Page last updated: 2024-08-16

trimethoprim and folic acid

trimethoprim has been researched along with folic acid in 112 studies

Research

Studies (112)

Timeframe	Studies, this research(%)	All Research%
pre-1990	76 (67.86)	18.7374
1990's	8 (7.14)	18.2507
2000's	16 (14.29)	29.6817
2010's	10 (8.93)	24.3611
2020's	2 (1.79)	2.80

Authors

Authors	Studies
Bognar, A; Khanam, N; Kwon, YK; Lu, W; Melamud, E; Rabinowitz, JD	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hood, K; Roberts, GC	1
Bayley, PM; Hood, K; Roberts, GC	1
Bateson, MC; Hayes, JP; Pendharkar, P	1
Colman, N; Herbert, V	1
Elsborg, L; Hjortshøj, A; Jensen, E	1
Bernstein, LS	1
Audebert, A; Bousser, J; Zittoun, J; Zittoun, R	1
Birdsall, B; Burgen, AS; Feeney, J; Roberts, GC; Way, JL	1
Lietman, PS; Rogers, HJ	1
Deeg, HJ; Graham, TC; Meyers, JD; Storb, R; Weiden, PL	1
Saunders, JE; Wickramasinghe, SN	1
Borkenstein, M; Gleispach, H; Stögmann, W	1
Riggenbach, H; Then, RL	1
Greenwood, D; O'Grady, F	1
Girdwood, RH	3
Rollo, IM	2
O'Grady, F	1
Sher, N	1
Bushby, SR	1
Gurney, JD; Hughes, DT; Jenkins, GC	1
Lewin, LM; Pholpramool, C; Ruchirawat, S; Verawatnapakul, V	1
Matthews, RG; Rohlman, CE	1
Allegra, CJ; Beaver, J; Boarman, D; Chabner, B; Kovacs, JA; Lewis, M; Masur, H; Parrillo, JE	1
Jankó, M; Juhász, P; Tóth, L; Vukmirovits, G	1
Hitchings, GH	4
Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ	1
Davis, RE	1
Hamilton-Miller, JM	1
Bygbjerg, IC; Hørding, M; Lund, JT	1
D'Arcy, A; Oefner, C; Winkler, FK	1
Davis, M; Gall, EP; Maricic, M	1
Morrison, JF; Stone, SR	1
Burman, LG	1
Rosenberg, IH; Selhub, J; Zimmerman, J	1
Sirotnak, FM	1
O'Grady, FW	1
Davis, RE; Jackson, JM	2
Elsborg, L; Hjortshoj, A; Jensen, E	1
Asbjornsen, G	1
Navarro, J	1
Salter, AJ	1
Robenberg, IH	1
Cooper, M; Koutts, J; Van der Weyden, MB	1
Hall, DH; Johnson, JR	1
Herbert, V	1
Burchall, JJ	1
Reddy, MS; Reinbold, GW; Williams, FD	1
Fernex, M; Hamza, B; Havas, L; Rehm, W	1
Mandula, BB; Mosteller, RD	1
Lindahl, A	1
Karlin, R; Levrat, R	1
Bowes, D; Cohen, H; Green, R; Metz, J; Miller, S; Spector, I	1
Da Costa, AJ; Girdwood, RH; Samson, RR	1
Hill, AV; Kerr, DN	1
Chanarin, I; England, JM	1
Green, R; Metz, J; Sive, J	1
Parkin, JM; Poskitt, EM	1
Christiansen, LV; Lindahl, A; Toft, JE	1
Dulaney, EL; Marx, LM	1
Deering, RA; Michrina, CA	1
Ausina, VR; Coll, PF; Mirelis, BO; Prats, GP; Vernis, JV	1
Biasini, A; Biasini, G; Dalla Villa, A; Marchisio, P; Principi, N	1
Harris, RE	1
Kleimola, T; Soininen, K	1
Morizon, G; Santos, M	1
Birdsall, B; Burgen, AS; Feeney, J; Gronenborn, A; Kaptein, R; Roberts, GC	1
Hagen, MD; White, RD	1
Glover, TW; Hecht, F	1
Richter, M; Seydel, JK; Wempe, E	1
Cayley, PJ; Dunn, SM; King, RW	1
Popov, N	1
Itai, A; Mizutani, MY; Tomioka, N	1
Herrington, MB	1
Bagnara, AS; Nott, SE	1
Doles, J; Stephens, KE; Stone, DM	1
Huang, EY; Mohler, AM; Rohlman, CE	1
Bertino, JS; Naderer, O; Nafziger, AN	1
McPartlin, J; Quinlivan, EP; Scott, J; Weir, DG	1
Kokue, E; Miyashiro, S; Mizuno, Y; Takeuchi, H; Tominaga, M; Toride, Y	1
Lalukotta, K; Saravana, S	1
Andersen, HS; Danielsen, M; Wind, A	1
Brennan, JD; Brook, MA; Chen, Y; Hodgson, RJ; Long, H; Organ, M; Tleugabulova, D; Zhang, Z; Zhao, X	1
Brennan, JD; Brook, MA; Covey, T; Hodgson, RJ; Kovarik, P	1
Birdsall, B; Feeney, J; Polshakov, VI	1
Jia, R; Li, N; Zhu, R	1
Brochet, M; Couvé, E; Glaser, P; Poyart, C; Zouine, M	1
DeRose, EF; Howell, EE; Jackson, MR; Krahn, JM; London, RE	1
Chopra, S; Dooling, RM; Horner, CG; Howell, EE	1
Giske, CG; Kahlmeter, G; Wisell, KT	1
Brown, HA	1
Lambert, W; Navarrete, O; Storozhenko, S; Stove, C; Van Daele, J; Van Der Straeten, D	1
Afzal, S; Andersen, EW; Andersen, JT; Andersen, NL; Broedbaek, K; Jimenez-Solem, E; Keiding, N; Petersen, M; Poulsen, HE; Torp-Pedersen, C	1
Anderson, AC; Ferreira, JJ; G-Dayanandan, N; Keshipeddy, S; Reeve, SM; Scocchera, E; Wright, DL	1
Chirakul, S; Currie, BJ; Drew, HR; Keim, P; Mima, T; Podnecky, NL; Rhodes, KA; Sarovich, DS; Schupp, JM; Schweizer, HP; Wuthiekanun, V	1
Barbé, J; Cortés, P; Erill, I; Llagostera, M; Sánchez-Osuna, M	1
Deng, J; Gu, J; Song, Y; Yang, J; Zhou, Z	1

