| Anderson, AC; Joska, TM | 1 |
| Anderson, AC; Beierlein, JM; Bolstad, ES; Fillingham, YA; Joska, TM; Pelphrey, PM; Popov, VM; Wright, DL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF; Talreja, T; Zeng, Y | 1 |
| Borhani, DW; Campbell, SR; Dixon, RW; Fairchild, RG; Kisliuk, RL; Leung, AK; Micca, PL; Queener, SF; Reynolds, RC; Riordan, JM; Sedwick, WD; Suling, WJ; Waud, WR | 1 |
| Bennett, BC; Dealwis, CG; Lee, RE; Simmerman, RF; Xu, H | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Knuckley, B; Luo, Y; Thompson, PR | 1 |
| Gangjee, A; Kisliuk, RL; Li, W; Yang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Gangjee, A; Jain, HD; Kisliuk, RL; Queener, SF | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Aboge, GO; Fujisaki, K; Goo, YK; Igarashi, I; Jia, H; Namikawa, K; Nishikawa, Y; Sunaga, F; Suzuki, H; Terkawi, MA; Tsuji, N; Xuan, X | 1 |
| Gangjee, A; Kisliuk, RL; Li, W; Qiu, Y | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barrow, EW; Barrow, WW; Berlin, KD; Bourne, CR; Bourne, PC; Bunce, RA | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Borrmann, S; Kiara, SM; Masseno, V; Mwai, L; Nzila, A; Ochola, I; Okombo, J | 1 |
| Cody, V; Gangjee, A; Kisliuk, RL; Li, W; Makin, J; Pace, J; Piraino, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Cody, V; Gangjee, A; Green, DW; Ihnat, M; Li, W; Lin, L; Pace, J; Queener, SF; Warnke, LA; Zeng, Y | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Gangjee, A; Guo, X; Jain, HD; Kisliuk, RL; Phan, J; Queener, SF | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Gangjee, A; Ihnat, M; Kisliuk, RL; Raghavan, S; Shenoy, S; Zaware, N | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Kaur, M; Sachdeva, S; Singh, P | 1 |
| Bailey-Downs, LC; Gangjee, A; Ihnat, MA; Kisliuk, RL; Thorpe, JE; Zhao, Y | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Cody, V; Gangjee, A; Kisliuk, RL; Namjoshi, OA; Queener, SF; Raghavan, S | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brown-Driver, V; Cunningham, ML; Finn, J; Hilgers, MT; Hough, G; Kwan, BP; Lam, T; Nelson, KJ; Ong, V; Shaw, KJ; Trzoss, M | 1 |
| Arkile, MA; Degani, MS; Jadhav, NJ; Khambete, MP; Lele, AC; Rajan, MG; Raju, A; Ray, MK; Sarkar, D | 1 |
| Boesche, M; Crowther, GJ; Dasari, KS; Drewes, G; El Bakkouri, M; Fox, AM; Ghidelli-Disse, S; He, P; Hillesland, HK; Hui, R; Jones, JC; Keyloun, KR; Krahn, MM; Lafuente-Monasterio, MJ; Leonard, SE; Leroy, D; Maly, DJ; Mo, JS; Ojo, KK; Reid, MC; Rivas, KL; Van Voorhis, WC | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Kaur, J; Kaur, S; Singh, P | 1 |
| Alverson, JB; Anderson, AC; Hajian, B; Keshipeddy, S; Lombardo, MN; Priestley, ND; Reeve, SM; Scocchera, E; Sochia, AE; Wright, DL | 1 |
| Bastian, A; Gangjee, A; Ihnat, MA; Kisliuk, R; Zaware, N | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
| Barks, J; Brockman, A; Gould, J; Hopper, AT; Radke, JB; Sibley, LD; Thomas, S; Wise, A; Zou, Y | 1 |
| Bera, S; Mondal, D | 1 |
| Asghar, I; Bibi, A; Bibi, M; Farooq, U; Hassan, A; Khan, FA; Qureshi, NA; Rashid, U; Sadiq, A; Salman, M; Shaheen, N; Ullah, A; Umer, D | 1 |
| Deon, D; Ebert, MCCJC; Forge, D; Gagnon, M; Ji, X; Lemay-St-Denis, C; Marinier, A; Pelletier, JN; Ruediger, E; Saint-Jacques, K; Shi, G; Toulouse, JL; Vanden Eynde, JJ | 1 |
| Amyes, SG; Smith, JT | 1 |
| Acar, J; Burchall, JJ; Goldstein, FW; Harvey, RJ; Pattishall, KH | 1 |
| Hood, K; Roberts, GC | 1 |
| Henkens, RW; Kitchell, BB | 1 |
| Roberts, GC | 1 |
| Aversa, F; Martelli, MF; Rambotti, P; Velardi, A | 1 |
| Bayley, PM; Hood, K; Roberts, GC | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Roberts, GC; Way, JL | 1 |
| Schalhorn, A; Wilmanns, W | 1 |
| Grey, D; Hamilton-Miller, JM | 1 |
| Brenner, S; Sheldon, R | 1 |
| Hynes, JB; McCullough, JL; Weinstein, GD | 1 |
| Lietman, PS; Rogers, HJ | 1 |
| Girdwood, RH | 1 |
| Jackson, RC; Niethammer, D | 1 |
| Verbov, JL | 1 |
| Feeney, J | 1 |
| Birdsall, B; Bowden, K; Feeney, J; Hall, AD; Roberts, GC | 1 |
| Hung, A; Pictet, R; Thillet, J | 1 |
| Liddle, BJ; Marsden, JR | 1 |
| Hitchings, GH | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ | 1 |
| Boerbooms, AM; Jeurissen, ME; van de Putte, LB | 1 |
| Burns, JL; Hedin, LA; Lien, DM | 1 |
| Ablin, AR; Albo, VC; Bleyer, WA; Finklestein, JZ; Gaynon, PS; Grossman, NJ; Littman, PS; Novak, LT; Pyesmany, AF; Steinherz, PG | 1 |
| Bussiere, JL; Cure, H; Mizony, MH; Ristori, JM; Thevenet, JP | 1 |
| Absil, J; Pictet, R; Stone, SR; Thillet, J | 1 |
| Davis, RE | 1 |
