trimethoprim has been researched along with diaveridine in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (59.38) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukunaga, JY; Hansch, C; Jow, PY | 1 |
| Blaney, JM; Dietrich, SW; Hansch, C; Reynolds, MA | 1 |
| Richards, WG; So, SS | 1 |
| Hansch, C; Li, RL; Poe, M; Selassie, CD | 1 |
| Chan, JH; Roth, B | 1 |
| Debnath, G; Fang, ZX; Hansch, C; Kaufman, BT; Klein, TE; Langridge, R; Li, RL; Selassie, CD | 1 |
| Baccanari, DP; Champness, JN; Ferone, R; Hyde, RM; Rauckman, BS; Roth, B | 1 |
| Li, RL; Poe, M | 1 |
| Doweyko, AM | 1 |
| Aig, E; Roth, B | 1 |
| Fang, ZX; Hansch, C; Kaufman, BT; Klein, T; Langridge, R; Li, RL; Selassie, CD | 1 |
| Crippen, GM; Ghose, AK | 2 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Hopfinger, AJ | 1 |
| Blaney, JM; Hansch, C; Langridge, R; Li, R | 1 |
| Blaney, JM; Dietrich, SW; Hansch, C; Jow, PY; Reynolds, MA | 1 |
| Dietrich, SW; Hansch, C; Li, RL | 1 |
| Hansch, C; Kaufman, BT; Li, R | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Li, R; Selassie, CD | 1 |
| Battershell, C; Hopfinger, AJ; Malhotra, D | 1 |
| Crippen, GM | 1 |
| Loukas, YL | 1 |
| Intaraudom, C; Kamchonwongpaisan, S; Sirichaiwat, C; Thebtaranonth, Y; Vanichtanankul, J; Yuthavong, Y | 1 |
| Chaturongakul, S; Jiarpinitnun, C; Nilchan, N; Nowwarat, T; Phetsang, W | 1 |
| Giegler, G; Tömpe, P | 1 |
| Cushion, MT; Foy, JM; Kim, CK; Linke, MJ; Walzer, PD | 1 |
| Blagburn, BL; Butler, JM; Lindsay, DS; Rippey, NS | 1 |
| Nishikawa, M; Ogino, T; Ohta, T; Ono-Ogata, T; Yamagata, H | 1 |
| Liu, ZY; Sun, ZL; Wan, L; Wu, Y | 1 |
| Kong, XJ; Li, B; Li, JY; Li, SH; Liu, XW; Qin, Z; Yang, YJ | 1 |
| Ahmed, S; Chen, M; Han, X; Kong, D; Liu, Z; Pan, Y; Peng, D; Sheng, F; Tao, Y; Wang, Y; Yuan, Z | 1 |
32 other study(ies) available for trimethoprim and diaveridine
| Article | Year |
|---|---|
Quantitative structure-activity relationships of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Escherichia coli; Folic Acid Antagonists; Mathematics; Mice; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Streptococcus; Structure-Activity Relationship | 1977 |
Quantitative structure-activity relationship of 5-(X-benzyl)-2,4-diaminopyrimidines inhibiting bovine liver dihydrofolate reductase.
Topics: Animals; Cattle; Folic Acid Antagonists; In Vitro Techniques; Liver; Models, Biological; Pyrimidines; Structure-Activity Relationship | 1979 |
Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
Topics: Drug Design; Folic Acid Antagonists; Neural Networks, Computer; Pyrimidines; Regression Analysis; Structure-Activity Relationship | 1992 |
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Topics: Diamines; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Molecular Structure; Protein Binding; Pyrimidines; Structure-Activity Relationship | 1991 |
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 14. 2,3-Dihydro-1-(2,4-diamino-5-pyrimidyl)-1H-indenes as conformationally restricted analogues of trimethoprim.
Topics: Animals; Anti-Infective Agents; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Rats; Stereoisomerism; Structure-Activity Relationship; Trimethoprim | 1991 |
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Drug Design; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes.