Reviews

11 review(s) available for trimethoprim and folic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced anaemias. Drugs, 1976, Volume: 11, Issue:5 Topics: Anemia; Anemia, Aplastic; Anemia, Megaloblastic; Anemia, Sideroblastic; Anticonvulsants; Bone Marrow; Chloramphenicol; Chromosomes; Contraceptives, Oral; Drug Hypersensitivity; Erythrocytes; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Leukemia; Trimethoprim	1976
Synergy of trimethoprim-sulfamethoxazole. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Animals; Bacteria; Conjugation, Genetic; Dihydropteroate Synthase; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Genetics, Microbial; Mice; Microbial Sensitivity Tests; Mutation; Sulfamethoxazole; Tetrahydrofolates; Thymidine; Trimethoprim	1975
Clinical chemistry of folic acid. Advances in clinical chemistry, 1986, Volume: 25 Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim	1986
The antimicrobial activities of trimethoprim and sulfonamides. Scandinavian journal of infectious diseases, 1986, Volume: 18, Issue:1 Topics: Bacteria; Drug Synergism; Folic Acid; Humans; Microbial Sensitivity Tests; Sulfonamides; Tetrahydrofolate Dehydrogenase; Trimethoprim; Urinary Tract Infections	1986
Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man. The Journal of infectious diseases, 1973, Volume: 128 Topics: Agranulocytosis; Aminobenzoates; Anemia; Bile; Biological Transport, Active; Bone Marrow; Bone Marrow Cells; Depression, Chemical; DNA; Female; Folic Acid; Folic Acid Antagonists; Food; Humans; Intestinal Absorption; Leukopenia; Neutrophils; Pregnancy; Sulfamethoxazole; Sulfonamides; Tetrahydrofolates; Thrombocytopenia; Trimethoprim	1973
Mechanism of action of trimethoprim-sulfamethoxazole. II. The Journal of infectious diseases, 1973, Volume: 128 Topics: Amino Acid Sequence; Animals; Anura; Bacteria; Binding Sites; Drug Combinations; Fishes; Folic Acid; Folic Acid Antagonists; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Kinetics; Oxidoreductases; Protein Binding; Rabbits; Rats; Species Specificity; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim; Turtles	1973
Combination of folic acid and folinic acid antagonists in human and veterinary medicine. Chemotherapy, 1973, Volume: 19, Issue:3 Topics: Animal Diseases; Animals; Antimalarials; Bacterial Infections; Drug Therapy, Combination; Dysentery, Bacillary; Folic Acid; Folic Acid Antagonists; Gonorrhea; Humans; Salmonella Infections; Sulfamethoxazole; Syphilis; Trimethoprim	1973
[Sulfamethoxazole-trimethoprim and megaloblastic anemia]. Ugeskrift for laeger, 1974, Apr-08, Volume: 136, Issue:15 Topics: Anemia, Macrocytic; Bone Marrow Diseases; Drug Combinations; Folic Acid; Humans; Sulfamethoxazole; Trimethoprim	1974
Dihydrofolate reductase inhibitors as antimicrobial agents and their potentiation by sulfonamides. CRC critical reviews in clinical laboratory sciences, 1970, Volume: 1, Issue:4 Topics: Anti-Bacterial Agents; Antimalarials; Antiprotozoal Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Drug Combinations; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kidney; Lactobacillus; Proguanil; Pyrimidines; Sulfamethoxazole; Sulfonamides; Trimethoprim	1970
Trimethoprim and enterococci in urinary tract infections: new perspectives on an old issue. The Journal of antimicrobial chemotherapy, 2008, Volume: 62, Issue:1 Topics: Anti-Bacterial Agents; Enterococcus; Folic Acid; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Models, Animal; Trimethoprim; Urinary Tract Infections	2008