| Graham, RM; Macfarlane, AW; Ng, HW; Verbov, JL | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, N | 1 |
| D'Arcy, A; Oefner, C; Winkler, FK | 1 |
| Sonneveld, P; van der Steuijt, K | 1 |
| Davis, M; Gall, EP; Maricic, M | 1 |
| Gutterman, LA; Thomas, MH | 1 |
| Frain, JB | 1 |
| Camp, RD; Dover, JS; Thomas, DR | 1 |
| Morrison, JF; Stone, SR | 1 |
| Andrews, PR; Sadek, M; Spark, MJ; Winkler, DA | 1 |
| Roth, B | 1 |
| Blakley, RL; Howell, EE; Kraut, J; London, RE; Warren, MS | 1 |
| Chen, GX; Mueller, C; Wendlinger, M; Zolg, JW | 1 |
| Goto, E; Kitaoka, S; Konno, T; Miyaji, T; Terasawa, M; Tsuchiya, S | 1 |
| Al-Rubeai, M; Dale, JW | 1 |
| Goodford, PJ | 1 |
| Melick, C; Tan-Pong, L; Yogev, R | 1 |
| Niordson, AM; Ullman, S; Zachariae, H | 1 |
| Sirotnak, FM | 1 |
| Gauldie, J; Hiebert, M; Hillcoat, BL; Marshall, L | 1 |
| Robenberg, IH | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Morrison, NE | 1 |
| Gauldie, J; Hillcoat, BL; Marshall, L | 1 |
| Edelberg, SB | 1 |
| Burchall, JJ | 1 |
| Freisheim, JH; Smith, CC | 1 |
| Green, R; Metz, J; Sive, J | 1 |
| Freisheim, JH; Guzy, PM; Smith, CC | 1 |
| Deering, RA; Michrina, CA | 1 |
| Davis, RE; Icke, GC; Thom, J | 1 |
| Blakley, RL; Cocco, L; London, RE; Montgomery, JA; Roth, B; Temple, C | 1 |
| Birdsall, B; Feeney, J; Kompis, I; Kroehn, A; Müller, K; Pascual, C; Roberts, GC; Then, RL | 1 |
| Scott, JM; Weir, DG | 1 |
| Dan, M; Shapira, I | 1 |
| Attardi, G; Masters, JN; Morandi, C; Mottes, M | 1 |
| Kröhn, A | 1 |
| Baccanari, DP; Baker, DJ; Beddell, CR; Champness, JN; Dann, JG; Ferone, R; Goodford, PJ; Kuyper, LF; Norrington, FE; Roth, B; Stammers, DK | 1 |
| Dunn, SM; King, RW | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Gronenborn, A; Kaptein, R; Roberts, GC | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Gronenborn, A; Roberts, GC; Wyeth, P | 1 |
| Bock, JL; Pierce, R | 1 |
| Fletcher, R; Gober, J; Hande, K | 1 |
| Loutit, JS; Musgrave, DR; Potter, AA | 1 |
| Beach, BJ; Howell, SB; Woods, WG | 1 |
| Lewis, IJ; Mainwaring, D; Martin, J | 1 |
| Cayley, PJ; Dunn, SM; King, RW | 1 |
| Baccanari, DP; Joyner, SS | 1 |
| Baker, DJ; Beddell, CR; Champness, JN; Goodford, PJ; Norrington, FE; Smith, DR; Stammers, DK | 1 |
| Bush, K; Freudenberger, JS; Meyers, E; Slusarchyk, DS; Sykes, RB | 1 |
| Coccia, P; Filipovich, A; Kersey, JH; Kim, T; Krivit, W; Levitt, S; McGlave, P; Nesbit, ME; O'Leary, M; Ramsay, NK; Woods, W | 1 |
| Henson, E; McClarty, G; Wang, LL | 1 |
| Briand, C; Gilli, R; Makarov, A; Protasevich, I; Sasso, S | 1 |
| Bauer, CJ; Birdsall, B; Cheung, HT; Feeney, J; Frenkiel, TA; Gradwell, MJ; Kuyper, L; Martorell, G; Polshakov, VI | 1 |
| Itai, A; Mizutani, MY; Tomioka, N | 1 |
| Ko, RC; So, NN; Wong, PC | 1 |
| Horii, T; Morimatsu, K; Sano, G | 1 |
| Briand, CM; Gilli, RM; Rimet, OS; Sari, JC; Sasso, SP | 1 |
| Bertani, LE; Campbell, JL | 1 |
| Briand, C; Gilli, R; Lopez, C; Sari, JC; Sasso, S | 1 |
| Asselbergs, FA; Widmer, R | 1 |
| De Benedetti, F; Martini, A; Ravelli, A; Viola, S | 1 |
| de Groot, K; Gross, WL; Heller, M; Nölle, B; Paulsen, J; Reinhold-Keller, E; Tatsis, E | 1 |
| Hao, H; Tyshenko, MG; Walker, VK | 1 |
| Gumpel, JM; Steuer, A | 1 |
| Richards, AJ | 1 |
| Gabriëls, G; Greven, J; Stockem, E | 1 |
| Feller, G; Gerday, C; Glansdorff, N; Xu, Y | 1 |
| Lalukotta, K; Saravana, S | 1 |
| Cunningham, A; Escuyer, V; Ross, LJ; White, EL | 1 |
| Ament, K; Bökkerink, JP; Brouwer, C; De Abreu, RA; Hoogerbrugge, PM; Keizer-Garritsen, JJ; Lambooy, LH; ter Riet, PG; Trijbels, FJ; van Wering, ER; Veerman, AJ | 1 |
| Cabezas-Herrera, J; García-Cánovas, F; Navarro-Martínez, MD; Navarro-Perán, E; Rodríguez-López, JN; Ruiz-Gómez, J | 1 |
| Dawson, J; Sathi, N | 1 |
| Brown, ED; Daigle, DM; Hughes, DW; Jackson, SG; Junop, MS; Mallik, D; Mayer, S; Organ, MG; Sulek, M; Summerfield, RL | 1 |
| Jia, R; Li, N; Zhu, R | 1 |
| Chen, H; Hapka, D; Li, Q; Vallera, DA; Wagner, CR | 1 |
| Carroll, MJ; Lee, AL; Mauldin, RV | 1 |
| Lambert, W; Navarrete, O; Storozhenko, S; Stove, C; Van Daele, J; Van Der Straeten, D | 1 |
| Benkovic, SJ; Bhattacharya, C; Chen, S; Fahmi, NE; Hecht, SM; Jin, Y; Wang, L | 1 |
| De Clercq, DJ; De Smet, AS; Defever, D; Karalic, I; Lievens, S; Risseeuw, MD; Tavernier, J; Van Calenbergh, S | 1 |
| Bhakta, S; Degani, MS; Kamil, TK; Lele, AC; Mishra, DA | 1 |
| Johnsson, K; Prifti, E; Xue, L | 1 |
| Bao, X; Chan, HK; Chan, T; Li, J; Lu, X; Velkov, T; Zhou, F; Zhou, QT; Zhu, L | 1 |
| Fu, TY; Huang, SJ; Lin, FL; Tan, KT; Wang, XY; Wu, CC | 1 |
