trimethoprim has been researched along with cycloguanil in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genther, CS; Smith, CS | 1 |
| Crippen, GM; Ghose, AK | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Queener, SF | 1 |
| Marlowe, CK; Santi, DV; Selassie, CD | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Cichero, E; Espinoza, S; Gainetdinov, RR; Tonelli, M | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
| Booth, RG; Hansch, C; Neal, RA; Santi, DV; Sertsrivanich, R; Sirawaraporn, W | 1 |
| Basco, LK; Le Bras, J | 1 |
| Kamchonwongpaisan, S; Tarnchompoo, B; Taweechai, S; Vanichtanankul, J; Yuthavong, Y; Yuvaniyama, J | 1 |
| Borrmann, S; Kiara, SM; Masseno, V; Mwai, L; Nzila, A; Ochola, I; Okombo, J | 1 |
| Blundell, TL; Dias, MV; Domingues, RR; Paes Leme, AF; Tyrakis, P | 1 |
1 review(s) available for trimethoprim and cycloguanil
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
13 other study(ies) available for trimethoprim and cycloguanil
| Article | Year |
|---|---|
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Triazines | 1977 |
Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: a demonstration using Escherichia coli dihydrofolate reductase inhibitors.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Models, Molecular; Protein Conformation; Structure-Activity Relationship | 1985 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.
Topics: Folic Acid Antagonists; Fungal Proteins; Kinetics; Pneumocystis; Structure-Activity Relationship; Triazines | 1995 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
Topics: Absorption, Physicochemical; Animals; Biguanides; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2017 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Leishmania tropica; Proguanil; Pyrimethamine; Pyrimidines; Triazines; Trimethoprim | 1988 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Lethal Dose 50; Malaria, Falciparum; Nonlinear Dynamics; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1997 |
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Topics: Algorithms; Animals; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Folic Acid Antagonists; Humans; Kinetics; Mass Spectrometry; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Binding; Pyrimethamine; Recombinant Proteins; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 2005 |
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Genotype; Inhibitory Concentration 50; Kenya; Methotrexate; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2009 |
Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs.
Topics: Bacterial Proteins; Calorimetry; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Proguanil; Protein Conformation; Pyrimethamine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 2014 |