Trials

3 trial(s) available for trimethoprim and folic acid

Article	Year
Cotrimoxazole and folate metabolism. Lancet (London, England), 1976, Aug-14, Volume: 2, Issue:7981 Topics: Biological Assay; Drug Combinations; Folic Acid; Follow-Up Studies; Humans; Iodine Radioisotopes; Lacticaseibacillus casei; Radioisotope Dilution Technique; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections	1976
The clinical, haematological and bacteriological effects of long-term treatment with co-trimoxazole. The Journal of antimicrobial chemotherapy, 1975, Volume: 1, Issue:1 Topics: Adult; Aged; Blood Cell Count; Bone Marrow; Bronchitis; Clinical Trials as Topic; Drug Combinations; Female; Folic Acid; Hemoglobinometry; Humans; Male; Middle Aged; Respiratory Tract Infections; Sulfamethoxazole; Time Factors; Trimethoprim	1975
Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:11 Topics: Administration, Oral; Adult; Anti-Infective Agents, Urinary; Creatinine; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Trimethoprim	1997

Other Studies

98 other study(ies) available for trimethoprim and folic acid

Article	Year
A domino effect in antifolate drug action in Escherichia coli. Nature chemical biology, 2008, Volume: 4, Issue:10 Topics: Computer Simulation; Escherichia coli; Escherichia coli Proteins; Folic Acid Antagonists; Gas Chromatography-Mass Spectrometry; Multienzyme Complexes; Peptide Synthases; Tetrahydrofolate Dehydrogenase; Trimethoprim	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Ultraviolet difference-spectroscopic studies of substrate and inhibitor binding to Lactobacillus casei dihydrofolate reductase. The Biochemical journal, 1978, May-01, Volume: 171, Issue:2 Topics: Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Methotrexate; Protein Binding; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Trimethoprim	1978
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R. The Biochemical journal, 1979, Feb-01, Volume: 177, Issue:2 Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim	1979
Cotrimoxazole and folate metabolism. Lancet (London, England), 1976, Oct-30, Volume: 2, Issue:7992 Topics: Folic Acid; Folic Acid Antagonists; Humans; Sulfamethoxazole; Trimethoprim	1976
Folate status during long-term therapy with trimethoprim and sulphadiazine. Chemotherapy, 1978, Volume: 24, Issue:5 Topics: Adult; Aged; Biological Assay; Bronchitis; Chronic Disease; Drug Therapy, Combination; Female; Folic Acid; Humans; Lacticaseibacillus casei; Male; Middle Aged; Sulfadiazine; Time Factors; Trimethoprim	1978
Adverse reactions to trimethoprim-sulfamethoxazole, with particular reference to long-term therapy. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Adult; Aged; Bacterial Infections; Blood Cell Count; Blood Cells; Blood Platelets; Child; Drug Combinations; Drug Eruptions; Drug Evaluation; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Gastrointestinal Diseases; Hematologic Diseases; Hemoglobins; Humans; Long-Term Care; Male; Middle Aged; Sulfamethoxazole; Trimethoprim; Vitamin B 12	1975
[Macrocytic animia due to the combination trimethoprim-sulfamethoxazole]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975, Jan-20, Volume: 51, Issue:4 Topics: Adult; Alcoholism; Anemia, Macrocytic; Anti-Infective Agents; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Sulfamethoxazole; Trimethoprim	1975
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase. Biochemistry, 1975, Jul-29, Volume: 14, Issue:15 Topics: Amides; Aminopterin; Binding Sites; Carbon Isotopes; Carboxylic Acids; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1975
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes. Biochemical pharmacology, 1977, Sep-01, Volume: 26, Issue:17 Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine	1977
Effect of trimethoprim-sulfamethoxazole on hematological recovery after total body irradiation and autologous marrow infusion in dogs. Transplantation, 1979, Volume: 28, Issue:3 Topics: Animals; Blood Platelets; Bone Marrow Transplantation; Dogs; Drug Therapy, Combination; Folic Acid; Granulocytes; Pneumonia, Pneumocystis; Radiation Chimera; Sulfamethoxazole; Transplantation, Autologous; Trimethoprim	1979
Results of three years' experience with the deoxyuridine suppression test. Acta haematologica, 1977, Volume: 58, Issue:4 Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; Evaluation Studies as Topic; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Mercaptopurine; Sulfamethoxazole; Thioguanine; Trimethoprim; Vitamin B 12 Deficiency	1977
[Sulfametrol/trimethoprim (Lidaprim)--modification of the folic acid level and therapeutic value in pediatrics]. Wiener medizinische Wochenschrift (1946), 1979, Feb-15, Volume: 129, Issue:3 Topics: Age Factors; Bronchopneumonia; Child; Child, Preschool; Drug Combinations; Female; Folic Acid; Humans; Infant; Male; Otitis Media; Sulfanilamides; Trimethoprim; Urinary Tract Infections	1979
Dihydrofolate reductases in some folate-requiring bacteria with low trimethoprim susceptibility. Antimicrobial agents and chemotherapy, 1978, Volume: 14, Issue:1 Topics: Bacteria; Drug Resistance, Microbial; Folic Acid; Folic Acid Antagonists; Tetrahydrofolate Dehydrogenase; Trimethoprim	1978
Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli. Journal of clinical pathology, 1976, Volume: 29, Issue:2 Topics: Drug Synergism; Escherichia coli; Folic Acid; Microbial Sensitivity Tests; Models, Biological; Nephelometry and Turbidimetry; Sulfamethoxazole; Time Factors; Trimethoprim; Urinary Bladder; Urinary Tract Infections	1976
Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Lacticaseibacillus casei; Leucovorin; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Pyrimidines; Sulfalene; Sulfonamides; Trimethoprim	1975
The nature of possible adverse reactions to co-trimoxazole. Scandinavian journal of infectious diseases. Supplementum, 1976, Issue:8 Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12	1976
Trimethoprim-sulfamethoxazole: A reappraisal. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Bacteria; Bacterial Infections; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Sulfamethoxazole; Trimethoprim	1975
Prophylactic chemotherapy with low-dosage trimethoprim-sulfamethoxazole following acute urinary tract infections in children. Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No Topics: Ampicillin; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Escherichia coli Infections; Folic Acid; Humans; Infant; Methenamine; Nitrofurantoin; Proteus Infections; Recurrence; Streptococcal Infections; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections	1975
Mode of action of the antifertility sulphonamides: lack of effects on folate metabolism. Contraception, 1990, Volume: 42, Issue:6 Topics: Animals; Dimethyl Sulfoxide; Drug Combinations; Epididymis; Fertility; Folic Acid; Liver; Male; Prostate; Pyrimethamine; Rats; Rats, Inbred F344; Seminal Vesicles; Sulfacetamide; Sulfamerazine; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Sulfonamides; Trimethoprim	1990
Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli. Journal of bacteriology, 1990, Volume: 172, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; Bacterial Proteins; Cell Survival; Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Folic Acid; Hemostasis; Inosine; Microbial Sensitivity Tests; Purines; Ribonucleotides; Sulfathiazole; Sulfathiazoles; Trimethoprim	1990
Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents. The Journal of infectious diseases, 1989, Volume: 160, Issue:2 Topics: 4-Aminobenzoic Acid; Animals; Drug Combinations; Drug Evaluation, Preclinical; Folic Acid; Pneumocystis; Quinazolines; Rats; Sulfamethoxazole; Toxoplasma; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Trimetrexate	1989
Acute monosymptomatic aseptic meningitis caused by Toxoplasma gondii. Acta paediatrica Hungarica, 1985, Volume: 26, Issue:1 Topics: Acute Disease; Child, Preschool; Drug Combinations; Folic Acid; Humans; Male; Meningitis; Meningitis, Aseptic; Pyrimethamine; Staining and Labeling; Sulfamethoxazole; Toxoplasmosis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1985
Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1989, Volume: 25, Issue:4 Topics: Animals; Bacteria; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Methotrexate; Molecular Conformation; Molecular Structure; Nobel Prize; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim	1989
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase. Biochemistry, 1989, May-30, Volume: 28, Issue:11 Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1989
Reversal of activity of trimethoprim against gram-positive cocci by thymidine, thymine and 'folates'. The Journal of antimicrobial chemotherapy, 1988, Volume: 22, Issue:1 Topics: Folic Acid; Microbial Sensitivity Tests; Staphylococcus; Streptococcus; Thymidine; Thymine; Trimethoprim	1988
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:6 Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Drug Combinations; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Leukopenia; Pneumonia, Pneumocystis; Prospective Studies; Sulfamethoxazole; Thrombocytopenia; Time Factors; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
Crystal structure of human dihydrofolate reductase complexed with folate. European journal of biochemistry, 1988, Jun-01, Volume: 174, Issue:2 Topics: Binding Sites; Catalysis; Crystallography; Enzyme Inhibitors; Folic Acid; Fourier Analysis; Humans; Methotrexate; Models, Molecular; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction	1988
Megaloblastic pancytopenia in a patient receiving concurrent methotrexate and trimethoprim-sulfamethoxazole treatment. Arthritis and rheumatism, 1986, Volume: 29, Issue:1 Topics: Abscess; Breast Diseases; Cough; Drug Combinations; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Megaloblasts; Methotrexate; Middle Aged; Neutrophils; Pancytopenia; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1986
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues. Biochimica et biophysica acta, 1986, Feb-14, Volume: 869, Issue:3 Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim	1986
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine. The American journal of clinical nutrition, 1987, Volume: 46, Issue:3 Topics: Animals; Binding Sites; Biological Transport; Folic Acid; Folic Acid Antagonists; Intestinal Absorption; Intestine, Small; Jejunum; Kinetics; Male; Pyrimethamine; Rats; Rats, Inbred Strains; Trimethoprim	1987
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase. Biochimica et biophysica acta, 1973, Mar-15, Volume: 302, Issue:1 Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim	1973