8 review(s) available for trimethoprim and methotrexate
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
NMR studies of interactions of ligands with dihydrofolate reductase.
Topics: Drug Interactions; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Conformation; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1990 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
Design of dihydrofolate reductase inhibitors from X-ray crystal structures.
Topics: Binding Sites; Folic Acid Antagonists; Methotrexate; Molecular Conformation; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1986 |
Drug-induced megaloblastic change.
Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim | 1980 |
Repositioning of DHFR Inhibitors.
Topics: Anti-Infective Agents; Antineoplastic Agents; Drug Repositioning; Folic Acid Antagonists; Humans; Methotrexate; Pteridines; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2016 |
2 trial(s) available for trimethoprim and methotrexate
| Article | Year |
|---|---|
Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood.
Topics: Administration, Oral; Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting features. Early conclusions of study CCG-106 by the Childrens Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
178 other study(ies) available for trimethoprim and methotrexate
| Article | Year |
|---|---|
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Triazines | 1977 |
Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines.
Topics: Animals; Anti-Bacterial Agents; Cattle; Chemical Phenomena; Chemistry; Escherichia coli; Escherichia coli Infections; Folic Acid Antagonists; Liver; Mice; Molecular Structure; Quinazolines; Staphylococcus aureus; Structure-Activity Relationship | 1990 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
Topics: Binding Sites; Folic Acid Antagonists; Kinetics; Methotrexate; Microbial Sensitivity Tests; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines | 1984 |
Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.
Topics: Chemical Phenomena; Chemistry; Folic Acid Antagonists; Molecular Conformation; Quinazolines; Streptococcus; Structure-Activity Relationship; Triazines | 1983 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Pyrimidines; Solubility | 1982 |
Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.
Topics: Folic Acid Antagonists; Humans; Peptide Synthases; Pyrimidines; Tumor Cells, Cultured | 1995 |
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Candidiasis; Cell Division; Cell Line; Crystallography, X-Ray; Drug Design; Drug Resistance, Multiple; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Mice, SCID; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Pneumonia, Pneumocystis; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1996 |
2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Liver; Mice; Molecular Structure; Neoplasms, Experimental; Pneumocystis; Pyrimidines; Rats; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1996 |
Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Methylation; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimetabolites, Antineoplastic; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamic Acid; Humans; Liver; Methotrexate; Mycobacterium avium; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Design; Folic Acid Antagonists; Glutamates; Guanine; Humans; Liver; Models, Molecular; Molecular Conformation; Pemetrexed; Pneumocystis; Pyrimidines; Pyrroles; Rats; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Resistance, Neoplasm; Escherichia coli; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Molecular Conformation; Peptide Synthases; Pneumocystis; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 2002 |
Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and
Topics: Antineoplastic Agents; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Glutamic Acid; Humans; Lacticaseibacillus casei; Peptide Synthases; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 2003 |
Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim.
Topics: Amino Acid Sequence; Bacillus anthracis; Base Sequence; Chromatography, High Pressure Liquid; Culture Media; DNA Primers; Escherichia coli; Folic Acid Antagonists; Gene Transfer, Horizontal; Molecular Sequence Data; Molecular Weight; Plasmids; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Thrombin; Trimethoprim; Trimethoprim Resistance | 2004 |
Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads.
