Page last updated: 2024-08-16

trimethoprim and iclaprim

trimethoprim has been researched along with iclaprim in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hawser, S; Islam, K; Schneider, P1
Fritsche, TR; Jones, RN; Sader, HS1
Barrow, EW; Barrow, WW; Berlin, KD; Bourne, CR; Bourne, PC; Bunce, RA1
Brown-Driver, V; Chen, Z; Creighton, C; Cunningham, M; Finn, J; G C, K; Hilgers, M; Kohnen, L; Kwan, B; Lam, T; Li, X; Nelson, K; Shaw, KJ; Stidham, M; Trzoss, M; Zhang, J1
Brown-Driver, V; Cunningham, ML; Finn, J; Hilgers, MT; Hough, G; Kwan, BP; Lam, T; Nelson, KJ; Ong, V; Shaw, KJ; Trzoss, M1
Bandera, M; Dale, GE; Haldimann, A; Laue, H; Lociuro, S; Mukhija, S; Oefner, C; Parisi, S; Schulz, H; Weiss, L1
Dale, GE; Lociuro, S; Oefner, C; Parisi, S; Schulz, H1
Huang, DB1
Bryant, AE; Gomi, S; Huang, DB; Katahira, E; Stevens, DL1

Other Studies

9 other study(ies) available for trimethoprim and iclaprim

ArticleYear
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria.
    Bioorganic & medicinal chemistry letters, 2003, Dec-01, Volume: 13, Issue:23

    Topics: Animals; Drug Resistance, Bacterial; Folic Acid Antagonists; Lung; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Pyrimidines; Sepsis; Staphylococcus aureus; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim Resistance; Vancomycin

2003
Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Anti-Bacterial Agents; Enterococcus faecalis; Europe; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Hospitalization; Humans; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrimidines; Staphylococcus aureus; Streptococcus; United States

2009
Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Microbial Sensitivity Tests; Protein Structure, Secondary; Protein Structure, Tertiary; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase

2010
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
    Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18

    Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quinazolines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

2011
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
    Journal of medicinal chemistry, 2014, Feb-13, Volume: 57, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Drug Resistance, Bacterial; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Models, Molecular; Quinazolines; Sepsis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

2014
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 63, Issue:4

    Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrimidines; Staphylococcus aureus; Tetrahydrofolate Dehydrogenase; Trimethoprim

2009
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.
    Acta crystallographica. Section D, Biological crystallography, 2009, Volume: 65, Issue:Pt 8

    Topics: Anti-Bacterial Agents; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Isomerism; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Multienzyme Complexes; Mutant Proteins; NADP; Protein Structure, Tertiary; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trimethoprim

2009
Extracellular and intracellular activity of iclaprim against Listeria monocytogenes.
    International journal of antimicrobial agents, 2019, Volume: 53, Issue:1

    Topics: Anti-Bacterial Agents; Colony Count, Microbial; Folic Acid Antagonists; Listeria monocytogenes; Microbial Sensitivity Tests; Microbial Viability; Pyrimidines; Trimethoprim

2019
The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.
    Journal of medical microbiology, 2019, Volume: 68, Issue:3

    Topics: Anti-Bacterial Agents; Bacterial Toxins; Biological Assay; Exotoxins; Folic Acid Antagonists; Methicillin-Resistant Staphylococcus aureus; Pyrimidines; Staphylococcus aureus; Trimethoprim; Vancomycin; Virulence Factors

2019