Co-trimaxazole therapy: place and prospects. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacteriuria; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Fetus; Folic Acid; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pyrimidines; Recurrence; Respiratory Tract Infections; Sulfamethoxazole; Thymidine; Trimethoprim	1973
Trimethoprim-sulphamethoxazole effect on folate metabolism. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2 Topics: Adolescent; Adult; Animals; Anti-Bacterial Agents; Biological Assay; Drug Combinations; Drug Resistance, Microbial; Female; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Male; Middle Aged; Pediococcus; Pyrimidines; Rabbits; Species Specificity; Sulfamethoxazole; Tetrahydrofolates; Trimethoprim	1973
Trimethoprim-sulphamethoxazole: long-term therapy and folate levels. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2 Topics: Ampicillin; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Biological Assay; Chronic Disease; Drug Combinations; Erythrocytes; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Lacticaseibacillus casei; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim	1973
[Folate levels during long-term therapy with trimethoprim and sulphadiazine]. Ugeskrift for laeger, 1973, Jun-25, Volume: 135, Issue:26 Topics: Adult; Aged; Biological Assay; Bone Marrow Cells; Bronchitis; Drug Combinations; Feces; Female; Folic Acid; Folic Acid Deficiency; Humans; Lacticaseibacillus casei; Male; Middle Aged; Sulfadiazine; Time Factors; Trimethoprim; Tritium	1973
The effect of different serum concentrations of antimicrobial agents on the Lactobacillus casei folate assay. Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology, 1974, Volume: 82, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; Biological Assay; Carbenicillin; Chloramphenicol; Depression, Chemical; Dose-Response Relationship, Drug; Drug Combinations; Erythromycin; Folic Acid; In Vitro Techniques; Lacticaseibacillus casei; Lincomycin; Penicillin G; Penicillin V; Sulfamethoxazole; Trimethoprim	1974
[Biological tolerance of the trimethoprim-sulfamethoxazole combination in pediatrics. Its influence on serum folic and folinic acid levels]. Therapeutique (La Semaine des hopitaux), 1972, Volume: 48, Issue:10 Topics: Adolescent; Age Factors; Anti-Infective Agents; Bacterial Infections; Child; Child, Preschool; Drug Eruptions; Drug Tolerance; Evaluation Studies as Topic; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant; Infant, Newborn; Leucovorin; Male; Pyrimidines; Sulfamethoxazole; Trimethoprim; Vomiting	1972
The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Anti-Infective Agents; Child; Child, Preschool; Chromosome Aberrations; Drug Combinations; Drug Eruptions; Female; Folic Acid; Folic Acid Antagonists; Gastrointestinal Diseases; Haplorhini; Hematologic Diseases; Humans; Infant; Infant, Newborn; Kidney Diseases; Lymphatic Diseases; Lymphocyte Activation; Male; Middle Aged; Pregnancy; Pyrimidines; Rats; Sulfamethoxazole; Thyroid Neoplasms; Trimethoprim	1973
Drugs and folic acid absorption. Gastroenterology, 1972, Volume: 63, Issue:2 Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim	1972
Effect ot trimethoprim on folate metabolism in human bone marrow. Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:3 Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA; Drug Synergism; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Male; Middle Aged; Pyrimidines; Thymidine; Thymine; Trimethoprim; Tritium; Vitamin B 12 Deficiency	1973
Isolation and characterization of mutants of bacteriophage T4 resistant to folate analogs. Virology, 1973, Volume: 53, Issue:2 Topics: Coliphages; Culture Media; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Hot Temperature; Mutation; Osmotic Fragility; Phenotype; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim	1973
Biochemical background of trimethoprim-sulphamethoxazole. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2 Topics: Aminobenzoates; Animals; Anti-Bacterial Agents; Bacteria; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Mice; Microbial Sensitivity Tests; Plasmodium; Proteus Infections; Proteus vulgaris; Pyrimidines; Sulfamethoxazole; Tetrahydrofolates; Thymidylate Synthase; Trimethoprim	1973
Sulfonamide resistance of propionibacteria: nutrition and transport. Antimicrobial agents and chemotherapy, 1973, Volume: 4, Issue:3 Topics: Aminobenzoates; Biological Transport; Culture Media; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Propionibacterium; Sulfadiazine; Sulfonamides; Trimethoprim	1973
Kinetics of derepression of the tryptophan operon of Escherichia coli and Salmonella typhimurium under different culture conditions. Journal of molecular biology, 1973, Nov-15, Volume: 80, Issue:4 Topics: Aniline Compounds; Anthranilate Synthase; Culture Media; Enzyme Repression; Escherichia coli; Folic Acid; Genes, Regulator; Histidine; Kinetics; Methionine; Nucleic Acid Hybridization; Operon; Peptide Biosynthesis; RNA, Bacterial; RNA, Messenger; Salmonella typhimurium; Sulfur Radioisotopes; Temperature; Thiazoles; Trimethoprim; Tritium; Tryptophan; Tryptophan Synthase	1973
Indications for control mechanisms in purine and pyrimidine biosynthesis as revealed by studies with inhibitors. Advances in enzyme regulation, 1974, Volume: 12 Topics: Animals; Carboxy-Lyases; Carboxylic Acids; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Models, Biological; Orotic Acid; Purines; Pyrimidines; Rats; Sulfonamides; Trimethoprim; Uracil Nucleotides	1974
