trimethoprim has been researched along with dihydrofolate in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bognar, A; Khanam, N; Kwon, YK; Lu, W; Melamud, E; Rabinowitz, JD | 1 |
| Bayley, PM; Hood, K; Roberts, GC | 1 |
| Hitchings, GH | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ | 1 |
| Itai, A; Mizutani, MY; Tomioka, N | 1 |
| McPartlin, J; Quinlivan, EP; Scott, J; Weir, DG | 1 |
| Brochet, M; Couvé, E; Glaser, P; Poyart, C; Zouine, M | 1 |
| DeRose, EF; Howell, EE; Jackson, MR; Krahn, JM; London, RE | 1 |
| Chopra, S; Dooling, RM; Horner, CG; Howell, EE | 1 |
| Brown, HA | 1 |
10 other study(ies) available for trimethoprim and dihydrofolate
| Article | Year |
|---|---|
A domino effect in antifolate drug action in Escherichia coli.
Topics: Computer Simulation; Escherichia coli; Escherichia coli Proteins; Folic Acid Antagonists; Gas Chromatography-Mass Spectrometry; Multienzyme Complexes; Peptide Synthases; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2008 |
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.
Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1979 |
Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.
Topics: Animals; Bacteria; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Methotrexate; Molecular Conformation; Molecular Structure; Nobel Prize; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim | 1989 |
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1989 |
Rational automatic search method for stable docking models of protein and ligand.
Topics: Algorithms; Computer Simulation; Folic Acid; Hydrogen Bonding; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Ribonuclease T1; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 1994 |
Mechanism of the antimicrobial drug trimethoprim revisited.
Topics: 4-Aminobenzoic Acid; Anti-Bacterial Agents; Escherichia coli; Folic Acid; Folic Acid Antagonists; Pteridines; Tetrahydrofolates; Trimethoprim | 2000 |
A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae.
Topics: Anti-Bacterial Agents; Dihydropteroate Synthase; DNA, Bacterial; Drug Resistance, Bacterial; Folic Acid; Gene Amplification; Gene Dosage; Oligonucleotide Array Sequence Analysis; Streptococcal Infections; Streptococcus agalactiae; Sulfonamides; Trimethoprim | 2008 |
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Topics: Catalysis; Crystallography, X-Ray; Folic Acid; Ligands; Models, Molecular; NADP; Protein Structure, Tertiary; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2007 |
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.
Topics: Binding Sites; Catalysis; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Folic Acid; Folic Acid Antagonists; NADP; Osmosis; Oxidation-Reduction; Protein Structure, Quaternary; Sorbitol; Sweetening Agents; Tetrahydrofolate Dehydrogenase; Trimethoprim; Water | 2008 |
New mechanism for a classic folate inhibitor.
Topics: Escherichia coli; Folic Acid; Folic Acid Antagonists; Molecular Structure; Signal Transduction; Trimethoprim | 2008 |