Topics: Animals; Anti-Bacterial Agents; Binding Sites; Chickens; Escherichia coli; Folic Acid Antagonists; Indicators and Reagents; Liver; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neisseria gonorrhoeae; Plasmodium berghei; Protein Conformation; Pyrimidines; Rats; Structure-Activity Relationship; Trimethoprim | 1987 |
Quantitative structure-activity relationships for the inhibition of Escherichia coli dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Pyrimidines; Structure-Activity Relationship; Trimethoprim | 1988 |
The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Lactoylglutathione Lyase; Lyases; Microcomputers; Models, Chemical; Models, Molecular; Molecular Conformation; Saccharomyces cerevisiae; Structure-Activity Relationship; Thermodynamics | 1988 |
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.
Topics: Animals; Anti-Bacterial Agents; Chickens; Escherichia coli; Folic Acid Antagonists; Molecular Conformation; Pyrimidines; Structure-Activity Relationship; Trimethoprim | 1987 |
Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Topics: Animals; Chickens; Crystallography; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Mathematics; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1986 |
Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: a demonstration using Escherichia coli dihydrofolate reductase inhibitors.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Models, Molecular; Protein Conformation; Structure-Activity Relationship | 1985 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Theory and application of molecular potential energy fields in molecular shape analysis: a quantitative structure--activity relationship study of 2,4-diamino-5-benzylpyrimidines as dihydrofolate reductase inhibitors.
Topics: Escherichia coli; Folic Acid Antagonists; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Thermodynamics; Trimethoprim | 1983 |
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines | 1984 |
Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-act
Topics: Binding Sites; Computers; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Models, Molecular; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1982 |
Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
Topics: Animals; Cattle; Escherichia coli; Folic Acid Antagonists; Kinetics; Liver; Models, Theoretical; Pyrimidines; Structure-Activity Relationship | 1980 |
Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
Topics: Animals; Cattle; Escherichia coli; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Pyrimidines; Structure-Activity Relationship | 1981 |
A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver.
Topics: Animals; Cattle; Chickens; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Pyrimidines; Species Specificity | 1982 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Pyrimidines; Solubility | 1982 |
Inhibition of dihydrofolate reductase: structure-activity correlations of quinazolines based upon molecular shape analysis.
Topics: Chemical Phenomena; Chemistry, Physical; Folic Acid Antagonists; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 1981 |
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin | 1997 |
Adaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Topics: Algorithms; Folic Acid Antagonists; Multivariate Analysis; Pyrimidines; Quantitative Structure-Activity Relationship; Regression Analysis; Tetrahydrofolate Dehydrogenase | 2001 |
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Models, Molecular; Mutation; Plasmodium falciparum; Protein Binding; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 2004 |
Halogenated trimethoprim derivatives as multidrug-resistant Staphylococcus aureus therapeutics.
Topics: Anti-Bacterial Agents; Drug Synergism; Halogenation; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Structure-Activity Relationship; Sulfamethoxazole; Trimethoprim | 2018 |
[Polarographic determination of diaveridine in biological samples].
Topics: Animals; Humans; Polarography; Pyrimidines; Rats; Rats, Inbred Strains; Trimethoprim | 1990 |
Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia.
Topics: Animals; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Male; Pneumonia, Pneumocystis; Pyrimethamine; Pyrimidines; Rats; Rats, Inbred Strains; Sulfadiazine; Sulfadoxine; Sulfamethoxazole; Trimethoprim | 1988 |
Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine.
Topics: Animals; Anti-Infective Agents; Cell Line; Coccidiostats; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Folic Acid Antagonists; Humans; Male; Neospora; Pyrimethamine; Pyrimidines; Skin; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim | 1996 |
Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Drug Therapy, Combination; Escherichia coli; Mutagenicity Tests; Mutagens; Mutation; Nitrites; Primaquine; Pyrimethamine; Pyrimidines; Rats; Salmonella typhimurium; Trimethoprim | 2002 |
Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Male; Metabolic Networks and Pathways; Microsomes, Liver; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Swine; Trimethoprim | 2012 |
Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry.
Topics: Animal Feed; Animals; Calibration; Chickens; Chromatography, High Pressure Liquid; Pyrimidines; Reproducibility of Results; Tandem Mass Spectrometry; Trimethoprim | 2016 |
Broad-spectrum monoclonal antibody and a sensitive multi-residue indirect competitive enzyme-linked immunosorbent assay for the antibacterial synergists in samples of animal origin.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Haptens; Honey; Limit of Detection; Meat; Milk; Pyrimidines; Trimethoprim | 2019 |