Topics: 4-Aminopyridine; Amino Acid Sequence; Anti-Bacterial Agents; Bacillus anthracis; Bacillus cereus; Binding Sites; Drug Design; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Models, Molecular; Sequence Alignment; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2006 |
Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.
Topics: Alkynes; Amino Acid Sequence; Animals; Antiprotozoal Agents; Benzene Derivatives; Cryptosporidium; Folic Acid Antagonists; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxazolidinones; Pyrimidines; Sequence Homology, Amino Acid; Stereoisomerism; Tetrahydrofolate Dehydrogenase; Toxoplasma | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Escherichia coli; Folic Acid Antagonists; Humans; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pyrimidines; Pyrroles; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 2007 |
Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
Topics: Animals; Boron; Boron Neutron Capture Therapy; Cell Line, Tumor; Crystallography, X-Ray; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Rats; Tetrahydrofolate Dehydrogenase | 2007 |
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase.
Topics: Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Bacillus anthracis; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cytosine; Humans; Methotrexate; Models, Molecular; Molecular Sequence Data; Protein Conformation; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Trimethoprim Resistance | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Fluorescent Dyes; Hydrolases; Minocycline; Models, Biological; Molecular Structure; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Streptomycin; Tetracycline | 2008 |
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
Topics: Animals; Antineoplastic Agents; Drug Design; Escherichia coli; Folic Acid Antagonists; Humans; Models, Molecular; Pyrimidines; Pyrroles; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Topics: Alkylation; Anti-Infective Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Babesia; Base Sequence; Cloning, Molecular; DNA Primers; DNA, Protozoan; Escherichia coli; Folic Acid Antagonists; Gene Expression; Genes, Protozoan; Molecular Sequence Data; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2008 |
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates.
Topics: Enzyme Inhibitors; Folic Acid Antagonists; Humans; Models, Molecular; Pyrimidines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Topics: Bacillus anthracis; Models, Molecular; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Genotype; Inhibitory Concentration 50; Kenya; Methotrexate; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2009 |
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Topics: Animals; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Receptor Protein-Tyrosine Kinases; Tetrahydrofolate Dehydrogenase | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Topics: Animals; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Glutamic Acid; Humans; Liver; Models, Molecular; Molecular Structure; Mycobacterium avium; Oxidation-Reduction; Pneumocystis carinii; Pyrimidines; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Chick Embryo; Drug Screening Assays, Antitumor; Humans; Indoles; Male; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Structure-Activity Relationship; Sulfhydryl Compounds; Thymidylate Synthase; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents.
Topics: Antineoplastic Agents; Benzaldehydes; Cell Line, Tumor; Drug Design; Folic Acid Antagonists; Humans; Indoles; Models, Molecular; Protein Conformation; Pyrimidines; Tetrahydrofolate Dehydrogenase | 2012 |
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Drug Screening Assays, Antitumor; Humans; Indenes; Melanoma, Experimental; Mice; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Topics: Amination; Aniline Compounds; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Models, Molecular; Mycobacterium avium; Pneumocystis carinii; Pyridines; Pyrimidines; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Drug Resistance, Bacterial; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Models, Molecular; Quinazolines; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2014 |
Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors.
Topics: | 2015 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Topics: Antimalarials; Calcium; Cell Line, Tumor; Hep G2 Cells; Humans; Malaria, Falciparum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protozoan Proteins | 2016 |
Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2016 |
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.
Topics: | 2016 |
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Mice; Pemetrexed; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Thymidylate Synthase; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2017 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.
Topics: Animals; Antiparasitic Agents; Dogs; Female; Folic Acid Antagonists; Humans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Mice; Molecular Structure; Piperazines; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis | 2019 |
Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase.
Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leishmania; Molecular Structure; Parasitic Sensitivity Tests; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2021 |
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Topics: | 2020 |
The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor, R388.
Topics: Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1976 |
Two distinct types of trimethoprim-resistant dihydrofolate reductase specified by R-plasmids of different compatibility groups.
Topics: Chromosomes, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Phenotype; Plasmids; Protein Biosynthesis; Species Specificity; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Trimethoprim | 1977 |
Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase.
Topics: Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Methotrexate; Protein Binding; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1978 |
Effect of temperature on fluorescence and circular dichroism of Escherichia coli dihydrofolate reductase and its complexes.
Topics: Circular Dichroism; Escherichia coli; Ligands; Methotrexate; NADP; Protein Conformation; Pyrimethamine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1978 |
Origins of specificity in the binding of small molecules to dihydrofolate reductase.
Topics: Hydrogen-Ion Concentration; Ligands; Methotrexate; Protein Binding; Protein Conformation; Spectrophotometry; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1977 |
Trimethoprim-induced elevation of dihydrofolate reductase activity in human leukocytes.
Topics: Electrophoresis, Cellulose Acetate; Enzyme Activation; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Molecular Weight; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim | 1978 |
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.
Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1979 |
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase.
Topics: Amides; Aminopterin; Binding Sites; Carbon Isotopes; Carboxylic Acids; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1975 |
[High-voltage electrophoresis of dihydrofolate reductase from Escherichia coli W 3110 (author's transl)].
Topics: Electrophoresis, Cellulose Acetate; Escherichia coli; Folic Acid Antagonists; Isoenzymes; Methotrexate; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1977 |
Trimethoprim-resistant bacteria: cross-resistance patterns.
Topics: Aspartic Acid; Bacteria; Bacterial Infections; Cross Reactions; Drug Resistance, Microbial; Humans; Methotrexate; Proguanil; Pyrimethamine; R Factors; Species Specificity; Trimethoprim; Urine | 1977 |
Regulatory mutants of dihydrofolate reductase in Escherichia coli K12.