[Effect of combined trimethoprim-sulfamethoxazole on level of folates in blood]. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1972, Volume: 42, Issue:1 Topics: Anti-Bacterial Agents; Biological Assay; Drug Combinations; Drug Synergism; Erythrocytes; Evaluation Studies as Topic; Fever; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Methionine; Pyrimidines; Sulfamethoxazole; Time Factors; Trimethoprim; Vitamin B 12	1972
Trimethoprim-sulphamethoxazole and folate metabolism. Pathology, 1973, Volume: 5, Issue:1 Topics: Adult; Animals; Anti-Bacterial Agents; Biological Assay; Drug Combinations; Drug Resistance, Microbial; Female; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Male; Pediococcus; Pyrimidines; Rabbits; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim	1973
Trimethoprim-sulphamethoxazole therapy and folate nutrition. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Jul-21, Volume: 47, Issue:28 Topics: Adult; Anti-Infective Agents; Blood Cell Count; Bone Marrow Examination; Bronchopneumonia; Female; FIGLU Test; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Hemoglobins; Humans; Infant; Pneumonia, Pneumococcal; Pregnancy; Protein Deficiency; Puerperal Infection; Pyrimidines; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections	1973
Co-trimoxazole as a possible cause of folate depletion. British journal of haematology, 1973, Volume: 25, Issue:2 Topics: Anemia, Macrocytic; Anti-Infective Agents; Drug Combinations; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Pyrimidines; Sulfamethoxazole; Trimethoprim	1973
Mechanism of action of trimethoprim-sulfamethoxazole. I. The Journal of infectious diseases, 1973, Volume: 128 Topics: Aminobenzoates; Bacteria; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Sulfamethoxazole; Tetrahydrofolates; Trimethoprim	1973
Toxicity of co-trimoxazole in nutritional haematinic deficiency. Postgraduate medical journal, 1973, Volume: 49, Issue:574 Topics: Anemia, Aplastic; Anemia, Macrocytic; Blood Cell Count; Folic Acid; Folic Acid Deficiency; Humans; Iron; Middle Aged; Nalidixic Acid; Nutrition Disorders; Pyelonephritis; Sulfamethoxazole; Trimethoprim; Urea; Vitamin B 12; Vitamin B 12 Deficiency	1973
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis. British medical journal, 1972, Mar-11, Volume: 1, Issue:5801 Topics: Adult; Aged; Agranulocytosis; Anemia, Macrocytic; Anemia, Pernicious; Anti-Infective Agents; Arthritis, Rheumatoid; Blood Platelets; Erythrocyte Count; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Middle Aged; Pyrimidines; Reticulocytes; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim; Vitamin B 12; Vitamin B 12 Deficiency	1972
Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow. Journal of clinical pathology, 1972, Volume: 25, Issue:3 Topics: Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Pyrimidines; Thymidine; Trimethoprim; Tritium	1972
Effect of trimethoprim-sulphamethoxazole combination on folate metabolism in malnourished children. Archives of disease in childhood, 1972, Volume: 47, Issue:254 Topics: Anti-Infective Agents; Blood Platelets; Child, Preschool; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Folic Acid Antagonists; Hemoglobins; Histidine; Humans; Infant; Kwashiorkor; Male; Nutrition Disorders; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections; Vitamin B 12	1972
[Sulfamethoxazole-Trimethoprim. A review of the side-effects in long-term treatment with particular attention to folic acid metabolism and hematological changes]. Ugeskrift for laeger, 1972, Nov-13, Volume: 134, Issue:46 Topics: Aged; Anemia, Macrocytic; Anti-Infective Agents; Catheterization; Cross Infection; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Middle Aged; Pyrimidines; Sulfamethoxazole; Trimethoprim	1972
A folic acid linked system in bacterial cell wall synthesis? The Journal of antibiotics, 1971, Volume: 24, Issue:10 Topics: Cell Wall; Folic Acid; Folic Acid Antagonists; Proteus; Trimethoprim	1971
Inhibitors of DNA precursor metabolism in Dictyostelium discoideum. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:5 Topics: Aminopterin; Antimetabolites; Dictyostelium; DNA; Floxuridine; Folic Acid; Hydroxyurea; Methotrexate; Time Factors; Trimethoprim	1982
Exogenous thymidine and reversal of the inhibitory effect of sulfamethoxazole-trimethoprim on streptococci. European journal of clinical microbiology, 1984, Volume: 3, Issue:5 Topics: Agar; Anti-Bacterial Agents; Caseins; Culture Media; Drug Combinations; Folic Acid; Protein Hydrolysates; Streptococcus; Sulfamethoxazole; Thymidine; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1984
Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole). Acta paediatrica Scandinavica, 1984, Volume: 73, Issue:6 Topics: Agranulocytosis; Amoxicillin; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Eosinophilia; Female; Folic Acid; Humans; Infant; Male; Neutropenia; Otitis Media; Risk; Sulfamethoxazole; Time Factors; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1984
Acute urinary tract infections and subsequent problems. Clinical obstetrics and gynecology, 1984, Volume: 27, Issue:4 Topics: Acute Disease; Aminoglycosides; Anti-Bacterial Agents; Bacteriuria; Cystitis; Drug Combinations; Female; Fetus; Folic Acid; Humans; Male; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Pyelonephritis; Recurrence; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections	1984
