Page last updated: 2024-08-16

trimethoprim and mercaptopurine

trimethoprim has been researched along with mercaptopurine in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (42.86)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (23.81)	29.6817
2010's	6 (28.57)	24.3611
2020's	1 (4.76)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Jedrzejczak, WW; Siekierzyński, M	1
Saunders, JE; Wickramasinghe, SN	1
Ablin, AR; Albo, VC; Bleyer, WA; Finklestein, JZ; Gaynon, PS; Grossman, NJ; Littman, PS; Novak, LT; Pyesmany, AF; Steinherz, PG	1
Aherne, GW; Burton, NK	1
Hirose, S; Noto, N; Sugaya, N; Wakabayashi, Y	1
Garson, OM; Spitzer, G	1
Ryrie, DR; Tanna, MK; Tattersall, RB; Toghill, PJ	1
Lennard, L; Lilleyman, JS; Maddocks, JL; Rees, CA	1

Reviews

1 review(s) available for trimethoprim and mercaptopurine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for trimethoprim and mercaptopurine

Article	Year
Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood. Lancet (London, England), 1986, Feb-22, Volume: 1, Issue:8478 Topics: Administration, Oral; Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1986
Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting features. Early conclusions of study CCG-106 by the Childrens Cancer Study Group. Lancet (London, England), 1988, Oct-22, Volume: 2, Issue:8617 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988

Article

Year

Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood.

Lancet (London, England), 1986, Feb-22, Volume: 1, Issue:8478

Topics: Administration, Oral; Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1986

Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting features. Early conclusions of study CCG-106 by the Childrens Cancer Study Group.

Lancet (London, England), 1988, Oct-22, Volume: 2, Issue:8617

Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1988

Other Studies

18 other study(ies) available for trimethoprim and mercaptopurine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Nitroblue tetrazolium (NBT) test: criteria for false positivity and its use in practice. Folia haematologica (Leipzig, Germany : 1928), 1976, Volume: 103, Issue:1 Topics: Adult; Bacterial Infections; Cyclophosphamide; False Positive Reactions; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Nitroblue Tetrazolium; Recurrence; Remission, Spontaneous; Sulfamethoxazole; Tetrazolium Salts; Trimethoprim; Vincristine	1976
Results of three years' experience with the deoxyuridine suppression test. Acta haematologica, 1977, Volume: 58, Issue:4 Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; Evaluation Studies as Topic; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Mercaptopurine; Sulfamethoxazole; Thioguanine; Trimethoprim; Vitamin B 12 Deficiency	1977
The effect of cotrimoxazole on the absorption of orally administered 6-mercaptopurine in the rat. Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:1 Topics: Administration, Oral; Animals; Drug Combinations; Drug Interactions; Male; Mercaptopurine; Metabolic Clearance Rate; Rats; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1986
[A case of pulmonary nocardiosis in malignant lymphoma under VEMP therapy]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1985, Volume: 26, Issue:7 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Therapy, Combination; Humans; Lung Diseases; Lymphoma; Male; Mercaptopurine; Nocardia Infections; Prednisolone; Sulfamethoxazole; Trimethoprim; Vincristine	1985
Lymphoblastic leukemia with marked eosinophilia: a report of two cases. Blood, 1973, Volume: 42, Issue:3 Topics: Adolescent; Blood Cell Count; Bone Marrow Examination; Cytarabine; Eosinophilia; Female; Humans; Karyotyping; Leukemia, Lymphoid; Mercaptopurine; Mycoses; Sulfamethoxazole; Thioguanine; Trimethoprim; Vincristine	1973
Induction of remission in myeloblastic and monoblastic leukaemia in adults with rubidomycin. Acta haematologica, 1971, Volume: 46, Issue:2 Topics: Adolescent; Adult; Aged; Alopecia; Ampicillin; Anemia, Aplastic; Antibiotics, Antineoplastic; Blood Platelets; Blood Transfusion; Cardiomyopathies; Cephaloridine; Electrocardiography; Female; Heart; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Paresthesia; Remission, Spontaneous; Sulfamethoxazole; Thrombocytopenia; Trimethoprim	1971
Disturbance of 6-mercaptopurine metabolism by cotrimoxazole in childhood lymphoblastic leukaemia. Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:2 Topics: Absorption; Adolescent; Child; Child, Preschool; Drug Combinations; Drug Interactions; Female; Guanine Nucleotides; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Sulfamethoxazole; Thionucleotides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1984