Topics: Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Genotype; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1976 |
In vitro screening of biochemical activity of folic acid antagonists in skin.
Topics: Animals; Animals, Newborn; Chlorobenzenes; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Psoriasis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Skin; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1977 |
Inhibition by trimethoprim of some effects of epidermal growth factor on human fibroblasts in tissue culture.
Topics: Cells, Cultured; Epidermal Growth Factor; Fibroblasts; gamma-Aminobutyric Acid; Humans; Methotrexate; Peptides; Thymidine; Trimethoprim | 1976 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12 | 1976 |
The effect of trimethoprim on cellular transport of methotrexate and its cytotoxicity to human lymphoblastoid cells in vitro.
Topics: Biological Transport; Cell Line; Drug Interactions; Humans; Lymphocytes; Methotrexate; Tetrahydrofolates; Trimethoprim | 1976 |
[Pulmonary hypersensitive reactions].
Topics: Adolescent; Adult; Aged; Chlorpromazine; Drug Hypersensitivity; Humans; Lung Diseases; Methotrexate; Middle Aged; Sulfonamides; Trimethoprim | 1976 |
Methotrexate and trimethoprim-sulphamethoxazole.
Topics: Aged; Drug Interactions; Female; Humans; Methotrexate; Pancytopenia; Skin Ulcer; Trimethoprim | 1991 |
Interactions between inhibitors of dihydrofolate reductase.
Topics: Benzenesulfonates; Binding Sites; Escherichia coli; Folic Acid Antagonists; Histidine; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Pyrimidines; Sulfonamides; Trimethoprim | 1989 |
In vivo selected promoter and ribosome binding site up-mutations: demonstration that the Escherichia coli bla promoter and a Shine-Dalgarno region with low complementarity to the 16 S ribosomal RNA function in Bacillus subtilis.
Topics: Animals; Bacillus subtilis; Base Sequence; Binding Sites; Escherichia coli; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Methotrexate; Mice; Molecular Sequence Data; Mutation; Plasmids; Promoter Regions, Genetic; Ribosomes; RNA, Ribosomal; RNA, Ribosomal, 16S; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Trimethoprim | 1989 |
Drug interactions with methotrexate.
Topics: Aged; Drug Combinations; Drug Eruptions; Drug Interactions; Female; Humans; Leg Dermatoses; Methotrexate; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1989 |
Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.
Topics: Animals; Bacteria; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Methotrexate; Molecular Conformation; Molecular Structure; Nobel Prize; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim | 1989 |
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1989 |
Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole.
Topics: Aged; Aged, 80 and over; Drug Combinations; Drug Interactions; Female; Humans; Methotrexate; Pancytopenia; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1989 |
Isolation and characterization of dihydrofolate reductase from trimethoprim-susceptible and trimethoprim-resistant Pseudomonas cepacia.
Topics: Culture Media; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Isoelectric Focusing; Methotrexate; Microbial Sensitivity Tests; Molecular Weight; Peptide Mapping; Pseudomonas; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1989 |
[Pancytopenia during treatment of rheumatoid arthritis with methotrexate after administration of trimethoprim-sulfamethoxazole].
Topics: Anti-Infective Agents; Arthritis, Rheumatoid; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Pancytopenia; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1987 |
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
Topics: Amino Acid Sequence; Animals; Binding Sites; DNA; DNA, Recombinant; Drug Resistance; Drug Stability; Escherichia coli; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mice; Molecular Sequence Data; Mutation; NADP; Protein Conformation; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1988 |
Near fatal drug interactions with methotrexate given for psoriasis.
Topics: Aged; Aged, 80 and over; Drug Interactions; Female; Humans; Methotrexate; Naproxen; Necrosis; Pancytopenia; Psoriasis; Skin; Skin Ulcer; Trimethoprim | 1987 |
Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase.
Topics: Escherichia coli; Folic Acid Antagonists; Humans; Isomerism; Kinetics; Methotrexate; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1988 |
Crystal structure of human dihydrofolate reductase complexed with folate.
Topics: Binding Sites; Catalysis; Crystallography; Enzyme Inhibitors; Folic Acid; Fourier Analysis; Humans; Methotrexate; Models, Molecular; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1988 |
Concurrent analysis of methotrexate, trimethoprim, sulphamethoxazole and their major metabolites in plasma by high-performance liquid chromatography.
Topics: Child; Chromatography, High Pressure Liquid; Humans; Leukemia, Lymphoid; Methotrexate; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Trimethoprim | 1987 |
Megaloblastic pancytopenia in a patient receiving concurrent methotrexate and trimethoprim-sulfamethoxazole treatment.
Topics: Abscess; Breast Diseases; Cough; Drug Combinations; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Megaloblasts; Methotrexate; Middle Aged; Neutrophils; Pancytopenia; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole.
Topics: Arthritis, Rheumatoid; Bone Marrow Diseases; Drug Combinations; Drug Interactions; Female; Humans; Methotrexate; Middle Aged; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole.
Topics: Aged; Anti-Infective Agents, Urinary; Arthritis; Drug Combinations; Humans; Male; Methotrexate; Psoriasis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1987 |
Pancytopenia induced by the interaction between methotrexate and trimethoprim-sulfamethoxazole.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Drug Combinations; Drug Therapy, Combination; Female; Humans; Methotrexate; Pancytopenia; Psoriasis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1987 |
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1986 |
Conformational energy calculations and electrostatic potentials of dihydrofolate reductase ligands: relevance to mode of binding and species specificity.