Bioavailability of a combination preparation of trimethoprim and folic acid. The Journal of international medical research, 1983, Volume: 11, Issue:5 Topics: Adult; Biological Availability; Drug Combinations; Female; Folic Acid; Humans; Male; Trimethoprim	1983
[Fragile X chromosome syndrome: a chromosomal defect associated with mental retardation]. Revista medica de Chile, 1983, Volume: 111, Issue:6 Topics: Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Sex Chromosome Aberrations; Trimethoprim; Vitamin B 12	1983
Photo-CIDNP studies of the influence of ligand binding on the surface accessibility of aromatic residues in dihydrofolate reductase. Biochemistry, 1980, May-27, Volume: 19, Issue:11 Topics: Folic Acid; Histidine; Lacticaseibacillus casei; Lasers; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Photochemistry; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim	1980
Thrombocytopenia secondary to trimethoprim-sulfamethoxazole. Southern medical journal, 1983, Volume: 76, Issue:4 Topics: Acute Disease; Child, Preschool; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Middle Aged; Otitis Media; Platelet Count; Sulfamethoxazole; Thrombocytopenia; Trimethoprim	1983
Antibiotics containing trimethoprim and the fragile X chromosome. The New England journal of medicine, 1983, Feb-03, Volume: 308, Issue:5 Topics: Anti-Bacterial Agents; Child, Preschool; Folic Acid; Folic Acid Antagonists; Fragile X Syndrome; Humans; Male; Sex Chromosome Aberrations; Trimethoprim	1983
Mechanism of action of the folate blocker diaminodiphenylsulfone (dapsone, DDS) studied in E. coli cell-free enzyme extracts in comparison to sulfonamides (SA). International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1980, Volume: 48, Issue:1 Topics: 4-Aminobenzoic Acid; Dapsone; Dose-Response Relationship, Drug; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Microbial Sensitivity Tests; Mycobacterium leprae; Structure-Activity Relationship; Sulfonamides; Trimethoprim	1980
Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase. Biochemistry, 1981, Feb-17, Volume: 20, Issue:4 Topics: Escherichia coli; Fluorescence; Folic Acid; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase; Trimethoprim	1981
[Molecular biology aspects of the antimicrobial effect of synthetic chemotherapeutic agents]. Zeitschrift fur arztliche Fortbildung, 1982, Aug-01, Volume: 76, Issue:15 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Biotransformation; Delayed-Action Preparations; Drug Combinations; Folic Acid; Humans; Mandelic Acids; Methenamine; Molecular Biology; Nalidixic Acid; Nitrofurans; Structure-Activity Relationship; Sulfamerazine; Sulfonamides; Trimethoprim; Urinary Tract Infections	1982
Rational automatic search method for stable docking models of protein and ligand. Journal of molecular biology, 1994, Oct-21, Volume: 243, Issue:2 Topics: Algorithms; Computer Simulation; Folic Acid; Hydrogen Bonding; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Ribonuclease T1; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim	1994
Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Analytical biochemistry, 1994, Feb-01, Volume: 216, Issue:2 Topics: 4-Aminobenzoic Acid; Carbon Radioisotopes; Escherichia coli; Folic Acid; Sulfathiazole; Sulfathiazoles; Time Factors; Trimethoprim	1994
The toxicity of antifolates in Babesia bovis. International journal for parasitology, 1993, Volume: 23, Issue:3 Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate	1993
Folate-sensitive and aphidicolin-inducible fragile sites are expressed in the genome of the domestic cat. Cancer genetics and cytogenetics, 1993, Volume: 65, Issue:2 Topics: Animals; Aphidicolin; Caffeine; Cats; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Female; Folic Acid; Male; Trimethoprim	1993
Protein expression in response to folate stress in Escherichia coli. Journal of bacteriology, 1997, Volume: 179, Issue:17 Topics: Bacterial Proteins; Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Folic Acid; Folic Acid Antagonists; Glycine; Heat-Shock Proteins; Inosine; Isoelectric Point; Methionine; Thymine; Trimethoprim	1997
Mechanism of the antimicrobial drug trimethoprim revisited. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:15 Topics: 4-Aminobenzoic Acid; Anti-Bacterial Agents; Escherichia coli; Folic Acid; Folic Acid Antagonists; Pteridines; Tetrahydrofolates; Trimethoprim	2000
Digested bacterial cell powder (DBCP) as a source of reduced-form folates for pigs: use of a trimethoprim-resistant strain and the bioavailability of folates in DBCP. Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:5 Topics: Animals; Biological Availability; Brevibacterium; Drug Resistance, Microbial; Folic Acid; Oxidation-Reduction; Powders; Swine, Miniature; Trimethoprim	2001
Myelotoxicity due to methotrexate - an iatrogenic cause. European journal of haematology, 2003, Volume: 71, Issue:4 Topics: Aged; Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Iatrogenic Disease; Methotrexate; Middle Aged; Trimethoprim	2003
Use of folic acid casei medium reveals trimethoprim susceptibility of Lactobacillus species. Letters in applied microbiology, 2004, Volume: 38, Issue:3 Topics: Anti-Infective Agents; Culture Media; Deoxyribonucleosides; Drug Resistance, Bacterial; Folic Acid; Folic Acid Antagonists; Lactobacillus; Microbial Sensitivity Tests; Thymidine Phosphorylase; Thymine; Trimethoprim	2004
Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography. Analytical chemistry, 2004, May-15, Volume: 76, Issue:10 Topics: Buffers; Chromatography, Affinity; Chromatography, Liquid; Ethylene Oxide; Folic Acid; Phase Transition; Porosity; Proteins; Pyrimethamine; Silanes; Silicon Dioxide; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim	2004
Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns. Analytical chemistry, 2005, May-15, Volume: 77, Issue:10 Topics: Automation; Binding Sites; Buffers; Chromatography, Affinity; Coumaric Acids; Fluorescein; Folic Acid; Image Interpretation, Computer-Assisted; Osmolar Concentration; Proteins; Pyrimethamine; Sensitivity and Specificity; Silicon Dioxide; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim	2005
Effects of co-operative ligand binding on protein amide NH hydrogen exchange. Journal of molecular biology, 2006, Mar-03, Volume: 356, Issue:4 Topics: Amides; Bacterial Proteins; Deuterium; Folic Acid; Hydrogen; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Ligands; Models, Molecular; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Trimethoprim	2006
[Development and application of screening method for steroid dihydrofolate reductase inhibitors by high performance capillary electrophoresis]. Se pu = Chinese journal of chromatography, 2007, Volume: 25, Issue:2 Topics: Alcohol Oxidoreductases; Electrophoresis, Capillary; Enzyme Inhibitors; Folic Acid; Methotrexate; Trimethoprim	2007
A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae. Journal of bacteriology, 2008, Volume: 190, Issue:2 Topics: Anti-Bacterial Agents; Dihydropteroate Synthase; DNA, Bacterial; Drug Resistance, Bacterial; Folic Acid; Gene Amplification; Gene Dosage; Oligonucleotide Array Sequence Analysis; Streptococcal Infections; Streptococcus agalactiae; Sulfonamides; Trimethoprim	2008
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 2007, Dec-25, Volume: 46, Issue:51 Topics: Catalysis; Crystallography, X-Ray; Folic Acid; Ligands; Models, Molecular; NADP; Protein Structure, Tertiary; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim	2007
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase. The Journal of biological chemistry, 2008, Feb-22, Volume: 283, Issue:8 Topics: Binding Sites; Catalysis; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Folic Acid; Folic Acid Antagonists; NADP; Osmosis; Oxidation-Reduction; Protein Structure, Quaternary; Sorbitol; Sweetening Agents; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water	2008
New mechanism for a classic folate inhibitor. Nature chemical biology, 2008, Volume: 4, Issue:10 Topics: Escherichia coli; Folic Acid; Folic Acid Antagonists; Molecular Structure; Signal Transduction; Trimethoprim	2008
Isolation and characterisation of an antifolate insensitive (afi1) mutant of Arabidopsis thaliana. Plant biology (Stuttgart, Germany), 2013, Volume: 15, Issue:1 Topics: Arabidopsis; Arabidopsis Proteins; Chromosome Mapping; Chromosomes, Plant; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Plant; Genetic Markers; Methotrexate; Mutation; Phenotype; Seedlings; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Trimethoprim; Up-Regulation	2013
Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. Epidemiology and infection, 2013, Volume: 141, Issue:8 Topics: Abortion, Spontaneous; Adult; Anti-Infective Agents, Urinary; Cohort Studies; Denmark; Female; Folic Acid; Folic Acid Antagonists; Humans; Pregnancy; Pregnancy Trimester, First; Proportional Hazards Models; Regression Analysis; Risk Factors; Socioeconomic Factors; Trimethoprim; Young Adult	2013
Trimethoprim during the 3 months before pregnancy: malformations in children. Prescrire international, 2016, Volume: 25, Issue:167 Topics: Abnormalities, Drug-Induced; Anti-Infective Agents, Urinary; Female; Folic Acid; Folic Acid Antagonists; Humans; Pregnancy; Trimethoprim	2016
Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations. Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13 Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Folic Acid; Folic Acid Antagonists; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Trimethoprim	2016
Mechanisms of Resistance to Folate Pathway Inhibitors in mBio, 2017, 09-05, Volume: 8, Issue:5 Topics: Anti-Bacterial Agents; Burkholderia pseudomallei; Drug Resistance, Multiple, Bacterial; Folic Acid; Folic Acid Antagonists; Humans; Melioidosis; Metabolic Networks and Pathways; Microbial Sensitivity Tests; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance; Trimethoprim, Sulfamethoxazole Drug Combination	2017
Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim. Microbial genomics, 2020, Volume: 6, Issue:11 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Biological Evolution; Escherichia coli; Folic Acid; Humans; Microbial Sensitivity Tests; Sulfonamides; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance	2020
Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs. Microbiology spectrum, 2021, 12-22, Volume: 9, Issue:3 Topics: Anti-Bacterial Agents; Biological Transport; Drug Resistance, Bacterial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Gene Deletion; Genome, Bacterial; Glutathione; Humans; Periplasm; Trimethoprim	2021