Topics: Aminopterin; Chemical Phenomena; Chemistry, Physical; Crystallization; Escherichia coli; Lactobacillus; Ligands; Methotrexate; Models, Molecular; Protein Conformation; Species Specificity; Stereoisomerism; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum.
Topics: Chromatography, Affinity; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Malaria; Methotrexate; NADP; Plasmodium falciparum; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1987 |
Trimethoprim interference in methotrexate assay by an enzyme inhibition assay kit.
Topics: Diagnostic Errors; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Reagent Kits, Diagnostic; Trimethoprim | 1986 |
Purification and characterization of dihydrofolate reductase from Mycobacterium phlei.
Topics: Folic Acid Antagonists; Hydrogen-Ion Concentration; Methotrexate; Mycobacterium; Mycobacterium phlei; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Escherichia coli; Hydrogen Bonding; Macromolecular Substances; Methotrexate; Nitrogen; Oxygen; Phospholipases A; Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water; X-Ray Diffraction | 1985 |
Radioenzymatic assay for trimethoprim in very small serum samples.
Topics: Humans; Iodine Radioisotopes; Methotrexate; Reagent Kits, Diagnostic; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1985 |
Trimethoprim-sulphamethoxazole in gonorrhoea.
Topics: Anti-Infective Agents; Female; Folic Acid Antagonists; Gonorrhea; Humans; Male; Methotrexate; Microbial Sensitivity Tests; Pyrimidines; Trimethoprim | 1971 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro.
Topics: Animals; Biodegradation, Environmental; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chromatography, Gel; Cycloheximide; Drug Stability; Electrophoresis; Enzyme Activation; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Liver Neoplasms; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triamterene; Trimethoprim | 1971 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim | 1972 |
Effect of lipid-soluble esters of methotrexate on DNA synthesis in human skin.
Topics: Aminopterin; Depression, Chemical; DNA; Esters; Humans; Lipids; Methotrexate; Pyrimethamine; Skin; Solubility; Temperature; Time Factors; Trimethoprim; Tritium; Uridine | 1974 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein Binding; Pteridines; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1974 |
Purification and properties of dihydrofolate reductase from cultured mammalian cells.
Topics: Cell Line; Cells, Cultured; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Methotrexate; Molecular Weight; Polysaccharides; Potassium Chloride; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Trimethoprim; Urea | 1973 |
[Treatment with sulphamethoxazole-trimethoprim (Bactrim) as the possible cause of pulmonary changes].
Topics: Child, Preschool; Drug Combinations; Humans; Lung Diseases; Male; Methotrexate; Pneumonia; Radiography; Sulfamethoxazole; Trimethoprim | 1973 |
Comparative biochemistry of dihydrofolate reductase.
Topics: Animals; Anura; Biochemical Phenomena; Biochemistry; Escherichia coli; Fishes; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Malaria; Methotrexate; Nephropidae; Proteus vulgaris; Pyridines; Pyrimidines; Quinazolines; Rana pipiens; Rats; Staphylococcus; Taenia; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Turtles | 1971 |
Levels of dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to substituted pyrimidines, triazines and MTX.
Topics: Chromatography, Gel; Culture Media; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid Antagonists; Methotrexate; Methyltransferases; Protein Binding; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1971 |
Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.
Topics: Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Pyrimidines; Thymidine; Trimethoprim; Tritium | 1972 |
Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Folic Acid Antagonists; Genetics, Microbial; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Methyltransferases; Mutation; Proguanil; Pyrimethamine; Streptococcus; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1972 |
Inhibitors of DNA precursor metabolism in Dictyostelium discoideum.
Topics: Aminopterin; Antimetabolites; Dictyostelium; DNA; Floxuridine; Folic Acid; Hydroxyurea; Methotrexate; Time Factors; Trimethoprim | 1982 |
A microbiological assay for the measurement of methotrexate in biological fluids.
Topics: Anti-Bacterial Agents; Binding, Competitive; Biological Assay; Humans; Lacticaseibacillus casei; Methotrexate; Protein Binding; Radioimmunoassay; Reagent Kits, Diagnostic; Trimethoprim | 1983 |
Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase.
Topics: Animals; Cattle; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lacticaseibacillus casei; Liver; Magnetic Resonance Spectroscopy; Methotrexate; Protein Binding; Pyrimethamine; Streptococcus; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1983 |
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.
Topics: Binding Sites; Folic Acid Antagonists; Indicators and Reagents; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Conformation; Protein Binding; Structure-Activity Relationship; Trimethoprim | 1984 |
Possible role of methotrexate in trimethoprim-sulfamethoxazole-induced acute megaloblastic anemia.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Drug Synergism; Female; Humans; Methotrexate; Middle Aged; Sulfamethoxazole; Trimethoprim | 1984 |
Multiple forms of human dihydrofolate reductase messenger RNA. Cloning and expression in Escherichia coli of their DNA coding sequence.
Topics: Base Sequence; Cell Line; Deoxyribonucleotides; DNA, Recombinant; Drug Resistance; Electrophoresis, Agar Gel; Escherichia coli; Genetic Code; Humans; Methotrexate; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Transformation, Bacterial; Trimethoprim | 1982 |
Molecular graphics in the design of peptide analogues.
Topics: Captopril; Computers; Folic Acid Antagonists; Methotrexate; Minicomputers; Pancreatic Elastase; Peptides; Protein Conformation; Structure-Activity Relationship; Trimethoprim | 1982 |
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
Topics: Enzymes; Escherichia coli; Folic Acid Antagonists; Methotrexate; Models, Molecular; Molecular Conformation; Receptors, Drug; Trimethoprim; X-Ray Diffraction | 1982 |
Kinetics of ternary complex formation between dihydrofolate reductase, coenzyme, and inhibitors.
Topics: Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Methotrexate; NADP; Protein Binding; Pyrimethamine; Pyrimidines; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Photo-CIDNP studies of the influence of ligand binding on the surface accessibility of aromatic residues in dihydrofolate reductase.
Topics: Folic Acid; Histidine; Lacticaseibacillus casei; Lasers; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Photochemistry; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Histidine residues of Lactobacillus casei dihydrofolate reductase: paramagnetic relaxation and deuterium-exchange studies and partial assignments.
Topics: Histidine; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Trimethoprim interference in methotrexate assays.
Topics: Autoanalysis; Humans; Lacticaseibacillus casei; Methotrexate; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Trimethoprim interferes with serum methotrexate assay by the competitive protein binding technique.
Topics: Adult; Binding, Competitive; Chemical Phenomena; Chemistry; Drug Combinations; False Positive Reactions; Humans; Lacticaseibacillus casei; Leukemia, Lymphoid; Male; Methotrexate; Radioimmunoassay; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Thymine metabolism in Pseudomonas aeruginosa strain 1: the presence of a salvage pathway.
Topics: Culture Media; Methotrexate; Pseudomonas aeruginosa; Pyrimidines; Thymine; Trimethoprim | 1982 |
Influence of co-trimoxazole on methotrexate pharmacokinetics in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Drug Combinations; Drug Interactions; Female; Humans; Intestinal Absorption; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Protein Binding; Radioimmunoassay; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1981 |
Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia.
Topics: Adolescent; Anti-Infective Agents; Antineoplastic Agents; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Jejunum; Leukemia, Lymphoid; Malabsorption Syndromes; Male; Methotrexate; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1982 |
Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli; Fluorescence; Folic Acid; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1981 |
Dihydrofolate reductase hysteresis and its effect of inhibitor binding analyses.
Topics: Binding Sites; Escherichia coli; Isoenzymes; Kinetics; Methotrexate; NADP; Oxidation-Reduction; Protein Binding; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1981 |
The binding of trimethoprim to bacterial dihydrofolate reductase.
Topics: Crystallization; Escherichia coli; Fourier Analysis; Macromolecular Substances; Methotrexate; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1981 |
Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans.
Topics: Aminopterin; Animals; Candida albicans; Cattle; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; NADP; Trimethoprim | 1982 |
Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclophosphamide; Female; Graft vs Host Reaction; Humans; Leukemia; Male; Methotrexate; Prognosis; Quality of Life; Trimethoprim; Whole-Body Irradiation | 1982 |
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine | 1994 |
Thermal denaturation of bacterial and bovine dihydrofolate reductases and their complexes with NADPH, trimethoprim and methotrexate.
Topics: Animals; Calorimetry, Differential Scanning; Cattle; Escherichia coli; Hot Temperature; Isoelectric Point; Liver; Methotrexate; NADP; Osmolar Concentration; Protein Denaturation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1995 |
Solution structure of bound trimethoprim in its complex with Lactobacillus casei dihydrofolate reductase.
Topics: Amino Acid Sequence; Animals; Chickens; Escherichia coli; Hydrogen Bonding; Lacticaseibacillus casei; Liver; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Sequence Data; Solutions; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1994 |
Rational automatic search method for stable docking models of protein and ligand.
Topics: Algorithms; Computer Simulation; Folic Acid; Hydrogen Bonding; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Ribonuclease T1; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 1994 |
Angiostrongylus cantonensis: characterization of thymidylate synthetase.
Topics: Ammonium Sulfate; Angiostrongylus cantonensis; Animals; Chemical Fractionation; Chromatography, Affinity; Chromatography, Gel; Deoxyuracil Nucleotides; Electrophoresis, Polyacrylamide Gel; Kinetics; Methotrexate; Tetrahydrofolates; Thymidylate Synthase; Trimethoprim | 1994 |
Purification and characterization of dihydrofolate reductase of Plasmodium falciparum expressed by a synthetic gene in Escherichia coli.
Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Design; Enzyme Reactivators; Escherichia coli; Genes, Protozoan; Genes, Synthetic; Genetic Code; Inclusion Bodies; Methotrexate; Molecular Sequence Data; Plasmodium falciparum; Protein Denaturation; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1994 |
Thermodynamic study of dihydrofolate reductase inhibitor selectivity.
Topics: Animals; Escherichia coli; Folic Acid Antagonists; Methotrexate; Mice; NADP; Protein Folding; Temperature; Thermodynamics; Trimethoprim; Trimetrexate | 1994 |
The isolation and characterization of the gene (dfr1) encoding dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe.
Topics: Base Sequence; Chromosome Mapping; Cloning, Molecular; DNA, Fungal; Gene Expression; Genes, Fungal; Humans; Methotrexate; Molecular Sequence Data; Restriction Mapping; RNA, Fungal; RNA, Messenger; Schizosaccharomyces; Sequence Alignment; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1994 |
Thermodynamic study of folate analogue binding to dihydrofolate reductases from different species.
Topics: Animals; Calorimetry; Cattle; Escherichia coli; Folic Acid Antagonists; Liver; Methotrexate; NADP; Oxidation-Reduction; Species Specificity; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim; Trimetrexate | 1993 |
Use of the Escherichia coli chromosomal DHFR gene as selection marker in mammalian cells.
Topics: Animals; CHO Cells; Cricetinae; Cytomegalovirus; Escherichia coli; Flow Cytometry; Gene Expression; Genes, Bacterial; Genetic Markers; Genetic Vectors; Methotrexate; Mice; Promoter Regions, Genetic; Rabbits; Restriction Mapping; Tetrahydrofolate Dehydrogenase; Transfection; Trimethoprim | 1995 |
Macrophage activation syndrome in systemic juvenile rheumatoid arthritis successfully treated with cyclosporine.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Juvenile; Bone Marrow; Child; Cyclosporine; Humans; Macrophage Activation; Male; Methotrexate; Phagocytes; Pneumonia, Pneumocystis; Sulfamethoxazole; Trimethoprim | 1996 |
Therapy for the maintenance of remission in sixty-five patients with generalized Wegener's granulomatosis. Methotrexate versus trimethoprim/sulfamethoxazole.
Topics: Adolescent; Adult; Aged; Child; Drug Therapy, Combination; Female; Granulomatosis with Polyangiitis; Humans; Male; Methotrexate; Middle Aged; Prednisone; Remission Induction; Sulfamethoxazole; Trimethoprim | 1996 |
Isolation and characterization of a dihydrofolate reductase gene mutation in methotrexate-resistant Drosophila cells.
Topics: Animals; Cell Line; DNA; Drosophila; Drug Resistance; Folic Acid Antagonists; Kinetics; Methotrexate; Models, Molecular; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1996 |
Methotrexate and trimethoprim: a fatal interaction.
Topics: Aged; Arthritis, Rheumatoid; Drug Interactions; Fatal Outcome; Female; Humans; Methotrexate; Trimethoprim | 1998 |
Re: Interaction between methotrexate and trimethoprim.
Topics: Antirheumatic Agents; Drug Interactions; Folic Acid Antagonists; Humans; Methotrexate; Trimethoprim | 1998 |
Potassium-sparing renal effects of trimethoprim and structural analogues.
Topics: Animals; Anti-Infective Agents; Blood Pressure; Chlorides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glomerular Filtration Rate; Kidney; Male; Methotrexate; Potassium; Pyrimethamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium; Time Factors; Trimethoprim | 2000 |
Moritella cold-active dihydrofolate reductase: are there natural limits to optimization of catalytic efficiency at low temperature?
Topics: Amino Acid Sequence; Catalysis; Cloning, Molecular; Cold Temperature; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Kinetics; Methotrexate; Molecular Sequence Data; Molecular Weight; Moritella; NADP; Protein Conformation; Protein Denaturation; Sequence Homology, Amino Acid; Temperature; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2003 |
Myelotoxicity due to methotrexate - an iatrogenic cause.
Topics: Aged; Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Iatrogenic Disease; Methotrexate; Middle Aged; Trimethoprim | 2003 |
Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase.
Topics: Amino Acid Sequence; Chromatography, Liquid; Cloning, Molecular; Enzyme Inhibitors; Enzyme Stability; Escherichia coli; Hydrogen-Ion Concentration; Methotrexate; Molecular Sequence Data; Molecular Weight; Mycobacterium tuberculosis; Potassium Chloride; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2004 |
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.
Topics: Child; Child, Preschool; Female; Folic Acid Antagonists; Genotype; Humans; Male; Methotrexate; Methyltransferases; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim | 2005 |
Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia.
Topics: Anti-Bacterial Agents; Catechin; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Microbial Sensitivity Tests; Stenotrophomonas maltophilia; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance | 2005 |
Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Prescriptions; Humans; Medication Errors; Methotrexate; Pancytopenia; Penicillins; Trimethoprim | 2007 |
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.
Topics: Binding Sites; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Escherichia coli; Folic Acid Antagonists; Guanidines; Methotrexate; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2006 |
[Development and application of screening method for steroid dihydrofolate reductase inhibitors by high performance capillary electrophoresis].
Topics: Alcohol Oxidoreductases; Electrophoresis, Capillary; Enzyme Inhibitors; Folic Acid; Methotrexate; Trimethoprim | 2007 |
Self-assembly of antibodies by chemical induction.
Topics: Antibodies, Monoclonal; CD3 Complex; Cyclization; Dimerization; Immunoglobulin Variable Region; Methotrexate; Nanoparticles; Protein Array Analysis; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2008 |
Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Ligands; Methotrexate; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2009 |
Isolation and characterisation of an antifolate insensitive (afi1) mutant of Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Chromosome Mapping; Chromosomes, Plant; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Plant; Genetic Markers; Methotrexate; Mutation; Phenotype; Seedlings; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Trimethoprim; Up-Regulation | 2013 |
Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.
Topics: Biocatalysis; Biphenyl Compounds; Chemical Phenomena; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Folic Acid Antagonists; Indicators and Reagents; Isomerism; Methotrexate; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Phenylalanine; Recombinant Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2013 |
Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation.
Topics: Binding Sites; HEK293 Cells; Humans; Indicators and Reagents; Ligands; Methotrexate; Molecular Structure; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2015 |
A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range.
Topics: Carbocyanines; Cell Membrane; Escherichia coli; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HEK293 Cells; Humans; Methotrexate; Protein Engineering; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2016 |
The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models.
Topics: Anions; Anti-Bacterial Agents; Biological Transport; Cations; Cell Line; Ciprofloxacin; Drug Interactions; HEK293 Cells; Humans; Kinetics; Methotrexate; Organic Anion Transporters; Peptides; Trimethoprim | 2018 |
Small-Molecule Modulated Affinity-Tunable Semisynthetic Protein Switches.
Topics: Biotin; Fluorescent Dyes; Methotrexate; Nucleic Acids; Proteins; Streptavidin; Sulfonamides; Trimethoprim | 2022 |